Partial protective effects of melatonin on cadmium-induced changes in hematological characteristics in rats

2021 ◽  
pp. 1-7
Author(s):  
İhsan Kısadere ◽  
Mehmet Faruk Aydın ◽  
İlknur Ündağ
Keyword(s):  
Protective Effects ◽  
Induced Changes

scholarly journals Quantitative Proteomic Analysis of Plasma after Remote Ischemic Conditioning in a Rhesus Monkey Ischemic Stroke Model

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1164
Author(s):  
Siying Song ◽  
Linlin Guo ◽  
Di Wu ◽  
Jingfei Shi ◽  
Yunxia Duan ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Rhesus Monkey ◽  
Proteomic Analysis ◽  
Complement C3 ◽  
Protective Effects ◽  
Plasma Proteome ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning ◽  
Metabolism Regulation ◽  
Induced Changes

Background: Animal and clinical studies have shown that remote ischemic conditioning (RIC) has protective effects for cerebral vascular diseases, with induced humoral factor changes in the peripheral blood. However, many findings are heterogeneous, perhaps due to differences in the RIC intervention schemes, enrolled populations, and sample times. This study aimed to examine the RIC-induced changes in the plasma proteome using rhesus monkey models of strokes. Methods: Two adult rhesus monkeys with autologous blood clot-induced middle cerebral artery (MCA) occlusion underwent RIC interventions twice a week for five consecutive weeks. Each RIC treatment included five cycles of five minutes of ischemia alternating with five minutes of reperfusion of the forearm. The blood samples were taken from the median cubital vein of the monkeys at baseline and immediately after each week’s RIC stimulus. The plasma samples were isolated for a proteomic analysis using mass spectrometry (MS). Results: Several proteins related to lipid metabolism (Apolipoprotein A-II and Apolipoprotein C-II), coagulation (Fibrinogen alpha chain and serpin), immunoinflammatory responses (complement C3 and C1), and endovascular hemostasis (basement membrane-specific heparan sulfate proteoglycan) were significantly modulated after the RIC intervention. Many of these induced changes, such as in the lipid metabolism regulation and anticoagulation responses, starting as early as two weeks following the RIC intervention. The complementary activation and protection of the endovascular cells occurred more than three weeks postintervention. Conclusions: Multiple protective effects were induced by RIC and involved lipid metabolism regulation (anti-atherogenesis), anticoagulation (antithrombosis), complement activation, and endovascular homeostasis (anti-inflammation). In conclusion, this study indicates that RIC results in significant modulations of the plasma proteome. It also provides ideas for future research and screening targets.

scholarly journals Sirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and Neurodegenerative Diseases

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1574
Author(s):  
Ciprian N. Silaghi ◽  
Marius Farcaș ◽  
Alexandra M. Crăciun
Keyword(s):  
Neurodegenerative Diseases ◽  
Wide Spectrum ◽  
Metabolic Adaptation ◽  
High Morbidity ◽  
Protective Effects ◽  
Sirtuin 3 ◽  
Age Related ◽  
Genetic Interventions ◽  
Induced Changes

Age-associated cardiovascular and neurodegenerative diseases lead to high morbidity and mortality around the world. Sirtuins are vital enzymes for metabolic adaptation and provide protective effects against a wide spectrum of pathologies. Among sirtuins, mitochondrial sirtuin 3 (SIRT3) is an essential player in preserving the habitual metabolic profile. SIRT3 activity declines as a result of aging-induced changes in cellular metabolism, leading to increased susceptibility to endothelial dysfunction, hypertension, heart failure and neurodegenerative diseases. Stimulating SIRT3 activity via lifestyle, pharmacological or genetic interventions could protect against a plethora of pathologies and could improve health and lifespan. Thus, understanding how SIRT3 operates and how its protective effects could be amplified, will aid in treating age-associated diseases and ultimately, in enhancing the quality of life in elders.

scholarly journals Protective Effects of Salicornia europaea on UVB-Induced Misoriented Cell Divisions in Skin Epithelium

Cosmetics ◽  
2020 ◽  
Vol 7 (2) ◽  
pp. 44
Author(s):  
Natsumi Doi ◽  
Hiro Togari ◽  
Kenji Minagi ◽  
Koichi Nakaoji ◽  
Kazuhiko Hamada ◽  
...  
Keyword(s):  
Cell Division ◽  
Protective Effects ◽  
Salicornia Europaea ◽  
Basal Keratinocytes ◽  
Exposed Skin ◽  
Correct Orientation ◽  
Compensatory Proliferation ◽  
Skin Morphogenesis ◽  
Induced Changes

Correct orientation of cell division is extremely important in the maintenance, regeneration, and repair of continuously proliferating tissues, such as the epidermis. Regulation of the axis of division of epidermal cells prevents the apoptosis-induced compensatory proliferation, and eventually the cancer. Thus, the orientation of cell division is critical for maintaining the tissue architecture. In this study, we investigated the effects of S. europaea extract on the texture of human skin and the behavior of these cells during skin morphogenesis. In sun-exposed skin, S. europaea improved the texture. A multilayered, highly differentiated in vitro skin model indicated that, S. europaea extract suppressed the UVB-induced changes in the morphology of basal keratinocytes. Orientation of cell division was determined by measuring the axis of mitosis in the vertical sections of our experimental model. Analyses of the digital images revealed that S. europaea preserved the axis of division of basal keratinocytes from UVB-induced perturbations. Our findings uncover a new mechanism by which S. europaea responds to the spindle misorientation induced by UVB.

Protective effects of Etlingera elatior extract on lead acetate-induced changes in oxidative biomarkers in bone marrow of rats

2010 ◽  
Vol 48 (10) ◽  
pp. 2688-2694 ◽  
Author(s):  
Nagaraja Haleagrahara ◽  
Tan Jackie ◽  
Srikumar Chakravarthi ◽  
Mallikarjuna Rao ◽  
Thanikachalam Pasupathi
Keyword(s):  
Bone Marrow ◽  
Lead Acetate ◽  
Protective Effects ◽  
Induced Changes ◽  
Oxidative Biomarkers ◽  
Etlingera Elatior

scholarly journals Effects of oral and intraperitoneal magnesium treatment against cadmium-induced oxidative stress in plasma of rats

2012 ◽  
Vol 63 (3) ◽  
pp. 247-254 ◽  
Author(s):  
Aleksandra Buha ◽  
Zorica Bulat ◽  
Danijela Đukić-Ćosić ◽  
Vesna Matović
Keyword(s):  
Oxidative Stress ◽  
Rat Plasma ◽  
Control Group ◽  
Protective Agent ◽  
Protective Effects ◽  
Negative Effects ◽  
Sod Activity ◽  
Total Oxidative Status ◽  
Intraperitoneal Treatment ◽  
Induced Changes

Cadmium (Cd) has been recognised as one of the most important environmental and industrial pollutants, and up-to-date investigations have shown that one of the mechanisms of its toxicity is associated with the induction of oxidative stress. The aim of this study was to determine the connection between acute oral and intraperitoneal exposure to Cd and parameters indicative of oxidative stress in the plasma of rats, as well as to examine the potential protective effect of magnesium (Mg) in conditions of acute oral and intraperitoneal Cd poisoning. The experiment was performed on male albino Wistar rats (n=40) randomly divided into control group, Cdor group that received 30 mg kg-1 b.w. Cd by oral gavage, Cd+Mgor group that orally received 50 mg kg-1 b.w. Mg one hour before oral Cd, Cdip group that received 1.5 mg kg-1 b.w. Cd intraperitoneally, and Cd+Mgip group that intraperitoneally received 3 mg kg-1 b.w. Mg 10 min before intraperitoneal Cd. The animals were sacrifi ced 24 h after treatment and the following parameters were measured: superoxidedismutase activity, superoxide anion, total oxidative status, advanced oxidation protein products, and malondialdehyde. All parameters of oxidative stress in rat plasma were negatively affected by Cd treatment with more pronounced negative effects after intraperitoneal treatment, with the exception of superoxide dismutase (SOD) activity. Although both oral and intraperitoneal Mg pretreatment had protective effects, more pronounced benefi cial effects were observed after oral administration, since it managed to completely prevent Cd-induced changes in the investigated parameters. The observed results support the use of Mg as potential protective agent against toxic effects caused by Cd.

Protective effects of phyllanthin, a lignan from Phyllanthus amarus, against progression of high fat diet induced metabolic disturbances in mice

RSC Advances ◽  
2016 ◽  
Vol 6 (63) ◽  
pp. 58343-58353 ◽  
Author(s):  
Sneha Jagtap ◽  
Pragyanshu Khare ◽  
Priyanka Mangal ◽  
Kanthi Kiran Kondepudi ◽  
Mahendra Bishnoi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lipid Peroxidation ◽  
Glucose Metabolism ◽  
High Fat Diet ◽  
Phyllanthus Amarus ◽  
Protective Effects ◽  
Liver Inflammation ◽  
High Fat ◽  
Metabolic Disturbances ◽  
Induced Changes

Phyllanthin delayed the progression of high fat diet induced changes affecting lipid and glucose metabolism such as adiposity, hypertriglyceridemia, fatty liver, inflammation, lipid peroxidation and insulin resistance.

scholarly journals Influence of methyl and isopropyl N-methyl antranilates on carbon tetrachloride-induced changes in rat liver morphology and function

2013 ◽  
Vol 11 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Niko Radulovic ◽  
Pavle Randjelovic ◽  
Nikola Stojanovic ◽  
Ivan Ilic ◽  
Ana Miltojevic
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Serum Levels ◽  
Protective Effects ◽  
Liver Lesions ◽  
Human Diet ◽  
Histopathological Evaluation ◽  
Liver Morphology ◽  
And Function ◽  
Induced Changes

The aim of the present study was to examine potential protective effects of methyl N-methylanthranilate (M) and isopropyl N-methylanthranilate (I) in a rat model of acute intoxication with carbon tetrachloride (CCl4) by tracking the changes in liver morphology and function. Serum transaminase and bilirubin were significantly elevated in animals treated with CCl4 alone. A pretreatment with M and I prior to the administration of CCl4 significantly prevented the increase of serum levels of liver damage markers. Histopathological evaluation of the livers of the test animals also revealed that M and I reduced the incidence of liver lesions. Our experiments showed that both M and I possess protective effect in CCl4-induced liver damage in rats. The results are of interest due to the presence of natural or synthetic M in the human diet.

scholarly journals Protective effects of oestradiol against cadmium-induced changes in blood parameters and oxidative damage in rats

2014 ◽  
Vol 65 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Jelena Mladenović ◽  
Branka Ognjanović ◽  
Nataša Đorđević ◽  
Miloš Matić ◽  
Veroljub Knežević ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Oxygen Free Radicals ◽  
Redox Balance ◽  
Blood Parameters ◽  
Enzymatic Antioxidants ◽  
Protective Effects ◽  
Antioxidant Defences ◽  
Biochemical Effects ◽  
Endogenous Antioxidants ◽  
Induced Changes

Summary The aim of this study was to investigate the protective effects of oestradiol (E2, 4 mg kg-1 b.w. i.p.) against cadmium-induced (Cd, 2 mg kg-1 b.w. i.p.) blood changes in rats. Cadmium induced a significant decline in haemoglobin, haematocrit, and total erythrocyte, lymphocyte, and thrombocyte count, whereas total leukocytes and granulocytes increased. A significant increase was also observed in serum cholesterol, triglycerides, glucose, AST, and ALT activities, whereas total protein and albumin levels dropped significantly. Administration of E2 in combination with Cd alleviated most of these adverse effects. In terms of oxidative stress, Cd significantly increased oxygen-free radicals (O2 •- and H2O2) in neutrophils and lipid peroxidation in erythrocytes, whereas E2 treatment reversed these changes to control values. Acute Cd poisoning significantly lowered antioxidant enzyme (SOD and CAT) activity and the level of non-enzymatic antioxidants (GSH and vitamin E), while increasing in GSSG. Treatments with E2 reversed Cd-induced effects on the antioxidant defences and significantly lowered Cd-induced oxidative damage in erythrocytes. This study suggests that exogenous E2 effectively restores redox balance in rat erythrocytes and counters adverse haematological and biochemical effects of Cd poisoning. It also improves the antioxidant capacity of erythrocytes, acting in synergy with endogenous antioxidants.

scholarly journals AMELIORATIVE EFFECTS OF PHYTOANDROGEN AND ANTIOXIDANT ON HISTOARCHITECTURE OF PERMETHRIN INDUCED CHANGES IN GOAT TESTIS

2017 ◽  
Vol 9 (10) ◽  
pp. 183 ◽  
Author(s):  
Shivani Bhardwaj ◽  
Rajnesh K Sharma
Keyword(s):  
Vitamin C ◽  
Testicular Tissue ◽  
Interstitial Space ◽  
Seminiferous Tubules ◽  
Control Group ◽  
Tribulus Terrestris ◽  
Protective Effects ◽  
Group I ◽  
Induced Changes ◽  
Experimental Group

Objective: Protective effects of Tribulus terrestris (TT) and vitamin C were studied against permethrin induced changes in the histoarchitecture of goat testis.Methods: Hydroalcoholic extract of the fruits of Tribulus terrestris was prepared by maceration method and the extractive value was calculated. Fresh stock solution of permethrin (1mg/ml) in dimethyl sulphoxide and Tribulus terrestris (1mg/ml) in distilled water were prepared. Testicular tissues were cultured in TCM-199 nutrition media at 39℃ with 95% humidity and 5% CO₂ in the CO₂ incubator. Cultured testicular tissue was grouped as control having only the nutritive media, experimental group I(EI) received two doses of permethrin (100µg/ml and 200µg/ml), experimental group II(EII) was administered doses of permethrin along with vitamin C(0.1µM/ml) and experimental group III(EIII) was supplemented with doses of permethrin along with Tribulus terrestris (100µg/ml). All the groups were tested for 4 hr. and 8hr. for histoarcitectural studies.Results: Histological alterations were observed such as distorted shape of seminiferous tubules, decreased luminal and interstitial space, reduction in the population of spermatocytes, spermatozoa and spermatids in treated (E1) group as compared to control group. Maximum damage was detected at a higher dose of permethrin (200µg/ml) for 8h in contrast to lower doses (100 4h and 8h). Thus, it is concluded that permethrin has both dose and time-dependent effects. Protective groups (E2 and E3) imparted ameliorative effects by reestablishing shape of seminiferous tubules, decreasing luminal and interstitial space, increased population of spermatocyte, spermatozoa, and spermatids as compared with treated groups (E1)Conclusion: It has been reported that permethrin affects male fertility by inducing detrimental changes in the structure and function of seminiferous tubules. Both vitamin C and TT have the ability to mitigate the effect of pesticide. TT shows aphrodisiac activity against permethrin induced alterations in goat testis.

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