scholarly journals Laser-ablative synthesis of stable size-tunable Bi nanoparticles and their functionalization for radiotherapy applications

2021 ◽  
Vol 2058 (1) ◽  
pp. 012010
Author(s):  
G V Tikhonowski ◽  
A A Popov ◽  
E A Popova-Kuznetsova ◽  
S M Klimentov ◽  
P N Prasad ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Biomedical Applications ◽  
Colloidal Stability ◽  
Colloidal Solutions ◽  
Image Guided ◽  
Fs Laser ◽  
Mean Size ◽  
Size Dispersion ◽  
By Products ◽  
Bi Nanoparticles

Abstract Nanoformulations of high-Z elements can improve therapeutic outcome in radiotherapy-based treatment of tumors, but current nanomedicine implementations in radiotherapy still need biocompatible, non-toxic nano-agents exhibiting low polydispersity and high colloidal stability. Here, we elaborate methods of femtosecond (fs) laser ablation in water and organic solvents to fabricate stable aqueous colloidal solutions of ultrapure elemental Bi nanoparticles (NPs) and characterize them. We show that fs laser ablation of Bi target leads to the formation of spherical elemental Bi NPs having 25 nm mean size and wide size-dispersion. NPs prepared in water undergo fast conversion into 400-500 nm flake-like nanosheets, while NPs prepared in acetone demonstrate a high colloidal stability. We then employ methods of fs laser fragmentation to control mean size and size dispersion of Bi NPs. Stable aqueous solution of Bi NPs suitable for biomedical applications can be obtained by coating with Pluronic® F-127. We finally show that surface modification of Bi NPs increases its colloidal stability in phosphate buffer saline (PBS) solution by more than 6 fold. Exempt of any toxic synthetic by-products, laser-ablated Bi NPs present a novel appealing nanoplatform for image-guided combination photo- and radiotherapy.

scholarly journals Laser-Ablative Synthesis of Stable Aqueous Solutions of Elemental Bismuth Nanoparticles for Multimodal Theranostic Applications

Nanomaterials ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1463
Author(s):  
Julia C. Bulmahn ◽  
Gleb Tikhonowski ◽  
Anton A. Popov ◽  
Andrey Kuzmin ◽  
Sergey M. Klimentov ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Femtosecond Laser Ablation ◽  
Infrared Range ◽  
Biological Applications ◽  
Bismuth Nanoparticles ◽  
Image Guided ◽  
Near Ir ◽  
Mean Size ◽  
Theranostic Applications ◽  
Size Dispersion

Elemental bismuth (Bi) nanoparticles (NPs), with the high atomic density of the Bi nuclei, could serve as efficient targeted agents for cancer treatment, with applications such as contrast agents for computed tomography (CT) imaging, sensitizers for image-guided X-ray radiotherapy, and photothermal therapy. However, the synthesis of elemental Bi NPs suitable for biological applications is difficult using conventional chemical routes. Here, we explore the fabrication of ultrapure Bi-based nanomaterials by femtosecond laser ablation from a solid Bi target in ambient liquids and characterize them by a variety of techniques, including TEM, SEM, XRD, FTIR, Raman, and optical spectroscopy. We found that laser-ablative synthesis using an elemental Bi solid target leads to the formation of spherical Bi NPs having the mean size of 20–50 nm and a low size-dispersion. The NPs prepared in water experience a fast (within a few minutes) conversion into 400–500 nm flake-like nanosheets, composed of bismuth subcarbonates, (BiO)2CO3 and (BiO)4CO3(OH)2, while the NPs prepared in acetone demonstrate high elemental stability. We introduce a procedure to obtain a stable aqueous solution of elemental Bi NPs suitable for biological applications, based on the coating of Bi NPs prepared in acetone with Pluronic® F68 and their subsequent transfer to water. We also show that the laser-synthesized elemental Bi NPs, due to their vanishing band gap, exhibit remarkable absorption in the infrared range, which can be used for the activation of photothermal therapy in the near IR-to-IR window with maximum optical transparency in biological media. Exempt of any toxic synthetic by-products, laser-ablated elemental Bi NPs present a novel appealing nanoplatform for combination image-guided photoradiotherapies.

scholarly journals Laser-Ablative Synthesis of Isotope-Enriched Samarium Oxide Nanoparticles for Nuclear Nanomedicine

Nanomaterials ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 69 ◽  
Author(s):  
Elena Popova-Kuznetsova ◽  
Gleb Tikhonowski ◽  
Anton A. Popov ◽  
Vladimir Duflot ◽  
Sergey Deyev ◽  
...  
Keyword(s):  
Colloidal Stability ◽  
Laser Energy ◽  
Aqueous Dispersion ◽  
Oxide Nanoparticles ◽  
Local Concentration ◽  
Samarium Oxide ◽  
Beta Emitters ◽  
Wide Range ◽  
Fs Laser ◽  
Mean Size

Nuclear nanomedicine is an emerging field, which utilizes nanoformulations of nuclear agents to increase their local concentration at targeted sites for a more effective nuclear therapy at a considerably reduced radiation dosage. This field needs the development of methods for controlled fabrication of nuclear agents carrying nanoparticles with low polydispersity and with high colloidal stability in aqueous dispersions. In this paper, we apply methods of femtosecond (fs) laser ablation in deionized water to fabricate stable aqueous dispersion of 152Sm-enriched samarium oxide nanoparticles (NPs), which can capture neutrons to become 153Sm beta-emitters for nuclear therapy. We show that direct ablation of a 152Sm-enriched samarium oxide target leads to widely size- and shape-dispersed populations of NPs with low colloidal stability. However, by applying a second fs laser fragmentation step to the dispersion of initially formed colloids, we achieve full homogenization of NPs size characteristics, while keeping the same composition. We also demonstrate the possibility for wide-range tuning of the mean size of Sm-based NPs by varying laser energy during the ablation or fragmentation step. The final product presents dispersed solutions of samarium oxide NPs with relatively narrow size distribution, having spherical shape, a controlled mean size between 7 and 70 nm and high colloidal stability. The formed NPs can also be of importance for catalytic and biomedical applications.

scholarly journals Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 261
Author(s):  
Orlando Donoso-González ◽  
Lucas Lodeiro ◽  
Álvaro E. Aliaga ◽  
Miguel A. Laguna-Bercero ◽  
Soledad Bollo ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Colloidal Stability ◽  
Biomedical Application ◽  
Drug Loading ◽  
Gold Nanostars ◽  
Raman Optical Activity ◽  
Cationic Group ◽  
Low Cytotoxicity ◽  
Stability Limits ◽  
Zeta Potential Analysis

Gold nanostars (AuNSs) exhibit modulated plasmon resonance and have a high SERS enhancement factor. However, their low colloidal stability limits their biomedical application as a nanomaterial. Cationic β-cyclodextrin-based polymer (CCD/P) has low cytotoxicity, can load and transport drugs more efficiently than the corresponding monomeric form, and has an appropriate cationic group to stabilize gold nanoparticles. In this work, we functionalized AuNSs with CCD/P to load phenylethylamine (PhEA) and piperine (PIP) and evaluated SERS-based applications of the products. PhEA and PIP were included in the polymer and used to functionalize AuNSs, forming a new AuNS-CCD/P-PhEA-PIP nanosystem. The system was characterized by UV–VIS, IR, and NMR spectroscopy, TGA, SPR, DLS, zeta potential analysis, FE-SEM, and TEM. Additionally, Raman optical activity, SERS analysis and complementary theoretical studies were used for characterization. Minor adjustments increased the colloidal stability of AuNSs. The loading capacity of the CCD/P with PhEA-PIP was 95 ± 7%. The physicochemical parameters of the AuNS-CCD/P-PhEA-PIP system, such as size and Z potential, are suitable for potential biomedical applications Raman and SERS studies were used to monitor PhEA and PIP loading and their preferential orientation upon interaction with the surface of AuNSs. This unique nanomaterial could be used for simultaneous drug loading and SERS-based detection.

scholarly journals Aloe Vera-Mediated Te Nanostructures: Highly Potent Antibacterial Agents and Moderated Anticancer Effects

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 514
Author(s):  
David Medina-Cruz ◽  
Ada Vernet-Crua ◽  
Ebrahim Mostafavi ◽  
María Ujué González ◽  
Lidia Martínez ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Aqueous Media ◽  
Aloe Vera ◽  
Multidrug Resistant ◽  
Dermal Fibroblasts ◽  
Anticancer Properties ◽  
Green Approach ◽  
Anticancer Effects ◽  
Synthesis Of Nanomaterials ◽  
By Products

Cancer and antimicrobial resistance to antibiotics are two of the most worrying healthcare concerns that humanity is facing nowadays. Some of the most promising solutions for these healthcare problems may come from nanomedicine. While the traditional synthesis of nanomaterials is often accompanied by drawbacks such as high cost or the production of toxic by-products, green nanotechnology has been presented as a suitable solution to overcome such challenges. In this work, an approach for the synthesis of tellurium (Te) nanostructures in aqueous media has been developed using aloe vera (AV) extracts as a unique reducing and capping agent. Te-based nanoparticles (AV-TeNPs), with sizes between 20 and 60 nm, were characterized in terms of physicochemical properties and tested for potential biomedical applications. A significant decay in bacterial growth after 24 h was achieved for both Methicillin-resistant Staphylococcus aureus and multidrug-resistant Escherichia coli at a relative low concentration of 5 µg/mL, while there was no cytotoxicity towards human dermal fibroblasts after 3 days of treatment. AV-TeNPs also showed anticancer properties up to 72 h within a range of concentrations between 5 and 100 µg/mL. Consequently, here, we present a novel and green approach to produce Te-based nanostructures with potential biomedical applications, especially for antibacterial and anticancer applications.

Fabrication and Characterization of Si Nano-Columns by Femtosecond Laser

2012 ◽  
Vol 16 ◽  
pp. 15-20 ◽  
Author(s):  
Omid Tayefeh Ghalehbeygi ◽  
Vural Kara ◽  
Levent Trabzon ◽  
Selcuk Akturk ◽  
Huseyin Kizil
Keyword(s):  
Laser Ablation ◽  
Femtosecond Laser ◽  
Laser Beam ◽  
Chemical Etching ◽  
Silicon Surface ◽  
Laser Pulses ◽  
Laser Beam Profile ◽  
Fs Laser ◽  
Fabrication And Characterization

We fabricated Si Nano-columns by a femtosecond laser with various wavelengths and process parameters, whilst the specimen was submerged in water. The experiments were carried out by three types of wavelengths i.e. 1030 nm, 515nm, 343nm, with 500 fs laser pulses. The scales of these spikes are much smaller than micro spikes that are constructed by laser irradiation of silicon surface in vacuum or gases like SF6, Cl2. The Si nano-columns of 300 nm or less in width were characterized by SEM measurements. The formation of these Si Nano-columns that were revealed by SEM observation, indicates chemical etching with laser ablation occurred when surface exposed by laser beam. We observed 200 nm spikes height at the center of laser beam profile and the ones uniform in height at lateral incident area.

Pre-coating layered double hydroxide nanoparticles with albumin to improve colloidal stability and cellular uptake

2015 ◽  
Vol 3 (16) ◽  
pp. 3331-3339 ◽  
Author(s):  
Zi Gu ◽  
Huali Zuo ◽  
Li Li ◽  
Aihua Wu ◽  
Zhi Ping Xu
Keyword(s):  
Layered Double Hydroxide ◽  
Cellular Uptake ◽  
Biomedical Applications ◽  
Colloidal Stability ◽  
New Strategy ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

We introduced a new strategy of albumin pre-coating to effectively stabilise layered double hydroxide (LDH) nanoparticles for biomedical applications.

scholarly journals INFRARED PHOTOLUMINESCENCE SPECTRA OF PBS NANOPARTICLES PREPARED BY LANGMUIR–BLODGETT AND LASER ABLATION METHODS

2014 ◽  
Vol 54 (6) ◽  
pp. 426-429 ◽  
Author(s):  
Zdeněk Remes ◽  
Tomas Novak ◽  
Jiri Stuchlik ◽  
The-ha Stuchlikova ◽  
Vladislav Dřínek ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Spectral Range ◽  
Near Infrared ◽  
Infrared Region ◽  
Thin Layers ◽  
Photoluminescence Intensity ◽  
Photoluminescence Spectra ◽  
Colloidal Solutions ◽  
Pbs Nanoparticles ◽  
Langmuir Blodgett

We optimized the optical setup originally designed for the photoluminescence measurements in the spectral range 400‒1100 nm. New design extends the spectral range into the near infrared region 900‒1700 nm and allows the colloidal solutions measurements in cuvettes as well as the measurements of nanoparticles deposited in the form of thin films on glass substrates. The infrared photoluminescence spectra of the PbS nanoparticles prepared by the Langmuir–Blodgett technique show the higher photoluminescence intensity and the shift to the shorter wavelengths compared to the infrared photoluminescence spectra of the PbS nanoparticles prepared by the laser ablation from PbS target. We aslo proved the high stability of PbS nanoparticles prepared in the form of thin layers.

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