Rosiglitazone maleate increases weight gain and body fat content in growing lambs

2016 ◽  
Vol 56 (7) ◽  
pp. 1185
Author(s):  
F. T. Fahri ◽  
I. J. Clarke ◽  
D. W. Pethick ◽  
R. D. Warner ◽  
F. R. Dunshea
Keyword(s):  
Growth Performance ◽  
Meat Quality ◽  
Feed Intake ◽  
Plasma Metabolites ◽  
Peroxisome Proliferator ◽  
Model Assessment ◽  
Peroxisome Proliferator Activated Receptor ◽  
Entire Study ◽  
Fat Depots ◽  
Muscle Ph

Thiazolidinediones (TZD) are synthetic orally active peroxisome proliferator-activated receptor γ ligands used in the treatment of diabetes mellitus. The peroxisome proliferator-activated receptor γ gene plays an important role in regulating fat cell development, energy balance, and lipid metabolism in adipose and skeletal muscle tissue. There is interest in pharmacologic or nutritional means that may complement genetic techniques to improve growth and carcass composition of lambs and the major aim of the present study was to determine whether TZD impact on growth performance and meat quality of growing lambs. An initial study with four cross-bred lambs confirmed that rosiglitazone maleate is absorbed after oral dosing for 7 days. A second study was conducted with 30 cross-bred lambs to investigate the effects of sex (ewe vs wether) and dose of orally administered rosiglitazone maleate (0, 8 and 24 mg/day) for 55 days on growth performance, body composition, plasma metabolites and insulin and meat quality. Feed intake tended to increase linearly with dose of TZD (1521, 1816 and 1878 g/day for 0, 8 and 24 mg/day, P = 0.07) over the entire study, and particularly during the second half of the study (P < 0.05). There were both linear (P = 0.05) and quadratic (P = 0.04) responses in average daily gain to TZD (215, 270 and 261 g/day) with the quadratic response being most pronounced over the second half of the study (P = 0.004). As a result of the increased feed intake back fat (9.4, 11.1 and 13.5 mm, P < 0.001) and carcass fat (27.5%, 29.2% and 30.1%, P = 0.05) increased linearly with dose of TZD. However, there was no effect of TZD on internal fat depots. Plasma non-esterified acid concentrations increased linearly (0.37, 0.39 and 0.41 mM, P = 0.01) whereas plasma insulin concentrations (23.2, 26.9 and 20.9 mU/L, P = 0.05) and the homeostatic model assessment (6.82, 7.73 and 5.98, P = 0.05) exhibited quadratic responses to TZD. There were no significant effects of TZD on muscle pH, temperature or colour although muscle pH was higher at any temperature in ewes (+ 0.05 of a pH unit, P = 0.036) than in wethers. In conclusion, these data confirm that rosiglitazone maleate was rapidly absorbed from the digestive tract of growing ruminant lambs and was metabolically active. Oral TZD treatment appeared to mitigate against the inhibitory effect of carcass fatness on feed intake but the additional energy consumed was in turn deposited as fat.

Desirable effects of dietary 4-O-methyl-glucuronoarabinoxylan from the Echinacea plant on growth performance, thigh meat quality and development of small intestine in female Partridge-Shank broilers

2020 ◽  
Vol 60 (2) ◽  
pp. 288
Author(s):  
Qing-Chang Ren ◽  
Jing-Jing Xuan ◽  
Chuan-Yan Che ◽  
Xin-Chao Yan ◽  
Zhong-Ze Hu
Keyword(s):  
Small Intestine ◽  
Growth Performance ◽  
Meat Quality ◽  
Dietary Supplementation ◽  
Bodyweight Gain ◽  
Lower Percentage ◽  
Feed Ratio ◽  
Muscle Ph ◽  
Access To Water

In this trial we aimed to assess the effects of dietary supplementation of 4-O-methyl-glucuronoarabinoxylan (4OMG) on growth performance, thigh meat quality and small intestine development of female Partridge-Shank broilers. A total of 240 1-day-old female Partridge-Shank broilers were randomly distributed to four groups with three replicates of 20 within each group. Groups received either 0, 15, 20 or 25 g 4OMG/kg DM of diet. During the whole experiment of 60 days, broilers had ad libitum access to water and feed. At pen level, feed intake was recorded daily and broilers were weighed at the start and end of the experiment. For each group, three pens with a total of 20 broilers were randomly selected to determine the thigh meat quality and the small intestine development of broilers. Broilers fed diets with higher 4OMG had greater final liveweight (P = 0.004), daily bodyweight gain (P = 0.004) and gain-to-feed ratio (P &lt; 0.001), muscle pH values (P = 0.031) and redness (P = 0.001), duodenal weight index (P = 0.042), jejunal (P = 0.043) and ileal length (P = 0.049), duodenal (P &lt; 0.001) and ileal villus height (P = 0.008), but lower percentage of dead birds (P &lt; 0.001), drip loss (P = 0.042) and shear force value (P = 0.043) of the thigh muscles. These results indicate that increasing dietary supplementation of 4OMG may improve growth performance and meat quality of female Partridge-Shank broilers through better development of small intestine.

scholarly journals Growth Performance, Antioxidant Capacity, Lipid-Related Transcript Expression and the Economics of Broiler Chickens Fed Different Levels of Rutin

Animals ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 7 ◽  
Author(s):  
Fardos Hassan ◽  
Elshimaa Roushdy ◽  
Asmaa Kishawy ◽  
Asmaa Zaglool ◽  
Hammed Tukur ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Growth Performance ◽  
Broiler Chickens ◽  
Fatty Acid Synthase ◽  
Body Weight Gain ◽  
Density Lipoprotein ◽  
Basal Diet ◽  
Peroxisome Proliferator ◽  
High Concentration ◽  
Peroxisome Proliferator Activated Receptor

The effects of rutin on growth performance, hematological and biochemical profiles, antioxidant capacity, economics and the relative expression of selected antioxidants and lipid-related genes were studied in broiler chickens over 42 days. A total of 200 one-day-old female Ross-308 broiler chickens were distributed into four groups, with five replicates of 10 individuals per replicate. They were fed with 0 (control), 0.25, 0.5 or 1 g rutin/kg supplementation in their basal diet. Dietary rutin supplementation, especially the 1 g/kg diet, increased body weight gain, the protein efficiency ratio (p < 0.001) and both white blood cell and lymphocyte counts (p < 0.001). However, it had no effect on total protein, albumin, globulin, or alanine transaminase. A high concentration of rutin (0.5 and 1 g/kg) also significantly reduced serum total cholesterol, triacylglycerol and low-density lipoprotein cholesterol concentrations (p < 0.001), as well as malondialdehyde concentrations (p = 0.001). A high concentration diet also increased the activity of superoxide dismutase, catalase and glutathione peroxidase. Of the lipid-related genes examined, acetyl CoA carboxylase and fatty acid synthase were significantly down-regulated in the livers of rutin-fed individuals, whereas carnitine palmitoyl transferase 1 and peroxisome proliferator-activated receptor alpha were significantly up-regulated. Therefore, rutin supplementation at 1 g/kg has the potential to improve the productive performance and health status of broiler chickens.

scholarly journals Effects of dietary supplementation of guanidino acetic acid on growth performance, thigh meat quality and development of small intestine in Partridge-Shank broilers

2018 ◽  
Vol 156 (9) ◽  
pp. 1130-1137 ◽  
Author(s):  
Q. C. Ren ◽  
J. J. Xuan ◽  
X. C. Yan ◽  
Z. Z. Hu ◽  
F. Wang
Keyword(s):  
Acetic Acid ◽  
Small Intestine ◽  
Growth Performance ◽  
Meat Quality ◽  
Feed Intake ◽  
Dietary Supplementation ◽  
Thigh Muscle ◽  
Feed Ratio ◽  
Villus Height ◽  
Crypt Depth

AbstractThe current experiment aimed at assessing the effects of dietary supplementation of guanidino acetic acid (GAA) on growth performance, thigh meat quality and development of small intestine in broilers. A total of 360 1-day-old female broiler chicks were distributed randomly to four groups of 90 birds each, and each group received GAA dosages of 0, 0.4, 0.8 and 1.2 g/kg of feed dry matter. During the whole experiment of 60 days, broilers hadad libitumaccess to water and feed and the feed intake was recorded daily. All broilers were weighed before and after the experiment, and 30 broilers of each group were selected randomly to slaughter at the end. Increasing dietary supplementation of GAA increased final live weight and daily body weight gain, gain-to-feed ratio, thigh muscle pH value and fibre diameter of broilers, but decreased daily feed intake, drip loss, cooking loss, shear force value, hardness, gumminess and chewiness of thigh meat. In addition, increasing supplementation of GAA quadratically increased duodenal, jejunal and ileal villus height and width and ratio of villus height to crypt depth, but decreased crypt depth. The results indicated that GAA as a feed additive may support better development of small intestine, thereby resulting in improvement of growth performance and meat quality of broilers.

scholarly journals Changes in adipose tissue physiology during the first two weeks posthatch in chicks from lines selected for low or high body weight

2019 ◽  
Vol 316 (6) ◽  
pp. R802-R818 ◽  
Author(s):  
Yang Xiao ◽  
Guoqing Wang ◽  
Miranda E. Gerrard ◽  
Sarah Wieland ◽  
Mary Davis ◽  
...  
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Fat Mass ◽  
Peroxisome Proliferator ◽  
Adipocyte Size ◽  
Peroxisome Proliferator Activated Receptor ◽  
Nonesterified Fatty Acids ◽  
Development Patterns ◽  
Fat Depots ◽  
Enhancer Binding Protein

Chickens from lines selected for low (LWS) or high (HWS) body weight (BW) differ in appetite and adiposity. Mechanisms associated with the predisposition to becoming obese are unclear. The objective of the experiment was to evaluate developmental changes in depot-specific adipose tissue during the first 2 wk posthatch. Subcutaneous (SQ), clavicular (CL), and abdominal (AB) depots were collected at hatch (DOH) and days 4 (D4) and 14 (D14) posthatch for histological and mRNA measurements. LWS chicks had decreased SQ fat mass on a BW basis with reduced adipocyte size from DOH to D4 and increased BW and fat mass with unchanged adipocyte size from D4 to D14. HWS chicks increased in BW from DOH to D14 and increased in fat mass in all three depots with enlarged adipocytes in the AB depot from D4 to D14. Meanwhile, CCAAT/enhancer-binding protein-α, neuropeptide Y, peroxisome proliferator-activated receptor-γ, and acyl-CoA dehydrogenase mRNAs differed among depots between lines at different ages. Plasma nonesterified fatty acids were greater in LWS than HWS at D4 and D14. From DOH to D4, LWS chicks mobilized SQ fat and replenished the reservoir through hyperplasia, whereas HWS chicks were dependent on hyperplasia and hypertrophy to maintain adipocyte size and depot mass. From D4 to D14, adipose tissue catabolism and adipogenesis slowed. Whereas LWS fat depots and adipocyte sizes remained stable, HWS chicks rapidly accumulated fat in CL and AB depots. Chicks predisposed to be anorexic or obese have different fat development patterns during the first 2 wk posthatch.

scholarly journals Dietary β-Sitosterol Improves Growth Performance, Meat Quality, Antioxidant Status, and Mitochondrial Biogenesis of Breast Muscle in Broilers

Animals ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 71 ◽  
Author(s):  
Yefei Cheng ◽  
Yueping Chen ◽  
Jun Li ◽  
Hengman Qu ◽  
Yurui Zhao ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Growth Performance ◽  
Meat Quality ◽  
Mitochondrial Biogenesis ◽  
Oxidative Status ◽  
Superoxide Dismutase Activity ◽  
Breast Muscle ◽  
Peroxisome Proliferator ◽  
Scavenging Activity ◽  
Gain Ratio

The present study evaluated effects of β-sitosterol on growth performance, meat quality, oxidative status, and mitochondrial biogenesis of breast muscle in broilers. One-day-old chicks were allocated to five treatments of six replicates. Broilers were fed a basal diet supplemented either with 0 (control), 40, 60, 80, or 100 mg/kg β-sitosterol for 42 days. β-sitosterol linearly and quadratically reduced feed/gain ratio, lightness24h and cooking loss24h in breast muscle, whereas 2, 2-diphenyl-1-picrylhydrazyl scavenging activity of breast muscle followed an opposite trend. β-sitosterol linearly decreased drip loss24h and malondialdehyde content, whereas linearly increased pH24h, superoxide dismutase activity, and mRNA abundances of peroxisome proliferator-activated receptor γ coactivator 1α (PCG-1α) and mitochondrial transcription factor A (TFAM) in breast muscle. Compared with control, levels of β-sitosterol higher than 40 mg/kg reduced feed/gain ratio, muscular lightness24h, cooking loss24h, and malondialdehyde level, whereas increased muscular 2, 2-diphenyl-1-picrylhydrazyl scavenging activity, and mRNA abundances (except 60 mg/kg) of PCG-1α and TFAM. Eighty milligram/kilogram β-sitosterol increased muscular pH24h and superoxide dismutase activity, but decreased its drip loss24h. Therefore, β-sitosterol could improve growth performance and meat quality, oxidative status, and mitochondrial biogenesis of breast muscle in broilers. Furthermore, supplementation level of 80 mg/kg β-sitosterol is recommended for broiler diets.

Effect of expanded diets on growth performance, meat quality and carcass characteristics in finishing pigs

2017 ◽  
Author(s):  
Xin Jian Lei ◽  
Jun Bae ◽  
Ju Lee ◽  
Sang Lee ◽  
In Kim
Keyword(s):  
Growth Performance ◽  
Meat Quality ◽  
Soybean Meal ◽  
Feed Intake ◽  
Carcass Characteristics ◽  
Conversion Ratio ◽  
Feed Conversion Ratio ◽  
Finishing Pigs ◽  
Feed Conversion ◽  
Daily Gain

The objective of the study was to evaluate the effects of expanded diets on growth performance, meat quality, and carcass characteristics in finishing pigs. A total of 80 finishing pigs [(Landrace × Yorkshire) × Duroc] were randomly allotted to two dietary treatments: 1) unexpanded corn-soybean meal diets; 2) expanded corn-soybean meal diets. Each treatment consisted of ten replicate pens with four pigs (2 gilts and 2 barrows) per pen. There were no differences in daily feed intake and daily gain throughout the experiment (P less than 0.05). However, expanded diets decreased feed conversion ratio compared with unexpanded diets (P less than 0.05). Expanded diets had no effect on carcass characteristics and meat quality with the exception of increased sensory evaluation (color) of meat compared with unexpanded diets (P less than 0.05). In conclusion, expanded diets can improve feed conversion ratio but have no effect on daily gain and daily feed intake and sensory evaluation of meat color.

scholarly journals Growth Performance, Chemical Composition of Fillets, Liver and Intestinal Histology, and Expression of Lipid-Dependent Genes in Common Carp (Cyprinus carpio) Fed Artificial Diets

2020 ◽  
Vol 20 (12) ◽  
pp. 901-910
Author(s):  
Piotr Eljasik ◽  
Remigiusz Panicz ◽  
Małgorzata Sobczak ◽  
Jacek Sadowski ◽  
Teresa Ostaszewska
Keyword(s):  
Chemical Composition ◽  
Growth Performance ◽  
Common Carp ◽  
Mrna Level ◽  
Distinct Pattern ◽  
Peroxisome Proliferator ◽  
Feed Conversion ◽  
Intestinal Histology ◽  
Peroxisome Proliferator Activated Receptor ◽  
Acyl Coenzyme A

The study is a preface to redesign farming of carp, and the aim was to determine the influence of three artificial feeds on carp growth performance, chemical composition, intestinal and liver histology, and the expression of two main genes of fatty acid catabolism: acyl-coenzyme A oxidase 1 (acox1) and peroxisome proliferator-activated receptor  (ppar). The 61-days trials were run in set of 9 floating cages in triplicate (n=3 per diet). The results showed that zootechnical parameters (i.e. feed conversion ratio, protein efficiency ratio) significantly improved with increased level of fat in diet, for instance, the lowest FCR was noted for fish fed diet A (9.900.23% of fat). Additionally, gene expression analysis revealed that activity of acox1 and ppar in the liver depend on the fat level in carp diet. The expression of ppar and its target gene acox1 in the intestine of fish showed a distinct pattern in relation to liver samples, since feeds with high and low levels of fat exerted a comparable effect on the mRNA level of the studied genes. In conclusion, this study showed that the level of fat in common carp diets correlated with the level of lipids in the meat.

scholarly journals Enhancing Growth Performance, Organ Development, Meat Quality, and Bone Mineralisation of Broiler Chickens through Multi-Enzyme Super-Dosing in Reduced Energy Diets

Animals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2791
Author(s):  
Jacoba I. Bromfield ◽  
Louwrens C. Hoffman ◽  
Darwin Horyanto ◽  
Elham A. Soumeh
Keyword(s):  
Growth Performance ◽  
Meat Quality ◽  
Feed Intake ◽  
Broiler Chickens ◽  
Conversion Ratio ◽  
Feed Conversion Ratio ◽  
Energy Reduction ◽  
Organ Development ◽  
Feed Conversion ◽  
Negative Effect

This study identified the optimal multi-enzyme dose rate at three energy levels based on the production performance of broiler chickens. A 42-day grow out trial was conducted using 576 day-old mixed-sex ROSS308 broiler chickens in a 3 × 4 factorial arrangement in a completely randomized design. Diets consisting of three metabolizable energy (ME) levels: standard energy (STD), 150 kcal/kg energy reduction (STD-150), and 200 kcal/kg energy reduction (STD-200), were cross factored with four multi-enzyme inclusion levels (0, 350, 700, and 1000 g/ton). The average daily feed intake and feed conversion ratio increased linearly (p < 0.001) as the dietary ME was reduced, and the multi-enzyme addition improved the feed conversion ratio (p < 0.05) and mitigated the negative effect of the reduced energy diets (RED) on feed intake and feed conversion ratios. Carcass composition, organ weights, and meat quality were not affected by the experimental diets. The RED decreased abdominal fat weight (p < 0.05). Total ash, calcium, and phosphorous contents of the tibia bone were improved (p < 0.04) when the RED were supplemented with the multi-enzyme. Super-dosing multi-enzymes in RED mitigates the negative effect of ME reduction on growth performance while maintaining organ development and meat quality and improving bone mineral content.

scholarly journals Effect of Gender to Fat Deposition in Yaks Based on Transcriptomic and Metabolomics Analysis

2021 ◽  
Vol 9 ◽  
Author(s):  
Lin Xiong ◽  
Jie Pei ◽  
Xiaoyun Wu ◽  
Qudratullah Kalwar ◽  
Ping Yan ◽  
...  
Keyword(s):  
Meat Quality ◽  
Subcutaneous Fat ◽  
Focal Adhesions ◽  
Tca Cycle ◽  
Fat Deposition ◽  
Receptor Interaction ◽  
Peroxisome Proliferator ◽  
Steroid Synthesis ◽  
Peroxisome Proliferator Activated Receptor ◽  
Ppar Signaling

Fat deposition in yaks plays an important part in survival, multiplication, and meat quality. In this work, the characteristic of fat deposition in male yaks (MYs) and female yaks (FYs) and the regulations of gender to yak fat deposition were explored by mRNA-Seq and non-targeted metabolomics analyses. FYs possessed a higher body fat rate (BFR) of visceral fat, fat content in longissimus dorsi (LD) and liver, and subcutaneous fat thickness (p &lt; 0.05). The fat and cholesterol synthesis in liver and the fat transport in FY blood increased. The fat metabolism in yaks is the combined effect of carbohydrate, fatty acid, and amino acid metabolism by tricarboxylic acid (TCA) cycle, and an increase of triglyceride (TG) synthesis was accompanied by an increase of steroid synthesis. The high levels of myo-inositol and cortisol (COR) (p &lt; 0.01) activated the calcium signaling in FY subcutaneous fat, followed by the increase of adipocyte secretion, and resulted in more leptin (LEP) secretion (p &lt; 0.01). Then peroxisome proliferator-activated receptor (PPAR) signaling was activated by the focal adhesions and ECM–receptor interaction. Finally, the TG and steroid synthesis increased by the expression regulation of ME1, SCD, ELOVL6, DGAT2, DBI, LPL, CPT1, PLIN1, LIPA, DHCR24, and SQLE gene. The above genes can be considered as the candidate genes for yak with higher fat amount in molecular breeding in the future. This study can provide a theoretical basis for improving the meat quality and breeding of yaks.

scholarly journals A Comparison of Rice Straw and Whole-Crop Barley (Hordeum vulgare L.) Silage Supplements on Performance and Carcass Characteristics of Hanwoo (Bos taurus coreanae) Steers

2020 ◽  
Vol 10 (21) ◽  
pp. 7725
Author(s):  
Seung Hak Yang ◽  
Won Ho Kim ◽  
Suk-Nam Kang ◽  
Ki Choon Choi ◽  
Dahye Kim
Keyword(s):  
Growth Performance ◽  
Meat Quality ◽  
Rice Straw ◽  
Feed Intake ◽  
Bos Taurus ◽  
Live Weight ◽  
Control Treatment ◽  
Alpha Linolenic Acid ◽  
Marbling Score ◽  
Hordeum Vulgare L

This study aimed to analyze the effects of whole-crop barley silage (WCBS) and a high-concentrate diet combination to replace a rice straw/concentrate on growth performance, and meat quality of Hanwoo steers (HS). Twenty-four animals were allocated to two groups with a rice straw/concentrate control treatment (CON) and a WCBS/concentrate treatment group. The concentrate was offered to all animals based on live weight after a feeding trial of grass-based diets. Feed intake of WCBS was lower than the CON (p < 0.01) and intake of concentrate was lower in the WCBS group than the CON in all experimental phases (p < 0.01). WCBS increased backfat thickness (BFT) and slaughter weight (p > 0.05). The marbling score was slightly higher in the WCBS group (p > 0.05). WCBS-fed beef had higher crude fat, lower crude protein, and moisture contents. WCBS feeding increased the levels of alpha-linolenic acid (p < 0.01) and decreased arachidonic acid in meat (p < 0.02). Hanwoo steers fed WCBS/concentrate improved feed intake, carcass traits, meat price, palatability, and FA content compared to those fed rice straw/concentrate, suggesting that WCBS is a potential source for improving the growth performance and meat quality in Hanwoo steers with significant economic efficiency.

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