The Dose Determines the Stimulation (and Poison): Development of A Chemical Hormesis Database

1997 ◽  
Vol 16 (6) ◽  
pp. 545-559 ◽  
Author(s):  
Edward J. Calabrese ◽  
Linda A. Baldwin
Keyword(s):  
A Priori ◽  
Dose Range ◽  
Evaluation Criteria ◽  
Metabolic Effects ◽  
Growth Responses ◽  
Wide Range ◽  
Order Of Magnitude ◽  
Real Phenomenon ◽  
Effect Level ◽  
Taxonomic Groups

A comprehensive effort was undertaken to identify articles demonstrating chemical hormesis. Nearly 4000 potentially relevant articles were retrieved from preliminary computer searches utilizing various keyword descriptors and extensive cross-referencing. A priori evaluation criteria were established including study design features (e.g., number of doses, dose range), statistical analysis, and reproducibility of results. Evidence of chemical hormesis was judged to have occurred in approximately 350 of the 4000 studies evaluated. Chemical hormesis was observed in a wide range of taxonomic groups and involved agents representing highly diverse chemical classes, many of potential environmental relevance. Numerous biologic endpoints were assessed, with growth responses the most prevalent, followed by metabolic effects, longevity, reproductive responses, and survival. Hormetic responses were generally observed to be of limited magnitude with the average low-dose maximum stimulation approximately 50% greater than controls. The hormetic dose-response range was generally limited to about one order of magnitude with the upper end of the hormetic curve approaching the estimated no-observed-effect level (NOEL) for the particular endpoint. Based on the evaluation criteria, high to moderate evidence of hormesis was observed in studies comprised of ≥ doses with <3 doses in the hormetic zone. The present analysis suggests that chem ical hormesis is a reproducible and generalizable biologic phenomenon. Over the last decade advances have been made providing mechanistic insight helpful in explaining the phenomenon of chemical hormesis in multiple biologic systems with various endpoints. The reason for the uncertainty surrounding the existence of hormesis as a “real phenomenon” is believed to be the result of its relatively infrequent observation in the literature due to experimental design considerations, especially with respect to the number of doses, range of doses, and endpoint selection.

A general classification of U-shaped dose-response relationships in toxicology and their mechanistic foundations

1998 ◽  
Vol 17 (7) ◽  
pp. 353-364 ◽  
Author(s):  
Edward J Calabrese ◽  
Linda A Baldwin
Keyword(s):  
Dose Response ◽  
A Priori ◽  
Dose Range ◽  
Biological Mechanisms ◽  
Direct Stimulation ◽  
General Classification ◽  
Wide Range ◽  
Temporal Factors ◽  
Relationship Of

The development of a comprehensive database of chemical hormetic responses (i.e., U-or inverted U-shaped dose-response relationships) using objective a priori study design, statistical and study replication criteria has recently been reported.1An assessment of this database reveals the existence of a wide range of hormetic dose-reponse relationships including those demonstrating a direct stimulation or an overcompensation response to a disruption of homeostasis. These two broad types of hormetic responses are affected by temporal factors and display unique patterns of dose-range stimulation, magnitude of stimulatory response and relationship of the maximum stimulatory response to the NOAEL. A general classification of U-shaped dose-response relationships is proposed to provide a more organized framework to evaluate the highly distinctive and diverse hormetic responses within the context of establishing underlying biological mechanisms and exploring risk assessment implications.

scholarly journals A Systematic Review and Qualitative Synthesis Resulting in a Typology of Elementary Classroom Movement Integration Interventions

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Spyridoula Vazou ◽  
Collin A. Webster ◽  
Gregory Stewart ◽  
Priscila Candal ◽  
Cate A. Egan ◽  
...  
Keyword(s):  
Physical Activity ◽  
Teacher Collaboration ◽  
A Priori ◽  
Real Life ◽  
Dose Intensity ◽  
Routine Practice ◽  
Qualitative Synthesis ◽  
Wide Range ◽  
Meta Analyses ◽  
Movement Integration

Abstract Background/Objective Movement integration (MI) involves infusing physical activity into normal classroom time. A wide range of MI interventions have succeeded in increasing children’s participation in physical activity. However, no previous research has attempted to unpack the various MI intervention approaches. Therefore, this study aimed to systematically review, qualitatively analyze, and develop a typology of MI interventions conducted in primary/elementary school settings. Subjects/Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed to identify published MI interventions. Irrelevant records were removed first by title, then by abstract, and finally by full texts of articles, resulting in 72 studies being retained for qualitative analysis. A deductive approach, using previous MI research as an a priori analytic framework, alongside inductive techniques were used to analyze the data. Results Four types of MI interventions were identified and labeled based on their design: student-driven, teacher-driven, researcher-teacher collaboration, and researcher-driven. Each type was further refined based on the MI strategies (movement breaks, active lessons, other: opening activity, transitions, reward, awareness), the level of intrapersonal and institutional support (training, resources), and the delivery (dose, intensity, type, fidelity). Nearly half of the interventions were researcher-driven, which may undermine the sustainability of MI as a routine practice by teachers in schools. An imbalance is evident on the MI strategies, with transitions, opening and awareness activities, and rewards being limitedly studied. Delivery should be further examined with a strong focus on reporting fidelity. Conclusions There are distinct approaches that are most often employed to promote the use of MI and these approaches may often lack a minimum standard for reporting MI intervention details. This typology may be useful to effectively translate the evidence into practice in real-life settings to better understand and study MI interventions.

scholarly journals The Survival of Haloferax mediterranei under Stressful Conditions

2021 ◽  
Vol 9 (2) ◽  
pp. 336
Author(s):  
Laura Matarredona ◽  
Mónica Camacho ◽  
Basilio Zafrilla ◽  
Gloria Bravo-Barrales ◽  
Julia Esclapez ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Sea Water ◽  
Industrial Applications ◽  
Growth Responses ◽  
Haloferax Mediterranei ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Wide Range ◽  
High Metal ◽  
Plasma Mass Spectrometry

Haloarchaea can survive and thrive under exposure to a wide range of extreme environmental factors, which represents a potential interest to biotechnology. Growth responses to different stressful conditions were examined in the haloarchaeon Haloferax mediterranei R4. It has been demonstrated that this halophilic archaeon is able to grow between 10 and 32.5% (w/v) of sea water, at 32–52 °C, although it is expected to grow in temperatures lower than 32 °C, and between 5.75 and 8.75 of pH. Moreover, it can also grow under high metal concentrations (nickel, lithium, cobalt, arsenic), which are toxic to most living beings, making it a promising candidate for future biotechnological purposes and industrial applications. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) analysis quantified the intracellular ion concentrations of these four metals in Hfx. mediterranei, concluding that this haloarchaeon can accumulate Li+, Co2+, As5+, and Ni2+ within the cell. This paper is the first report on Hfx. mediterranei in which multiple stress conditions have been studied to explore the mechanism of stress resistance. It constitutes the most detailed study in Haloarchaea, and, as a consequence, new biotechnological and industrial applications have emerged.

scholarly journals Statistical Uncertainty of DNS in Geometries without Homogeneous Directions

2021 ◽  
Vol 11 (4) ◽  
pp. 1399
Author(s):  
Jure Oder ◽  
Cédric Flageul ◽  
Iztok Tiselj
Keyword(s):  
Channel Flow ◽  
A Priori ◽  
Time Integration ◽  
Navier Stokes ◽  
Statistical Uncertainty ◽  
Time Step ◽  
Order Of Magnitude ◽  
Averaging Time ◽  
The Individual ◽  
Time Required

In this paper, we present uncertainties of statistical quantities of direct numerical simulations (DNS) with small numerical errors. The uncertainties are analysed for channel flow and a flow separation case in a confined backward facing step (BFS) geometry. The infinite channel flow case has two homogeneous directions and this is usually exploited to speed-up the convergence of the results. As we show, such a procedure reduces statistical uncertainties of the results by up to an order of magnitude. This effect is strongest in the near wall regions. In the case of flow over a confined BFS, there are no such directions and thus very long integration times are required. The individual statistical quantities converge with the square root of time integration so, in order to improve the uncertainty by a factor of two, the simulation has to be prolonged by a factor of four. We provide an estimator that can be used to evaluate a priori the DNS relative statistical uncertainties from results obtained with a Reynolds Averaged Navier Stokes simulation. In the DNS, the estimator can be used to predict the averaging time and with it the simulation time required to achieve a certain relative statistical uncertainty of results. For accurate evaluation of averages and their uncertainties, it is not required to use every time step of the DNS. We observe that statistical uncertainty of the results is uninfluenced by reducing the number of samples to the point where the period between two consecutive samples measured in Courant–Friedrichss–Levy (CFL) condition units is below one. Nevertheless, crossing this limit, the estimates of uncertainties start to exhibit significant growth.

Applications of 3D printing in critical care medicine: A scoping review

2021 ◽  
pp. 0310057X2097665
Author(s):  
Natasha Abeysekera ◽  
Kirsty A Whitmore ◽  
Ashvini Abeysekera ◽  
George Pang ◽  
Kevin B Laupland
Keyword(s):  
Critical Care ◽  
Scoping Review ◽  
A Priori ◽  
Three Dimensional ◽  
Critical Care Medicine ◽  
Future Research ◽  
Care Practice ◽  
Three Dimensional Printing ◽  
Wide Range ◽  
Dimensional Printing

Although a wide range of medical applications for three-dimensional printing technology have been recognised, little has been described about its utility in critical care medicine. The aim of this review was to identify three-dimensional printing applications related to critical care practice. A scoping review of the literature was conducted via a systematic search of three databases. A priori specified themes included airway management, procedural support, and simulation and medical education. The search identified 1544 articles, of which 65 were included. Ranging across many applications, most were published since 2016 in non – critical care discipline-specific journals. Most studies related to the application of three-dimensional printed models of simulation and reported good fidelity; however, several studies reported that the models poorly represented human tissue characteristics. Randomised controlled trials found some models were equivalent to commercial airway-related skills trainers. Several studies relating to the use of three-dimensional printing model simulations for spinal and neuraxial procedures reported a high degree of realism, including ultrasonography applications three-dimensional printing technologies. This scoping review identified several novel applications for three-dimensional printing in critical care medicine. Three-dimensional printing technologies have been under-utilised in critical care and provide opportunities for future research.

scholarly journals Hierarchical Matching and Regression with Application to Photometric Redshift Estimation

2016 ◽  
Vol 12 (S325) ◽  
pp. 145-155
Author(s):  
Fionn Murtagh
Keyword(s):  
Information Structure ◽  
Data Analytics ◽  
A Priori ◽  
Sloan Digital Sky Survey ◽  
Photometric Redshifts ◽  
Merging Galaxies ◽  
Photometric Redshift ◽  
Sky Survey ◽  
Wide Range ◽  
Regression Problems

AbstractThis work emphasizes that heterogeneity, diversity, discontinuity, and discreteness in data is to be exploited in classification and regression problems. A global a priori model may not be desirable. For data analytics in cosmology, this is motivated by the variety of cosmological objects such as elliptical, spiral, active, and merging galaxies at a wide range of redshifts. Our aim is matching and similarity-based analytics that takes account of discrete relationships in the data. The information structure of the data is represented by a hierarchy or tree where the branch structure, rather than just the proximity, is important. The representation is related to p-adic number theory. The clustering or binning of the data values, related to the precision of the measurements, has a central role in this methodology. If used for regression, our approach is a method of cluster-wise regression, generalizing nearest neighbour regression. Both to exemplify this analytics approach, and to demonstrate computational benefits, we address the well-known photometric redshift or ‘photo-z’ problem, seeking to match Sloan Digital Sky Survey (SDSS) spectroscopic and photometric redshifts.

scholarly journals A Consistent Track-to-Track Fusion Method Based on Copula Theory

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Kelin Lu ◽  
K. C. Chang ◽  
Rui Zhou
Keyword(s):  
Probability Distributions ◽  
A Priori ◽  
Joint Probability ◽  
Network Connectivity ◽  
Consistent Estimate ◽  
Fusion Algorithm ◽  
Copula Theory ◽  
Wide Range ◽  
Primary Advantage ◽  
Joint Probability Distributions

This paper addresses the problem of distributed fusion when the conditional independence assumptions on sensor measurements or local estimates are not met. A new data fusion algorithm called Copula fusion is presented. The proposed method is grounded on Copula statistical modeling and Bayesian analysis. The primary advantage of the Copula-based methodology is that it could reveal the unknown correlation that allows one to build joint probability distributions with potentially arbitrary underlying marginals and a desired intermodal dependence. The proposed fusion algorithm requires no a priori knowledge of communications patterns or network connectivity. The simulation results show that the Copula fusion brings a consistent estimate for a wide range of process noises.

Growth responses in red deer hinds from 16-24 months of age when fed two energy levels during their second winter

1998 ◽  
Vol 1998 ◽  
pp. 141-141
Author(s):  
M H Davies ◽  
D W Deakin
Keyword(s):  
Growth Response ◽  
Red Deer ◽  
Energy Levels ◽  
Growth Restriction ◽  
Growth Responses ◽  
Wide Range ◽  
Feeding Regimes ◽  
Cost Of Production ◽  
Red Meats

It is important that venison competes with other red meats in efficiency and cost of production. The growth responses of farmed red deer during the first 15-18 months of life have been well defined under a wide range of feeding and daylength regimes (Davies, 1995). However there is a need to examine less intensive systems of production which aim to maximise growth from grazed grass, following various growth-restriction feeding regimes during winter. The objective of this experiment was to quantify the growth response in 16-24 month old hinds fed two contrasting feeding regimes during their second winter, followed by a period at pasture.

Surface bypass as a means of protecting downstream-migrating fish: lack of standardised evaluation criteria complicates evaluation of efficacy

2018 ◽  
Vol 69 (12) ◽  
pp. 1882 ◽  
Author(s):  
Elena-Maria Klopries ◽  
Zhiqun Daniel Deng ◽  
Theresa U. Lachmann ◽  
Holger Schüttrumpf ◽  
Bradly A. Trumbo
Keyword(s):  
Performance Studies ◽  
Pearson Correlation ◽  
Evaluation Criteria ◽  
Fish Passage ◽  
Performance Criteria ◽  
Design Criteria ◽  
Good Surface ◽  
Wide Range ◽  
Student’S T ◽  
Meta Analyses

Surface bypasses are downstream migration structures that can help reduce hydropower-induced damage to migrating fish. However, no comprehensive design concept that facilitates good surface bypass performance for a wide range of sites and species is available. This is why fish-passage efficiencies at recently built bypass structures vary widely between 0% and up to 97%. We reviewed 50 surface bypass performance studies and existing guidelines for salmonids, eels and potamodromous species to identify crucial design criteria for surface bypasses employed in North America, Europe and Australia. Two-tailed Pearson correlation of bypass efficiency and bypass design criteria shows that bypass entrance area (r=0.3300, P=0.0036) and proportion of inflow to the bypass (r=0.3741, P=0.0032) are the most influential parameters on bypass efficiency. However, other parameters such as guiding structures (P=0.2181, ordinary Student’s t-test) and trash-rack spacing (r=–0.1483, P=0.3951, Spearman correlation), although not statistically significant, have been shown to have an effect on efficiency in some studies. The use of different performance criteria and efficiency definitions for bypass evaluation hampers direct comparison of studies and, therefore, deduction of design criteria. To enable meta-analyses and improve bypass design considerations, we suggest a list of standardised performance parameters for bypasses that should be considered in future bypass-performance studies.

scholarly journals The Growth Kinetics of RhizoctoniasolaniAfter 1 MeV Electron Irradiation

2022 ◽  
Author(s):  
Ulyana Bliznyuk ◽  
Natalya Chulikova ◽  
Anna Malyuga
Keyword(s):  
Radial Growth ◽  
Radiation Treatment ◽  
Dose Range ◽  
Black Scurf ◽  
Phytopathogenic Fungus ◽  
Complete Suppression ◽  
Electron Radiation ◽  
Bacterial Diseases ◽  
Wide Range ◽  
Kinetics Of

Crops, especially potatoes, are prone to a wide range of fungal, viral and bacterial diseases, including black scurf caused by Rhizoctoniasolani. This study focused on the radiation treatment of the phytopathogenic fungus RhizoctoniasolaniKuhn, grown from sclerotium irradiated with 1 MeV electrons in the dose range from 20 to 4500 Gy. The doses absorbed by the sclerotia were determined using computer simulation. The growth of the fungus samples was monitored after 24, 48, 72, and 96 hours from the time of seeding. It was found that the dependence of the radial growth velocity of R. solani on the time after irradiation with doses ranging from 20to 1800 Gywas nonlinear. Irradiation at a dose over 4500 Gyled to complete suppression of the germination of R. solani sclerotia. Keywords: radiation treatment, electron radiation, radiation dose, sclerotia of Rhizoctoniasolani, Kuhn, radial velocity of growth

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