Role of Nrf2-antioxidant in radioprotection by root extract of Inula racemosa

Nematicidal potential of chloroform root extract of Inula racemosa and its fractions was investigated on egg hatching and mortality of root knot nematode Meloidogyne incognita. Egg masses and second stage juveniles (J2) of M. incognita were exposed to different concentrations (0.1-8.0 mg ml-1) of I. racemosa root extract and its fractions. Observations on egg hatch were recorded on 1st, 3rd, 5th, 7th and 9th day and those of mortality studies were recorded on 2nd, 4th, 6th, 8th and 10th day, respectively. Significant mortality as well as egg hatch inhibition was observed for all the tested components at 5 %. The root extract was found to be most effective in controlling egg hatching as complete inhibition was observed at 8.0 mg ml-1 concentration on 1stday of treatment and nonpolar fraction was most effective in causing mortality of J2 of M. incognita as 100 % inhibition was observed at 6.0 and 8.0 mg ml-1 concentration on 2nd day of treatment. Maximum inhibition of egg hatching was observed for root extract at 8.0 mg ml-1 concentration and 100 % mortality was observed for root extract as well as nonpolar fraction at the same concentration. The nonpolar fraction was most effective in causing mortality as maximum mortality was observed at 6.0 and 8.0 mg ml-1 concentration throughout the exposure time. Polar fraction was least effective among all the components both in egg hatch inhibition and J2 mortality of M. incognita. Both the activities showed concentrations as well as time dependence. Results show different role of tested components on egg hatching and mortality of root knot nematode. The root extract of I. racemosa and its fractions showed a potential to develop new nematicide.

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Investigations on remedial role of Rauwolfia serpentina root extract against carbofuran formulation induced genotoxicity in Channa punctatus

Journal of Environmental Biology ◽

10.22438/jeb/40/5/mrn-1075 ◽

2019 ◽

Vol 40 (5) ◽

pp. 1023-1028

Author(s):

V. Tiwari ◽

◽

S.P. Trivedi ◽

Keyword(s):

Channa Punctatus ◽

Root Extract ◽

Rauwolfia Serpentina

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The role of neem leaves as organic pesticides in chili pepper (Capsicum frutescens)

Nusantara Bioscience ◽

10.13057/nusbiosci/n100408 ◽

2018 ◽

Vol 10 (4) ◽

pp. 246-250 ◽

Cited By ~ 1

Author(s):

SOPIALENA SOPIALENA ◽

SURYA SILA ◽

ROSFIANSYAH ROSFIANSYAH ◽

JULI NURDIANA

Keyword(s):

Insect Pests ◽

Block Design ◽

Chili Pepper ◽

Fruit Rot ◽

Root Extract ◽

Capsicum Frutescens ◽

Neem Leaves ◽

Chili Peppers ◽

Organic Pesticides

Sopialena, Sila S, Rosfiansyah, Nurdiana J. 2018. The role of neem leaves as organic pesticides in chili pepper (Capsicum frutescens). Nusantara Bioscience 10: 246-250. The agricultural crops and horticultural plants are always under constant assault caused by diseases, insect pests, viruses, and other pathogens which may substantially reduce yield. Chili Pepper (Capsicum annum L.) is a popular horticultural plant of the Solanaceae family in Indonesia. Some serious diseases widely found in chili peppers, are anthracnose (Colletotrichum capsici), leaf spot (Cercospora capsici) and fruit rot (Phytophthora capsici). To manage the potential problems, this study is aimed to provide an explanatory knowledge of the use of plant-based pesticide to control the diseases in chili peppers. The information is meant to fill the knowledge gaps in the use of plant-based pesticide to control the chili diseases. The use of nonchemical pesticide benefits not only the environment but also as an organic strategy for disease management. This research used a randomized complete block design (RCBD) categorized into four groups and six different treatments. The organic pesticides were prepared from the extract of neem leaves, soursop leaves, lemongrass extract, tuba root extract, and kenikir/Cosmos caudatus extract). The result indicates that neem leaves are the most effective organic pesticides to control the chili pepper disease in Indonesia.

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Protective Role of Raphanus Sativus Root Extract on Paracetamol-Induced Hepatotoxicity in Albino Rats

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.77.1.41 ◽

2007 ◽

Vol 77 (1) ◽

pp. 41-45 ◽

Cited By ~ 7

Author(s):

Chaturvedi ◽

George ◽

Machacha

Keyword(s):

Lipid Peroxidation ◽

Raphanus Sativus ◽

Thiobarbituric Acid ◽

Protective Role ◽

Albino Rats ◽

Root Extract ◽

Dependent Manner ◽

Dose Dependent ◽

Serum Glutamate

The methanol extract of Raphanus sativus root extract showed a protective effect on paracetamol-induced hepatotoxicity in a dose-dependent manner. Degree of lipid peroxidation caused by paracetamol was measured in terms of thiobarbituric acid reactive substances (TBARS) and protection was measured in reference to serum glutamate oxaloacetate transaminase (SGOT), serum glutamate aspartate transaminase (SGPT), and blood and hepatic levels of antioxidants like glutathione and catalase. Administration of extract along with paracetamol showed significant protection. Levels of TBARS were found to be low, activities of SGOT and SGPT were low, while hepatic glutathione levels were significantly higher in experimental rats that received the mixture of paracetamol and the extract as compared to rats that received paracetamol only. Activities of catalase were also high in all experimental groups. Thus this study indicates the involvement of Raphanus sativus root extract with antioxidants like glutathione and catalase in rendering protection against paracetamol-induced lipid peroxidation and hepatotoxicity.

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Efficacy and safety of ashwagandha root extract in the treatment of insomnia, anxiety and reducing stress – literature review

Journal of Education, Health and Sport ◽

10.12775/jehs.2021.11.12.013 ◽

2021 ◽

Vol 11 (12) ◽

pp. 197-202

Author(s):

Karol Mazur ◽

Marcin Lewicki ◽

Dominika Mazur ◽

Agata Smoleń

Keyword(s):

Well Being ◽

Poor Quality ◽

Learning Ability ◽

Root Extract ◽

Efficacy And Safety ◽

Natural Substances ◽

Falling Asleep ◽

Reducing Stress

Insomnia, anxiety and stress are common complaints of people living today. Together, these factors can significantly reduce the quality of people's lives and disrupt relationships. Insomnia is a health problem connected with the difficulty falling asleep, waking early, waking during sleep, or poor quality of sleep, the consequences of which during the day are a feeling of being fatigue, reduced well-being, irritability, impaired concentration and learning ability. Anxiety is an emotional state related with anticipation of danger coming from the outside or coming from inside the organism, manifesting itself as feeling of uneasiness, tension, embarrassment, threat. Stress is a disturbance of body homeostasis caused by a physical or psychological factor. The aim of this study was to assess the efficacy and safety of ashwagandha root extract in the treatment of insomnia, anxiety and reducing stress. Our study material consisted of publications, which were found in PubMed, ResearchGate and Google Scholar databases. In order to find the proper publications, the search has been conducted with the use of a combination of key words like: ''ashawagandha'', ''insomnia'', ''anxiety'', ''stress". The first step was to find proper publications from the last 5 years. The second step was to carry out an overview of the found publications. Currently a lot of researches is being conducted to find natural substances that are just as effective as pharmacotherapy in the treatment of insomnia, anxiety and reducing stress, but without the side effects. Some researchers have focused their attention to the ashwagandha root extract. Results of mentioned studies proved the efficacy and safety of ashwagandha root extract. However, further research is needed to estabilish the role of ashwagandha root extract in the treatment of insomnia, anxiety and reducing stress.

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Modulation the Neuro-toxicity Induced by Aluminum Chloride in Rats Using Beetroots and Broccli Extracts

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2018/v25i330100 ◽

2019 ◽

pp. 1-18

Author(s):

Abeer Ali Al-Balawi ◽

Yousri Mohamed Ahmed ◽

Ashwag Albukhari ◽

Shareefa A. ALGhamdi ◽

Mustafa A. Zeyadi ◽

...

Keyword(s):

Oxidative Stress ◽

Aluminum Chloride ◽

Aluminum Toxicity ◽

Antioxidant Properties ◽

Female Rats ◽

Favorable Effect ◽

Control Group ◽

Root Extract ◽

Reference Drug

Backgound: The generation of oxidative stress can be referred to Aluminium toxic effect in animals and humans. This study aimed to evaluate the role of broccoli (Br) and beetroot (Be) extarcts as antioxidant that prevents oxidative stress that associated with aluminum toxicity. Materials and Methods: Fifty Wister female rats were grouped into five groups (each 10 rats): Group 1: control group, administered drinking water only. Group 2: (Neurogenerative) which were induced by oral administration of aluminum chloride (20 mg/kg b.w) daily for one month. Group 3: Rats given aluminum chloride were treated with Rivastigmine (Ri) (1 mg/kg b.w) as a reference drug daily for five weeks. Group 4: Rats given aluminum chloride were treated with beet root extract (50 mg/kg b.w) daily for six weeks. Group 5. Rats given aluminum chloride were treated with broccoli extract (50 mg/kg b.w) daily for five weeks. Results: (AlCl3) group showed a significant increase in Ach level (P<0.05) and a non-significant change in DOP and NE levels compared to control. (AlCl3+Be) was non-significant (P˂0.05) change in Ach, DOP and NE levels compared to (AlCl3) group and showed a significant (P<0.05) increase in Ach level compared to control. (AlCl3+Br) showed a significant (P<0.05) increase in NE level and non-significant (P˂0.05) change in Ach and DOP levels compared to (AlCl3) group. (AlCl3+Ri) showed a significant (P<0.05) increase in Ach, DOP and NE levels compared to (AlCl3) group. Also, showed a significant (P<0.05) increase in Ach and NE compared to control. Conclusion: Neuroprotective role of broccoli in the present study which may result from its antioxidant properties due to its bioactive content such as glucosinolate, isothiocyanate, Sulforaphane, and flavonoids. Therefore, Broccoli can have a favorable effect on neurotoxicity due to their antioxidant and anti-inflammatory properties.

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A Review on the Role of an Important Medicinal Plant Inula Racemosa Hook. F. in Asthma Management

International Journal of Global Science Research ◽

10.26540/ijgsr.v4.i2.2017.83 ◽

2017 ◽

Vol 4 (2) ◽

Author(s):

Prachi Sharma ◽

Prahlad dube

Keyword(s):

Medicinal Plant ◽

Asthma Management ◽

Inula Racemosa ◽

Important Medicinal Plant

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A CHEMICAL BASIS FOR PLANT RESISTANCE TO GRASS GRUB AND BLACK BEETLE LARVAE (COLEOPTERA : SCARABAEIDAE)

Proceedings of the New Zealand Grassland Association ◽

10.33584/jnzg.1975.37.1442 ◽

1975 ◽

pp. 126-131

Author(s):

O.R.W. Sutherland

Keyword(s):

Medicago Sativa ◽

Plant Resistance ◽

Insect Pests ◽

Feeding Deterrents ◽

Feeding Deterrent ◽

Root Extract ◽

Costelytra Zealandica ◽

Lotus Pedunculatus ◽

Pasture Plants

Crude extracts of root of the resistant pasture plants lucerne (Medicago sativa) and Lotus pedunculatus contain strong feeding deterrents for third instar Costelytra zealandica and Heteronychus arutor larvae. Purified saponins isolated from active crude lucerne root extract markedly reduce grass grub feeding and have an ED of 0.019%. Black beetle larvae are even more sensitive to the material. Separate and chemically distinct feeding deterrent fractions, active against the two insects, have been isolated from Lotus pedunculatus root. The role of feeding deterrents in mediating the non-preference of these insect pests for lucerne and Lotus is discussed.

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Anti-Convulsant Activity ofBoerhaavia diffusa: Plausible Role of Calcium Channel Antagonism

Evidence-based Complementary and Alternative Medicine ◽

10.1093/ecam/nep192 ◽

2011 ◽

Vol 2011 ◽

pp. 1-7 ◽

Cited By ~ 18

Author(s):

Mandeep Kaur ◽

Rajesh Kumar Goel

Keyword(s):

Calcium Channel ◽

Phenolic Compound ◽

Methanolic Extract ◽

Folk Medicine ◽

Bay K 8644 ◽

Root Extract ◽

Chloroform Fraction ◽

Dose Dependent ◽

Boerhaavia Diffusa

“Ethnopharmacological” use of roots ofBoerhaavia diffusa(B. diffusa) in the treatment of epilepsy in Nigerian folk medicine and reports showing the presence of a calcium channel antagonistic compound “liriodendrin” in its roots, led us to undertake the present study. The study was designed to investigate the methanolic root extract ofB. diffusaand its different fractions including liriodendrin-rich fraction for exploring the possible role of liriodendrin in its anti-convulsant activity. Air-dried roots ofB. diffusawere extracted with methanol by cold maceration. The methanol soluble fraction of extract thus obtained was successively extracted to obtain liriodendrin-rich fraction and two side fractions, that is, chloroform fraction and phenolic compound fraction. Anti-convulsant activity of methanolic extract (1000, 1500 and 2000 mg kg-1, intraperitoneally (i.p.)) and its different fractions, that is, liriodendrin-rich fraction (10, 20 and 40 mg kg-1, i.p., chloroform fraction (20 mg kg-1, i.p.) and phenolic compound fraction (1 mg kg-1, i.p.) were studied in pentylenetetrazol (PTZ)-induced seizures (75 mg kg-1, i.p.). The crude methanolic extract ofB. diffusaand only its liriodendrin-rich fraction showed a dose-dependent protection against PTZ-induced convulsions. The liriodendrin-rich fraction also showed significant protection against seizures induced by BAY k-8644. These findings reiterated the anti-convulsant activity of methanolic extract ofB. diffusaroots. Furthermore, it can be concluded that the observed anti-convulsant activity was due to its calcium channel antagonistic action as this activity was retained only in the liodendrin-rich fraction, which has additionally been confirmed by significant anti-convulsant activity of liriodendrin-rich fraction in BAY k-8644-induced seizures.

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