scholarly journals Microenvironmental determinants of organized iPSC-cardiomyocyte tissues on synthetic fibrous matrices

2021 ◽  
Vol 9 (1) ◽  
pp. 93-107
Author(s):  
Samuel J. DePalma ◽  
Christopher D. Davidson ◽  
Austin E. Stis ◽  
Adam S. Helms ◽  
Brendon M. Baker

This work provides microenvironmental design parameters to optimize iPSC-cardiomyocyte tissues formed on tunable synthetic matrices that mimic myocardial ECM.

Author(s):  
C J R Sheppard

The confocal microscope is now widely used in both biomedical and industrial applications for imaging, in three dimensions, objects with appreciable depth. There are now a range of different microscopes on the market, which have adopted a variety of different designs. The aim of this paper is to explore the effects on imaging performance of design parameters including the method of scanning, the type of detector, and the size and shape of the confocal aperture.It is becoming apparent that there is no such thing as an ideal confocal microscope: all systems have limitations and the best compromise depends on what the microscope is used for and how it is used. The most important compromise at present is between image quality and speed of scanning, which is particularly apparent when imaging with very weak signals. If great speed is not of importance, then the fundamental limitation for fluorescence imaging is the detection of sufficient numbers of photons before the fluorochrome bleaches.


Currently, the professional construction community information field is largely filled with the topic of creating a comfortable living environment. However, architectural and engineering design that corresponds to the concept of sustainable development is currently hindered due to the lack of a formed conceptual framework that reveals the meaning of the term "comfort", as well as a criteria list that determines the indoor environment quality in the Russian Federation regulatory and technical framework. The article offers some components of a comfortable living environment, within which the parameters of designing the internal environment of premises are highlighted. A comparative analysis of the national standards of the Russian Federation regulating the design of the internal space of residential and public buildings, with international "green" standards for a number of parameters was carried out. It is concluded that it is necessary to update the Russian regulatory and technical base taking into account the international experience of "green" standards.


2016 ◽  
Vol 22 (2(99)) ◽  
pp. 48-51
Author(s):  
D.S. Kalynychenko ◽  
◽  
Ye.Yu. Baranov ◽  
M.V. Poluian ◽  
◽  
...  

Author(s):  
P.Venu Gopala Rao ◽  
Eslavath Raja ◽  
Ramakrishna Gandi ◽  
G. Ravi Kumar

IoT (Internet of Things) has become most significant area of research to design an efficient data enabled services with the help of sensors. In this paper, a low-cost system design for e-healthcare service to process the sensitive health data is presented. Vital signs of the human body are measured from the patient location and shared with a registered medical professional for consultation. Temperature and heart rate are the major signals obtained from a patient for the initial build of the system. Data is sent to a cloud server where processing and analysis is provided for the medical professional to analyze. Secure transmission and dissemination of data through the cloud server is provided with an authentication system and the patient could be able to track his data through a smart phone on connecting to the cloud server. A prototype of the system along with its design parameters has been discussed.


Author(s):  
V. E. Perekutnev ◽  
V. V. Zotov

Upgrading of hoisting machines aims to improve their performance, to reduce risk of accidents, and to cut down operational and capital costs. One of the redesign solutions is replacement of steel cables by rubber cables. This novation can extend life of pulling members, decrease diameters of drive and guide wheels and, consequently, elements of the whole hoisting machines: rotor, reducing gear, motor. This engineering novation needs re-designing of hoisting machines; thus, the new design should be validated, in particular, strength characteristics of the machine members. This article considers a drive wheel of a hoisting machine with a pulling belt. In order to justify the potential range of design parameters with regard to safety factor, the numerical models of different-design drive wheels are developed and their operation with pulling belt (rubber cable) is simulated in the SolidWorks environment. The data on the stress state of the wheel elements are analyzed, the most loaded points are identified, and the maximal stresses on the sidewall surface and in the spokes of wheels of different designs are plotted.


Author(s):  
Nikolay S. Shulaev ◽  
◽  
Valeriya V. Pryanichnikova ◽  
Ramil R. Kadyrov ◽  
Inna V. Ovsyannikova ◽  
...  

The most essential scientifific and practical task in the area of ecological safety of pipelines operation is the development and improvement of methods of purifification and restoration of oil-contaminated soils. One of the most effificient and cost effective methods is electrochemical purifification, that does not require the use of expensive chemical reagents and soil excavation. However, the consideration of non-uniform contamination of various soil sections is required. The article examines the features of the organization and technological infrastructure for electrochemical purifification of non-uniformly contaminated soils when using a single electrical energy source, a method for calculating the design parameters of the corresponding installation is proposed. Effificient purifification of non-uniformly contaminated soil when using a specifified voltage is possible through the use of different-sized electrodes. For each soil type, the amount of transmitted electric charge required for soil purifification is determined by the concentration of the contaminant. Allocation of cathodes and anodes as parallel batteries and their connection using individual buses is an effective and energy-effificient solution, since an almost-uniform electric fifield is created in an inter-electrode space, thus allowing the reduction of the interelectrode resistance of the medium.


Sign in / Sign up

Export Citation Format

Share Document