Anticancer Potential of Compounds from the Brazilian Blue Amazon

Planta Medica ◽  
2020 ◽  
Author(s):  
Diego V. Wilke ◽  
Paula C. Jimenez ◽  
Paola C. Branco ◽  
Paula Rezende-Teixeira ◽  
Amaro E. Trindade-Silva ◽  
...  
Keyword(s):  
Natural Products ◽  
Small Molecule ◽  
Marine Natural Products ◽  
Molecular Targets ◽  
Mechanisms Of Action ◽  
Marine Organisms ◽  
Genetic Characteristics ◽  
Species Inventory ◽  
Modest Contribution ◽  
Marine Compounds

Abstract“Blue Amazon” is used to designate the Brazilian Economic Exclusive Zone, which covers an area comparable in size to that of its green counterpart. Indeed, Brazil flaunts a coastline spanning 8000 km through tropical and temperate regions and hosting part of the organisms accredited for the countryʼs megadiversity status. Still, biodiversity may be expressed at different scales of organization; besides species inventory, genetic characteristics of living beings and metabolic expression of their genes meet some of these other layers. These metabolites produced by terrestrial creatures traditionally and lately added to by those from marine organisms are recognized for their pharmaceutical value, since over 50% of small molecule-based medicines are related to natural products. Nonetheless, Brazil gives a modest contribution to the field of pharmacology and even less when considering marine pharmacology, which still lacks comprehensive in-depth assessments toward the bioactivity of marine compounds so far. Therefore, this review examined the last 40 years of Brazilian natural products research, focusing on molecules that evidenced anticancer potential–which represents ~ 15% of marine natural products isolated from Brazilian species. This review discusses the most promising compounds isolated from sponges, cnidarians, ascidians, and microbes in terms of their molecular targets and mechanisms of action. Wrapping up, the review delivers an outlook on the challenges that stand against developing groundbreaking natural products research in Brazil and on a means of surpassing these matters.

scholarly journals Marine natural products from sponges (Porifera) of the order Dictyoceratida (2013 to 2019); a promising source for drug discovery

RSC Advances ◽  
2020 ◽  
Vol 10 (57) ◽  
pp. 34959-34976
Author(s):  
Enas Reda Abdelaleem ◽  
Mamdouh Nabil Samy ◽  
Samar Yehia Desoukey ◽  
Miaomiao Liu ◽  
Ronald J. Quinn ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Marine Natural Products ◽  
Biological Activities ◽  
Marine Organisms ◽  
Promising Source ◽  
Secondary Natural Products

Marine organisms have been considered an interesting target for the discovery of different classes of secondary natural products with wide-ranging biological activities.

scholarly journals Marine Natural Products: A Source of Novel Anticancer Drugs

Marine Drugs ◽  
2019 ◽  
Vol 17 (9) ◽  
pp. 491 ◽  
Author(s):  
Shaden A. M. Khalifa ◽  
Nizar Elias ◽  
Mohamed A. Farag ◽  
Lei Chen ◽  
Aamer Saeed ◽  
...  
Keyword(s):  
Natural Products ◽  
Anticancer Drugs ◽  
Marine Natural Products ◽  
Molecular Mechanisms ◽  
Biological Effects ◽  
Marine Organisms ◽  
New Drugs ◽  
Bioactive Metabolites ◽  
Chemical Structures ◽  
The Impact

Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

scholarly journals Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets

2012 ◽  
Vol 12 (10) ◽  
pp. 1159-1184 ◽  
Author(s):  
Poyil Pratheeshkumar ◽  
Chakkenchath Sreekala ◽  
Zhuo Zhang ◽  
Amit Budhraja ◽  
Songze Ding ◽  
...  
Keyword(s):  
Natural Products ◽  
Cancer Prevention ◽  
Molecular Targets ◽  
Mechanisms Of Action

scholarly journals Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Justus Amuche Nweze ◽  
Florence N. Mbaoji ◽  
Yan-Ming Li ◽  
Li-Yan Yang ◽  
Shu-Shi Huang ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Marine Natural Products ◽  
Neglected Tropical Diseases ◽  
Marine Organisms ◽  
New Drugs ◽  
Screening Methods ◽  
Pharmaceutical Industries

Abstract Background Malaria and neglected communicable protozoa parasitic diseases, such as leishmaniasis, and trypanosomiasis, are among the otherwise called diseases for neglected communities, which are habitual in underprivileged populations in developing tropical and subtropical regions of Africa, Asia, and the Americas. Some of the currently available therapeutic drugs have some limitations such as toxicity and questionable efficacy and long treatment period, which have encouraged resistance. These have prompted many researchers to focus on finding new drugs that are safe, effective, and affordable from marine environments. The aim of this review was to show the diversity, structural scaffolds, in-vitro or in-vivo efficacy, and recent progress made in the discovery/isolation of marine natural products (MNPs) with potent bioactivity against malaria, leishmaniasis, and trypanosomiasis. Main text We searched PubMed and Google scholar using Boolean Operators (AND, OR, and NOT) and the combination of related terms for articles on marine natural products (MNPs) discovery published only in English language from January 2016 to June 2020. Twenty nine articles reported the isolation, identification and antiparasitic activity of the isolated compounds from marine environment. A total of 125 compounds were reported to have been isolated, out of which 45 were newly isolated compounds. These compounds were all isolated from bacteria, a fungus, sponges, algae, a bryozoan, cnidarians and soft corals. In recent years, great progress is being made on anti-malarial drug discovery from marine organisms with the isolation of these potent compounds. Comparably, some of these promising antikinetoplastid MNPs have potency better or similar to conventional drugs and could be developed as both antileishmanial and antitrypanosomal drugs. However, very few of these MNPs have a pharmaceutical destiny due to lack of the following: sustainable production of the bioactive compounds, standard efficient screening methods, knowledge of the mechanism of action, partnerships between researchers and pharmaceutical industries. Conclusions It is crystal clear that marine organisms are a rich source of antiparasitic compounds, such as alkaloids, terpenoids, peptides, polyketides, terpene, coumarins, steroids, fatty acid derivatives, and lactones. The current and future technological innovation in natural products drug discovery will bolster the drug armamentarium for malaria and neglected tropical diseases.

scholarly journals Biologically active marine natural products and their molecular targets discovered using a chemical genetics approach

2020 ◽  
Vol 37 (5) ◽  
pp. 617-633 ◽  
Author(s):  
David E. Williams ◽  
Raymond J. Andersen
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Molecular Targets ◽  
Chemical Genetics ◽  
Biologically Active

This review presents examples that illustrate the effectiveness of using a chemical genetics approach for the discovery of biologically active marine natural products and their molecular targets.

scholarly journals Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Marine Drugs ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 49
Author(s):  
Alejandro M. S. Mayer ◽  
Aimee J. Guerrero ◽  
Abimael D. Rodríguez ◽  
Orazio Taglialatela-Scafati ◽  
Fumiaki Nakamura ◽  
...  
Keyword(s):  
Nervous System ◽  
Natural Products ◽  
Natural Product ◽  
Therapeutic Strategies ◽  
Mechanisms Of Action ◽  
Marine Natural Product ◽  
Lead Compounds ◽  
Antiviral Activities ◽  
Marine Compounds ◽  
Anti Inflammatory

The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported by a growing number of investigators from 54 countries. The peer-reviewed literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities for 123 marine natural products, 111 marine compounds with antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in contrast 79 marine compounds displayed miscellaneous mechanisms of action which upon further investigation may contribute to several pharmacological classes. Therefore, in 2016–2017, the preclinical marine natural product pharmacology pipeline generated both novel pharmacology as well as potentially new lead compounds for the growing clinical marine pharmaceutical pipeline, and thus sustained with its contributions the global research for novel and effective therapeutic strategies for multiple disease categories.

scholarly journals Biomedical applications and therapeutic potential of marine natural products and marine algae

2021 ◽  
Vol 4 (3) ◽  
pp. 76-82
Author(s):  
Sofia Khanam ◽  
Aman Prakash
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Therapeutic Potential ◽  
Marine Organisms ◽  
Terrestrial Plants ◽  
Primary Metabolites ◽  
Human Needs ◽  
Marine Products ◽  
Marine Flora ◽  
Novel Structures

Recently there is an increase in the interest in the secondary or non-primary metabolites produced by the marine flora and fauna. It has become the center of attraction of chemists and pharmacologists in the previous decades. Stakeholders of the natural viewpoint emphasize that the examination of new and unusual organic molecules from marine organisms while the synthetic stakeholders' faiths in targeting these novel structures for the development of new analogs and new synthetic strategies and methodologies. The chemistry of marine organisms has changed dramatically in concern of investigating rationale. Analogous to the examination of terrestrial plants, many of the recent research and studies have concentrated on the potential application of marine extracted products in the treatment, curing of human diseases, and various other works. Marine products are the major components having biomedical-oriented natural products which can be used for various purposes. Marine natural products have enough potential to work prominently and also assisting in various kinds of human needs and works. In this review, we will be focusing on prominently their works, role in biomedical-related aspects.

scholarly journals Overview of bioactivity studies on marine natural products

2021 ◽  
Vol 944 (1) ◽  
pp. 012029
Author(s):  
N P Zamani ◽  
L Rahman ◽  
R L Rosada ◽  
W Tirtama
Keyword(s):  
Natural Products ◽  
Product Development ◽  
Mass Production ◽  
Marine Natural Products ◽  
Research Collaboration ◽  
Gap Analysis ◽  
Raw Materials ◽  
Marine Organisms ◽  
Future Research ◽  
Marine Biodiversity

Abstract Marine natural products are sourced from marine biodiversity as natural raw materials for various commercial products. This study aims to review natural products of marine organisms and gap analysis for future research or challenges. A total of 109 references from 24 countries were collected. The analysis was carried out quantitatively and qualitatively. The bioactive compounds produced wereantioxidants, antibacterial, anticancer, antimicrobial, anti-fouling, antifungal, and anti-tumoral substances. Some marine organisms that can store chemical compounds through secondary metabolite processes are mangroves, seagrasses, macroalgae, microalgae, soft corals, molluscs, echinoderms, gastropods, cnidarians, sponges, fungi, and bacteria. Most of the papers only discuss the identification stage of the active compound, and some focus on product development. There are very few studies on prospects of commercialization and mass production. The problem to achieve mass production is due to the lack of interdisciplinary research collaboration. Future research challenges need to develop a transdisciplinary approach to study bioprospection research from upstream to downstream, starting from the potential identification of bioactive ingredients, product development, the availability of raw materials for mass production as well as commercialization and marketing.

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