scholarly journals Synthetic biology meets tissue engineering

2016 ◽  
Vol 44 (3) ◽  
pp. 696-701 ◽  
Author(s):  
Jamie A. Davies ◽  
Elise Cachat
Keyword(s):  
Tissue Engineering ◽  
Synthetic Biology ◽  
Life Support ◽  
State Of The Art ◽  
Living Cells ◽  
Extracellular Matrices ◽  
Fetal Life ◽  
Normal Human ◽  
Future Work ◽  
Made In

Classical tissue engineering is aimed mainly at producing anatomically and physiologically realistic replacements for normal human tissues. It is done either by encouraging cellular colonization of manufactured matrices or cellular recolonization of decellularized natural extracellular matrices from donor organs, or by allowing cells to self-organize into organs as they do during fetal life. For repair of normal bodies, this will be adequate but there are reasons for making unusual, non-evolved tissues (repair of unusual bodies, interface to electromechanical prostheses, incorporating living cells into life-support machines). Synthetic biology is aimed mainly at engineering cells so that they can perform custom functions: applying synthetic biological approaches to tissue engineering may be one way of engineering custom structures. In this article, we outline the ‘embryological cycle’ of patterning, differentiation and morphogenesis and review progress that has been made in constructing synthetic biological systems to reproduce these processes in new ways. The state-of-the-art remains a long way from making truly synthetic tissues, but there are now at least foundations for future work.

scholarly journals A comparative analysis of synthetic genetic oscillators

2010 ◽  
Vol 7 (52) ◽  
pp. 1503-1524 ◽  
Author(s):  
Oliver Purcell ◽  
Nigel J. Savery ◽  
Claire S. Grierson ◽  
Mario di Bernardo
Keyword(s):  
Experimental Data ◽  
Comparative Analysis ◽  
Time Delay ◽  
Synthetic Biology ◽  
Gene Regulatory Networks ◽  
Network Topology ◽  
Regulatory Networks ◽  
State Of The Art ◽  
Gene Regulatory ◽  
Future Work

Synthetic biology is a rapidly expanding discipline at the interface between engineering and biology. Much research in this area has focused on gene regulatory networks that function as biological switches and oscillators. Here we review the state of the art in the design and construction of oscillators, comparing the features of each of the main networks published to date, the models used for in silico design and validation and, where available, relevant experimental data. Trends are apparent in the ways that network topology constrains oscillator characteristics and dynamics. Also, noise and time delay within the network can both have constructive and destructive roles in generating oscillations, and stochastic coherence is commonplace. This review can be used to inform future work to design and implement new types of synthetic oscillators or to incorporate existing oscillators into new designs.

Hydrogels as Extracellular Matrices for Skeletal Tissue Engineering: State-of-the-Art and Novel Application in Organ Printing

2007 ◽  
Vol 13 (8) ◽  
pp. 1905-1925 ◽  
Author(s):  
Natalja E. Fedorovich ◽  
Jacqueline Alblas ◽  
Joost R. de Wijn ◽  
Wim E. Hennink ◽  
Ab J. Verbout ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
State Of The Art ◽  
Extracellular Matrices ◽  
Skeletal Tissue ◽  
Engineering State ◽  
Organ Printing

scholarly journals Bioinspired Networks of Communicating Synthetic Protocells

2021 ◽  
Vol 8 ◽  
Author(s):  
Patrick J. Grimes ◽  
Agostino Galanti ◽  
Pierangelo Gobbo
Keyword(s):  
Tissue Engineering ◽  
Synthetic Biology ◽  
Regenerative Medicine ◽  
Living Cells ◽  
Chemical Signals ◽  
Biological Cells ◽  
Bottom Up ◽  
Grand Challenges ◽  
The Past

The bottom-up synthesis of cell-like entities or protocells from inanimate molecules and materials is one of the grand challenges of our time. In the past decade, researchers in the emerging field of bottom-up synthetic biology have developed different protocell models and engineered them to mimic one or more abilities of biological cells, such as information transcription and translation, adhesion, and enzyme-mediated metabolism. Whilst thus far efforts have focused on increasing the biochemical complexity of individual protocells, an emerging challenge in bottom-up synthetic biology is the development of networks of communicating synthetic protocells. The possibility of engineering multi-protocellular systems capable of sending and receiving chemical signals to trigger individual or collective programmed cell-like behaviours or for communicating with living cells and tissues would lead to major scientific breakthroughs with important applications in biotechnology, tissue engineering and regenerative medicine. This mini-review will discuss this new, emerging area of bottom-up synthetic biology and will introduce three types of bioinspired networks of communicating synthetic protocells that have recently emerged.

Biological Production of (S)-acetoin: A State-of-the-Art Review

2019 ◽  
Vol 19 (25) ◽  
pp. 2348-2356 ◽  
Author(s):  
Neng-Zhong Xie ◽  
Jian-Xiu Li ◽  
Ri-Bo Huang
Keyword(s):  
Side Effects ◽  
Chemical Synthesis ◽  
State Of The Art ◽  
Optically Active ◽  
Considerable Progress ◽  
Future Prospects ◽  
Chiral Compound ◽  
Biological Production ◽  
Acetoin Production ◽  
Made In

Acetoin is an important four-carbon compound that has many applications in foods, chemical synthesis, cosmetics, cigarettes, soaps, and detergents. Its stereoisomer (S)-acetoin, a high-value chiral compound, can also be used to synthesize optically active drugs, which could enhance targeting properties and reduce side effects. Recently, considerable progress has been made in the development of biotechnological routes for (S)-acetoin production. In this review, various strategies for biological (S)- acetoin production are summarized, and their constraints and possible solutions are described. Furthermore, future prospects of biological production of (S)-acetoin are discussed.

scholarly journals The first 10 years of the international coordination network for standards in systems and synthetic biology (COMBINE)

2020 ◽  
Vol 17 (2-3) ◽  
Author(s):  
Dagmar Waltemath ◽  
Martin Golebiewski ◽  
Michael L Blinov ◽  
Padraig Gleeson ◽  
Henning Hermjakob ◽  
...  
Keyword(s):  
Synthetic Biology ◽  
Data Model ◽  
Computational Models ◽  
Life Sciences ◽  
The Past ◽  
Challenges And Opportunities ◽  
Stakeholder Workshop ◽  
Software Engineers ◽  
Future Work ◽  
Modeling In Biology

AbstractThis paper presents a report on outcomes of the 10th Computational Modeling in Biology Network (COMBINE) meeting that was held in Heidelberg, Germany, in July of 2019. The annual event brings together researchers, biocurators and software engineers to present recent results and discuss future work in the area of standards for systems and synthetic biology. The COMBINE initiative coordinates the development of various community standards and formats for computational models in the life sciences. Over the past 10 years, COMBINE has brought together standard communities that have further developed and harmonized their standards for better interoperability of models and data. COMBINE 2019 was co-located with a stakeholder workshop of the European EU-STANDS4PM initiative that aims at harmonized data and model standardization for in silico models in the field of personalized medicine, as well as with the FAIRDOM PALs meeting to discuss findable, accessible, interoperable and reusable (FAIR) data sharing. This report briefly describes the work discussed in invited and contributed talks as well as during breakout sessions. It also highlights recent advancements in data, model, and annotation standardization efforts. Finally, this report concludes with some challenges and opportunities that this community will face during the next 10 years.

Factors of Dementia Caregiver Burden Differentially Contribute to Desire to Institutionalize

2021 ◽  
pp. 089198872110361
Author(s):  
John T. Martin ◽  
Kimberly R. Chapman ◽  
Christopher Was ◽  
Mary Beth Spitznagel
Keyword(s):  
Factor Analysis ◽  
Linear Regression ◽  
Factor Structure ◽  
Caregiver Burden ◽  
Living Arrangements ◽  
Regression Analyses ◽  
Loved One ◽  
Dementia Caregiver ◽  
Future Work ◽  
Made In

The experience of dementia caregiver burden is multidimensional. Little is known about how different aspects of burden contribute to the consideration of moving a loved one to a structured living facility. In the present study, caregiver burden (Zarit Burden Interview; ZBI) and consideration of structured living arrangements (Desire to Institutionalize Scale; DIS) were self-reported by 339 caregivers. Exploratory factor analysis was used to determine the ZBI factor structure; these factors were then examined via hierarchical linear regression for prediction of DIS. Factor analysis indicated a 4-factor ZBI solution: Impact on Life, Guilt, Embarrassment/Frustration, and Escape/Uncertainty. Regression analyses indicated that only Escape/Uncertainty ( p < .001) was associated with DIS. Of the 4 identified factors of caregiver burden, desire to escape the caregiving role was most related to consideration of structured living arrangements. Future work should explore longitudinal contribution of this factor to determine its role in actual changes made in living arrangements.

Scaffolds for Bone Tissue Engineering: State of the art and new perspectives

2017 ◽  
Vol 78 ◽  
pp. 1246-1262 ◽  
Author(s):  
Livia Roseti ◽  
Valentina Parisi ◽  
Mauro Petretta ◽  
Carola Cavallo ◽  
Giovanna Desando ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
State Of The Art ◽  
Engineering State

scholarly journals Additive manufacturing of PLA-based scaffolds intended for bone regeneration and strategies to improve their biological properties

e-Polymers ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 571-599
Author(s):  
Ricardo Donate ◽  
Mario Monzón ◽  
María Elena Alemán-Domínguez
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Bone Regeneration ◽  
Polylactic Acid ◽  
State Of The Art ◽  
Biological Properties ◽  
Design Stage ◽  
Bone Scaffolds ◽  
Regeneration Of Bone

AbstractPolylactic acid (PLA) is one of the most commonly used materials in the biomedical sector because of its processability, mechanical properties and biocompatibility. Among the different techniques that are feasible to process this biomaterial, additive manufacturing (AM) has gained attention recently, as it provides the possibility of tuning the design of the structures. This flexibility in the design stage allows the customization of the parts in order to optimize their use in the tissue engineering field. In the recent years, the application of PLA for the manufacture of bone scaffolds has been especially relevant, since numerous studies have proven the potential of this biomaterial for bone regeneration. This review contains a description of the specific requirements in the regeneration of bone and how the state of the art have tried to address them with different strategies to develop PLA-based scaffolds by AM techniques and with improved biofunctionality.

Developments in Rechargeable Mno2Electrodes for Lithium Batteries

1988 ◽  
Vol 135 ◽  
Author(s):  
Michael M Thackeray
Keyword(s):  
Lithium Batteries ◽  
Lithium Battery ◽  
Electrode Materials ◽  
State Of The Art ◽  
Structural Features ◽  
Rechargeable Batteries ◽  
Current State ◽  
Alternative Systems ◽  
Battery Technology ◽  
Made In

AbstractConsiderable efforts are in progress to develop rechargeable batteries as alternative systems to the nickel-cadmium battery. In this regard, several advances have been made in ambient-temperature lithium battery technology, and specifically in the engineering of rechargeable lithium/manganese dioxide cells. This paper reviews the current state of the art in rechargeable Li/MnO2battery technology; particular attention is paid to the structural features of various MnO2electrode materials which influence their electrochemical and cycling behaviour in lithium cells.

Progress and Prospects for the Development of Computer-Generated Actors for Military Simulation: Part 1-Introduction and Background

2003 ◽  
Vol 12 (3) ◽  
pp. 311-325 ◽  
Author(s):  
Martin R. Stytz ◽  
Sheila B. Banks
Keyword(s):  
Research Area ◽  
Background Information ◽  
Life Cycle Costs ◽  
Material Management ◽  
Reasoning System ◽  
Force Structure ◽  
The Cost ◽  
Future Work ◽  
Level Training ◽  
Made In

The development of computer-generated synthetic environments, also calleddistributed virtual environments, for military simulation relies heavily upon computer-generated actors (CGAs) to provide accurate behaviors at reasonable cost so that the synthetic environments are useful, affordable, complex, and realistic. Unfortunately, the pace of synthetic environment development and the level of desired CGA performance continue to rise at a much faster rate than CGA capability improvements. This insatiable demand for realism in CGAs for synthetic environments arises from the growing understanding of the significant role that modeling and simulation can play in a variety of venues. These uses include training, analysis, procurement decisions, mission rehearsal, doctrine development, force-level and task-level training, information assurance, cyberwarfare, force structure analysis, sustainability analysis, life cycle costs analysis, material management, infrastructure analysis, and many others. In these and other uses of military synthetic environments, computer-generated actors play a central role because they have the potential to increase the realism of the environment while also reducing the cost of operating the environment. The progress made in addressing the technical challenges that must be overcome to realize effective and realistic CGAs for military simulation environments and the technical areas that should be the focus of future work are the subject of this series of papers, which survey the technologies and progress made in the construction and use of CGAs. In this, the first installment in the series of three papers, we introduce the topic of computer-generated actors and issues related to their performance and fidelity and other background information for this research area as related to military simulation. We also discuss CGA reasoning system techniques and architectures.

Sign in / Sign up

Export Citation Format

Share Document