scholarly journals Biological warfare: the history of microbial pathogens, biotoxins and emerging threats

2020 ◽  
Vol 41 (3) ◽  
pp. 116
Author(s):  
Alexa M Kaufer ◽  
Torsten Theis ◽  
Katherine A Lau ◽  
Joanna L Gray ◽  
William D Rawlinson

Bioterrorism is the deliberate misuse of a pathogen (virus, bacterium or other disease-causing microorganisms) or biotoxin (poisonous substance produced by an organism) to cause illness and death amongst the population. Bioterrorism and biological warfare (biowarfare) are terms often used interchangeably. However, bioterrorism is typically attributed to the politically motivated use of biological weapons by a rogue state, terrorist organisation or rogue individual whereas biological warfare refers to a country’s use of bioweapons. Although rare, bioterrorism is a rapidly evolving threat to global security due to significant advancements in biotechnology in recent years and the severity of agents that could be exploited. The pursuit of publicity plays a vital role in bioterrorism. The success of a biological attack is often calculated by the extent of terror resulting from the event, psychological disruption of society and political breakdown, rather than the lethal effects of the agent used.


1990 ◽  
Vol 9 (1) ◽  
pp. 122-126 ◽  
Author(s):  
Erhard Geissler

In agreement with the overwhelming number of experts, I certainly share the view of Chevier and Hansen that the Biological Weapons Convention needs to be strengthened. Of course it is still a matter of discussion whether the military utility of biological and toxin weapons (hereafter, respectively, BW and TW) changed after the introduction of biotechnology. It is impossible, however, to ignore the 1986 statement of the U.S. Department of Defense (1988), that:… perhaps the most significant event in the history of biological weapons development has been the advent of biotechnology. It enables the development of new microorganisms and products with new, unorthodox characteristics… Conceptually, then, a nation or terrorist group can design a biological weapon to meet a variety of contingencies or needs… The break through and the subsequent achievements make biological warfare much more feasible and effective for countries which either are not bound by the convention or which choose to violate it.



2009 ◽  
Vol 16 (3) ◽  
pp. 213-247 ◽  
Author(s):  
Shiwei Chen

AbstractChinese allegations that the United States used biological weapons against Chinese troops and Korean civilians is one of the most shocking episodes of the Korean War. While the Chinese government repeatedly reprimanded the U.S. government for its uncivilized combat behavior, the U.S. government vigorously issued denials, treating the charges as an extreme propaganda maneuver applied by China in that moment of military crisis, ideological fervor, and political passion. Since then, a huge amount of scholarship has been produced on the allegation.1 None, however, provided a persuasive conclusion on the incident, mainly due to the lack of reliable sources.



Author(s):  
Anthony Rimmington

Stalin's Secret Weapon is a gripping account of the early history of the globally significant Soviet biological weapons program, including its key scientists, its secret experimental bases and the role of intelligence specialists, establishing beyond doubt that the infrastructure created by Stalin continues to form the core of Russia's current biological defense network. Anthony Rimmington has enjoyed privileged access to an array of newly available sources and materials, including declassified British Secret Intelligence Service reports. The evidence contained therein has led him to conclude that the program, with its network of dedicated facilities and proving grounds, was far more extensive than previously considered, easily outstripping those of the major Western powers. As Rimmington reveals, many of the USSR's leading infectious disease scientists, including those focused on pneumonic plague, were recruited by the Soviet military and intelligence services. At the dark heart of this bacteriological archipelago lay Stalin, and his involvement is everywhere to be seen, from the promotion of favored researchers to the political repression and execution of the lead biological warfare specialist, Ivan Mikhailovich Velikanov.



Author(s):  
Christopher Brooke

This is the first full-scale look at the essential place of Stoicism in the foundations of modern political thought. Spanning the period from Justus Lipsius's Politics in 1589 to Jean-Jacques Rousseau's Emile in 1762, and concentrating on arguments originating from England, France, and the Netherlands, the book considers how political writers of the period engaged with the ideas of the Roman and Greek Stoics that they found in works by Cicero, Seneca, Epictetus, and Marcus Aurelius. The book examines key texts in their historical context, paying special attention to the history of classical scholarship and the historiography of philosophy. The book delves into the persisting tension between Stoicism and the tradition of Augustinian anti-Stoic criticism, which held Stoicism to be a philosophy for the proud who denied their fallen condition. Concentrating on arguments in moral psychology surrounding the foundations of human sociability and self-love, the book details how the engagement with Roman Stoicism shaped early modern political philosophy and offers significant new interpretations of Lipsius and Rousseau together with fresh perspectives on the political thought of Hugo Grotius and Thomas Hobbes. The book shows how the legacy of the Stoics played a vital role in European intellectual life in the early modern era.



Author(s):  
Steven J. R. Ellis

Tabernae were ubiquitous among all Roman cities, lining the busiest streets and dominating their most crowded intersections, and in numbers not known by any other form of building. That they played a vital role in the operation of the city—indeed in the very definition of urbanization—is a point too often under-appreciated in Roman studies, or at best assumed. The Roman Retail Revolution is a thorough investigation into the social and economic worlds of the Roman shop. With a focus on food and drink outlets, and with a critical analysis of both archaeological material and textual sources, Ellis challenges many of the conventional ideas about the place of retailing in the Roman city. A new framework is forwarded, for example, to understand the motivations behind urban investment in tabernae. Their historical development is also unraveled to identify three major waves—or, revolutions—in the shaping of retail landscapes. Two new bodies of evidence underpin the volume. The first is generated from the University of Cincinnati’s recent archaeological excavations into a Pompeian neighborhood of close to twenty shop-fronts. The second comes from a field survey of the retail landscapes of more than a hundred cities from across the Roman world. The richness of this information, combined with an interdisciplinary approach to the lives of the Roman sub-elite, results in a refreshingly original look at the history of retailing and urbanism in the Roman world.



Author(s):  
Joachim Seng

Abstract : In his autobiographical accounts, Johann Wolfgang Goethe emphasizes the vital role that his father’s collections of books and art had for his own Bildung. In fact, the library of Johann Caspar Goethe (1710–1782) played a vital role in Goethe’s education and early studies while also attesting to his family background and status. However, soon after Johann Caspar’s death, his library was dissolved – and whereas Johann Wolfgang Goethe and other family members integrated some of the books into their own collections, the majority of objects were sold and dispersed. Today, a handwritten catalog commissioned by Goethe’s mother, Catharina Elisabeth Goethe, just before the sale (in 1793/1794), is a critical tool for reconstructing the collection. This article describes the history of Johann Caspar Goethe’s library, its dispersal as well as the efforts to reconstruct the collection. As the retrieval of the original copies from Johann Caspar’s library and the re-establishment of the original collection were impossible, the Freies Deutsches Hochstift has managed to collect equivalent titles and editions in order to restore a library that allows visitors to the Goethe-Haus in Frankfurt to learn about Goethe’s family background, the cultural setting of his upbringing, and early influences on his education.



2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Uzair Abbas ◽  
Bushra Imdad ◽  
Sikander Adil Mughal ◽  
Israr Ahmed Baloch ◽  
Afshan Mehboob Khan ◽  
...  

Abstract Objective MicroRNAs are known to regulate 60% of genes at post translational level. MicroRNAs including Micro RNA-29 family play a vital role in cellular activities and have validate role in numerous metabolic disorders inclusive of diabetes mellitus and its complications. While micro RNA profile changes years before the occurrence of disease. This cross-sectional study was conducted in non-diabetic adults of diabetic and non-diabetic parents to explore the early changes in expression of micro RNA-29 family as it can be served as early biomarker of type 2 diabetes in non-diabetic adults. This study was conducted from January 2019 to January 2021. Micro RNA was extracted from plasma of 50 participants and expression was compared through qPCR. While data was analyzed through SPSS version 21.0. Results 29a and 29b had lower expression in participants with family history of DM compared to those having no family history of DM (P < 0.0001). While micro RNA 29c was found to be significantly higher in participants with positive family history of type 2 diabetes as compared to those without family history of diabetes (P = 0.001).



2021 ◽  
Vol 2021 (2b) ◽  
pp. 35-40
Author(s):  
I. Stambler ◽  

Celebrating the 30th anniversary of Ukraine's independence, it is important to remember the historical achievements of Ukrainian science, to honor the heroes of the science of the past and to draw inspiration from their achievements for the development of science of the future. In this regard, the history of medicine, as a special academic discipline, plays a vital role an important academic and civic role, as it helps to trace the medical scientific achievements of the past and draw conclusions about their strengths and priorities for future national and international growth and development. Analyzing the scientific strengths and priorities of science and medicine in Ukraine, it is safe to say that biomedical gerontology is one of the most important scientific and historical values and priorities of Ukraine on a global scale. There are good reasons to continue and develop this tradition, building on the strengths that exist, drawing inspiration from the past and looking to the future. Currently, the development of biomedical gerontology is becoming increasingly important for Ukraine, given the rapid aging of the country's population. The resulting economic and social problems are related to the aging population, which puts biomedical gerontology as a discipline that seeks solutions to achieve healthy and productive longevity, at the forefront of social significance, demanding further development and support of this field for the sake of internal national stability, and to preserve the country's international contribution. It is hoped that the outstanding history of biomedical gerontology in Ukraine, its honorable historical place in national development and international cooperation, will inspire further growing support and development of this field in Ukraine and abroad.



2017 ◽  
Vol 31 (3) ◽  
pp. 322-340 ◽  
Author(s):  
David C Hendrickson

This essay offers a constitutional perspective on the American encounter with the problem of international order. Its point of departure is the American Founding, a subject often invisible in both the history of international thought and contemporary International Relations theory. Although usually considered as an incident within the domestic politics of the United States, the Founding displays many key ideas that have subsequently played a vital role in both international political thought and IR theory. The purpose of this essay is to explore these ideas and to take account of their passage through time, up to and including the present day. Those ideas shine a light not only on how we organize our scholarly enterprises but also on the contemporary direction of US foreign policy and the larger question of world order.



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