American Ginseng Supplementation Induces an Oxidative Stress in Postmenopausal Women

Objective. In menopause, reduction of estrogen hormone affects oxidative stress process in serum. Oxidative stress in saliva plays a significant role in the pathogenesis of oral diseases. The aim of this study was to investigate the total antioxidant capacity and lipid peroxidation in the serum and saliva of premenopausal and postmenopausal women. Methods. In this case control study, 50 postmenopausal women (case group) and 48 premenopausal women (control group) were selected. The unstimulated whole saliva and serum of the postmenopausal and premenopausal women were collected. The total antioxidant capacity (TAC) of the saliva and serum was measured by ferric reducing antioxidant power (FRAP). Also, malondialdehyde (MDA) was measured by thiobarbituric acid reactive substance (TBARS) method for serum and saliva. Then, the obtained data were analyzed by SPSS 17, whereby Mann–Whitney test and Spearman’s correlation test were used. P < 0.05 was considered statistically significant. Results. The postmenopausal group had significantly lower mean serum TAC and higher mean serum MDA than the control group ( P < 0 < 001 and P < 0.01 , respectively). The mean salivary TAC and MDA, however, did not differ significantly between the case and control group ( P = 0.64 and P = 0.08 , respectively). Conclusion. In postmenopausal women, with elevation of serum MDA and reduction of serum TAC, the extent of serum oxidative stress grows, but MDA and TAC levels of saliva do not change.

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Effect of moderate-intensity exercise on oxidative stress indices in metabolically healthy obese and metabolically unhealthy obese phenotypes in postmenopausal women

Menopause The Journal of The North American Menopause Society ◽

10.1097/gme.0b013e3182038ec1 ◽

2011 ◽

Vol 18 (6) ◽

pp. 646-653 ◽

Cited By ~ 14

Author(s):

Felicja Lwow ◽

Katarzyna Dunajska ◽

Andrzej Milewicz ◽

Diana Jedrzejuk ◽

Krzysztof Kik ◽

...

Keyword(s):

Oxidative Stress ◽

Postmenopausal Women ◽

Moderate Intensity ◽

Moderate Intensity Exercise ◽

Stress Indices ◽

Metabolically Healthy Obese ◽

Healthy Obese ◽

Metabolically Healthy

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Antioxidant Protection by American Ginseng in Pancreatic ß-Cells

The American Journal of Chinese Medicine ◽

10.1142/s0192415x08006399 ◽

2008 ◽

Vol 36 (05) ◽

pp. 981-988 ◽

Cited By ~ 21

Author(s):

Elaine Lin ◽

Yong Wang ◽

Sangeeta Mehendale ◽

Shi Sun ◽

Chong-Zhi Wang ◽

...

Keyword(s):

Oxidative Stress ◽

Hydrogen Peroxide ◽

American Ginseng ◽

Antioxidant Protection ◽

Ginsenoside Re ◽

Peripheral Tissues ◽

Glucose Levels ◽

Reduce Blood Glucose ◽

Dichlorofluorescin Diacetate ◽

High Concentrations

Hyperglycemia in diabetic conditions may cause oxidative stress in pancreatic ß-cells, leading to their dysfunction and insulin resistance within peripheral tissues. Previous studies suggest that American ginseng berry extract may have hypoglycemic effects, as well as offer antioxidant protection. We examined effects of American ginseng berry extract and ginsenoside Re in a pancreatic ß-cell line, MIN-6, to determine if these two properties are related. Cells were exposed to oxidative stress via hydrogen peroxide incubation and oxidative stress was measured by oxidation of 2′,7′-dichlorofluorescin diacetate. These cells showed a concentration-related response to hydrogen peroxide at 100–500 μM. In acute conditions where cells were treated with the extract for 10 min, we observed reduced oxidant injury suggesting direct scavenging effects. Chronic incubation of cells with the extract for 48 hours also demonstrated attenuation of oxidative stress. At high concentrations, Re showed a mild antioxidant effect in MIN-6 cells. Our insulin release observations also showed that the extract may help to increase insulin secretions from the cells. Our data suggest that the observed ability of ginseng to reduce blood glucose levels may be linked to its antioxidant effects on pancreatic ß-cells.

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