Study of homeostasis of the body of pigs with the addition of asparaginates to feed

The article presents the results of studying the effect of different doses of trace-elements combined with L-aspartic acid (asparaginase) on the overall homeostasis of the body of piglets. Traceelements play the main part in the composition of many organic compounds that maintain the stability of the buffer system of the colloidal state of the liquid and the osmotic pressure in the body. Scientists have proven that metal compounds in the inorganic form, in the composition of feed, are little absorbed by the body. Moreover, the increase of their doses in order to improve the level of assimilation in the body of animals, most often, causes the development of toxicosis. Therefore, the aim of the work was to study the effect of different amounts of trace-elements (Zn, Fe, Cu, Mn, Co) in the organic form combined with L-aspartic acid on the overall homeostasis of the body of piglets. In order to achieve this goal, we conducted an experiment on large white pigs in the conditions of a pig farm in the Saratov region. We have proved that in order to normalize the overall homeostasis, as well as to increase the productive indicators of fattening piglets, it is recommended to use a mineral complex based on L-aspartic acid in the amount of 10% of the daily norm of requirements for inorganic trace elements. This topic has not been sufficiently studied in the literature to date.

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Effect of chelates on gilts' colon microbiocenosis

Agrarian science ◽

10.32634/0869-8155-2021-345-2-42-44 ◽

2021 ◽

pp. 42-44

Author(s):

I. V. Ziruk ◽

V. V. Salautin ◽

M. E. Kopchekchi ◽

A. V. Egunova ◽

S. V. Shpul ◽

...

Keyword(s):

Amino Acids ◽

Trace Elements ◽

Aspartic Acid ◽

Large Intestine ◽

Living Cell ◽

The Body ◽

Inorganic Salts ◽

Optimal Conditions ◽

Normal Flora ◽

Mineral Additives

Mineral additives in the form of inorganic salts such as sulfates or oxides of various metals are poorly absorbed by the body. At the same time, the assimilation of salts of organic amino acids, which are more similar in structure to a living cell, occurs in a much greater volume, indicating that many organic forms of trace elements are more accessible than inorganic ones. The analysis and study of the effect of the mineral complex based on L-aspartic acid on the microbiological state of the contents of the rectum of pigs was carried out. The use of asparaginates in the diets in an amount of 10% contributed to the normalization of the microbiocenosis of the large intestine of animals, due to the creation of the most optimal conditions for the development of normal flora (lacto-and bifidobacteria) and a simultaneous slowdown in the reproduction of opportunistic microflora.

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EFFECT OF DIFFERENT DOSES OF PREDNISOLONE AND ADRENOCORTICOTROPHIC HORMONE (ACTH) ON LYMPHATIC LUNG CLEARANCE AND ON EXPERIMENTAL SILICOSIS

Acta Endocrinologica ◽

10.1530/acta.0.0630325 ◽

1970 ◽

Vol 63 (2) ◽

pp. 325-337

Author(s):

Carl-Johan Göthe

Keyword(s):

Lymph Nodes ◽

Lymphatic System ◽

The Body ◽

Lung Weight ◽

Lung Clearance ◽

Dust Transport ◽

Fine Particulate ◽

Quartz Dust ◽

Different Doses ◽

Stimulation Of

ABSTRACT The effect of three doses of prednisolone and ACTH respectively on the weight of the body, the lungs and the hilar lymph nodes was studied on rats killed one month after the intratracheal (i.t.) injection of 50 mg of fine-particulate quartz. The prednisolone was administered via the drinking water, and the ACTH was injected intraperitoneally during the period between the i.t. injection of quartz dust and the killing of the animals. Prednisolone causes the rats to become cachectic and reduces the weight of the hilar lymph nodes. It also retards the transport of quartz dust from the lungs via the lymphatics. All these effects increase with increasing doses of prednisolone. However, its effect on the lung weight is insignificant. ACTH does not affect the body weight, but retards the weight increase of the lungs and the hilar lymph nodes. These effects increase with increasing doses of ACTH, and seem to be connected with an ability of ACTH to promote the clearance of quartz dust from the lungs and hilar lymph nodes. The method used, however, does not make it possible to differentiate quantitatively between any ACTH effects on the bronchogenie and lymphatic lung-clearance mechanisms. Available data, however, indicate that the stimulation of the dust transport from the lungs and hilar lymph nodes is, at least to some extent, related to the lymphatic system.

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Scalable Approach to High Coverages on Oxides via Iterative Training of a Machine-Learning Algorithm

10.26434/chemrxiv.10288514.v1 ◽

2019 ◽

Author(s):

Andrew Medford ◽

Shengchun Yang ◽

Fuzhu Liu

Keyword(s):

Machine Learning ◽

Chemical Potential ◽

Learning Algorithm ◽

Absolute Error ◽

Low Energy ◽

Training Data ◽

High Coverage ◽

Metal Compounds ◽

Adsorption Energies ◽

The Stability

Understanding the interaction of multiple types of adsorbate molecules on solid surfaces is crucial to establishing the stability of catalysts under various chemical environments. Computational studies on the high coverage and mixed coverages of reaction intermediates are still challenging, especially for transition-metal compounds. In this work, we present a framework to predict differential adsorption energies and identify low-energy structures under high- and mixed-adsorbate coverages on oxide materials. The approach uses Gaussian process machine-learning models with quantified uncertainty in conjunction with an iterative training algorithm to actively identify the training set. The framework is demonstrated for the mixed adsorption of CHx, NHx and OHx species on the oxygen vacancy and pristine rutile TiO2(110) surface sites. The results indicate that the proposed algorithm is highly efficient at identifying the most valuable training data, and is able to predict differential adsorption energies with a mean absolute error of ~0.3 eV based on <25% of the total DFT data. The algorithm is also used to identify 76% of the low-energy structures based on <30% of the total DFT data, enabling construction of surface phase diagrams that account for high and mixed coverage as a function of the chemical potential of C, H, O, and N. Furthermore, the computational scaling indicates the algorithm scales nearly linearly (N1.12) as the number of adsorbates increases. This framework can be directly extended to metals, metal oxides, and other materials, providing a practical route toward the investigation of the behavior of catalysts under high-coverage conditions.

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THE CHARACTERISTICS OF ARTIFICIAL RICE WITH SEAWEED Eucheuma cottonii ADDITION AS A DIETARY FIBER SOURCE

Jurnal Ilmu dan Teknologi Kelautan Tropis ◽

10.29244/jitkt.v6i1.8641 ◽

2014 ◽

Vol 6 (1) ◽

Cited By ~ 1

Author(s):

Natalia Prodiana Setiawati ◽

Joko Santoso ◽

Sri Purwaningsih

Keyword(s):

Blood Glucose ◽

Dietary Fiber ◽

Dietary Fibre ◽

Extrusion Process ◽

The Body ◽

Starch Digestibility ◽

Food Commodities ◽

The Stability ◽

Extrusion Technology ◽

Eucheuma Cottonii

The utilization of local food commodities such as corn and cassava with seaweed addition as a dietary fiber source for producing artificial rice through extrusion technology is an alternative for food diversification. The research was carried out to find out the best composition (rice, corn, cassava, and seaweed) and temperature of extrusion process on making artificial rice and the influence of dietary fibre on sensory properties and physicochemical. The composition of rice, corn, and cassava in proportion of 1:3:1 with 20% seaweed, Eucheuma cottonii, addition and temperature extruder of 90 °C were selected as the best product for artificial rice. The sensory evaluation was 8.02±0.21 (people’s preference). In physicochemical properties, dietary fiber significantly affected on low bulk density and starch digestibility. This condition is very good for health especially in maintaining the stability of blood glucose in the body. Keywords: artificial rice, composition, extrusion, seaweed, dietary fibre, temperature

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A Study About How Different Doses of BI 1358894 Are Taken up in the Body and How Well They Are Tolerated in Healthy Japanese Men

Case Medical Research ◽

10.31525/ct1-nct03875001 ◽

2019 ◽

Author(s):

Keyword(s):

The Body ◽

Japanese Men ◽

Different Doses

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Substantiation the machine with a basket for the application of mineral fertilizers and other bulk materials with the upper arrangement of the feeding device

Mehanization and electrification of agricultural ◽

10.37204/0131-2189-2019-9-4 ◽

2019 ◽

pp. 37-43

Author(s):

Fesenko, H.

Keyword(s):

Fat Body ◽

Mineral Fertilizer ◽

The Body ◽

Mineral Fertilizers ◽

Analytical Mechanics ◽

Bulk Materials ◽

The Stability ◽

Working Bodies ◽

The Relationship ◽

Stable Flow

Purpose. Increasing the uniformity of distribution of mineral fertilizers and other bulk materials due to the stability of their feed from the body to the spreading working bodies using the top feeder. Methods. The following methods are used to achieve this aim: the method of comparing the differences between individual groups of fertilizers, the method of analyzing the properties of a new technical system, the method of functional inventiveness, and the methods of theoretical and analytical mechanics. Results. The traction body of the conveyor of the upper feed of the body fat body machine for mineral fertilizers and other bulk materials was substantiated and the relationship between the height of its scrapers and the distance between them was established, as well as the nature of the mineral fertilizer pressure on the curvilinear wall of the body. In addition, the design of the advanced body fertilizer spreader is justified, which ensures a stable flow of fertilizers from the body due to the improvement of the top feeder. Conclusions. Because of the conducted researches, the advantages of machines equipped with top feeder are found. They create the conditions for the forced feeding mineral fertilizers and other loose materials from the container to the distribution bodies, which is a prerequisite for their evenness on the surface. With this, the imperfection of known machines with the top feeder constrains their introduction into agricultural production. On this account, a more thoroughly constructed solution of the body feeder of the top feed is substantiated, in which the conveyor provides a stable supply of fertilizers from the body with reduced energy consumption during operation. Keywords: analysis, feed, upper device, conveyor, stability, fertilizers, flow ability, body.

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Novel Nanolipoidal Systems for the Management of Skin Cancer

Recent Patents on Drug Delivery & Formulation ◽

10.2174/1872211314666200817115700 ◽

2020 ◽

Vol 14 (2) ◽

pp. 108-125

Author(s):

Apoorva Singh ◽

Nimisha

Keyword(s):

Skin Cancer ◽

Survival Rates ◽

Cancer Therapeutics ◽

The Body ◽

Surgical Removal ◽

The Novel ◽

Skin Cancers ◽

Recent Developments ◽

Abnormal Cells ◽

The Stability

: Skin cancer, among the various kinds of cancers, is a type that emerges from skin due to the growth of abnormal cells. These cells are capable of spreading and invading the other parts of the body. The occurrence of non-melanoma and melanoma, which are the major types of skin cancers, has increased over the past decades. Exposure to ultraviolet radiations (UV) is the main associative cause of skin cancer. UV exposure can inactivate tumor suppressor genes while activating various oncogenes. The conventional techniques like surgical removal, chemotherapy and radiation therapy lack the potential for targeting cancer cells and harm the normal cells. However, the novel therapeutics show promising improvements in the effectiveness of treatment, survival rates and better quality of life for patients. Different methodologies are involved in the skin cancer therapeutics for delivering the active ingredients to the target sites. Nano carriers are very efficient as they have the ability to improve the stability of drugs and further enhance their penetration into the tumor cells. The recent developments and research in nanotechnology have entitled several targeting and therapeutic agents to be incorporated into nanoparticles for an enhancive treatment of skin cancer. To protect the research works in the field of nanolipoidal systems various patents have been introduced. Some of the patents acknowledge responsive liposomes for specific targeting, nanocarriers for the delivery or co-delivery of chemotherapeutics, nucleic acids as well as photosensitizers. Further recent patents on the novel delivery systems have also been included here.

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Polymer-Drug Conjugates as Nanotheranostic Agents

Journal of Nanotheranostics ◽

10.3390/jnt2010005 ◽

2021 ◽

Vol 2 (1) ◽

pp. 63-81

Author(s):

Sajana Manandhar ◽

Erica Sjöholm ◽

Johan Bobacka ◽

Jessica M. Rosenholm ◽

Kuldeep K. Bansal

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Treatment Options ◽

The Body ◽

Drug Conjugates ◽

Imaging Characteristics ◽

Wide Range ◽

Systemic Side Effects ◽

Theranostic Agents ◽

The Stability

Since the last decade, the polymer-drug conjugate (PDC) approach has emerged as one of the most promising drug-delivery technologies owing to several benefits like circumventing premature drug release, offering controlled and targeted drug delivery, improving the stability, safety, and kinetics of conjugated drugs, and so forth. In recent years, PDC technology has advanced with the objective to further enhance the treatment outcomes by integrating nanotechnology and multifunctional characteristics into these systems. One such development is the ability of PDCs to act as theranostic agents, permitting simultaneous diagnosis and treatment options. Theranostic nanocarriers offer the opportunity to track the distribution of PDCs within the body and help to localize the diseased site. This characteristic is of particular interest, especially among those therapeutic approaches where external stimuli are supposed to be applied for abrupt drug release at the target site for localized delivery to avoid systemic side effects (e.g., Visudyne®). Thus, with the help of this review article, we are presenting the most recent updates in the domain of PDCs as nanotheranostic agents. Different methodologies utilized to design PDCs along with imaging characteristics and their applicability in a wide range of diseases, have been summarized in this article.

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Metabolic and histochemical characteristics of fat and muscle tissues in homozygous or heterozygous pigs for the body composition QTL located on chromosome 7

Physiological Genomics ◽

10.1152/physiolgenomics.00270.2006 ◽

2007 ◽

Vol 30 (3) ◽

pp. 232-241 ◽

Cited By ~ 10

Author(s):

Julie Demars ◽

Juliette Riquet ◽

Marie-Pierre Sanchez ◽

Yvon Billon ◽

Jean-François Hocquette ◽

...

Keyword(s):

Body Composition ◽

Carcass Composition ◽

The Body ◽

Chromosome 7 ◽

Isolated Cells ◽

Large White ◽

Muscle Tissues ◽

Metabolism Enzymes ◽

Tissue Characteristics ◽

Qtl Effects

Quantitative trait loci (QTL) influencing many traits including backfat thickness and carcass composition have been detected on porcine chromosome 7 (SSC7) in an F2 cross between Large White (LW) and Meishan (MS) pigs. However, the genes and controlled pathways underlying the QTL effects on body phenotype remain unknown. This study aimed at investigating the tissue characteristics at metabolic and cellular levels in pigs that were either homozygous or heterozygous for a body composition SSC7 QTL. A backcross pig (BC3) was first progeny tested to confirm its heterozygoty for the SSC7 QTL; results on all offspring ( n = 80) confirmed the QTL effects on body fatness. This boar was then mated with three sows known to be heterozygous for this QTL. In the subset of pigs per genotype, we found that heterozygous LWQTL7/MSQTL7 pigs had smaller adipocytes in backfat, together with a lower basal rate of glucose incorporation into lipids and lower activities of selected lipogenic enzymes in backfat isolated cells, compared with homozygous LWQTL7/LWQTL7 pigs. A higher number of adipocytes was also estimated in backfat of LWQTL7/MSQTL7 animals compared with LWQTL7/LWQTL7 pigs. The SSC7 QTL did not influence oxidative and glycolytic metabolisms of longissimus and trapezius muscles, as estimated by the activities of specific energy metabolism enzymes, or the myofiber type properties. Altogether, this study provides new evidence for an altered adipocyte cellularity in backfat of pigs carrying at least one MS allele for the SSC7 QTL. Some candidate genes known for their functions on adipocyte growth and differentiation are suggested.

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