Practical Guide to Global Point-of-Care Testing

2016 ◽  
Keyword(s):  
Health Professionals ◽  
Indigenous Health ◽  
Point Of Care ◽  
Medical Science ◽  
Rapid Test ◽  
Health Science ◽  
Global Perspective ◽  
Access To Health Services ◽  
Point Of Care Testing ◽  
Practical Guide

Point-of-care testing (POCT) refers to pathology testing performed in a clinical setting at the time of patient consultation, generating a rapid test result that enables informed and timely clinical action to be taken on patient care. It offers patients greater convenience and access to health services and helps to improve clinical outcomes. POCT also provides innovative solutions for the detection and management of chronic, acute and infectious diseases, in settings including family practices, Indigenous medical services, community health facilities, rural and remote areas and in developing countries, where health-care services are often geographically isolated from the nearest pathology laboratory. A Practical Guide to Global Point-of-Care Testing shows health professionals how to set up and manage POCT services under a quality-assured, sustainable, clinically and culturally effective framework, as well as understand the wide global scope and clinical applications of POCT. The book is divided into three major themes: the management of POCT services, a global perspective on the clinical use of POCT, and POCT for specific clinical settings. Chapters within each theme are written by experts and explore wide-ranging topics such as selecting and evaluating devices, POCT for diabetes, coagulation disorders, HIV, malaria and Ebola, and the use of POCT for disaster management and in extreme environments. Figures are included throughout to illustrate the concepts, principles and practice of POCT. Written for a broad range of practicing health professionals from the fields of medical science, health science, nursing, medicine, paramedic science, Indigenous health, public health, pharmacy, aged care and sports medicine, A Practical Guide to Global Point-of-Care Testing will also benefit university students studying these health-related disciplines.

scholarly journals Hepatitis C Rapid Point-of-Care Testing and Laboratory-based Non-invasive Assessment of Liver Fibrosis among Drug Abusers: An Experience from Iran

2021 ◽  
Vol 24 (2) ◽  
pp. 94-100
Author(s):  
Mohammad Reza Hedayati-Moghaddam ◽  
Hossein Soltanian ◽  
Majid Danaee ◽  
Seyed Ahmad Vahedi
Keyword(s):  
Hepatitis C ◽  
Liver Fibrosis ◽  
Drug Treatment ◽  
Drug Users ◽  
Point Of Care ◽  
Rapid Test ◽  
Hcv Infection ◽  
Point Of Care Testing ◽  
Non Invasive ◽  
Test Kit

Background: People who use drugs, particularly injection drug users (IDUs) are known as the major source of hepatitis C virus (HCV) infection. This study was performed to determine the prevalence of HCV infection using rapid point-of-care testing and to assess liver fibrosis by non-invasive lab tests among addict populations of Mashhad, Iran. Methods: In this cross-sectional study, drug users who referred to drug treatment and harm reduction centers of Mashhad were enrolled during March and December 2019. A rapid test kit was used to assess the presence of anti-HCV antibodies and a real-time PCR was performed to confirm the infection. The AST-platelet ratio index (APRI) and fibrosis-4 (FIB-4) score were used to investigate liver fibrosis in patients with positive HCV RNA. A P value <0.05 was considered as significant. Results: A total of 390 drug users aged 15–74 years were assessed. Sixty-four individuals showed positive results for anti-HCV (16.4%), of whom 58 blood samples were available for PCR test. The viremic rate among the latter group was calculated at 84.5% (49/58); the total viremia prevalence was 12.8% (49/384). Multivariate analysis revealed that being single (P = 0.040) or divorced/ widow (P = 0.011) and history of drug injection (P<0.001) and tattoos (P = 0.021) were significantly associated with current HCV infection. Using APRI and FIB-4 indices, significant liver fibrosis was identified in 14.3% and 18.4% of cases, respectively. Conclusion: HCV infection screening using rapid tests and examining liver fibrosis by non-invasive lab tests appear to be practicable and useful among poor populations in settings such as drug treatment centers.

Current Point-of-Care testing in cancer and future perspectives: a systematic review

2020 ◽  
Vol 30 (Supplement_2) ◽  
Author(s):  
M Rodrigues ◽  
I Andrade ◽  
R Cruz
Keyword(s):  
Systematic Review ◽  
Early Detection ◽  
Point Of Care ◽  
Low Cost ◽  
Rapid Test ◽  
Point Of Care Testing ◽  
Screening Programs ◽  
Low Resource ◽  
Resource Limited ◽  
Prevalent Disease

Abstract Introduction Cancer is the most prevalent disease worldwide, causing a major impact on society. Early detection and monitorization of the tumour can provide a more effective treatment. Point-of-care (POC) testing allows the patient to have a handheld test that gives the results rapidly. No expertise or special knowledge is required which is vital namely when carried out in low-resource areas. Recent studies analysed established and emerging biomarkers and how to incorporate them into POC devices, but a systematic review reporting the existing POC platforms for cancer is still not available. Objectives This systematic review aims to report current and recent advances for point-of-care testing in cancer. Methodology A literature review was conducted through research in the databases “PubMed” and “B-On” for relevant reviews published in the last ten years, using the keywords “Point-of-care testing” AND “Cancer” AND “Rapid Test” AND “Cancer detection”. Results In 2015 there were eight commercially available POC tests for prostate, bladder, colorectal, cervical, HPV-causing head and neck cancer, liver, breast and lung cancer. After 2018 a small number of POC devices were tested in screening programs and multicentric studies, and more recently, promising novel POC prototypes for early detection of cancer, namely a 3D prototype micro device for multiple singleplex RNA expression analysis in liver cancer and a POC microscopy prototype for digital diagnostics of breast cancer lymph node metastases, with potential to be used in resource-limited settings. Conclusion The use of POC testing can deliver accurate, fast results, and in the case of cancer it is no exception, contributing to the progression of treatment and reduction in cancer-related deaths. In low-resource settings a POC test is fundamental and it should be simple and low-cost. But there are limitations in the tests which is a challenge for improvement and investigation in the future.

scholarly journals Point of care testing: lateral flow technology and beyond

2006 ◽  
Vol 27 (2) ◽  
pp. 70 ◽  
Author(s):  
Stuart Hazell ◽  
Hugh Swingler
Keyword(s):  
Point Of Care ◽  
Medical Science ◽  
Laboratory Medicine ◽  
Lateral Flow ◽  
Economic Pressure ◽  
Point Of Care Testing ◽  
The Real ◽  
Real Cost

For the last 50 years the pathology industry has been centralised and built around a strong skills base in laboratory medicine. Over recent decades, that skills base has been diluted as advances in technology have seen automation takeover many laboratory-based functions. These changes have, perversely, been driven by advances in medical science. With advances in medicine has come the demand for more intervention (testing) and the concomitant economic pressure to reduce the real cost of pathology testing as access is expanded.

scholarly journals Portable RT-PCR system: A Rapid and Scalable Diagnostic Tool for COVID-19 Testing

2021 ◽  
Author(s):  
Hosam M Zowawi ◽  
Thamer H Alenazi ◽  
Waleed S AlOmaim ◽  
Ahmad Wazzan ◽  
Abdullah Alsufayan ◽  
...  
Keyword(s):  
Point Of Care ◽  
Rapid Test ◽  
Standard Of Care ◽  
Test Results ◽  
Rt Pcr ◽  
Point Of Care Testing ◽  
System A ◽  
Portable System ◽  
Remote Sites ◽  
User Friendly

Combating the ongoing coronavirus disease 2019 (COVID-19) pandemic demands accurate, rapid, and point-of-care testing with fast results to triage cases for isolation and treatment. The current testing relies on RT-PCR, which is routinely performed in well-equipped laboratories by trained professionals at specific locations. However, during busy periods high numbers of samples queued for testing can delay the test results, impacting upon efforts to reduce the infection risk. Besides, the absence of well-established laboratories at remote sites and low-resourced environments can contribute to a silent spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These reasons compel the need to accommodate point-of-care testing for COVID-19 that meets the ASSURED criteria (Affordable, Sensitive, Specific, User-friendly, Rapid, robust, Equipment-free, and Deliverable). This study assessed the agreement and accuracy of the portable Biomeme SARS-CoV-2 system against the gold standard tests. Nasopharyngeal and nasal swabs were used. Of the 192 samples tested using the Biomeme SARS-CoV-2 system, the results from 189 samples (98.4%) were in agreement with the reference standard-of-care RT-PCR testing for SARS-CoV-2. The portable system generated simultaneous results for nine samples in 80 mins with high positive and negative percent agreements of 99.0% and 97.8%, respectively. We performed separate testing in a sealed glove box, offering complete biosafety containment. Thus, the Biomeme SARS-CoV-2 system can help decentralize COVID-19 testing and offer rapid test results for patients in remote and low-resourced settings. Single Sentence Summary The Biomeme SARS-CoV-2 system can help decentralize COVID-19 testing and offer rapid test results for patients in remote sites and low-resourced settings.

365 Point-of-care testing for bladder cancer – the UBC Rapid test on the concile® Ω100 reader platform provides quantitative results

2013 ◽  
Vol 12 (1) ◽  
pp. e365 ◽  
Author(s):  
T. Todenhöfer ◽  
J. Hennenlotter ◽  
R. Ritter ◽  
U. Hoffmann ◽  
P. Blutbacher ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Point Of Care ◽  
Rapid Test ◽  
Point Of Care Testing ◽  
Quantitative Results

Point-of-care troponin testing and management of patients with acute coronary syndrome: a systematic review

2020 ◽  
Vol 15 (2) ◽  
pp. 1-16
Author(s):  
Huiyun Du ◽  
So Ting Chan ◽  
Parichat Wonggom ◽  
Peter Newman ◽  
Rosy Tirimacco ◽  
...  
Keyword(s):  
Systematic Review ◽  
Emergency Department ◽  
Acute Coronary Syndrome ◽  
Cardiac Troponin ◽  
Point Of Care ◽  
Clinical Care ◽  
Grey Literature ◽  
Rapid Test ◽  
Point Of Care Testing ◽  
Coronary Syndrome

Background Early identification of acute coronary syndrome is crucial for a patient's likelihood of survival. Point-of-care testing of cardiac troponin is a rapid test of cardiac troponin that can be conducted closer to where clinical care is delivered, with a significant shorter turnaround time. Point-of-care testing of troponin may improve timely diagnosis of acute coronary syndrome. Aim To examine existing evidence on the effectiveness of point-of-care testing of troponin for acute coronary syndrome management in the emergency department. Methods A systematic review of randomised controlled trials was conducted across databases, and grey literature. Results No study evaluated adherence to acute coronary syndrome management guidelines. One of the five studies that assessed length of stay showed a statistically significant reduction (P=0.035). Two of the three studies that measured time to disposition in emergency department demonstrated statistically significant effects (P=0.04 vs P=0.05) favouring point-of-care testing of troponin. One study demonstrated statistically significant effects on successful discharge to home from emergency department (P=0.001). No significant effects were reported for mortality or accuracy. Conclusion Point-of-care testing of troponin can significantly reduce time to disposition in emergency department and successful discharge home. Translation of this evidence into clinical practice is recommended.

scholarly journals Performance of the Atlas Genetics Rapid Test for Chlamydia trachomatis and Womenʼs Attitudes Toward Point-Of-Care Testing

2018 ◽  
Vol 45 (11) ◽  
pp. 723-727 ◽  
Author(s):  
Lea E. Widdice ◽  
Yu-Hsiang Hsieh ◽  
Barbara Silver ◽  
Mathilda Barnes ◽  
Perry Barnes ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Point Of Care ◽  
Rapid Test ◽  
Point Of Care Testing

Development of a Gold Nanoparticle-Based Colorimetric Sensor for Water for Injection At-Line Impurity Testing

2020 ◽  
pp. 247263032097818
Author(s):  
Saskia Reichelt ◽  
Elke Boschke ◽  
Olena Reinhardt ◽  
Thomas Walther ◽  
Felix Lenk
Keyword(s):  
Septic Shock ◽  
Point Of Care ◽  
Rapid Test ◽  
Sample Volume ◽  
Gram Negative Bacteria ◽  
Point Of Care Testing ◽  
Limulus Amebocyte Lysate ◽  
Regulatory Requirements ◽  
Gram Negative ◽  
Line Process

The best-known rapid test using gold nanoparticles (AuNPs) is the human chorionic gonadotropin pregnancy test. AuNPs are a powerful tool in point-of-care testing because of their flexibility, modifiability, and visibility. Here, we report a method to detect impurities for at-line process control in water-for-injection (WFI) manufacturing through the example of endotoxins. If a distinct concentration of these amphipathic molecules, originated from gram-negative bacteria, enters the human body, it will result in septic shock, followed by organ failure and possibly death. Every fluid given parenterally is subject to strict regulatory requirements and therefore endotoxin testing. Through use of traditional methods like the limulus amebocyte lysate (LAL) test, it takes more than 2 h to complete. With the presented method, one-fifth of the sample volume is sufficient compared with the LAL test. Once the assay components have been mixed, the result can be interpreted visually within 2 min without the use of further instruments.

Testing for resistance: Point-of-care testing as a communicational tool in antibiotic prescribing

2018 ◽  
Vol 14 (3) ◽  
pp. 229-240
Author(s):  
Johanna Lindell
Keyword(s):  
Point Of Care ◽  
Rapid Test ◽  
Antibiotic Use ◽  
Treatment Recommendation ◽  
Antibiotic Prescribing ◽  
Communicative Practices ◽  
Effective Strategies ◽  
Reactive Protein ◽  
Point Of Care Test ◽  
Test Result

As antibiotic resistance becomes a growing health emergency, effective strategies are needed to reduce inappropriate antibiotic use. In this article, one such strategy – communicative practices associated with the C-reactive protein point-of care test – is investigated. Building on a collection of 31 videorecorded consultations from Danish primary care, and using conversation analysis, this study finds that the rapid test can be used throughout the consultation to incrementally build the case for a nonantibiotic treatment recommendation, both when the test result is forecast and reported. The study also finds that the format of reports of elevated results differs from that of ‘normal’ results, resulting in a subtle shift of authority from doctor to test.

Sign in / Sign up

Export Citation Format

Share Document