scholarly journals Energy balance in rats given chronic hormone treatment

1989 ◽  
Vol 61 (3) ◽  
pp. 445-452 ◽  
Author(s):  
Christopher J. H. Woodward ◽  
Peter W. Emery
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Body Size ◽  
Energy Balance ◽  
Hormone Treatment ◽  
High Energy ◽  
Fat Free Mass ◽  
Sprague Dawley ◽  
The Difference ◽  
And Control

1. Sprague–Dawley rats were given corticosterone for 4 to 14 d either by subcutaneous injection (50 mg/kg body-weight per d) or as a higher dose in the diet (1 g/kg diet). Energy balance was calculated using the comparative carcass technique.2. Corticosterone significantly suppressed growth rate by at least 50% (P < 0·001 in all experiments). The reduction in growth was more marked in males than in females.3. Hormone treatment significantly reduced metabolizable intake (kJ/d) in males but not in females. Expressed relative to either metabolic body size (kg body-weight0·75) or fat-free mass, metabolizable intake tended to be increased in the treated groups.4. Energy expenditure, calculated as the difference between metabolizable intake and gain and expressed as kJ/d, did not differ between treated and control rats. Relative to either metabolic body size or fat-free mass, expenditure was consistently increased in treated rats. This change was statistically significant in five of the eight comparisons.5. The corticosterone-treated rat is characterized by high energy intake and expenditure relative to its body size and growth rate. Alterations in the relative sizes of different lean tissues may contribute to these changes.

Diet-induced obesity in the Sprague–Dawley rat: dietary manipulations and their effect on hypothalamic neuropeptide energy balance systems

2005 ◽  
Vol 33 (5) ◽  
pp. 1068-1072 ◽  
Author(s):  
J.G. Mercer ◽  
Z.A. Archer
Keyword(s):  
Body Weight ◽  
Energy Balance ◽  
Body Weight Gain ◽  
High Energy ◽  
Dietary Manipulation ◽  
Sprague Dawley ◽  
Outbred Population ◽  
Diet Induced Obesity ◽  
Sprague Dawley Rat ◽  
Obesogenic Diet

The SD (Sprague–Dawley) rat model of DIO (diet-induced obesity) is reported to exhibit a clear segregation into susceptible and resistant subpopulations shortly after transfer to a HE (high energy) diet. This does not appear to be the case for rats sourced in the U.K., where body weight gain on obesogenic HE diet is normally distributed, as might be anticipated for a polygenic trait in an outbred population. Many of the energy balance effects of dietary manipulation in this model (e.g. supplementation of HE diet with the liquid diet, Ensure; energy intake and defence of body weight following withdrawal of obesogenic diet) appear to be characteristics of the diets being manipulated rather than subject traits. The activities of energy balance-related hypothalamic signals are affected by diet and the development of DIO, but may not be able to differentiate between different diets and the relative levels of obesity that develop.

Body Composition Modifications Due to the “Search, Rescue and Survival Training” in Male Military Firefighter Cadets

2021 ◽  
Author(s):  
Thiago Ramos de Barros ◽  
Verônica Pinto Salerno ◽  
Thalita Ponce ◽  
Míriam Raquel Meira Mainenti
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Repeated Measures ◽  
Food Restriction ◽  
Physical Exertion ◽  
High Energy ◽  
The Body ◽  
Fat Free Mass ◽  
Sleep Restriction ◽  
Fat Percentage

ABSTRACT Introduction To train and prepare cadets for a career as firefighters in Rio de Janeiro, the second-year students of the Officers Training Course are submitted to a Search, Rescue, and Survival Training (SRST) course, which is characterized by long periods of high physical exertion and sleep restriction during a 9-day instruction module, and food restriction during a 7-day survival module. The present study investigated changes in the body composition of 39 male cadets submitted to SRST during training and 4 weeks of recovery with no restrictions in food consumption. Materials and Methods Each cadet was evaluated by anthropometric measurements at six time points: pre-SRST; after the first module; after the second module; and after 1, 2, and 4 weeks of recovery. Measurements included body girths and skinfolds, to estimate trunk (chest and waist) and limbs (arm and thigh) dimensions, as well as body composition. Repeated measures ANOVA and Friedman test were applied (depending on each data distribution). Results Statistically significant decreases in body weight (76.2; 69.8-87.2 to 63.9; 58.9-73.5 kg) and fat free mass (FFM, 69.2; 63.7-77.2 to 60.1; 56.2-68.0 kg) were observed following the second module of SRST. Following a single week of recovery, the FFM returned to pre-SRST values. Body weight returned to pre-training levels in 2 weeks. Body fat percentage and mass also significantly decreased during SRST (9.0; 7.7-12.3 to 6.5; 5.1-9.3% and 6.9; 5.6-10.0 to 6.9; 5.6-10.0 kg, respectively), which showed a slower and more gradual recovery that reached pre-SRST values after 4 weeks. The girths of arm, thigh, chest and waist significantly decreased due to SRST. The girths of the limbs (arm and thigh) returned to pre-training values after one month of recovery, while the girths of the trunk (chest and waist) did not return to pre-SRST values during the study period. Conclusions The findings suggest that men who experience periods of high energy demands and sleep restriction followed by a period of food restriction will endure unavoidable physical consequences that can be mostly reversed by a 1-month recovery.

Protein appetite is increased after central leptin-induced fat depletion

2007 ◽  
Vol 293 (4) ◽  
pp. R1468-R1473 ◽  
Author(s):  
Michael F. Wiater ◽  
Bryan D. Hudson ◽  
Yvette Virgin ◽  
Sue Ritter
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Body Fat ◽  
Caloric Intake ◽  
Sprague Dawley ◽  
Body Protein ◽  
Macronutrient Selection ◽  
Daily Diet ◽  
Nadir Point ◽  
And Control

Leptin reduces body fat selectively, sparing body protein. Accordingly, during chronic leptin administration, food intake is suppressed, and body weight is reduced until body fat is depleted. Body weight then stabilizes at this fat-depleted nadir, while food intake returns to normal caloric levels, presumably in defense of energy and nutritional homeostasis. This model of leptin treatment offers the opportunity to examine controls of food intake that are independent of leptin's actions, and provides a window for examining the nature of feeding controls in a “fatless” animal. Here we evaluate macronutrient selection during this fat-depleted phase of leptin treatment. Adult, male Sprague-Dawley rats were maintained on standard pelleted rodent chow and given daily lateral ventricular injections of leptin or vehicle solution until body weight reached the nadir point and food intake returned to normal levels. Injections were then continued for 8 days, during which rats self-selected their daily diet from separate sources of carbohydrate, protein, and fat. Macronutrient choice differed profoundly in leptin and control rats. Leptin rats exhibited a dramatic increase in protein intake, whereas controls exhibited a strong carbohydrate preference. Fat intake did not differ between groups at any time during the 8-day test. Despite these dramatic differences in macronutrient selection, total daily caloric intake did not differ between groups except on day 2. Thus controls of food intake related to ongoing metabolic and nutritional requirements may supersede the negative feedback signals related to body fat stores.

scholarly journals Features of body weight growth in meat breeds heifers

2016 ◽  
Vol 18 (2) ◽  
Author(s):  
R. S. Oseredchuk ◽  
N. P. Babik ◽  
V. V. Fedorovych ◽  
E. I. Fedorovych ◽  
V. R. Dutka
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Weight Changes ◽  
Body Weight Changes ◽  
Relative Growth ◽  
Weight Growth ◽  
Rate Of Increase ◽  
The Difference ◽  
Tension Increase ◽  
Better Than

The data on the dynamics of body weight changes, absolute and average daily gains, frequency rate of increase in body weight, relative growth rate and intensity of body weight growth of Limousine and Volyn Meat breeds heifers. Both studied breeds characterized by different body weight at different age periods. Newborn Limousine breed heifers are weighed 2,7 kg more (P < 0.05) than Volyn Meat breed heifers; at 3 months age the difference was 8.5 kg (P < 0.05) at 6 months – 14.6 kg, at 9 month – 20.8 kg (P < 0.05), at 12 months – 25,6 kg (P < 0.05), at 15–months – 31.9 (P<0,05), and at 18 months – 23.5 kg. Total and average daily gains in animals of both breeds were the highest for a period of 3 to 6 months of age. In the period from birth to 15 months of age preference for average daily gains were in Limousine, however, the difference was statistically significant only for the period of 0 – 3 months and amounted to 63,9 g (P < 0,05). From 15 to 18 months of age Limousine slightly conceded to Volyn Meat breeds on this parameter. In animals of both breeds magnification of body weight increased with age, but over the entire period (from birth to 18 months) this parameter in Volyn Meat heifers was 0.6 times better than Limousine heifers. The coefficients of relative intensity and tension increase of body weight in animals of both breeds were highest in the period from birth to 3 months of age. With age, these indicators declined. Mainly, the advantage was in Volyn meat breed heifers, but the difference was not statistically significant.

scholarly journals Detoxification of a toxic variety of Jatropha curcas using heat and chemical treatments, and preliminary nutritional evaluation with rats

2003 ◽  
Vol 21 (1) ◽  
pp. 51 ◽  
Author(s):  
E. M. Aregheore ◽  
K. Becker ◽  
H.P.S. Makkar
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Food Intake ◽  
Jatropha Curcas ◽  
Nutritive Value ◽  
Body Weight Loss ◽  
Casein Diet ◽  
Sprague Dawley ◽  
Chemical Treatments ◽  
Diet Control

Seeds from a toxic variety of Jatropha curcas (Capo Verde, Nicaragua) were processed, defatted and ground to obtain the meal. The meal was subjected to heat and 14 different chemical treatments to detoxify the meal of lectin and phorbolesters. Heat treatment inactivated lectin, but not phorbolester. One of the treatments reduced phorbolesters to a tolerable level of 0.09 mg/g. The treated meals with other ingredients were used in diets to assess acceptance and nutritive value of detoxified Jatropha curcas meal in two experiments. Experiments 1 and 2 had twelve (12) male weanling rats each, Sprague Dawley strain, 28-30 days old, pre-experimental average body weights of 8379±7.2 and 84.6±6.4 g, respectively. They were divided into three groups according to body weight and fed casein diet (control) and two diets in which Jatropha curcas was the protein source. In experiment 1, the rats accepted diet 1, but did not fully accept diet 2. Food intake, growth rate, protein efficiency ratio (PER) and food transformation index (T1) were significantly better (P<0.05) in diet 1 than in the casein and diet 2. In experiment 2, casein diet was better (P<0.05) in food intake, growth rate, PER and TI than diets 1 and 2. Food intake with Jatropha meal was significantly reduced and the rats had drastic body weight loss (P<0.05) and this might be due to the presence of phorbolesters in the diets. Generally, the presence of phorbolesters in food has significant effect on its acceptance. Jatropha meal obtained from treatment 3 had a crude protein (CP) content of 68%, far higher than the CP content of most oilseed meals (soyabean). This treatment seems a better method of detoxifying Jatropha curcas meal for livestock but in economic terms it is expensive to produce a meal from it.

Inheritance of geographic variation in body size, and countergradient variation in growth rates, in the southern brown bandicoot Isoodon obesulus.

2000 ◽  
Vol 22 (1) ◽  
pp. 9 ◽  
Author(s):  
ML Hale
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Body Size ◽  
Geographic Variation ◽  
Growth Rates ◽  
Habitat Type ◽  
Adaptive Divergence ◽  
Common Environment ◽  
Countergradient Variation ◽  
Large Animals

The inheritance of geographic variation in body size in the southern brown bandicoot (Isoodon obesulus) was investigated through a common-environment crossbreeding experiment. The geographic variation in body size is related to habitat type, suggesting that it may be adaptive. Adults from two locations in Western Australia, Perth (large animals) and Albany (small animals), were collected and offspring from both hybrid and non-hybrid matings were reared under controlled conditions. All four variables examined (head length, pes length, ear length and body weight) were found to possess a large genetic component, supporting the interpretation that the geographic variation in size is adaptive. The three length variables initially showed additive genetic variation, although the variation in body weight displayed dominance. Genetically controlled differences in growth rate were also detected, with the smaller animals, found in the relatively poorer environment, possessing the faster intrinsic growth rate. Thus, not only does there appear to be adaptive divergence in initial body size, but the countergradient variation in growth rates provides additional evidence for adaptive divergence in this species.

No effect of dietary calcium on body weight of lean and obese mice and rats

2004 ◽  
Vol 286 (4) ◽  
pp. R669-R677 ◽  
Author(s):  
Qinmin Zhang ◽  
Michael G. Tordoff
Keyword(s):  
Body Weight ◽  
Body Weight Gain ◽  
Calcium Content ◽  
High Energy ◽  
Dietary Calcium ◽  
Simple Relation ◽  
Normal Weight ◽  
The Body ◽  
High Energy Density ◽  
Sprague Dawley

Recent epidemiological and animal studies have led to the hypothesis that low dietary calcium intakes contribute to obesity. Here, we evaluated whether calcium influenced the body weight of normal-weight and obese rodents. All experiments involved female C57BL/6J mice or Sprague-Dawley rats fed normal- or high-energy-density diets (3.8 or 4.7 kcal/g). Calcium intake was manipulated by allowing mice to drink sweetened 30 mM CaCl2 solution or feeding mice and rats diets differing in calcium content (0.2%, 0.6%, or 1.8% Ca2+). Blood samples were taken from rats to confirm that the diets had their intended effects on metabolism. There were no effects of the calcium manipulations on energy intake, body weight, or carcass fat content and no simple relation between calciotropic hormones and body weight. One experiment found a significant decrease in body weight gain of lean and obese rats fed the 1.8% Ca2+ diet, but we suspect that this was due to forced consumption of the unpalatable diet, reducing growth. These studies provide little support for the hypothesis that dietary calcium contributes to the etiology or maintenance of obesity.

Energy balance and body composition during US Army special forces training

2013 ◽  
Vol 38 (4) ◽  
pp. 396-400 ◽  
Author(s):  
Lee M. Margolis ◽  
Jennifer Rood ◽  
Catherine Champagne ◽  
Andrew J. Young ◽  
John W. Castellani
Keyword(s):  
Body Composition ◽  
Energy Balance ◽  
Body Mass ◽  
Skinfold Thickness ◽  
High Energy ◽  
Negative Energy ◽  
Fat Free Mass ◽  
Energy Deficit ◽  
Special Forces ◽  
Small Unit

Small Unit Tactics (SUT) is a 64-day phase of the Special Forces Qualification Course designed to simulate real-world combat operations. Assessing the metabolic and physiological responses of such intense training allows greater insights into nutritional requirements of soldiers during combat. The purpose of this study was to examine energy balance around specific training events, as well as changes in body mass and composition. Data were collected from 4 groups of soldiers (n = 36) across 10-day periods. Participants were 28 ± 5 years old, 177 ± 6 cm tall, and weighed 83 ± 7 kg. Doubly labeled water (D218O) was used to assess energy expenditure. Energy intake was calculated by subtracting energy in uneaten foods from known energy in distributed foods in individually packaged combat rations or in the dining facility. Body composition was estimated from skinfold thickness measurements on days 0 and 64 of the course. Simulated urban combat elicited that largest energy deficit (11.3 ± 2.3 MJ·day−1 (2700 ± 550 kcal·day−1); p < 0.05), and reduction in body mass (3.3 ± 1.9 kg; p < 0.05), during SUT, while energy balance was maintained during weapons familiarization training and platoon size raids. Over the entire course body mass decreased by 4.2 ± 3.7 kg (p < 0.01), with fat mass decreasing by 2.8 ± 2.0 kg (p < 0.01) and fat-free mass decreasing by 1.4 ± 2.8 kg (p < 0.05). The overall reduction in body mass suggests that soldiers were in a negative energy balance during SUT, with high energy deficit being observed during strenuous field training.

Demonstration of in vivo metabolic effects of 3,5-di-iodothyronine

1996 ◽  
Vol 149 (2) ◽  
pp. 319-325 ◽  
Author(s):  
M Cimmino ◽  
F Mion ◽  
F Goglia ◽  
Y Minaire ◽  
A Géloën
Keyword(s):  
Body Weight ◽  
Energy Expenditure ◽  
Octanoic Acid ◽  
Control Level ◽  
Metabolic Effects ◽  
Daily Energy Expenditure ◽  
Sprague Dawley ◽  
Daily Energy ◽  
And Control

Abstract The objective of the present study was to test in vivo the metabolic effects of 3,5-di-iodothyronine (3,5-T2) in unanesthetized and unrestrained male Sprague–Dawley rats. Amino acid and lipid metabolisms were investigated by breath tests using as tracers the 13C-carboxyl-labeled molecules of leucine, α-ketoisocaproic acid (KIC) and octanoic acid, in four different groups of rats: hypothyroid animals (receiving propylthiouracil (PTU) and iopanoic acid), hypothyroid animals treated with either a daily i.p. injection of 3,5-T2 (25 μg/100 g body weight), or triiodothyronine (T3) (1 μg/100 g body weight), and control euthyroid animals receiving equivalent volumes of the vehicle solutions. Energy expenditure was measured by continuous monitoring of O2 consumption and CO2 production in these different groups. Daily energy expenditure was decreased by 30% in PTU-treated rats. The chronic treatments with 3,5-T2 and T3 restored daily energy expenditure to the control level. 13CO2 recovered in breath following the i.v. injection of octanoic acid-[1-13C] was decreased in hypothyroid animals compared with control animals (P<0·05) and restored to control values by T3 and 3,5-T2 treatments. The 13CO2 recovered in breath after i.v. injection of leucine-[1-13C]was increased in PTU-treated compared with control animals (P<0·05). Chronic treatment with either 3,5-T2 or T3 restored 13CO2 to control values. Excretion of 13CO2 recovered in breath following the i.v. injection of KIC-[1-13C] was increased in PTU-treated compared with control animals. Chronic treatments with either 3,5-T2 or T3 did not restore KIC decarboxylation. These results suggest that 3,5-T2 exerts metabolic effects on energy expendi ture, on both lipid β-oxidation and leucine metabolism in hypothyroid rats. We conclude that 3,5-T2 is a metabolically active iodothyronine. Journal of Endocrinology (1996) 149, 319–325

scholarly journals Stress facilitates body weight gain in genetically predisposed rats on medium-fat diet

2003 ◽  
Vol 285 (4) ◽  
pp. R791-R799 ◽  
Author(s):  
Chantal Michel ◽  
Barry E. Levin ◽  
Ambrose A. Dunn-Meynell
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Dentate Gyrus ◽  
Energy Homeostasis ◽  
Body Weight Gain ◽  
High Energy ◽  
The Body ◽  
Central Nucleus ◽  
Sprague Dawley ◽  
Dorsomedial Nucleus

To assess the interaction between stress and energy homeostasis, we immobilized male Sprague-Dawley rats prone to diet-induced obesity (DIO) or diet resistance (DR) once for 20 min and then fed them either low-fat (4.5%) chow or a medium-fat (31%), high-energy (HE) diet for 9 days. Stressed, chow-fed DIO rats gained less, while stressed DIO rats on HE diet gained more body weight and had higher feed efficiency and plasma leptin levels than unstressed controls. Neither stress nor diet affected DR body weight gain. While stress-induced plasma corticosterone levels did not differ between phenotypes, DIO rats were initially more active in an open field and had higher hippocampal dentate gyrus and CA1 glucocorticoid receptor (GR) mRNA than DR rats, regardless of prior stress or diet. HE diet intake was associated with raised dentate gyrus and CA1 GR and amygdalar central nucleus (CeA) corticotropin-releasing hormone (CRH) mRNA expression, while stress was associated with reduced hypothalamic dorsomedial nucleus Ob-R mRNA and CeA CRH specifically in DIO rats fed HE diet. Thus a single stress triggers a complex interaction among weight gain phenotype, diet, and stress responsivity, which determines the body weight and adiposity of a given individual.

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