The Triglycerides and Glucose Index is Negatively Associated with Insulin Secretion in Young Adults with Normal Weight

2022 ◽  
Vol 54 (01) ◽  
pp. 33-36
Author(s):  
Luis E. Simental-Mendía ◽  
Rita Gómez-Díaz ◽  
Niels H. Wacher ◽  
Fernando Guerrero-Romero
Keyword(s):  
Insulin Resistance ◽  
Young Adults ◽  
Insulin Secretion ◽  
Waist Circumference ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Cross Sectional ◽  
Negatively Associated ◽  
Tyg Index

AbstractSeveral studies have supported the usefulness of the triglycerides and glucose (TyG) index as a surrogate measure of insulin resistance; however, it has not been evaluated in insulin secretion. The aim of this study was to assess the association between the TyG index and insulin secretion in young adults with normal weight. Apparently healthy non-pregnant women and men, aged 18 to 23 years, were enrolled in a cross-sectional study. Overweight, obesity, pregnancy, smoking, alcohol consumption, diabetes, liver disease, renal disease, cardiovascular disease, and neoplasia were the exclusion criteria. Normal weight was defined by a body mass index (BMI)≥18.5<25.0 kg/m2 and the TyG index was calculated as the Ln [fasting triglycerides (mg/dl) x fasting glucose (mg/dl)]/2. A total of 1676 young adults with normal-weight, 1141 (68%) women, and 535 (32%) men were enrolled. Of them, 269 (16%) individuals exhibited insulin resistance; 213 (12.7%) women and 56 (3.3%) men. The linear regression analysis adjusted by gender, BMI, and waist circumference showed a significant association between the TyG index and HOMA-B (B=−35.90; 95% CI:−68.25 to−3.54, p=0.03) in the overall population. An additional analysis adjusted by BMI and waist circumference revealed that the TyG index is significantly associated with HOMA-B in subjects with and without insulin resistance (B=−104.73; 95% CI:−204.28 to−5.18, p=0.03 and B=−74.72; 95% CI:−108.04 to−41.40, p<0.001). The results of this study showed that the TyG index is negatively associated with insulin secretion in young adults with normal weight.

scholarly journals The association between elevated serum uric acid levels and islet β-cell function indexes in newly diagnosed type 2 diabetes mellitus: a cross-sectional study

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4515 ◽  
Author(s):  
Yimeng Hu ◽  
Jie Liu ◽  
Huiqiong Li ◽  
Hui Zhu ◽  
Linjie Liu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Secretion ◽  
Serum Lipids ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Islet Function ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
Cross Sectional

Background Serum uric acid (UA) has been reported as a risk factor for type 2 diabetes mellitus (T2DM). However, whether serum UA is associated with insulin resistance and insulin secretion, and the effect of gender on it in the case of the existed association, both remain undefined. Methods A cross-sectional study was designed and performed, which enrolled a total of 403 newly diagnosed T2DM patients (mean age, 50.21 ± 13.34 years (62.5% males)). Clinical characteristics and islet function indexes of all participants were analyzed based on gender-specific tertiles of serum UA levels. In addition, multiple linear regression analysis was conducted to investigate covariates associated with islet function indexes. Results The mean levels of serum UA were 331.05 μmol/L (interquartile range (IQR): 60.6, 400.9 μmol/L) and 267.9 μmol/L (IQR: 204.7, 331.9 μmol/L) in men and women, respectively. The values of insulin secretion indexes involving AUCins30/glu30, AUCins120/glu120 and total insulin disposition index (DI120) in females were significantly higher than those in males. Apart from the homeostasis model assessment insulin resistance of men, serum UA was positively associated with insulin secretion and insulin resistance indexes both in men and women. Multivariable linear regression analysis showed serum UA exerted an independent impact on insulin secretion in females, but not on insulin resistance. In males, islet function was simultaneously affected by serum UA age, body mass index (BMI), and serum lipids. Conclusion Serum UA harbored a positive correlation with insulin secretion and insulin resistance indexes in newly diagnosed T2DM patients, which was influenced by gender, BMI, serum lipids. Hence, serum UA may be considered as a predictor for islet function in clinical practice.

Sex Dependent Association of Vitamin D with Insulin Resistance

2021 ◽  
Author(s):  
Xin Chen ◽  
Chang Chu ◽  
Cornelia Doebis ◽  
Volker von Baehr ◽  
Berthold Hocher
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Animal Studies ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Multivariate Linear Regression Analysis ◽  
Double Blind ◽  
Cross Sectional ◽  
Entire Study

Abstract Background Animal studies suggested that vitamin D might decrease insulin resistance. Estrogen increased insulin sensitivity and glucose tolerance in rodents. However, sex-specific association of vitamin D with insulin resistance in humans remains unclear. Objectives To investigate the sex-dependency of the association of insulin resistance and 25(OH)D in a large Caucasian population. Methods Cross-sectional study from out-patients’ blood samples with measurements of 25(OH)D and HOMA-IR drawn at exactly the same day (N=1887). This cohort was divided into three groups: i) group with vitamin D deficiency (n=1190), ii) group with vitamin D sufficiency (N=686)), iii) vitamin D excess groups (n=11), the vitamin D excess group was excluded from further analysis due to the small size. Results Analysis of the entire study population showed that serum 25-hydroxyvitamin D was inversely associated with HOMA-IR (rs=-0.19, P&lt;0.0001). When considering the vitamin D status, this association was only seen in the vitamin D deficiency group, but not in the vitamin D sufficient group. The correlation was sex-dependent: HOMA-IR was inversely correlated with vitamin D in women with vitamin D deficiency (rs=-0.26, P&lt;0.0001) but not in men with vitamin D deficiency (rs=0.01, P=0.714). After multivariate linear regression analysis considering confounding factors, this relationship was again only seen in women. Conclusion Vitamin D was inversely and independently associated with insulin resistance only in women with vitamin D deficiency. Based on our data, we suggest that in particular vitamin D deficient women might benefit from vitamin D substitution by improving insulin resistance. This, however, needs to be proven in adequately designed double-blind placebo-controlled clinical studies.

Role of Thyroid Deficiency on Adiponectin, Leptin, and Metabolic Status in Visceral Obesity: A Cross-Sectional Study

2017 ◽  
Vol 49 (09) ◽  
pp. 667-672 ◽  
Author(s):  
Lachezar Lozanov ◽  
Desislava Gorcheva ◽  
Bojan Lozanov ◽  
Radka Argirova ◽  
Veselina Koleva ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Serum Insulin ◽  
Visceral Obesity ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Metabolic Status ◽  
Cross Sectional ◽  
Secondary Resistance ◽  
Positive Correlations ◽  
Hypothyroid Patients

AbstractHypothyroidism results in disturbances of metabolism influencing many regulatory systems and active molecules as adipocytokines. Objective of the study was to investigate leptin and adiponectin in patients with visceral obesity and hypothyroidism in relation to metabolic status, insulin resistance and systemic inflammation. A total of 118 patients (59 hypothyroid and 59 euthyroid) were enrolled divided into four age-matched groups according to body wеight (BMI) and thyroid function. Laboratory panel includes TSH, FT4, FT3 (CMIA), adiponectin and leptin (ELISA), IL- 6 (ECLIA), CRP, insulin, glucose, apolipoprotein B and lipoprotein (a) - Lp(a). Hypothyroid patients revealed significant positive correlations of TSH, adiponectin and Lp(a). Their medians of 10.4 mU/l, 12.5 µg/ml and 116.3 mg/l respectively were significantly higher than in euthyroid patients- 1.5 mU/l, 6.26 µg/ml and 32.0 mU/l (p < 0.0001). Leptin in both obese groups was significantly higher than in patients with normal weight. Leptin in hypothyroid patients was lower but not significant to euthyroid ones (9.7 ng/ml vs 13.4 ng/ml respectively, p = 0.16), correlated negatively to TSH and positively to CRP, IL-6, ApoB, Lp(a) and BMI. HOMA-IR and serum insulin at 120 min in OGTT were significantly higher in hypothyroid than in euthyroid patients independent of BMI (p < 0.001). Adiponectin, insulin resistance and chronic inflammation indices in hypothyroid patients correlated positively to TSH, BMI and atherogenic lipoproteins subclasses ApoB/Lp(a). Increased adiponectin in thyroid deficiency could be due to secondary resistance of adiponectin receptors or appeared as a compensatory pathogenetic factor in hypothyroidism.

scholarly journals Biochemical and clinical characterization of metabolic phenotypes: a cross-sectional study from Maracaibo city, Venezuela

F1000Research ◽  
2019 ◽  
Vol 7 ◽  
pp. 230
Author(s):  
Valmore Bermudez ◽  
Joselyn Rojas ◽  
Juan Salazar ◽  
Maria Sofia Martinez ◽  
Luis Carlos Olivar ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Coronary Event ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Related Factors ◽  
Cross Sectional ◽  
Metabolic Phenotypes ◽  
Event Risk ◽  
Obese Subjects ◽  
Healthy Obese

Background: In 1980, Reuben Andresen observed that in certain individuals, obesity did not increase mortality, introducing an atypical phenotype called “healthy obese”. Other studies reported that 10-15 % of lean individuals presented insulin resistance, hyperglycemia and dyslipidemia. The objective of this study was to evaluate biochemical and clinical characteristics of metabolic phenotypes in Maracaibo city. Methods: A descriptive, cross-sectional sub-analysis of The Maracaibo City Metabolic Syndrome Prevalence Study, with a randomized multistage sampling was performed including 1226 non diabetic individuals from both sexes. For phenotype definition, the subjects were first classified according to their BMI into Normal-Weight, Overweight and Obese; then divided in metabolically healthy and unhealthy using a two-step analysis cluster being predictive variables: HOMA2-IR, HOMA2-βcell, triglycerides. To evaluate the relationship with coronary risk, a multiple logistic regression model was performed. Results: In the studied population, 43.9% (n=538) were healthy normal weight, 5.2% (n=64) unhealthy normal weight, 17.4% (n=217) healthy obese and 33.5% (n=411) unhealthy obese subjects. Atypical phenotypes, Metabolically Unhealthy Normal-Weight (MUNW) was more frequent in males (56.3%), whereas Metabolically Unhealthy Obese (MUO) was more frequent in females (51.3%). This phenotypes had a higher coronary event risk, especially for obese individuals (MHO: OR=1.85 CI95%: 1.11-3.09; p=0.02 and MUO: OR=2.09 CI95%: 1.34-3.28; p<0.01). Conclusion: Individuals with atypical metabolic phenotypes are common in Maracaibo city. Related factors may include insulin resistance, basal glucose, and triglycerides levels. Lastly, obese subjects show a higher coronary event risk even those with normal metabolic status.

scholarly journals A Cross-Sectional Study: Predicting Health Risks Among Female University Students

2020 ◽  
Vol 13 (1) ◽  
pp. 316-322
Author(s):  
Qassim I. Muaidi ◽  
Mohammad Ahsan
Keyword(s):  
Waist Circumference ◽  
Health Risks ◽  
Visceral Fat ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Anthropometric Measurements ◽  
Height Ratio ◽  
Visceral Fat Area ◽  
Cross Sectional ◽  
Waist Height Ratio

Background: Good health is very important in our lives and plays a significant role. Many health risks are associated with an unhealthy lifestyle. These risks are responsible for raising the risk of chronic heart diseases and other health complications. Females are not exempted from these issues. Objective: To identify the obesity-associated health risks of female students by using selected anthropometric measurements. Methods: A cross-sectional study was conducted including 300 females aged 20.82 ± 5.23 years from the college of applied medical sciences, Imam Abdulrahman bin Faisal University. The anthropometric measurements (body mass index, percentage of body fat, visceral fat area, waist circumference, waist-hip ratio,and waist-height ratio) were taken with the help of an auto-calibrated bioelectric impedance device. The waist-height ratio was determined by dividing waist circumference with height. Cross tabulation was done to scrutinize the participant’s levels at risk and high risk. Linear regression analysis was done to see the relationship and prediction between selected anthropometric measurements. Results: The finding showed that BMI level was high in 55% of participants, Waist-height ratio over the average level was 46.67% and 21% of participants had a visceral fat area on risk. Linear regression analysis showed a strong association among body mass index, percentage of body fat, visceral fat area, waist circumference, waist-hip ratio,and waist-height ratio and statistically significant to each other at the 0.01 level. Conclusion: The selected anthropometric measurements can be used to identify health-related risks. Though, when any anthropometric measurement dichotomized as standard or high, BMI is the best measure to predict health risk.

Gender Differences in Cardiometabolic Risk Factors in Metabolically Healthy Normal Weight Adults with Central Obesity

2017 ◽  
Vol 126 (05) ◽  
pp. 309-315
Author(s):  
Katarína Šebeková ◽  
Melinda Csongová ◽  
Radana Gurecká ◽  
Zora Krivošíková ◽  
Jozef Šebek
Keyword(s):  
Blood Pressure ◽  
Waist Circumference ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Central Obesity ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Cross Sectional ◽  
Fasting Plasma ◽  
Metabolically Healthy

AbstractWe investigated whether metabolically healthy normal weight adults with central obesity display worse cardiometabolic profile compared with their centrally lean counterparts. This retrospective, cross-sectional study, comprised 1 135 subjects (64% females) aged 18-to-81 years, presenting ≤2 components of metabolic syndrome. They were classified as centrally lean (waist-to-height ratio (WHtR)<0.5 and waist circumference<80 cm in females and<94 cm in males) or presenting central obesity (WHtR ≥0.5, regardless of waist circumference). Data on blood pressure, glucose homeostasis, lipid profile, renal function, high-sensitive C-reactive protein (hsCRP), uric acid, adiponectin, leptin, and soluble receptor for advanced glycation end products were compared between the groups, separately in males and females. 5.7% of males and 6.9% of females presented WHtR ≥0.5. Compared with centrally lean subjects, those with central obesity had higher BMI-adjusted fasting plasma glucose (p<0.001), and leptin levels (p<0.05); females also presented higher blood pressure (p<0.001), while males had higher hsCRP concentrations (p=0.021). These changes associated with significantly higher BMI-adjusted odds to present fasting plasma glucose >5.6 mmol/l in both genders, higher odds to present hsCRP >3 mg/l in males, and those to present elevated blood pressure in females. Our analysis suggests that in metabolically healthy normal weight subjects WHtR ≥0.5 might indicate “early increased health risk”.

scholarly journals Spine Curvature Analysis between Participants with Obesity and Normal Weight Participants: A Biplanar Electromagnetic Device Measurement

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Manuel González-Sánchez ◽  
Jin Luo ◽  
Raymond Lee ◽  
Antonio I. Cuesta-Vargas
Keyword(s):  
Waist Circumference ◽  
Thoracic Kyphosis ◽  
Sagittal Plane ◽  
Lumbar Vertebrae ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Reference Points ◽  
Global Coordinate System ◽  
Cross Sectional ◽  
Electromagnetic Device

To analyse and compare standing thoracolumbar curves in normal weight participants and participants with obesity, using an electromagnetic device, and to analyse the measurement reliability.Material and Methods. Cross-sectional study was carried out. 36 individuals were divided into two groups (normal-weight and participants with obesity) according to their waist circumference. The reference points (T1–T8–L1–L5and both posterior superior iliac spines) were used to perform a description of thoracolumbar curvature in the sagittal and coronal planes. A transformation from the global coordinate system was performed and thoracolumbar curves were adjusted by fifth-order polynomial equations. The tangents of the first and fifth lumbar vertebrae and the first thoracic vertebra were determined from their derivatives. The reliability of the measurement was assessed according to the internal consistency of the measure and the thoracolumbar curvature angles were compared between groups.Results. Cronbach’s alpha values ranged between 0.824 (95% CI: 0.776–0.847) and 0.918 (95% CI: 0.903–0.949). In the coronal plane, no significant differences were found between groups; however, in sagittal plane, significant differences were observed for thoracic kyphosis.Conclusion. There were significant differences in thoracic kyphosis in the sagittal plane between two groups of young adults grouped according to their waist circumference.

scholarly journals Higher toenail selenium is associated with increased insulin resistance risk in omnivores, but not in vegetarians

2020 ◽  
Author(s):  
Qiuyun Gu ◽  
Xueying Cui ◽  
Kun Du ◽  
Bian Wang ◽  
Wei Cai ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Inductively Coupled Plasma ◽  
Linear Regression Analysis ◽  
Fasting Blood Glucose ◽  
Resistance Index ◽  
Cross Sectional Study ◽  
Fasting Insulin ◽  
Dietary Intakes ◽  
Cross Sectional ◽  
Resistance Risk

Abstract Background The relationship between selenium (Se) and insulin resistance remains unclear. We aim to explore the association between toenail Se levels and insulin resistance through a cross-sectional study comprising Chinese vegetarians and matched omnivores. Methods In this study, we enrolled 220 vegetarians and 220 omnivores matched by age and sex from Shanghai. The inductively coupled plasma mass spectrometry method was used to measure toenail Se levels. Dietary Se intakes were assessed by the 24-hour dietary recall method. Blood samples were collected to measure fasting blood glucose level and fasting insulin concentrations. Insulin resistance index（HOMA-IR）and insulin secretion index（HOMA-B）were calculated to evaluate insulin resistance. Multi-linear regression analysis was performed to determine the association between toenail Se levels and insulin resistance, after adjusting for confounders. Results The mean ages of vegetarians (76 vegans, 144 lacto-ovo-vegetarians) and omnivores were 35.96±8.73years and 35.23±8.93 years, respectively. Of these, 180 (81.8%) were female and 40 (18.2%) were male. No association was found between toenail Se levels and insulin resistance in vegetarians. However, the concentration of Se in toenails was positively correlated with fasting insulin levels ( β =1.030, 95% CI : 0.393 to 1.667) and HOMA-IR ( β =0.245, 95% CI : 0.098 to 0.392) in omnivores, after multivariate adjustment for age, sex, BMI, alcohol consumption, income, and daily dietary intakes (energy, protein, fat, carbohydrate, and fiber). This positive relationship persisted only in omnivores whose dietary Se intake was above 60 μg/d. Conclusions Higher toenail Se levels were associated with increased insulin resistance risk in Chinese omnivores whose dietary Se intake was above 60 μg/d, but not in vegetarians. These findings create awareness on the association of dietary Se intake above 60 μg/d with the risk of insulin resistance.

Normal weight obesity among young adults in Trinidad and Tobago: prevalence and associated factors

2017 ◽  
Vol 29 (2) ◽  
Author(s):  
Cherrita Ramsaran ◽  
Rohan G. Maharaj
Keyword(s):  
Young Adults ◽  
Waist Circumference ◽  
Trinidad And Tobago ◽  
Associated Factors ◽  
Adult Population ◽  
Normal Weight ◽  
Normal Body Mass Index ◽  
Fat Percentage ◽  
Cross Sectional ◽  
Normal Weight Obesity

Abstract Background: Patients with normal weight obesity (NWO) have a normal body mass index (BMI) but elevated body fat percentage (BF%), thereby increasing their risk of cardiovascular and metabolic disorders. The purpose of this research was to determine the prevalence of NWO and its associated factors in a sample of young adults in Trinidad and Tobago (T&T). Methods: A cross sectional study involving a convenience non-voluntary sample of participants with a normal BMI of 18.5–24.9 kg/m2 was conducted. The following information was collected: history, basic anthropometric measurements, including BF% via the Tanita Ironman Body Composition Analyzer (BC554), physical examination and basic blood investigations. Participants were divided into two groups; normal BF% (<23.1% males, <33.3% females) and elevated BF% (≥23.1% males, ≥33.3% females). Results: Two hundred and thirty-six students participated, F:M (2.1:1), aged 18–28 years [Mean 21.33 (SD 2.5)], mean BMI 21.66 (SD 1.9). A response rate of 80.3%. The prevalence of NWO for this population was 19.9% [95% confidence interval (CI) 15.1–25.7]. Males 14.4% (95% CI 10.3–19.7) and females 5.5% (95% CI 3.1–9.5). Variables with a statistically significant association with NWO included gender, waist circumference, waist-to-hip ratio (WHR), systolic blood pressure (BP), the ratio of total cholesterol (TC) to high density lipoprotein and in females, the presence of polycystic ovarian syndrome (PCOS) (p<0.05). Binary logistic regression revealed that predictors of NWO were male gender and waist circumference. Conclusions: One in five of this young adult population was found to have NWO. Long-term studies are recommended to study the full implications of these findings.

scholarly journals Association of dietary patterns with BMI and waist circumference in a low-income neighbourhood in Brazil

2010 ◽  
Vol 104 (6) ◽  
pp. 908-913 ◽  
Author(s):  
Diana Barbosa Cunha ◽  
Renan Moritz Varnier Rodrigues de Almeida ◽  
Rosely Sichieri ◽  
Rosangela Alves Pereira
Keyword(s):  
Waist Circumference ◽  
Low Income ◽  
Dietary Patterns ◽  
Eating Habits ◽  
Linear Regression Analysis ◽  
Positive Association ◽  
Population Based ◽  
Cross Sectional Study ◽  
Protective Role ◽  
Cross Sectional

Traditional analysis of food intake usually fails to show an association between energy and nutrient intake and indicators of obesity. The analysis of food patterns can contribute to the understanding of the association between eating habits and anthropometric indicators. A population-based cross-sectional study was carried out on a low-income neighbourhood in the Rio de Janeiro metropolitan area, and 1009 subjects between 20 and 65 years of age completed an FFQ. Dietary patterns were identified by means of factor analysis, and their associations with BMI and waist circumference (WC) were ascertained by applying a linear regression analysis. Three main dietary patterns were identified: a mixed pattern, which included cereals, fish and shrimp, vegetables, roots, fruits, eggs, meat and caffeinated beverages; a Western pattern, which consisted of ‘fast foods’, soft drinks, juices, cakes, cookies, milk and dairy, sweets and snacks; a traditional pattern, which included rice, beans, bread, sugar, fats and salad dressings. After adjusting for age and energy intake, we found that the traditional dietary pattern was inversely associated with BMI (β = − 1·14, P < 0·001) and WC (β = − 14·9, P = 0·002) among females. Additionally, a positive association between the Western pattern and WC (β = 12·8, P = 0·02) was observed for females. A diet based on rice and beans may have a protective role against weight gain in women.

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