scholarly journals Estimation of Fluoride and Sirtuin1 in Patients with Diabetic Nephropathy in Kolar District of Karnataka, India

2021 ◽  
Author(s):  
Sai Deepika R. ◽  
KN Shashidhar ◽  
Raveesha A. ◽  
Muninarayana C.
Keyword(s):  
Diabetic Nephropathy ◽  
Statistical Analysis ◽  
Cross Sectional Study ◽  
Cellular Damage ◽  
P Value ◽  
Distributed Data ◽  
Cross Sectional ◽  
Middle Income ◽  
Normally Distributed

Abstract Objective Prevalence of type-2 diabetes mellitus (DM) and diabetic nephropathy is growing rapidly in Asian countries, affecting low- and middle-income groups. One of the epidemiological issues of Kolar district is fluorosis; advanced glycation end product, carboxymethyl lysine (CML), and a molecule of interest Sirtuin1 are employed in the present study. In the correlation of fluoride with sirtuin1and CML with sirtuin1 of cases lies the important rationale of the study to assess the extent of kidney damage. Materials and Methods This is a comparative cross-sectional study with three groups, each with 70 patients, as follows: G1, control; G2, diabetes with diabetic nephropathy; and G3, type-2 DM without any complications. Informed written consent was obtained from all study patients. All the routine investigations were performed by fully automated Vitro 5, 1 Fs, Vitros. Fasting insulin was analyzed by Vitro eCI and glycated hemoglobin was estimated by BioRad D10. Sirtuin1, CML, and fructosamine were estimated by double antibody sandwich technique. Statistical Analysis The statistical analysis was performed by SPSS 20 (IBM) software. Means of normally distributed data were compared using analysis of variance (ANOVA), and not normally distributed data were compared by Kruskal–Wallis test. A p- value of < 0.05 was considered statistically significant. Results A decrease in sirtuin1, serum, and urine fluoride of group 2 (34.74 [25.08–53.2], 0.24 [0.2–0.5], and 0.24 [0.16–0.41]) was observed compared with other groups. Increased CML and fluoride act as prooxidant, restricting the effect of sirtuin1 on cellular damage, causing further complications such as increased insulin resistance and decreased insulin sensitivity. Conclusion The alterations in serum sirtuin1 levels indicate the severity of damage due to stress during hyperglycemia and fluoride toxicity; hence, sirtuin1 can be considered as biomarker of aging. Subsequently, the correlation of CML, estimated glomerular filtration rate (eGFR), and fluoride with sirtuin1 indicates that increasing sirtuin1 may defend the forthcoming damage and could be considered in therapeutics.

scholarly journals Pattern analysis of S. haematobium infection and elimination in the area of Alsuki, Sudan

2021 ◽  
Vol 8 (3) ◽  
pp. 1059
Author(s):  
Rawia A. Abdelshafie ◽  
Abdalla I. Abdalla Mohamed
Keyword(s):  
Risk Factors ◽  
Statistical Analysis ◽  
Health Program ◽  
Pattern Analysis ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
The People ◽  
The Impact

Background: The aim of this study was to determine the current conditions of children of the selected area, for the purpose of measuring the new effective health program for schistosomiasis disease eliminations and obtain the prevalence intensity and risk factors of S. haematobium among school children in the study area.Methods: A descriptive cross-sectional study was used to screen school going children of all the ages from five randomly selected schools from Alsuki region. A statistical analysis derived from data formulated based on 1062 samples aged between 6 and 15 years attending the selected schools during the period testing within 6 months were enrolled.Results: The impact of health awareness program was measured usefully and the responded factor for reducing the Schistosomiasis diseases was significantly became less than (0.05). Therefore, the actual qualified fitting degree and applicability was significantly becoming (p value=0.001).Conclusions: This research concluded that the prediction of Schistosomiasis diseases due to the risk Ratio of the collected data for those who did not attended awareness over the people who attended program became (0.248).

scholarly journals Association between Acne and Body Mass Index: A Hospital Based Cross Sectional Study

2018 ◽  
Vol 16 (1) ◽  
pp. 53-56
Author(s):  
Saraswoti Neupane ◽  
Binamra Basnet ◽  
Tara Devi Sharma
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Acne Vulgaris ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
P Value ◽  
Cross Sectional ◽  
Middle Income ◽  
Medical College ◽  
Middle Income Countries

Introduction: Acne vulgaris is a common and chronic inflammatory skin disease of pilosebaceous unit. Obesity is one of the biggest problems in western life style but nowadays, the problem is increasing even in low and middle-income countries. Body Mass Index (BMI) is used to accurately measure obesity.Objective: To find out the association between different categories of BMI and severity of acne.Materials and methods: This was a cross sectional prospective study conducted in the outpatient department of Gandaki Medical College from January to July, 2017. All the newly diagnosed patients with acne were included in the study. Height and weight of the patients was recorded and BMI was calculated. BMI was categorized as underweight, normal weight, overweight and obese. Type of lesions were noted and severity of acne was graded from 1 to 4.Statistical analysis was performed using SPSS version 17.0 for windows. One-way Analysis of Variance between groups (ANOVA) test was applied. P value of less than 0.05 was considered significant.Results: There were altogether 249 patients with acne. Age of the patients ranged from 10 to 44 years with mean age of 20.82 ±5.9 years. Most of the patients were in the age group of 11-20 years. Female: male ratio was 1:1.4. Majority of patients (65.5%) had normal BMI. Most of the patients had Grade 2 acne (52.6%). There was no significant association between the BMI and severity of acne (p=0.129).Conclusion: There was no significant association between BMI and severity of acne.

scholarly journals Association between poor psychosocial conditions and diabetic nephropathy in Japanese type 2 diabetes patients: A cross-sectional study

2017 ◽  
Vol 9 (1) ◽  
pp. 162-172 ◽  
Author(s):  
Hiroyo Ninomiya ◽  
Naoto Katakami ◽  
Taka-aki Matsuoka ◽  
Mitsuyoshi Takahara ◽  
Hitoshi Nishizawa ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Psychosocial Conditions ◽  
Diabetes Patients

scholarly journals The Association Between Time in Range %, and Physical & Functional Indices Amongst Older People With Type 2 Diabetes: A Cross Sectional Study

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A477-A478
Author(s):  
Yamit Basson-Shleymovich ◽  
Tali Cukierman-Yaffe ◽  
Tal Yahalom-Peri ◽  
Michal Azmon
Keyword(s):  
Lower Extremity ◽  
Older People ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Lower Extremity Strength ◽  
Increased Risk ◽  
Time In Range

Abstract Diabetes is a major public health burden associated with high mortality, morbidity, hospitalization and health care services utilization rates. People with diabetes have an increased risk for mobility disability compared to those without diabetes, after controlling for age. People with diabetes also have a higher risk for falls and fractures. Data from the last several years suggests that this increased risk is not only due to diabetes co-morbidities but also due to an accelerated decline in physical capacity due to lower muscle quality and a more rapid decline in muscle mass (sarcopenia) and lower extremity strength over time. HBA1C is a measure of average glucose levels; however, it does not provide information about glycemic variability, or daily patterns of glycemia. In the last several years, several organizations have published consensus statements on the role of continuous glucose monitoring (CGM) in glucose control. The use of CGM has brought about the development of many glucose indices, amongst them is: Time In Range% (TIR) of 70–180 mg/dL (3.9–10 mmol/L). Less is known regarding the association between TIR and sarcopenia, muscle mass loss that leads to deterioration in mobility, disabilities and decline in physical indices in older people with diabetes. Aims: To assess among older people with diabetes type 2, the cross sectional association between: TIR and aerobic capacity, gait speed, strength, balance and frailty indices. Methods: A cross sectional study, conducted amongst people with diabetes over the age of 60. Participants were provided with a blinded CGM system- (I Pro2 carelink, Medtronic) for 1 week and underwent elaborate physical-functional assessment in the beginning and at the end of that week. The association between the % of time in range (Time in Range-TIR) and several physical indices was determined using linear regression. Results: This analysis pertains to 55 men and women who completed the evaluation. After adjustment for age and gender, we found that 1% increase in TIR was associated with a 0.341 higher score on the 30 second Sit to Stand score (a measure of lower extremity strength) (P-value=0.02), a 0.351 higher score on the BERG scale (a measure of balance) (P-value=0.01), a 0.271 lower score on the timed up and go score (a measure of fall risk and balance) (P-value=0.008), a 0.289 higher score on the 6-minute walk score (a measure of aerobic capacity and endurance) (P-value=0.02) and a 0.261 lower score on the 360 turn test (a measure of dynamic balance) (P-value=0.0004). The same was not observed for the relationship between HGA1C & physical indices.

scholarly journals Proteinuria Pasien Diabetes Melitus dan Obesitas Poli Penyakit Dalam RS Ibnu Sina Makassar

2019 ◽  
Vol 1 (1) ◽  
pp. 35-44
Author(s):  
Indah Lestari ◽  
Dzul Rizka ◽  
Prema Hapsari ◽  
Pratiwi L Basri ◽  
Nur Hidayah
Keyword(s):  
Diabetes Mellitus ◽  
Waist Circumference ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Type 2 Dm ◽  
Class 1 ◽  
Obesity Patient ◽  
Prevalence Of Diabetes Mellitus

Background: The prevalence of diabetes mellitus in the world has increased which is certainly accompanied by a rapid increase in the incidence of its chronic complications like kidney disorders. Insulin resistance, the patophysiology of diabetes mellitus, also associated with obesity, which both are the main risk factors for cardiovascular events. Obesity also known as a risk factor for kidney disease that proved by the presence of proteinuria in obesity patients. Objective: To determine the correlation of obesity with occurrence of proteinuria in patients with type 2 DM in internal medicine polyclinic Ibnu Sina Hospital Makassar. Method: A cross sectional study on 32 type 2 DM patients at Ibnu Sina Hospital as measured by body weight, height and waist circumference. Urinalysis examination is also performed at that time. Results: In this study, there were 4 patients (12,5%) patients with proteinuria (+), 1 patient (3.1%) with proteinuria (++), 2 patients (6.3%) with proteinuria (+++) and 1 patient (3.1%) with proteinuria (++++). According to BMI, we found that 17 patients (53.1%) were overweight,  5 patients (15.6%) were class 1 obesity, no class 2 obesity patient, and 1 patients (3.1%) were class 3 obesity. In Waist circumference examination we found that  in normal waist circumference group there is 1 patient that did not has proteinuria while in the  abnormal waist circumference group, 8 patients out of 31 patients have proteinuria. After doing statistical analysis to assess the correlation of obesity with proteinuria obtained p value> 0.05. Similarly, the correlation analysis waist circumference with proteinuria obtained p value> 0.05. Conclusion: There is no correlation between obesity and proteinuria as well as waist circumference and proteinuria correlation in type 2 DM patients.

scholarly journals Psychological Effects Related to Accident among Victims

2020 ◽  
Vol 1 (1) ◽  
pp. 1-9
Author(s):  
Mugahed Al-Khader ◽  
Fahad Mohammed Ali Al Mirdef
Keyword(s):  
Statistical Analysis ◽  
Cross Sectional Study ◽  
Psychological Effects ◽  
High Rate ◽  
Traumatic Experience ◽  
P Value ◽  
Negative Feeling ◽  
Cross Sectional ◽  
The Road ◽  
Post Traumatic

Purpose: The aim of this study is to assess the psychological effect related to accident among victims in Najran City hospitals, Saudi Arabia. Study Design: A cross sectional study. Subjects and Methods: This is a descriptive study of cross-sectional design conducted in Najran City hospitals. The study population encompasses all patients of post-traumatic accidents that were admitted to Najran City hospitals during the data collection period. The patients were invited to participate in the study. Non-probability convenience sampling method was used. A questionnaire was devised, developed, and administered to measure the psychological effects related to accident among victims. For statistical analysis, descriptive measures, including frequency, percentage, arithmetic mean, standard deviation, and p-value were employed. Results: The study reveals that more than half of the studied victims (57.8%) were between 21 to 30 years old. All of them were males, indicating high rate of causalities in Najran City among youngsters. In terms of post-traumatic experience, the study reveals that 82.2% of the respondents had negative feelings about themselves. The victims also complained of several other psychological effects. In addition, certain cases of oversleep and excessive anxiety were recorded. The statistical analysis showed no significance between the studied psychological effects related to accident among victims in Najran City hospitals and their characteristics except in terms of marital status and work income. Conclusion: The study concludes that victims of accidents suffer psychologically in the post-traumatic phase. The injuries sustained after the incidents leave the victims suffering from negative feeling about themselves. Given these results, it is recommended that authorities should increase the road instructions to improve awareness of drivers. It is believed that the road instruction would increase road safety and minimize the risk of vehicle accidents.

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