No association of Brain-derived neurotrophic factor with striatal dopamine transporter availability in healthy subjects

Abstract Objective Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a key role in brain plasticity, synaptic function, neuronal survival, learning, and memory formation. We aimed to investigate the association of BDNF with dopamine transporter (DAT) availabilities measured by positron emission tomography (PET) in healthy subjects. Methods Thirty-five healthy, male subjects without brain injury, neuropsychological disorders were included in this study. The emission data were acquired over 90 mins with 50 frames after injection of 18F-FP-CIT using PET. Binding potentials (BPNDs) of ventral striatum (VST), caudate nucleus, putamen were measured with the simplified reference tissue method. The serum BDNF level (pg/mL) was measured through enzyme-linked immunosorbent assay method. Results Thirty-five healthy males with a mean age of 24.4 ± 2.7 years were included in this study. Multiple regression was done to investigate the association between striatal BPNDs from VST, caudate nucleus, putamen and serum BDNF after adjusting for age. None of striatal BPNDs from VST (p=0.8450), caudate nucleus (p=0.4783), and putamen (p=0.7994) were associated with serum BDNF. Conclusion Striatal DAT availabilities measured from PET were not associated with the serum BDNF in healthy subjects.

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Brain-derived neurotrophic factor as a suicide factor in mental disorders

Acta Neuropsychiatrica ◽

10.1017/neu.2014.27 ◽

2013 ◽

Vol 26 (6) ◽

pp. 356-363 ◽

Cited By ~ 14

Author(s):

Majda Grah ◽

Mate Mihanovic ◽

Nedjeljka Ruljancic ◽

Branka Restek-Petrovic ◽

Sven Molnar ◽

...

Keyword(s):

Mental Disorders ◽

Neurotrophic Factor ◽

Suicidal Behaviour ◽

Suicide Attempts ◽

Brain Plasticity ◽

Critical Role ◽

Brain Derived Neurotrophic Factor ◽

Enzyme Linked Immunosorbent Assay ◽

Potential Marker ◽

Serum Bdnf

ObjectiveBrain-derived neurotrophic factor (BDNF) plays a critical role in brain plasticity processes and serum levels have been demonstrated to be altered in patients with different mental disorder including suicidal behaviour. The objective of this study was to examine the association between serum BDNF levels as a possible peripheral indicator of suicide behaviour in subjects suffering from depression, personality disorders (PDs) and adjustment disorders (ADs) with or without suicide attempt.MethodsThe research included 172 randomly selected individuals suffering from recurrent depressive disorder (RDD; F 33.2), emotionally unstable PD (F 60.3) and AD (F 43.2), with or without attempted suicide according to the criteria of the ICD-10 (International Statistical Classification of Diseases and Related Health Problems 10th Revision) and 60 phenotypically health control subjects. In the group of patients, 73% subjects took some form of psychopharmacotherapy. Serum BDNF levels were measured by enzyme linked immunosorbent assay.ResultsSubjects with PD and AD with suicide attempts had significantly lower serum BDNF levels than those without suicide attempts. In groups of subjects with PD and AD, those taking psychopharmacotherapy had higher serum BDNF levels. In the group of subjects with RDD, there were no differences with respect to suicide attempts or psychopharmacotherapy. Logistical regression analysis was indicated that psychopharmcotherapy and serum BDNF levels statistically correlated with suicide attempts.ConclusionThe lower levels of BDNF in subjects suffering from PD and AD with suicide attempts, suggest that the serum BDNF level is a potential marker of suicidal behaviour, independent of mental disorders.

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Serum Brain-Derived Neurotrophic Factor Mediates the Relationship between Abdominal Adiposity and Executive Function in Middle Age

Journal of the International Neuropsychological Society ◽

10.1017/s1355617716000230 ◽

2016 ◽

Vol 22 (5) ◽

pp. 493-500 ◽

Cited By ~ 9

Author(s):

Sonya Kaur ◽

Mitzi M. Gonzales ◽

Takashi Tarumi ◽

Astrid Villalpando ◽

Mohammed Alkatan ◽

...

Keyword(s):

Executive Function ◽

Neurotrophic Factor ◽

Word Association ◽

Brain Plasticity ◽

Brain Derived Neurotrophic Factor ◽

Enzyme Linked Immunosorbent Assay ◽

Abdominal Adiposity ◽

Increased Risk ◽

And Performance ◽

The Relationship

AbstractObjectives: Excessive adipose tissue, especially in the abdominal area, is associated with increased risk of dementia in older adults. However, the mechanisms underlying this relationship are poorly understood. As increased adiposity is also associated with lower circulating levels of brain-derived neurotrophic factor (BDNF), a key molecule modulating brain plasticity and neuronal regeneration, we hypothesized that the changes in cognition that occur as a result of excessive abdominal adiposity would be driven by lower levels of circulating BDNF. Methods: Fasting blood samples were obtained from 60 participants aged 40–60 years (mean±SD=52.3±5.6) and BDNF levels were assessed with an enzyme linked immunosorbent assay. Abdominal adiposity was measured using a ratio of waist circumference to hip circumference (WHR). Participants also completed a neuropsychological assessment battery to assess executive function. Statistical mediation was assessed using traditional causal steps and nonparametric bootstrapping. Results: Higher WHR was significantly associated with poorer performance on the Controlled Oral Word Association (COWA) letter fluency test (β=−0.489; p=.003) and lower levels of circulating BDNF (β=−0.345; p=.006). Linear regression and bootstrapping methods indicated that BDNF fully mediated the relationship between WHR and performance on the COWA (β=0.60; 95% confidence interval [−3.79, −0.26]). Conclusions: The relationship between higher WHR and verbal fluency was fully statistically mediated by circulating BDNF levels. The BDNF pathway is thus a useful probable mechanism through which executive function decline occurs in individuals with high abdominal adiposity. BDNF enhancing interventions (physical exercise and dietary restriction) could thus be used to improve executive function in these individuals. (JINS, 2016, 22, 1–8)

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Serum and Aqueous Humor Levels of Brain-Derived Neurotrophic factor in Patients with Primary Open-Angle Glaucoma and Normal Tension Glaucoma

10.21203/rs.3.rs-300799/v1 ◽

2021 ◽

Author(s):

Yu Wan Cha ◽

Seong Taeck Kim

Keyword(s):

Aqueous Humor ◽

Neurotrophic Factor ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Brain Derived Neurotrophic Factor ◽

Normal Tension Glaucoma ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Open Angle ◽

Serum Bdnf

Abstract PurposeThis study designed to compare the levels of brain-derived neurotrophic factor (BDNF) in the serum and aqueous humor (AH) of patients with primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG).MethodsThis prospective, observational study consists of 30 patients with POAG, 30 patients with NTG, and 30 healthy controls. The serum and AH BDNF levels were assessed using an enzyme-linked immunosorbent assay.ResultsBDNF levels in serum and AH were markedly lower in the glaucoma groups (POAG and NTG) than in the control group (p < 0.05). When comparing the NTG and POAG groups, the average serum BDNF level was significantly lower in the NTG group than in the POAG group (p < 0.05). The difference in the mean BDNF levels in AH between the POAG and NTG groups was not statistically significant. (p = 0.538).ConclusionWe confirmed that serum BDNF levels were lower in patients with NTG than in those with POAG. BDNF could be a causative systemic biomarker in NTG.

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Effects of acupuncture versus cognitive behavioral therapy on brain-derived neurotrophic factor in cancer survivors with insomnia: an exploratory analysis

Acupuncture in Medicine ◽

10.1177/0964528421999395 ◽

2021 ◽

pp. 096452842199939

Author(s):

Kevin T Liou ◽

Sheila N Garland ◽

Q Susan Li ◽

Keimya Sadeghi ◽

Jamie Green ◽

...

Keyword(s):

Cognitive Behavioral Therapy ◽

Cancer Survivors ◽

Neurotrophic Factor ◽

Behavioral Therapy ◽

Brain Derived Neurotrophic Factor ◽

Exploratory Analysis ◽

Cognitive Behavioral ◽

Enzyme Linked Immunosorbent Assay ◽

Poor Sleep ◽

Serum Bdnf

Introduction: Decreased brain-derived neurotrophic factor (BDNF) is associated with poor sleep. This study examined the effects of acupuncture versus cognitive behavioral therapy for insomnia (CBT-I) on serum BDNF and sleep outcomes in cancer survivors with insomnia. Methods: This was an exploratory analysis of a randomized clinical trial (n = 160) comparing acupuncture versus CBT-I for cancer survivors with insomnia. Interventions were delivered over 8 weeks. Outcomes were assessed at baseline and week 8. Serum BDNF was evaluated with enzyme-linked immunosorbent assay (ELISA). Sleep was evaluated with the insomnia severity index and consensus sleep diary. Pearson correlations between BDNF and sleep outcomes were calculated. Data analysis was limited to 87 survivors who provided serum samples. Results: Among 87 survivors, the mean age was 61.9 (SD: 11.4) years, 51.7% were women, and 24.1% were non-White. Mean serum BDNF did not significantly increase in acupuncture (n = 50) or CBT-I (n = 37) groups. When analysis was restricted to patients with low baseline BDNF (i.e. levels below the sample median of 47.1 ng/mL), the acupuncture group (n = 22) demonstrated a significant 7.2 ng/mL increase in mean serum BDNF (P = 0.03), whereas the CBT-I group (n = 21) demonstrated a non-significant 2.9 ng/mL increase (P = 0.28). Serum BDNF was not significantly correlated with sleep outcomes (all P > 0.05). Conclusion: Among cancer survivors with insomnia and low baseline BDNF, acupuncture significantly increased serum BDNF levels; however, the clinical significance of this finding requires further investigation. Trial registration no. NCT02356575 (ClinicalTrials.gov)

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Correlation between Serum Brain-Derived Neurotrophic Factor Level and Depression Severity in Psoriasis Vulgaris Patients

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2019.142 ◽

2019 ◽

Vol 7 (4) ◽

pp. 583-586 ◽

Cited By ~ 1

Author(s):

Muhammad Sjahrir ◽

Irma Damayanti Roesyanto-Mahadi ◽

Elmeida Effendy

Keyword(s):

Negative Correlation ◽

Neurotrophic Factor ◽

Psoriasis Vulgaris ◽

Severity Index ◽

Brain Derived Neurotrophic Factor ◽

Enzyme Linked Immunosorbent Assay ◽

Depression Severity ◽

Bdnf Level ◽

Cross Sectional ◽

Serum Bdnf

BACKGROUND: Psoriasis vulgaris is a chronic inflammatory skin disorder that can lead to depression. There is a similarity in neurotrophic substance in the pathogenesis of psoriasis and depression; it’s called brain-derived neurotrophic factor (BDNF). BDNF level imbalance potentially affects the severity of psoriasis and depression. AIM: This study aims to know the correlation between serum BDNF level and depression severity in psoriasis vulgaris patient and also the correlation between serum BDNF level and psoriasis vulgaris severity. METHODS: This is an analytical cross-sectional study that 23 psoriasis vulgaris patients participated. All participants have performed serum BDNF level examination with enzyme-linked immunosorbent assay (ELISA). Depression severity assessed with Beck depression inventory-II (BDI-II) and psoriasis severity assessed with psoriasis area and severity index. Correlation between all variables was analysed with Spearman’s correlation test. RESULTS: Serum BDNF level and depression severity are a strongly negative correlation in psoriasis vulgaris patients (r = -0.667 with significant value p = 0.001). There is a moderate negative correlation between serum BDNF level with psoriasis vulgaris severity (r = -0.595 with significant value p = 0.003). CONCLUSION: In psoriasis vulgaris patients, a low level of serum BDNF may increase depression severity and psoriasis vulgaris severity.

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Decreased Serum Brain-Derived Neurotrophic Factor Concentrations 72 Hours Following Marathon Running

Frontiers in Physiology ◽

10.3389/fphys.2021.668454 ◽

2021 ◽

Vol 12 ◽

Author(s):

Astrid Roeh ◽

Stefan Holdenrieder ◽

Julia Schoenfeld ◽

Jan Haeckert ◽

Martin Halle ◽

...

Keyword(s):

Neurotrophic Factor ◽

Mixed Model ◽

Linear Mixed Model ◽

Brain Plasticity ◽

Recovery Period ◽

Brain Derived Neurotrophic Factor ◽

Marathon Running ◽

Fitness Level ◽

Beneficial Effects ◽

Serum Bdnf

Background: Physical exercise has been linked to beneficial effects on brain plasticity. One potential key mechanism for this relationship is an exercise-induced increase of brain-derived neurotrophic factor (BDNF). However, the kinetics of BDNF in athletes during training phase, extreme exercise competition, and recovery period have not been investigated so far.Methods: We assessed serum BDNF concentrations in 51 marathon runners (23% female, mean age 43 years) in a longitudinal study design over a period of 6 months. Assessments were conducted during the training period before the marathon and after the marathon race during short-term (24 to 72 h) and long-term (3 months) follow-ups. Potential confounders (fitness level, sex, and platelet count) were included in subsequent linear-model analyses.Results: Linear mixed-model analyses revealed a main effect of time for BDNF concentrations over the study period (F(4,89.389) = 4.296, p = 0.003). Values decreased significantly with the lowest values at 72 h after the marathon compared to baseline (p = 0.025), a finding that was more pronounced in the larger male cohort.Conclusion: Prolonged exercise induces a significant decrease in serum BDNF concentration 72 h post-exercise. We assume that this observation is mainly driven by regenerative mechanisms and a higher muscular utilization.

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A Meta-Analysis of Brain-Derived Neurotrophic Factor Effects on Brain Volume in Schizophrenia: Genotype and Serum Levels

Neuropsychobiology ◽

10.1159/000514126 ◽

2021 ◽

pp. 1-14

Author(s):

Anthony O. Ahmed ◽

Samantha Kramer ◽

Naama Hofman ◽

John Flynn ◽

Marie Hansen ◽

...

Keyword(s):

Neurotrophic Factor ◽

Psychotic Disorders ◽

Brain Volume ◽

Statistical Significance ◽

Brain Derived Neurotrophic Factor ◽

Volume Data ◽

Analytic Review ◽

Volume Measurements ◽

Meta Analyses ◽

Serum Bdnf

Aim: The Val66Met single-nucleotide polymorphism (SNP) on the BDNF gene has established pleiotropic effects on schizophrenia incidence and morphologic alterations in the illness. The effects of brain-derived neurotrophic factor (BDNF) on brain volume measurements are however mixed seeming to be less established for most brain regions. The current meta-analytic review examined (1) the association of the Val66Met SNP and brain volume alterations in schizophrenia by comparing Met allele carriers to Val/Val homozygotes and (2) the association of serum BDNF with brain volume measurements. Method: Studies included in the meta-analyses were identified through an electronic search of PubMed and PsycInfo (via EBSCO) for English language publications from January 2000 through December 2017. Included studies had conducted a genotyping procedure of Val66Met or obtained assays of serum BDNF and obtained brain volume data in patients with psychotic disorders. Nonhuman studies were excluded. Results: Study 1 which included 52 comparisons of Met carriers and Val/Val homozygotes found evidence of lower right and left hippocampal volumes among Met allele carriers with schizophrenia. Frontal measurements, while also lower among Met carriers, did not achieve statistical significance. Study 2 which included 7 examinations of the correlation between serum BDNF and brain volume found significant associations between serum BDNF levels and right and left hippocampal volume with lower BDNF corresponding to lower volumes. Discussion: The meta-analyses provided evidence of associations between brain volume alterations in schizophrenia and variations on the Val66Met SNP and serum BDNF. Given the limited number of studies, it remains unclear if BDNF effects are global or regionally specific.

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The influence of vigorous aerobic exercise on serum brain-derived neurotrophic factor and estradiol in young, healthy women as a function of the menstrual cycle

10.31234/osf.io/hwegb ◽

2021 ◽

Author(s):

Sarah Ahmad ◽

Rodney Hansen ◽

Matthew Schmolesky

Keyword(s):

Menstrual Cycle ◽

Aerobic Exercise ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Cycle Exercise ◽

Acute Bout ◽

Healthy Women ◽

Exercise Induced ◽

Induced Changes ◽

Serum Bdnf

AbstractResearch suggests strong inter-relationships between physical exercise, levels of brain-derived neurotrophic factor (BDNF), levels of estrogen, and the menstrual cycle, and yet no single study has examined these factors collectively in humans. The current study assessed the effect of an acute bout of vigorous aerobic exercise (20 minutes of stationary cycling at 80% of heart rate reserve) on serum BDNF and estradiol in healthy, eumenorrheic women, ages 18-28. In addition, this study determined whether basal BDNF or the exercise-induced increase in BDNF varies throughout the menstrual cycle. Thirty-four subjects were assigned to an experimental (n = 27) or control condition (n = 7). Exercise transiently increased both estradiol (51.2%) and BDNF (23.6%), and basal levels of BDNF and estradiol predicted the magnitude of the exercise-induced increases. Basal BDNF did not vary significantly throughout the menstrual cycle. Exercise-induced changes in BDNF did not correlate with menstrual cycle day or basal estradiol. Basal estradiol and basal BDNF showed a marginally significant positive correlation. Taken together, these results indicate that brief, vigorous aerobic exercise is sufficient to elevate both BDNF and estradiol in healthy women and that the menstrual cycle dramatically influences the magnitude of exercise-induced changes in estradiol, but not BDNF

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Serum Renalase Levels Are Predicted by Brain-Derived Neurotrophic Factor and Associated with Cardiovascular Events and Mortality after Percutaneous Coronary Intervention

Journal of Clinical Medicine ◽

10.3390/jcm7110437 ◽

2018 ◽

Vol 7 (11) ◽

pp. 437 ◽

Cited By ~ 1

Author(s):

I-Te Lee ◽

Wayne Sheu

Keyword(s):

Myocardial Infarction ◽

Percutaneous Coronary Intervention ◽

Neurotrophic Factor ◽

Strong Predictor ◽

Coronary Intervention ◽

Brain Derived Neurotrophic Factor ◽

Percutaneous Coronary ◽

Before And After ◽

Artery Disease ◽

Serum Bdnf

Circulating brain-derived neurotrophic factor (BDNF) predicts survival rate in patients with coronary artery disease (CAD). We examined the relationship between BDNF and renalase before and after percutaneous coronary intervention (PCI) and the role of renalase in patients with CAD. Serum BDNF and renalase levels were determined using blood samples collected before and after PCI. Incident myocardial infarction, stroke, and mortality were followed up longitudinally. A total of 152 patients completed the assessment. BDNF levels were not significantly changed after PCI compared to baseline levels (24.7 ± 11.0 vs. 23.5 ± 8.3 ng/mL, p = 0.175), although renalase levels were significantly reduced (47.5 ± 17.3 vs. 35.9 ± 11.3 ng/mL, p < 0.001). BDNF level before PCI was an independent predictor of reduction in renalase (95% confidence interval (CI): −1.371 to −0.319). During a median 4.1 years of follow-up, patients with serum renalase levels of ≥35 ng/mL had a higher risk of myocardial infarction, stroke, and death than those with renalase of <35 ng/mL (hazard ratio = 5.636, 95% CI: 1.444–21.998). In conclusion, our results show that serum BDNF levels before PCI were inversely correlated with the percentage change in renalase levels after PCI. Nevertheless, post-PCI renalase level was a strong predictor for myocardial infarction, stroke, and death.

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The Brain-Derived Neurotrophic Factor Functional Polymorphism and Hand Grip Strength Impact the Association between Brain-Derived Neurotrophic Factor Levels and Cognition in Older Adults in the United States

Biological Research For Nursing ◽

10.1177/10998004211065151 ◽

2022 ◽

pp. 109980042110651

Author(s):

Tingting Liu ◽

Hongjin Li ◽

Yvette P. Conley ◽

Brian A. Primack ◽

Jing Wang ◽

...

Keyword(s):

Older Adults ◽

Cognitive Function ◽

Cognitive Decline ◽

Grip Strength ◽

Mental Status ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Hand Grip Strength ◽

Hand Grip ◽

Serum Bdnf

Introduction Aging is associated with subtle cognitive decline in attention, memory, executive function, processing speed, and reasoning. Although lower brain-derived neurotrophic factor (BDNF) has been linked to cognitive decline among older adults, it is not known if the association differs among individuals with various BDNF Val66Met (rs6265) genotypes. In addition, it is not clear whether these associations vary by hand grip strength or physical activity (PA). Methods A total of 2904 older adults were included in this study using data from the Health and Retirement Study. Associations between serum BDNF and measures of cognitive function were evaluated using multivariable linear regression models stratified by Met allele status. PA and hand grip strength were added to the model to evaluate whether including these variables altered associations between serum BDNF and cognition. Results Mean age was 71.4 years old, and mean body mass index was 28.3 kg/m2. Serum BDNF levels were positively associated with higher total cognitive score (beta = 0.34, p = .07), mental status (beta = 0.16, p = .07), and word recall (beta = 0.22, p =.04) among Met carriers, while serum BDNF levels were negatively associated with mental status (beta = −0.09, p = .07) among non-Met carriers. Furthermore, associations changed when hand grip strength was added to the model but not when PA was added to the model. Conclusions The BDNF Val66Met variant may moderate the association between serum BDNF levels and cognitive function in older adults. Furthermore, such associations differ according to hand grip strength but not PA.

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