Targetable nano-delivery vehicles to deliver anti-bacterial small acid-soluble spore protein (SASP) genes

2021 ◽  
Author(s):  
Anne M. L. Barnard ◽  
James A. Cass
Keyword(s):  
Bacterial Infections ◽  
Treatment Options ◽  
Resistant Bacteria ◽  
Wild Type ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Specific Target ◽  
Delivery Vehicles ◽  
New Treatment

Interest in phage-based therapeutics is increasing, at least in part due to the need for new treatment options for infections caused by antibiotic-resistant bacteria. It is possible to use wild-type (WT) phages to treat bacterial infections, but it is also possible to modify WT phages to generate therapeutics with improved features. Here, we will discuss features of Phico Therapeutics’ SASPject technology, which modifies phages for use as targetable nano-delivery vehicles (NDV), to introduce antibacterial Small Acid Soluble Spore Protein (SASP) genes into specific target bacteria.

scholarly journals Antibiotic-Resistant Bacteria in Clams—A Study on Mussels in the River Rhine

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 571
Author(s):  
Nicole Zacharias ◽  
Iris Löckener ◽  
Sarah M. Essert ◽  
Esther Sib ◽  
Gabriele Bierbaum ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Sewage Treatment ◽  
Sewage Treatment Plant ◽  
Treatment Plant ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
River Rhine ◽  
Antibiotic Resistant Bacteria ◽  
Surrounding Water ◽  
Antibiotic Resistant

Bacterial infections have been treated effectively by antibiotics since the discovery of penicillin in 1928. A worldwide increase in the use of antibiotics led to the emergence of antibiotic resistant strains in almost all bacterial pathogens, which complicates the treatment of infectious diseases. Antibiotic-resistant bacteria play an important role in increasing the risk associated with the usage of surface waters (e.g., irrigation, recreation) and the spread of the resistance genes. Many studies show that important pathogenic antibiotic-resistant bacteria can enter the environment by the discharge of sewage treatment plants and combined sewage overflow events. Mussels have successfully been used as bio-indicators of heavy metals, chemicals and parasites; they may also be efficient bio-indicators for viruses and bacteria. In this study an influence of the discharge of a sewage treatment plant could be shown in regard to the presence of E. coli in higher concentrations in the mussels downstream the treatment plant. Antibiotic-resistant bacteria, resistant against one or two classes of antibiotics and relevance for human health could be detected in the mussels at different sampling sites of the river Rhine. No multidrug-resistant bacteria could be isolated from the mussels, although they were found in samples of the surrounding water body.

scholarly journals Immunotherapy and vaccination against infectious diseases

2020 ◽  
Author(s):  
Meinolf Ebbers ◽  
Christoph J. Hemmer ◽  
Brigitte Müller-Hilke ◽  
Emil C. Reisinger
Keyword(s):  
Infectious Disease ◽  
Infectious Diseases ◽  
Bacterial Infections ◽  
Treatment Options ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Therapeutic Antibodies ◽  
Immunomodulatory Drugs ◽  
Multidrug Resistant Bacteria ◽  
New Treatment

SummaryDue to the overuse of antibiotics, infections, in particular those caused by multidrug-resistant bacteria, are becoming more and more frequent. Despite the worldwide introduction of antibiotic therapy, vaccines and constant improvements in hygiene, the burden of multidrug-resistant bacterial infections is increasing and is expected to rise in the future. The development of monoclonal therapeutic antibodies and specific immunomodulatory drugs represent new treatment options in the fight against infectious diseases. This article provides a brief overview of recent advances in immunomodulatory therapy and other strategies in the treatment of infectious disease.

scholarly journals Development of coinage metal nanoclusters as antimicrobials to combat bacterial infections

2020 ◽  
Vol 8 (41) ◽  
pp. 9466-9480
Author(s):  
Dan Li ◽  
Beena Kumari ◽  
Jessa Marie Makabenta ◽  
Bailong Tao ◽  
Kun Qian ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Economic Loss ◽  
Resistant Bacteria ◽  
Metal Nanoclusters ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Coinage Metal ◽  
The Past

Infections from antibiotic-resistant bacteria have caused huge economic loss and numerous deaths over the past decades.

Water-soluble branched polymer for combined chemo-immunotherapy of bacterial infections

2021 ◽  
Author(s):  
Xiaomei Dai ◽  
Lele Yang ◽  
Qingqing Xu ◽  
Jifang Ma ◽  
Qiang Zhang ◽  
...  
Keyword(s):  
Public Health ◽  
Bacterial Infection ◽  
Bacterial Infections ◽  
Water Soluble ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Public Health Challenges ◽  
Significant Public Health ◽  
Therapeutic Alternatives

Bacterial infection is one of the most significant public health challenges due to the limited choices of antibiotics which can overcome antibiotic-resistant bacteria. The promising nonantibiotic therapeutic alternatives for antibiotic-resistant...

Phage Therapy: A Potential Solution for Antibiotic Resistance

2021 ◽  
Author(s):  
Chirag Choudhary ◽  
Keyword(s):  
Antibiotic Resistance ◽  
Bacterial Infections ◽  
Phage Therapy ◽  
Biological Agents ◽  
Resistant Bacteria ◽  
Potential Solution ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
The Future

The idea of using a virus to kill bacteria may seem counterintuitive, but it may be the future of treating bacterial infections. Before the COVID-19 pandemic, one of the most frightening biological agents were so-called “superbugs” – antibiotic resistant bacteria – which could not be treated with conventional therapeutics. When antibiotics were first developed, they were hailed as a panacea. A panacea they were not.

scholarly journals Levels and Treatment Options for Enteric and Antibiotic-Resistant Bacteria in Sewage from Sisimiut, Greenland

ISCORD 2013 ◽  
2013 ◽  
Author(s):  
Pernille Erland Jensen ◽  
Ragnhildur Gunnarsdottir ◽  
Henrik Rasmus Andersen ◽  
Grith Martinsen ◽  
Ellen Stærk Nicolajsen ◽  
...  
Keyword(s):  
Treatment Options ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant

scholarly journals Combatting antibiotic-resistant bacteria using nanomaterials

2019 ◽  
Vol 48 (2) ◽  
pp. 415-427 ◽  
Author(s):  
Akash Gupta ◽  
Shazia Mumtaz ◽  
Cheng-Hsuan Li ◽  
Irshad Hussain ◽  
Vincent M. Rotello
Keyword(s):  
Drug Delivery ◽  
Therapeutic Agents ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Nanomaterials as self-therapeutic agents and drug-delivery vehicles for antimicrobial therapies.

scholarly journals Editorial for the Special Issue: “Phage Therapy: A Biological Approach to Treatment of Bacterial Infections”

Antibiotics ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 721
Author(s):  
Saija Kiljunen
Keyword(s):  
Healthcare Costs ◽  
Bacterial Infections ◽  
Phage Therapy ◽  
Resistant Bacteria ◽  
Special Issue ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Biological Approach

The emergence of antibiotic-resistant bacteria presents a major challenge in terms of increased morbidity, mortality, and healthcare costs [...]

scholarly journals Repurposed kinase inhibitors and β-lactams as a novel therapy for antibiotic resistant bacteria

2017 ◽  
Author(s):  
Nathan Wlodarchak ◽  
Nathan Teachout ◽  
Rebecca Procknow ◽  
Jeff Beczkiewicz ◽  
Adam Schaenzer ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Treatment Options ◽  
Computational Modelling ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Novel Therapy ◽  
Antibiotic Resistant ◽  
Antibiotic Development ◽  
Human Kinase ◽  
Pathogenic Actinomycetes

AbstractAntibiotic resistant bacteria are an increasing global problem, and pathogenic actinomycetes and firmicutes are particularly challenging obstacles. These pathogens share several eukaryotic-like kinases that present antibiotic development opportunities. We used computational modelling to identify human kinase inhibitors that could be repurposed towards bacteria as part of a novel combination therapy. The computational model suggested a family of inhibitors, the imidazopyridine aminofurazans (IPAs), bind PknB with high affinity. We found that these inhibitors biochemically inhibit PknB, with potency roughly following the predicted models. A novel x-ray structure confirmed that the inhibitors bind as predicted and made favorable protein contacts with the target. These inhibitors also have antimicrobial activity towards Mycobacteria and Nocardia, and normally ineffective β-lactams can potentiate IPAs to more efficiently inhibit growth of these pathogens. Collectively, our data show thatin silicomodeling can be used as a tool to discover promising drug leads, and the inhibitors we discovered can synergize with clinically relevant antibiotics to restore their efficacy against bacteria with limited treatment options.

scholarly journals Prophylactic Administration of a Bacteriophage Cocktail Is Safe and Effective in Reducing Salmonella enterica Serovar Typhimurium Burden in Vivo

2021 ◽  
Author(s):  
Quentin Lamy-Besnier ◽  
Lorenzo Chaffringeon ◽  
Marta Lourenço ◽  
Rayford B. Payne ◽  
Jimmy T. Trinh ◽  
...  
Keyword(s):  
Side Effects ◽  
Bacterial Infections ◽  
Salmonella Enterica Serovar Typhimurium ◽  
Economic Loss ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Serovar Typhimurium ◽  
Selection Of

Foodborne bacterial infections cause worldwide economic loss. During an epidemic, the use of antibiotics to slow down the spread of the disease is not recommended because of their side effects on the resident microbiota and the selection of antibiotic-resistant bacteria.

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