Seroprevalence of specific antibodies during pregnancy and risk for early life infectious diseases

Chickenpox is now one of the last of the infectious diseases of childhood that remain mostly uncontrolled. An effective vaccine has been available for many years but has not been used for routine immunisation in many countries. This is because the effect of giving the vaccine in early life on the subsequent development of herpes zoster is not known; high immunisation rates are important to ensure that the age distribution does not shift towards older age groups in whom the disease is more serious; and the disease is generally considered innocuous, especially in childhood when about 95% of infections occur.

Download Full-text

Evaluation of Animal Welfare in Extensive and Intensive Dairy Farms and its Correlation to Infectious Diseases

10.21203/rs.3.rs-185168/v1 ◽

2021 ◽

Author(s):

Francesca Licitra ◽

Laura Perillo ◽

Francesco Antoci ◽

Giuseppe Piccione ◽

Claudia Giannetto ◽

...

Keyword(s):

Infectious Diseases ◽

Animal Welfare ◽

Bovine Herpesvirus ◽

T Test ◽

Farm Animals ◽

Housing System ◽

Check List ◽

Kendall’S Tau ◽

Kendall's Tau ◽

Specific Antibodies

Abstract Background: The welfare of farm animals has become a growing concern in recent years. This is the first study that assesses dairy cow welfare by the application of an impartial, reproducible, functional check-list based on risk analysis which provides a numerical animal welfare index to each farm. We tested the effect of two different management conditions, housing with free access to pasture and indoor housing, on dairy cows kept in 36 farms and concurrently carried out the evaluation of different infectious diseases. Animal welfare assessment was performed in each farm through the CReNBA’s check-list. Moreover, the prevalence of Mycobacterium avium subsp. paratuberculosis, Chlamydiophila abortus, Neospora caninum, Bovine Herpesvirus specific antibodies IgB and IgE and of Bovine Viral Diarrhea virus was tested in each farm through ELISA serological test. Unpaired t-Test was applied to assess differences among the two experimental groups; while, Kendall’s Tau coefficient (T) was determined to investigate the relationship between studied variables. Results: The result of each area provided an indication of the burden and importance of each of these on the final calculation of the animal welfare value. ELISA was positive with different mean percentages. The application of Unpaired t-Test showed that the intensive housing system group had higher percentages of Bovine Herpesvirus specific antibodies IgB compared to the extensive housing system group. The application of Kendall’s Tau coefficient showed different correlations between studied areas and infectious diseases. Conclusion: The hazard analysis areas assessed farming and management conditions of the farms, but these may have different effects as they are regulated by the animals’ ability to adapt and are therefore less important when establishing the final welfare value. Those farms with the highest prevalence of infections could be associated with a poor level of business management. A proper evaluation of the problems encountered and a more accurate application of the check-list could prevent and control the spread of infections in farms. Our results want to be a contribution in breeding which provides farmers and veterinarians the instruments to improve animal welfare and farm business performance.

Download Full-text

Childhood infectious diseases and old age cognitive functioning: a nationally representative sample of community-dwelling older adults

International Psychogeriatrics ◽

10.1017/s1041610220001404 ◽

2020 ◽

pp. 1-8

Author(s):

A. Rotstein ◽

S. Z. Levine

Keyword(s):

Risk Factors ◽

Older Adults ◽

Infectious Diseases ◽

Cognitive Functioning ◽

Old Age ◽

Early Life ◽

Representative Sample ◽

Community Dwelling ◽

Sensitivity Analyses ◽

Nationally Representative

ABSTRACT Background: Cumulative evidence suggests that health-related risk factors during midlife and old-age are associated with cognitive impairment. However, studies are needed to clarify the association between early-life risk factors and impaired cognitive functioning to increment existing knowledge. Objective: To examine the association between childhood infectious diseases and late-life cognitive functioning in a nationally representative sample of older adults. Participants: Eligible respondents were 2994 community-dwelling individuals aged 65–85. Measurements: Cognitive functioning was assessed using the Mini-Mental State Examination (MMSE). Childhood infectious diseases (i.e. chicken pox, measles, and mumps) were self-reported. The study covariates were age, sex, highest educational level achieved, smoking status, body mass index, and depression. The primary statistical analysis examined the association between the number of childhood infectious diseases and total MMSE scores, accounting for all study covariates. Regression models of progressive complexity were examined for parsimony. The robustness of the primary results was tested in 17 sensitivity analyses. Results: The most parsimonious model was a linear adjusted model (Bayesian Information Criterion = 12646.09). Late-life cognitive functioning significantly improved as the number of childhood infectious diseases increased (β = 0.18; 95% CI = 0.11, 0.26; p < 0.001). This effect was not significantly attenuated in all sensitivity analyses. Conclusion: The current study results are consistent with prior ecological findings indicating that some childhood infectious diseases are associated with better cognitive functioning in old-age. This points to an early-life modifiable risk factor associated with older-life cognitive functioning. Our results may reflect selective mortality and/or beneficial effects via hormetic processes.

Download Full-text

Pemberian MP-ASI dini dengan status gizi (PB/U) usia 4-7 bulan di Kecamatan Ratu Samban Kota Bengkulu

AcTion Aceh Nutrition Journal ◽

10.30867/action.v3i2.95 ◽

2018 ◽

Vol 3 (2) ◽

pp. 103

Author(s):

Rama Beka Sariy ◽

Betty Yosephin Simanjuntak ◽

Desri Suryani

Keyword(s):

Breast Milk ◽

Infectious Diseases ◽

Nutritional Status ◽

Early Life ◽

Statistical Test ◽

Cross Sectional ◽

The Third ◽

Cross Sectional Design ◽

Relationship Of ◽

The Relationship

Infants who fail to grow much occur in the third month or fourth month of early life. Early breastfeeding of the ASI causes mothers not to give breast milk and cause infectious diseases that result in stunting in infants. The purpose of this research is to find out the relationship of early breastfeeding with nutritional status (PB/U) age 4-7 months in Ratu Samban Sub-district of Bengkulu City. This research uses analytic observational with a cross-sectional design. The results showed the nutritional status of PB / U short category 18.3% and MP ASI early 66.7% while the statistical test showed probability (p) of 0.273 (p> 0.05). There is no correlation between early breastfeeding of MP and nutritional status of PB / U age 4-7 months in Ratu Samban Sub-district of Bengkulu City. Need to do re-research a using Cohort method and with other variables.Bayi yang gagal tumbuh banyak terjadi pada bulan ketiga atau bulan ke empat awal kehidupan. Pemberian MP ASI dini mengakibatkan ibu tidak berusaha memberikan ASI dan menyebabkan terjadinya penyakit infeksi yang mengakibatkan stunting pada balita. Tujuan dari penelitian ini adalah untuk mengetahui hubungan pemberian MP-ASI dini dengan status gizi (PB/U) pada bayi usia 4-7 bulan di Kecamatan Ratu Samban Kota Bengkulu. Jenis penelitian ini menggunakan observasional analitik dengan desain cross sectional. Hasil penelitian menunjukan status gizi PB/U kategori pendek 18,3% dan MP ASI dini 66,7% sedangkan uji statistik menunjukkan nilai probabilitas (p) sebesar 0,273 (p > 0,05). Tidak ada hubungan antara pemberian MP ASI dini dengan status gizi PB/U usia 4-7 bulan di Kecamatan Ratu Samban Kota Bengkulu . Hal ini berkaitan dengan pemberian makanan pendamping ASI sementara sebagai makanan prelaktal sebelum ASI ibu keluar dan diberikan dalam jumlah sedikit. Lebih baik dilakukan penelitian lanjutan dengan menggunakan metode Kohort dan dengan variabel lain.

Download Full-text

Impact of maternal antibodies and microbiota development on the immunogenicity of oral rotavirus vaccine in African, Indian, and European infants

Nature Communications ◽

10.1038/s41467-021-27074-1 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Edward P. K. Parker ◽

Christina Bronowski ◽

Kulandaipalayam Natarajan C. Sindhu ◽

Sudhir Babji ◽

Blossom Benny ◽

...

Keyword(s):

Low Income ◽

Early Life ◽

Maternal Antibodies ◽

Low Income Countries ◽

Rotavirus Vaccine ◽

Specific Antibodies ◽

Environmental Enteric Dysfunction ◽

The Uk ◽

Antibody Levels ◽

Microbiota Diversity

AbstractIdentifying risk factors for impaired oral rotavirus vaccine (ORV) efficacy in low-income countries may lead to improvements in vaccine design and delivery. In this prospective cohort study, we measure maternal rotavirus antibodies, environmental enteric dysfunction (EED), and bacterial gut microbiota development among infants receiving two doses of Rotarix in India (n = 307), Malawi (n = 119), and the UK (n = 60), using standardised methods across cohorts. We observe ORV shedding and seroconversion rates to be significantly lower in Malawi and India than the UK. Maternal rotavirus-specific antibodies in serum and breastmilk are negatively correlated with ORV response in India and Malawi, mediated partly by a reduction in ORV shedding. In the UK, ORV shedding is not inhibited despite comparable maternal antibody levels to the other cohorts. In both India and Malawi, increased microbiota diversity is negatively correlated with ORV immunogenicity, suggesting that high early-life microbial exposure may contribute to impaired vaccine efficacy.

Download Full-text

Impact of maternal antibodies and microbiota development on the immunogenicity of oral rotavirus vaccine in African, Indian, and European infants: a prospective cohort study

10.1101/2020.11.02.20224576 ◽

2020 ◽

Author(s):

Edward P. K. Parker ◽

Christina Bronowski ◽

Kulandaipalayam Natarajan C. Sindhu ◽

Sudhir Babji ◽

Blossom Benny ◽

...

Keyword(s):

Low Income ◽

Early Life ◽

Maternal Antibodies ◽

Low Income Countries ◽

Rotavirus Vaccine ◽

Specific Antibodies ◽

Environmental Enteric Dysfunction ◽

The Uk ◽

Antibody Levels ◽

Microbiota Diversity

Identifying risk factors for impaired oral rotavirus vaccine (ORV) efficacy in low-income countries may lead to improvements in vaccine design and delivery. We measured maternal rotavirus antibodies, environmental enteric dysfunction (EED), and bacterial gut microbiota development among infants receiving two doses of Rotarix in India (n = 307), Malawi (n = 119), and the UK (n = 60), using standardised methods across cohorts. ORV shedding and seroconversion rates were significantly lower in Malawi and India than the UK. Maternal rotavirus-specific antibodies in serum and breastmilk were negatively correlated with ORV response in India and Malawi, and this was mediated partly by a reduction in ORV replication. In the UK, ORV replication was not inhibited despite comparable maternal antibody levels. In both India and Malawi, pre-vaccination microbiota diversity was negatively correlated with ORV immunogenicity, suggesting that high early-life microbial exposure may contribute to impaired vaccine efficacy.

Download Full-text