scholarly journals Future of Decellularized Dental Pulp Matrix in Regenerative Endodontics

2022 ◽  
Author(s):  
Zohaib Khurshid ◽  
Ahmed Jamil Ahmed Alnaim ◽  
Ahmed Abdulhakim Ahmed Alhashim ◽  
Eisha Imran ◽  
Necdet Adanir
Keyword(s):  
Tissue Engineering ◽  
Dental Caries ◽  
Bone Grafting ◽  
Dental Pulp ◽  
Tooth Loss ◽  
Periodontal Diseases ◽  
Dental Tissue ◽  
Pulp Regeneration ◽  
Regenerative Endodontics ◽  
Synthetic Scaffolds

AbstractWith the advancements in tissue engineering, the repair and regeneration of oral/dental tissue are becoming possible and productive. Due to periodontal diseases, the tooth loses bone support resulting in tooth loss, but bone grafting stabilizes with new bone. It is seen that due to the progression of dental caries, pulp damage happens, and the vitality of the tooth is compromised. The current theme of dental pulp regeneration through biological and synthetic scaffolds, is becoming a potential therapy for pulp revitalization.

Role of tissue engineering in dental pulp regeneration

2012 ◽  
Vol 1 (2) ◽  
pp. 74
Author(s):  
SunitKumar Jurel ◽  
Shruti Sial ◽  
RaghuwarD Singh ◽  
Mayank Singh ◽  
DurgaS Gupta
Keyword(s):  
Tissue Engineering ◽  
Dental Pulp ◽  
Pulp Regeneration

scholarly journals The Applications of 3D Printing for Craniofacial Tissue Engineering

Micromachines ◽  
2019 ◽  
Vol 10 (7) ◽  
pp. 480 ◽  
Author(s):  
Owen Tao ◽  
Jacqueline Kort-Mascort ◽  
Yi Lin ◽  
Hieu M. Pham ◽  
André M. Charbonneau ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Dental Pulp ◽  
Fused Deposition Modeling ◽  
Alveolar Bone ◽  
Layer By Layer ◽  
Dental Tissue ◽  
Fused Deposition ◽  
Craniofacial Tissue ◽  
And Cartilage

Three-dimensional (3D) printing is an emerging technology in the field of dentistry. It uses a layer-by-layer manufacturing technique to create scaffolds that can be used for dental tissue engineering applications. While several 3D printing methodologies exist, such as selective laser sintering or fused deposition modeling, this paper will review the applications of 3D printing for craniofacial tissue engineering; in particular for the periodontal complex, dental pulp, alveolar bone, and cartilage. For the periodontal complex, a 3D printed scaffold was attempted to treat a periodontal defect; for dental pulp, hydrogels were created that can support an odontoblastic cell line; for bone and cartilage, a polycaprolactone scaffold with microspheres induced the formation of multiphase fibrocartilaginous tissues. While the current research highlights the development and potential of 3D printing, more research is required to fully understand this technology and for its incorporation into the dental field.

scholarly journals Dental pulp tissue engineering

2011 ◽  
Vol 22 (1) ◽  
pp. 3-13 ◽  
Author(s):  
Flávio Fernando Demarco ◽  
Marcus Cristian Muniz Conde ◽  
Bruno Neves Cavalcanti ◽  
Luciano Casagrande ◽  
Vivien Thiemy Sakai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Dental Pulp ◽  
Regeneration Capacity ◽  
Pulp Tissue ◽  
Regenerative Endodontics ◽  
Mesenchymal Tissue ◽  
Dental Pulp Tissue ◽  
Anatomical Arrangement ◽  
Exciting Time ◽  
The Ideal

Dental pulp is a highly specialized mesenchymal tissue that has a limited regeneration capacity due to anatomical arrangement and post-mitotic nature of odontoblastic cells. Entire pulp amputation followed by pulp space disinfection and filling with an artificial material cause loss of a significant amount of dentin leaving as life-lasting sequelae a non-vital and weakened tooth. However, regenerative endodontics is an emerging field of modern tissue engineering that has demonstrated promising results using stem cells associated with scaffolds and responsive molecules. Thereby, this article reviews the most recent endeavors to regenerate pulp tissue based on tissue engineering principles and provides insightful information to readers about the different aspects involved in tissue engineering. Here, we speculate that the search for the ideal combination of cells, scaffolds, and morphogenic factors for dental pulp tissue engineering may be extended over future years and result in significant advances in other areas of dental and craniofacial research. The findings collected in this literature review show that we are now at a stage in which engineering a complex tissue, such as the dental pulp, is no longer an unachievable goal and the next decade will certainly be an exciting time for dental and craniofacial research.

scholarly journals Dental Pulp Regeneration: Insights from Biological Processes

2017 ◽  
Vol 20 (1) ◽  
pp. 10-16
Author(s):  
Cristina Retana-Lobo DDS, MSD
Keyword(s):  
Tissue Engineering ◽  
Dental Pulp ◽  
Short Review ◽  
Biological Processes ◽  
Pulp Tissue ◽  
Pulp Regeneration ◽  
Dental Tissues ◽  
Current State ◽  
Signaling Mechanisms ◽  
Dental Pulp Tissue

One of the major approaches on dentistry research in this century is the development of biological strategies (tissue engineering) to regenerate/ biomineralize lost dental tissues. During dentin-pulp regeneration, the interaction between stem cells, signaling molecules, biomaterials and the microenvironment in the periapical area drives the process for dental pulp tissue engineering.  Understanding the signaling mechanisms and interactions involved with the biological process for the formation of a new tissue, is essential. The knowledge of the micro-environment is the key for the application of tissue engineering.  The present article is a short review of the current state of this topic, with the purpose of showing insights of pulp regeneration.

scholarly journals Antibacterial agent-releasing scaffolds in dental tissue engineering

2021 ◽  
Vol 13 (1) ◽  
pp. 43-47
Author(s):  
Zahra Gholami ◽  
Shirin Hasanpour ◽  
Samira Sadigh ◽  
Sana Johari ◽  
Zahra Shahveghar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Antimicrobial Agents ◽  
Periodontal Diseases ◽  
Base Material ◽  
Antimicrobial Activities ◽  
Synthesis Process ◽  
Oral Diseases ◽  
Dental Tissue ◽  
Inflammatory Reactions ◽  
Dental Tissue Engineering

It seems quite challenging in tissue engineering to synthesize a base material with a range of essential activities, including biocompatibility, nontoxicity, and antimicrobial activities. Various types of materials are synthesized to solve the problem. This study aimed to provide the latest relevant information for practitioners about antibacterial scaffolds in dental tissue engineering. The PubMed search engine was used to review the relevant studies with a combination of the following terms as search queries: tissue engineering, scaffolds, antimicrobial, dentistry, dental stem cells, and oral diseases. It is noteworthy to state that only the terms related to tissue engineering in dentistry were considered. The antimicrobial scaffolds support the local tissue regeneration and prevent adverse inflammatory reactions; however, not all scaffolds have such positive characteristics. To resolve this potential defect, different antimicrobial agents are used during the synthesis process. Innovative methods in guided tissue engineering are actively working towards new ways to control oral and periodontal diseases.

scholarly journals Dental Pulp Regeneration: Insights from Biological Processes

2017 ◽  
Vol 20 (1) ◽  
pp. 10-16
Author(s):  
Cristina Retana-Lobo DDS, MSD
Keyword(s):  
Tissue Engineering ◽  
Dental Pulp ◽  
Short Review ◽  
Biological Processes ◽  
Pulp Tissue ◽  
Pulp Regeneration ◽  
Dental Tissues ◽  
Current State ◽  
Signaling Mechanisms ◽  
Dental Pulp Tissue

One of the major approaches on dentistry research in this century is the development of biological strategies (tissue engineering) to regenerate/ biomineralize lost dental tissues. During dentin-pulp regeneration, the interaction between stem cells, signaling molecules, biomaterials and the microenvironment in the periapical area drives the process for dental pulp tissue engineering.  Understanding the signaling mechanisms and interactions involved with the biological process for the formation of a new tissue, is essential. The knowledge of the micro-environment is the key for the application of tissue engineering.  The present article is a short review of the current state of this topic, with the purpose of showing insights of pulp regeneration.

scholarly journals Epidemiological profile of patients utilizing dental public health services in the eThekwini and uMgungundlovu districts of KwaZulu-Natal province, South Africa

2020 ◽  
Vol 75 (10) ◽  
pp. 541-547
Author(s):  
Jimmy M Mthethwa ◽  
Ozayr H Mahomed ◽  
Veerasamy Yengopal
Keyword(s):  
Public Health ◽  
South Africa ◽  
Dental Caries ◽  
Tooth Loss ◽  
Periodontal Diseases ◽  
Adverse Outcomes ◽  
Cross Sectional ◽  
Kwazulu Natal ◽  
Clinical Records ◽  
Oral Conditions

INTRODUCTION: Oral conditions such as dental caries, periodontal diseases, tooth loss and trauma affect millions of people globally. These conditions can be prevented when detected early, thereby avoiding adverse outcomes. The prevalence of oral conditions has been reported in most provinces. However, there is a paucity of data in KwaZulu-Natal. AIM AND OBJECTIVE: This study aimed to determine the prevalence of oral conditions at public health facilities in two health districts in KwaZulu-Natal, South Africa. MATERIALS AND METHODS: A cross-sectional analytical study design was used to determine the nature of oral conditions treated in dental facilities in the eThekwini and uMgungundlovu districts, in KwaZulu-Natal. The study was conducted over a 5-month period (November 2018 - April 2019). After clinicians examined the patients they entered the data in the patients clinical records and selected information (routine medical history questions as well as 16 possible diagnosis codes) were entered into a data extraction template. The data were analyzed using statistical software SPSS. RESULTS: Dental caries was the most prevalent oral condition at 66.4% followed by periodontal disease at 11.7%, trauma at 7.3% and lastly tooth loss at 5.9% CONCLUSION: These findings contribute to knowledge on the prevalence of these oral conditions found in the province.

scholarly journals Downregulation of miR-224-5p Promotes Migration and Proliferation in Human Dental Pulp Stem Cells

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Zhihong Ke ◽  
Zailing Qiu ◽  
Tingting Xiao ◽  
Jianchai Zeng ◽  
Luning Zou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Root Canal ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Differentially Expressed ◽  
Pulp Regeneration ◽  
Regenerative Endodontics ◽  
Differentially Expressed Mirna ◽  
And Migration ◽  
Proliferation And Migration

Introduction. Pulp regeneration, as a treatment for pulp necrosis, has significant advantages over root canal therapy for the preservation of living pulp. To date, research on pulp regeneration has mainly focused on the transplantation of pulp stem cells into the root canal, but there is still a lack of research on the migration of pulp cells into the root canal via cell homing. Stem cells from the apical tooth papilla (SCAP) are recognized as multidirectional stem cells, but these cells are difficult to obtain. MicroRNAs are small noncoding RNAs that play crucial roles in regulating normal and pathologic functions. We hypothesized that some types of microRNAs might improve the migration and proliferation function of dental pulp stem cells (DPSCs), which are easily obtained in clinical practice, and as a result, DPSCs might replace SCAP and provide valuable information for regenerative endodontics. Methods. Magnetic activated cell sorting of DPSCs and SCAP was performed. Next-generation sequencing was performed to examine DPSCs and SCAP miRNAs expression and to identify the most significant differentially expressed miRNA. CCK-8 and transwell assays were used to determine the impact of this miRNA on DPSCs proliferation and migration. Results. The most significant differentially expressed miRNA between DPSCs and SCAP was miR-224-5p. Downregulating miR-224-5p promoted DPSCs proliferation and migration; the opposite results were observed when miR-224-5p was upregulated. Conclusion. MiR-224-5p promotes proliferation and migration in DPSCs, a finding that is of great significance for further exploring the role of dental pulp stem cells in regenerative endodontics.

SIGNIFICANCE AND NEED OF TREATMENT OF PERIAPICAL LESION

INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (07) ◽  
pp. 5-13
Author(s):  
S.R Pattan ◽  
◽  
P.S Bykod ◽  
P.U. Shetkar ◽  
S.V. Pattewar ◽  
...  
Keyword(s):  
Dental Caries ◽  
Infectious Diseases ◽  
Dental Pulp ◽  
Severe Pain ◽  
Tooth Loss ◽  
The Body ◽  
Periapical Lesion ◽  
Endodontic Disease ◽  
Periapical Inflammation ◽  
Effective Treatments

Dental caries, one of the most prevalent infectious diseases worldwide, affects approximately 80% of children and the majority of adults. Dental caries may result in endodontic disease, leading to dental pulp necrosis, periapical inflammation and bone desorption, severe pain, and tooth loss. Periapical inflammation may also increase inflammation in other parts of the body. Although many studies have attempted to develop therapies for this disease, there is still an urgent need for effective treatments.

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