scholarly journals The relationship of the oestrogen and progestin receptors in the abnormal uterus of the adult anovulatory rat. Effects of neonatal treatment with testosterone propionate or clomiphene citrate

1981 ◽  
Vol 196 (2) ◽  
pp. 557-565 ◽  
Author(s):  
J O White ◽  
P A Moore ◽  
M G Elder ◽  
L Lim
Keyword(s):  
Oestrogen Receptor ◽  
Testosterone Propionate ◽  
Clomiphene Citrate ◽  
Treated Group ◽  
Progestin Receptors ◽  
Treatment Groups ◽  
Receptor Interactions ◽  
Neonatal Administration ◽  
Relationship Of ◽  
The Relationship

The neonatal administration of testosterone propionate to Wistar rats resulted in anovulatory adults in persistent vaginal oestrus. Clomiphene citrate had a similar effect. In both groups of adults, hyperplasia of the uterine epithelium and occasional metaplasia was observed. The uterine nuclear and cytosol oestrogen and progestin receptors of these anovulatory rats were found to have affinities for their respective ligands similar to those of normal females. The nuclear oestrogen receptor comprised occupied and unoccupied components, as in normal females. The content of the nuclear oestrogen receptor was comparable with that of females in the late dioestrous or pro-oestrous phase. This content was higher in the clomiphene-treated group. Despite the relatively high nuclear oestrogen receptor content the content of progestin receptors, a putative index of the oestrogenic response, was lower in the treated rats than in normal adult females throughout the cycle. Administration of oestradiol to both treatment groups resulted in depletion of cytosol oestrogen receptor content 1 h later, which, however, was not reflected by an increase in the content of nuclear oestrogen receptors. There was no measurable increase in progesterone receptor content in treated rats after daily administration of oestrogen (5 microgram/rat) for 3 days. These changes in sex-hormone-receptor interactions involving an impairment of the normal oestrogenic response may be associated with the abnormal differentiation of the uterus in these sterile, anovulatory animals.

scholarly journals Progesterone therapy results in partial reversibility of uterine abnormalities of the adult anovulatory rat

1982 ◽  
Vol 202 (2) ◽  
pp. 535-541 ◽  
Author(s):  
J O White ◽  
P A Moore ◽  
M G Elder ◽  
L Lim
Keyword(s):  
Oestrogen Receptor ◽  
Wistar Rats ◽  
Testosterone Propionate ◽  
Clomiphene Citrate ◽  
Treated Group ◽  
Model System ◽  
Luminal Epithelium ◽  
Neonatal Treatment ◽  
Progestin Receptors ◽  
Biochemical Mechanisms

The effects of progesterone therapy (5 mg, administered subcutaneously daily for 6 days) on the abnormal uterus of adult anovulatory Wistar rats have been studied. These rats, rendered anovulatory by neonatal treatment with testosterone propionate or clomiphene citrate, displayed severe hyperplasia and metaplasia of the uterine luminal epithelium and a disproportionately high content of nuclear oestrogen receptor, as a result of constant oestrogen stimulation unrelieved by progesterone [White, Moore, Elder & Lim (1981) Biochem. J. 196, 557-565]. Progesterone therapy resulted in the virtual elimination of the hyperplasia and metaplasia and a corresponding decrease in the content of nuclear oestrogen receptor with the proportion of the unoccupied nuclear receptor being increased to values exhibited by normal cyclic females. There was also a decrease in the content of progestin receptors, a putative index of oestrogenic stimulation. Further, in the testosterone-treated group, progesterone therapy resulted in the restoration of oestrogen receptor translocational responses to oestradiol stimulation. Progesterone treatment of these anovulatory rats thus provides a model system for investigating the biochemical mechanisms underlying progestin antagonism and regulation of oestrogen-stimulated cell proliferation.

scholarly journals A comparison of the relationships between progestin receptors and oestrogen receptors in neural and non-neural target tissues of the rat during the oestrous cycle

1980 ◽  
Vol 190 (3) ◽  
pp. 691-695 ◽  
Author(s):  
S Thrower ◽  
L Lim
Keyword(s):  
Cerebral Cortex ◽  
Oestrogen Receptor ◽  
Oestrous Cycle ◽  
Oestrogen Receptors ◽  
Progestin Receptors ◽  
Progestin Receptor ◽  
Cyclic Changes ◽  
Relationship Of ◽  
The Relationship

Similar cyclic changes in the content of nuclear oestrogen receptor occurred in the hypothalamus, cerebral cortex, uterus and pituitary during the oestrous cycle. The relationship of the unoccupied to the total nuclear oestrogen receptor at each phase was similar in all these tissues. However, cyclic changes in the content of the cytosol progestin receptor occurred only in the uterus and pituitary (where they paralleled changes in the nuclear oestrogen receptor), but not in the hypothalamus or cerebral cortex.

Patterns of Symptom Distress in Adults Receiving Treatment for Lung Cancer

2002 ◽  
Vol 18 (3) ◽  
pp. 150-159 ◽  
Author(s):  
Mary E. Cooley ◽  
Thomas H. Short ◽  
Helene J. Moriarty
Keyword(s):  
Lung Cancer ◽  
Secondary Analysis ◽  
Symptom Distress ◽  
Course Of Illness ◽  
Lung Cancer Patients ◽  
Treatment Groups ◽  
Relationship Of ◽  
The Relationship ◽  
Over Time

Knowledge of the patterns of symptom distress in adults receiving treatment for lung cancer is an important first step in developing interventions that can potentially lessen symptom distress. The purposes of this secondary analysis were to describe the changes in patterns of symptom distress over time in adults receiving treatment for lung cancer, and to examine the relationship of selected demographic and clinical characteristics to symptom distress. Complete data were available for 117 patients. The patterns of symptom distress in adults receiving treatment for lung cancer varied between treatment groups and over time. Symptom distress scores were moderate to high on entry into the study, indicating that symptom management in newly diagnosed lung cancer patients is essential and should begin early in the course of illness. Moreover, clinical interventions should be tailored to the type of treatment. Various demographic and clinical variables were weak and inconsistent predictors of symptom distress, underscoring the importance of examining the role of psychosocial factors in mediating symptom distress.

An investigation into the efficacy of the Te Pari Patesco knife in providing a bare tip and the relationship between tail length and dag score in unmulesed Merino lambs

2012 ◽  
Vol 52 (7) ◽  
pp. 671
Author(s):  
J. E. Smith ◽  
R. G. Woodgate ◽  
C. A. Curnow ◽  
D. L. Michael ◽  
A. J. Van Burgel
Keyword(s):  
Tail Length ◽  
Treated Group ◽  
Treatment Groups ◽  
The Third ◽  
Tail Tip ◽  
The Relationship ◽  
Marking Time ◽  
Standard Gas

This study investigated dag accumulation between marking time and first shearing and wool cover of the tip of the tail in a total of 842 ewes and wethers, tailed either at the second or third joint using a standard gas knife or at the third joint using the Te Pari Patesco gas knife. Four hundred of the ewes had further measurements taken in 2011. The Te Pari-treated animals had significantly (P < 0.05) less wool on the tail tip than lambs treated with a standard gas knife. There were no significant differences in dag score between treatment groups in 2010; however, there were significantly (P < 0.05) less dags on animals in the Te Pari-treated group in 2011. This effect needs to be further investigated in a range of sheep genotypes, locations and seasons.

Comparative Analysis of Personality Structures of the Perpetrators of Aggressive and Non-aggressive Offense

2014 ◽  
Vol 6 (3) ◽  
pp. 94-103 ◽  
Author(s):  
A.S. Kalashnikova ◽  
T.G. Vasilenko
Keyword(s):  
Comparative Analysis ◽  
Statistical Analysis ◽  
Structural Analysis ◽  
Qualitative Analysis ◽  
Psychological Characteristics ◽  
Treatment Groups ◽  
Criminal Offenses ◽  
Violent Offenses ◽  
Relationship Of ◽  
The Relationship

The problem of the emergence of aggressive behavior is seen through the analysis of the relationship of proagressive and inhibiting aggression personality structures. The study involved 54 men serving sentences for criminal offenses, of which 24 were accused for violent offenses and 30 - for offenses without resorting to violence. We used questionnaires to study the proagressive and deterring aggression personality structures. Statistical analysis was performed to reveal significant differences between groups and to determine correlations. On this basis, the correlations were interpreted with the help of not only quantitative but also qualitative analysis. The results showed no significant differences in the level of expression of aggression and aggression inhibitors between treatment groups, but we identified qualitative differences in the structural analysis of data from individual psychological characteristics that are expected to distinguish aggressive offenders from the perpetrators without violence.

scholarly journals Adaptive increase in phytate digestibility by phosphorus-deprived rats and the relationship of intestinal phytase (EC 3.1.3.8) and alkaline phosphatase (EC 3.1.3.1) to phytate utilization

1983 ◽  
Vol 49 (1) ◽  
pp. 145-152 ◽  
Author(s):  
Robert J. Moore ◽  
Trygve L. Veum
Keyword(s):  
Alkaline Phosphatase ◽  
Inositol Phosphates ◽  
Enzymic Hydrolysis ◽  
Intestinal Alkaline Phosphatase ◽  
Alkaline Phytase ◽  
Treatment Groups ◽  
Phosphorus Deprivation ◽  
Relationship Of ◽  
The Relationship ◽  
Hydrolysis Of

1. The effects of phosphorus deprivation on phytate digestibility, phosphorus utilization and intestinal phytase (EC3.1.3.8) and alkaline phosphatase (EC3.1.3.1) in rats were investigated.2. P deprivation was achieved by giving rats a diet containing 3 g P/kg and resulted in hypophosphataemia, hypercalcaemia, hypercalciuria, and lower levels of P absorbed and retained, and calcium retained.3. Rats adapted to P deprivation by increasing the digestion of total dietary-P and phytate-P.4. Levels of intestinal alkaline phosphatase and alkaline phytase were not different between the two treatment groups.5. P deprivation in the rats given the marginal-P diet may be a result of a lower absorption of total dietary-P or increased absorption of inositol phosphates formed during the enzymic hydrolysis of phytate which are not readily utilized by the rat.6. These results suggest that intestinal phytase and alkaline phosphatase do not play a role in the adaptive increase in phytate digestibility by rats given marginal-P diets. The adaptation may result from enhanced phytase or alkaline phosphatase synthesis by the gastrointestinal microflora stimulated by a lower level of P in the digesta.

scholarly journals Age-related response of IL-4/Luc/CNS-1 transgenic miceto phthalic anhydrideexposure

2016 ◽  
Vol 68 (1) ◽  
pp. 145-154
Author(s):  
Ji Sung ◽  
Ji Kim ◽  
Jun Go ◽  
Eun Koh ◽  
Sung Song ◽  
...  
Keyword(s):  
Allergic Inflammation ◽  
Treated Group ◽  
Cell Number ◽  
Susceptibility To Infection ◽  
Dermal Thickness ◽  
Age Related ◽  
Therapeutic Compounds ◽  
Relationship Of ◽  
The Relationship ◽  
Old Mice

Age-related changes are associated with susceptibility to infection, malignancy, autoimmunity, response to vaccination and wound healing. To investigate the relationship of several pathological phenotypes of allergic inflammationto age, alterations in theIL-4 derived luciferase signal and general phenotype biomarkers were measured in young (2-month-old) and old (12-month-old) IL-4/Luc/CNS-1 transgenic (Tg) mice with phthalic anhydride (PA)-induced allergic inflammationfor 2 weeks. There was no difference in the ear phenotypes and thickness between young and old mice, although these levels were higher in the PA-treated group thantheacetone-olive oil (AOO)-treated group. The luciferase signal was detected in the mesenteric lymph node (ML), thymus and pancreas of both young and old PA-treated mice, but showed a greater increasein old Tg mice (exceptin thethymus). Agreaterincrease inthe epidermal thickness and dermal thickness was measured in old PA-treated mice than young PA-treated mice, while total mast cell number remainedconstant in both groups. Furthermore, the concentration of IgE was greater in young PA-treated mice than in old PA-treated mice,as wasthe expression of VEGF and IL-6. Taken together, theresults of this study showed that an animal?s age is an important factor that must be considered when PA-induced allergic inflammation in IL-4/Luc/CNS-1 Tg mice areinvestigated to screen for allergens and therapeutic compounds.

Attitudinal Study of Graphic Computer-Based Instruction for Punctuation

1986 ◽  
Vol 16 (3) ◽  
pp. 267-272 ◽  
Author(s):  
Carolena L. Smith
Keyword(s):  
Student Attitude ◽  
Attitude Questionnaire ◽  
Treatment Groups ◽  
Computer Based Instruction ◽  
Significant Difference ◽  
Computer Based ◽  
Based Instruction ◽  
Relationship Of ◽  
The Relationship

The purpose of this study was to evaluate the relationship of student attitude using graphic enhanced versus nongraphic enhanced computer-based instruction. Four intact groups were randomly assigned treatment. Two groups received graphic instruction and two groups received nongraphic computer-based instruction. An attitude questionnaire was administered to evaluate student attitude toward the graphic and nongraphic computer-based instruction. Results of t-tests indicated there was no significant difference in attitude scores between graphic and nongraphic treatment groups at the .05 level.

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