scholarly journals Impact of a mutation causing a deficiency of clotting factor on the incidence, productivity and reproduction of cows

2021 ◽  
Vol 273 ◽  
pp. 02031
Author(s):  
Natalia Kovalyuk ◽  
Natalia Basova ◽  
Mikhail Staroselov ◽  
Ludmila Yakusheva ◽  
Julia Shakhnazarova ◽  
...  
Keyword(s):  
Dairy Cattle ◽  
Clinical Manifestation ◽  
Clinical Condition ◽  
Genetic Defect ◽  
Reproductive Organs ◽  
Clotting Factor ◽  
New Knowledge ◽  
Newborn Calves ◽  
First Time

As a result of the study, new knowledge was obtained for the first time about the effect of the FXI locus polymorphism on the quality of reproduction in dairy cattle, the degree of influence of the FXI polymorphism on the frequency of development of pathologies of the reproductive organs, their clinical manifestation in individuals - carriers of the anomaly and healthy animals was established. The influence of the FXI locus polymorphism on embryonic and postembryonic mortality, clinical condition and safety of newborn calves in comparison with individuals without a genetic defect was determined.

scholarly journals Thermolability of factor VIII in donor fresh frozen blood plasma

2021 ◽  
Vol 66 (4) ◽  
pp. 593-609
Author(s):  
V. N. Lemondzhava ◽  
A. V. Chechetkin ◽  
A. G. Gudkov ◽  
V. Yu. Leushin ◽  
A. D. Kasianov ◽  
...  
Keyword(s):  
Factor Viii ◽  
Blood Plasma ◽  
Clotting Factor ◽  
Donor Blood ◽  
Fviii Activity ◽  
New Knowledge ◽  
Fresh Frozen ◽  
Technological Barriers ◽  
The Moment

A criterion of the quality of fresh frozen blood plasma (FFP) is the activity of clotting factor VIII (FVIII).Aim — to identify technological barriers in the study of FVIII thermolability and to describe the requirements for experiments, providing new knowledge about the thermolability of this factor.Basic information. An analysis of domestic and foreign publications devoted to the study of the mechanisms responsible for reducing the value of FVIII activity in donor blood plasma from the moment of donation to the moment of transfusion was carried out. Data on the decrease in FVIII activity at various stages of work with blood plasma are presented. An analysis of methods for preparing samples for studying changes in the values of FVIII in donor blood plasma was performed. The existence of contradictory conclusions about the infl uence on the change in FVIII at the thawing stage of various values of the effects on FFP and poor knowledge of the change in the indicator at the stage of heating to the transfusion temperature after the end of the phase transition in the samples was established. The fundamental differences in the methods of preparing and conducting experiments in previous works are determined. Methods for increasing the reliability of experimental results for studying the thermal lability of FVIII are proposed.

scholarly journals Quantitative assessment and impact of thermal treatment on quality of Holstein dairy cattle colostrum immunoglobulin and viscosity

2019 ◽  
Author(s):  
Abdulwahed Ahmed Hassan ◽  
Sebastian Ganz ◽  
Florian Schneider ◽  
Axel Wehrend ◽  
Izhar U.H. Khan ◽  
...  
Keyword(s):  
Dairy Cattle ◽  
Dynamic Viscosity ◽  
Measurement Methods ◽  
Thermal Treatments ◽  
Minimal Impact ◽  
Two Temperatures ◽  
Newborn Calves ◽  
Moderate Change ◽  
C 30

Abstract BackgroundBovine postpartum colostrum delivers a vital source of immunoglobulins (Igs) and other non-specific immune factors for passive transfer of immunity to newborn calves. Heat treatment of colostrum is an effective practice to reduce potential pathogens that can be transmitted to the newborn calves. Therefore, there is a need to determine optimized temperature and time that can minimally change IgG concentration and the viscosity (consistency) of colostrum. In order to preserve the quality and value of bovine postpartum colostrum, this study aimed to determine the IgG concentration, influence of different thermal treatments on the quality of colostrum and other properties including viscosity, fat and color.ResultsA total of 40 German Holstein dairy cattle first colostrum samples, collected after birth, were evaluated for color gradation, fat (%), colostrum IgG (mg mL-1), IgG (%Brix) and refractive index (nD) concentration, visual and dynamic viscosity and impact of different treatments (60 °C/60 min; 63.5°C/30 min and 72.0°C/15 s) on the viscosity. The color was graded from white-pale yellow to yellow and dark-yellowish, fat (1.4 - 8.2%) and IgG concentration (4 - 116 mg mL-1), Brix (8.5% - 35.4% Brix) and nD (1.3454 - 1.3905), respectively. The visual viscosity of first colostrum was classified into watery, liquid and thick consistency, whereas the dynamic viscosity and treated colostrum ranged from <10 to 219 and <10 to 3066 centipoise (cP), respectively. The consistency of treated samples were classified into liquid, thick and solid with significant change in the dynamic viscosity.ConclusionData revealed significant variation in the IgG values where both measurement methods showed high congruence with IgG classification. Due to the fact that individual IgG values were disparate, this significantly affected the colostrum consistency with different treatments. The study showed that colostrum containing IgG ≤80 mg mL-1 and ≤68 mg mL-1 treated at 60°C for 60 min and 63.5°C for 30 min showed a slight to moderate change in the consistency which suggests that these two temperatures and lengths of time that had a minimal impact on the consistency can be used to pasteurize colostrum.

scholarly journals An outbreak of dermatophilosis in a dairy cattle farm in the area of Thessaloniki.

2018 ◽  
Vol 51 (2) ◽  
pp. 145
Author(s):  
N. GIADINIS (Ν. ΓΙΑΔΙΝΗΣ) ◽  
M. N. SARIDOMICHELAKIS (Μ.Ν. ΣΑΡΙΔΟΜΙΧΕΛΑΚΗΣ) ◽  
A. F. KOUTINAS (Α. Φ. ΚΟΥΤΙΝΑΣ) ◽  
H. KARATZIAS (Χ. ΚΑΡΑΤΖΙΑΣ)
Keyword(s):  
Dairy Cattle ◽  
Skin Lesions ◽  
Disease Diagnosis ◽  
Zoonotic Potential ◽  
Cattle Farm ◽  
Clinical Appearance ◽  
The People ◽  
Newborn Calves ◽  
Long Acting ◽  
First Time

A retrospective study of an outbreak of dermatophilosis in a dairy cattle farm of 40 cows, 12 heifers, 15 bullocks and 10 newborn calves, in the area of Thessaloniki, is presented. To our knowledge this is the first time such an outbreak has been reported in Greece. In 62 of the 77 animals (80.5%) the characteristic skin lesions of the chronic form of the disease were found. None of the bullocks, which did not have access to the open yard, were clinically affected. The disease first appeared in the farm soon after a tractor had been used to dispose the manure from the yard. The mildly painful lesions, involving various parts of the hairy and glabrous skin, were characterized by dry and thick crusts, erythema, hyperpigmentation, erosions and alopecia. Due to the chronic nature of the disease, diagnosis was based on the clinical appearance and skin histopathology, where the organisms were demonstrated with difficulty within the keratin of the crusts, appearing as chains of two parallel rows of coccoid cells. Clinical resolution occurred within a few weeks after one injection of long-acting Oxytetracycline. No recurrence of the disease has ever been reported. Despite the zoonotic potential of dermatophilosis, none of the people who had been in contact with the infected cattle developed skin lesions.

Communication Sciences and Disorders PhD Graduates' Perceptions of Their PhD Program

2020 ◽  
Vol 5 (2) ◽  
pp. 463-478
Author(s):  
Elizabeth Crais ◽  
Melody Harrison Savage
Keyword(s):  
Detailed Examination ◽  
Career Expectations ◽  
Doctoral Preparation ◽  
Creative Solutions ◽  
Phd Education ◽  
Doctor Of Philosophy ◽  
First Time ◽  
Students Success ◽  
Phd Program

Purpose The shortage of doctor of philosophy (PhD)–level applicants to fill academic and research positions in communication sciences and disorders (CSD) programs calls for a detailed examination of current CSD PhD educational practices and the generation of creative solutions. The intended purposes of the article are to encourage CSD faculty to examine their own PhD program practices and consider the perspectives of recent CSD PhD graduates in determining the need for possible modifications. Method The article describes the results of a survey of 240 CSD PhD graduates and their perceptions of the challenges and facilitators to completing a PhD degree; the quality of their preparation in research, teaching, and job readiness; and ways to improve PhD education. Results Two primary themes emerged from the data highlighting the need for “matchmaking.” The first time point of needed matchmaking is prior to entry among students, mentors, and expectations as well as between aspects of the program that can lead to students' success and graduation. The second important matchmaking need is between the actual PhD preparation and the realities of the graduates' career expectations, and those placed on graduates by their employers. Conclusions Within both themes, graduate's perspectives and suggestions to help guide future doctoral preparation are highlighted. The graduates' recommendations could be used by CSD PhD program faculty to enhance the quality of their program and the likelihood of student success and completion. Supplemental Material https://doi.org/10.23641/asha.11991480

Advanced professional education for library staff: Criteria for program selection and compromises

2020 ◽  
Author(s):  
Elena Lindeman ◽  
◽  
Darya Moseeva ◽  
Keyword(s):  
Professional Education ◽  
Professional Training ◽  
Educational Organizations ◽  
Double Standards ◽  
Evaluation Influence ◽  
Information Activity ◽  
Program Selection ◽  
Staff Appraisal ◽  
New Knowledge

The quality of programs in library and information activity offered by various advanced professional training centers are discussed along with the issues and vectors of advanced training of the RNPLS&T staff. The RNPLS&T has to choose between expensive courses when new knowledge and skills are guaranteed, and online express courses (fast, easy, cheaply) where no new competences are guaranteed though employees get standard certificates. This trend facilitates establishing more and more online training centers that are just making money due to the demand for standardized certification. The double standards of education programs evaluation influence the quality of knowledge, though documented and certified. The authors argue that the above mentioned educational organizations have to be controlled, the more so, as the libraries are to accomplish their staff appraisal.

Resveratrol: A new potential therapeutic agent for melanoma?

2019 ◽  
Vol 26 ◽  
Author(s):  
Mohamad Hossein Pourhanifeh ◽  
Kazem Abbaszadeh-Goudarzi ◽  
Mohammad Goodarzi ◽  
Sara G.M. Piccirillo ◽  
Alimohammad Shafiee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Therapeutic Agent ◽  
Current Knowledge ◽  
Treatment Resistance ◽  
Anti Cancer ◽  
Apoptosis Inducer ◽  
Life Threatening ◽  
First Time

: Melanoma is the most life-threatening and aggressive class of skin malignancies. The incidence of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard anti-melanomatreatments such as chemotherapy, and 5-year survival rate of cases with melanoma who have metastatic form of disease is less than 10%. The contributing role of apoptosis, angiogenesis and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus, it is extremely urgent to search for complementary therapeutic approachesthat couldenhance the quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However, more clinical trials should be conducted to prove resveratrol efficacy. : Herein, for first time, we summarize current knowledge of anti-cancerous activities of resveratrol in melanoma.

scholarly journals Evaluation of the efficacy of hearing aids in older adults: a multiparametric longitudinal study protocol

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Domenico Cuda ◽  
Sara Ghiselli ◽  
Alessandra Murri
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Speech Perception ◽  
Hearing Aids ◽  
Assessment Tools ◽  
Elderly Subjects ◽  
Single Subject ◽  
Measurement Tools ◽  
First Time

Abstract Background Prevalence of hearing loss increases with age. Its estimated prevalence is 40–50 % in people over 75 years of age. Recent studies agree that declinein hearing threshold contribute to deterioration in sociality, sensitivity, cognition, and quality of life for elderly subjects. The aim of the study presented in this paper is to verify whether or not rehabilitation using first time applied Hearing Aids (HA) in a cohort of old people with hearing impairment improves both speech perception in a noisy environment over time and the overall health-related quality of life. Methods The monocentric, prospective, repeated measurements, single-subject, clinical observational study is to recruit 100 older adults, first-time HA recipients (≥ 65 years).The evaluation protocol is designed to analyze changes in specific measurement tools a year after the first HA usage in comparison with the evaluation before HA fitting. Evaluations will consist of multiparametric details collected through self-report questionnaires completed by the recipients and a series of commonly used audiometric measures and geriatric assessment tools. The primary indicator of changes in speech perception in noise to be used is the Italian version of Oldenburg Satz (OLSA) test whereas the indicator of changes in overall quality of life will be the Assessment of Quality of Life (AQoL) and Hearing Handicap Inventory for the Elderly (HHIE) questionnaires. The Montreal Cognitive Assessment (MoCA) will help in screening the cognitive state of the subjects. Discussion The protocol is designed to make use of measurement tools that have already been applied to the hearing-impaired population in order to compare the effects of HA rehabilitation in the older adults immediately before first HA usage (Pre) and after 1 year of experience (Post). This broad approach will lead to a greater understanding of how useful hearing influences the quality of life in older individuals, and therefore improves potentials for healthy aging. The data is to be analyzed by using an intrasubject endpoint comparison. Outcomes will be described and analyzed in detail. Trial registration This research was retrospectively registered underno. NCT04333043at ClinicalTrials.gov (http://www.clinicaltrials.gov/) on the 26 March 2020. This research has been registered with the Ethics Committee of the Area Vasta Emilia Nord under number 104, date of approval 17/07/2017.

Changes in alcohol history taking by psychiatric junior doctors: an audit

1995 ◽  
Vol 12 (1) ◽  
pp. 37-39 ◽  
Author(s):  
Simon J Taylor
Keyword(s):  
Illicit Drug ◽  
Statistical Significance ◽  
Inpatient Admission ◽  
Junior Doctors ◽  
History Taking ◽  
Drug Usage ◽  
Acute Psychiatric Wards ◽  
First Time

AbstractObjective: In recent years a number of articles have highlighted deficiencies in drinking histories taken by junior doctors. This study examines whether standards have improved as a result. It also examines for the first time: 1. the quality of drinking histories taken from patients following parasuicide; and 2. the quality of illicit drug usage histories.Method: An audit of case notes was undertaken of 114 patients admitted to a district hospital's acute psychiatric wards or assessed following overdose. Two periods were considered; one preceding many of the articles, and the second four years later.Results: There was an overall improvement from 58% of histories in 1988 having no mention of alcohol usage to 25% in 1992. (X2MH=10.57, p<0.01). There was, however, insufficient improvement of quantitative histories to reach statistical significance. Histories taken as part of an overdose assessment were not significantly different from those taken for inpatient admission. In 1992, 27% of patients had any illicit drug usage history recorded which represented a statistically significant improvement (X2MH=5.91, p<0.02) compared with four years earlier.Conclusions: Although improvements have been noted, alcohol and drug histories remain inadequate.

Evaluating quality of science in CGIAR research programs: Use of bibliometrics

2021 ◽  
pp. 003072702110242
Author(s):  
Max Rünzel ◽  
Paolo Sarfatti ◽  
Svetlana Negroustoueva
Keyword(s):  
Review Process ◽  
Research Output ◽  
Monitoring And Evaluation ◽  
Bibliometric Indicators ◽  
Scientific Publications ◽  
Practical Utilization ◽  
Research Programs ◽  
First Time ◽  
Quality Of Research

When evaluating Quality of Science (QoS) in the context of development initiatives, it is essential to define adequate criteria. The objective of this perspective paper is to show how altmetric and bibliometric indicators have been used to support the evaluation of QoS in the 2020 Review of the Phase 2-CGIAR Research Programs (CRPs, 2017–2022), where, for the first time, the Quality of Research for Development (QoR4D) frame of reference has been utilized across the entire CGIAR CRP portfolio. Overall, the CRP review showed a significant output of scientific publications during the period 2017–2020, with 4,872 articles, 220,101 references, and 7.1 citations per article. Additionally, wider interest in scientific publications is demonstrated by good to high altmetrics, with average attention scores ranging from 70.8 to 806.9 with an average of 425.1. The use of selected bibliometrics was shown to be an adequate tool, for use together with other qualitative indicators to evaluate the QoS in the 12 CRPs. The CRP review process clearly demonstrated that standardized, harmonized and consistent data on research output is paramount to provide high-quality quantitative instruments and should be a priority throughout the transition toward One CGIAR. Therefore, we conclude that the QoR4D framework should be augmented by standardized bibliometric indicators embedded in measurement frameworks within the new One CGIAR. Finally, its practical utilization in monitoring and evaluation should be supported with clear guidelines.

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