A Millennial Myosin Census

The past decade has seen a remarkable explosion in our knowledge of the size and diversity of the myosin superfamily. Since these actin-based motors are candidates to provide the molecular basis for many cellular movements, it is essential that motility researchers be aware of the complete set of myosins in a given organism. The availability of cDNA and/or draft genomic sequences from humans,Drosophila melanogaster, Caenorhabditis elegans, Arabidopsis thaliana,Saccharomyces cerevisiae, Schizosaccharomyces pombe, andDictyostelium discoideum has allowed us to tentatively define and compare the sets of myosin genes in these organisms. This analysis has also led to the identification of several putative myosin genes that may be of general interest. In humans, for example, we find a total of 40 known or predicted myosin genes including two new myosins-I, three new class II (conventional) myosins, a second member of the class III/ninaC myosins, a gene similar to the class XV deafness myosin, and a novel myosin sharing at most 33% identity with other members of the superfamily. These myosins are in addition to the recently discovered class XVI myosin with N-terminal ankyrin repeats and two human genes with similarity to the class XVIII PDZ-myosin from mouse. We briefly describe these newly recognized myosins and extend our previous phylogenetic analysis of the myosin superfamily to include a comparison of the complete or nearly complete inventories of myosin genes from several experimentally important organisms.

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553 Efficiency of new class III antiarrhythmic - Nibentan versus amiodarone for sinus rhythm restoration in paroxysmal atrial fibrillation patients

EP Europace ◽

10.1016/s1099-5129(05)80357-5 ◽

2005 ◽

Vol 7 ◽

pp. 121-121

Keyword(s):

Atrial Fibrillation ◽

Sinus Rhythm ◽

Paroxysmal Atrial Fibrillation ◽

Class Iii ◽

New Class

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Dofetilide, a New Class III Antiarrhythmic Drug Reduces Hospital Admissions for Congestive Heart Failure - Secondary Endpoints of the DIAMOND-CHF Study

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)83859-4 ◽

1998 ◽

Vol 31 (2) ◽

pp. 33A ◽

Cited By ~ 3

Author(s):

L Kaber

Keyword(s):

Heart Failure ◽

Congestive Heart Failure ◽

Antiarrhythmic Drug ◽

Hospital Admissions ◽

Class Iii ◽

New Class ◽

Class Iii Antiarrhythmic Drug ◽

Secondary Endpoints

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Comparison and Analysis of Computational Methods for Identifying N6 - methyladenosine Sites in Saccharomyces Cerevisiae

Current Pharmaceutical Design ◽

10.2174/1381612826666201109110703 ◽

2020 ◽

Vol 26 ◽

Author(s):

Pengmian Feng ◽

Lijing Feng ◽

Chaohui Tang

Keyword(s):

Saccharomyces Cerevisiae ◽

Computational Methods ◽

Computational Analysis ◽

Computational Prediction ◽

Experimental Methods ◽

Biological Processes ◽

Biological Functions ◽

Precise Location ◽

Future Directions ◽

The Past

Background and Purpose: N 6 -methyladenosine (m6A) plays critical roles in a broad set of biological processes. Knowledge about the precise location of m6A site in the transcriptome is vital for deciphering its biological functions. Although experimental techniques have made substantial contributions to identify m6A, they are still labor intensive and time consuming. As good complements to experimental methods, in the past few years, a series of computational approaches have been proposed to identify m6A sites. Methods: In order to facilitate researchers to select appropriate methods for identifying m6A sites, it is necessary to give a comprehensive review and comparison on existing methods. Results: Since researches on m6A in Saccharomyces cerevisiae are relatively clear, in this review, we summarized recent progresses on computational prediction of m6A sites in S. cerevisiae and assessed the performance of existing computational methods. Finally, future directions of computationally identifying m6A sites were presented. Conclusion: Taken together, we anticipate that this review will provide important guides for computational analysis of m 6A modifications.

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Molecular Basis of Fructose Utilization by the Wine Yeast Saccharomyces cerevisiae: a Mutated HXT3 Allele Enhances Fructose Fermentation

Applied and Environmental Microbiology ◽

10.1128/aem.02269-06 ◽

2007 ◽

Vol 73 (8) ◽

pp. 2432-2439 ◽

Cited By ~ 67

Author(s):

Carole Guillaume ◽

Pierre Delobel ◽

Jean-Marie Sablayrolles ◽

Bruno Blondin

Keyword(s):

Saccharomyces Cerevisiae ◽

Molecular Basis ◽

Alcoholic Fermentation ◽

Wine Yeast ◽

Glycolytic Flux ◽

Hexose Transporter ◽

Wine Yeasts ◽

Yeast Saccharomyces Cerevisiae ◽

High Fructose ◽

Fructose Fermentation

ABSTRACT Fructose utilization by wine yeasts is critically important for the maintenance of a high fermentation rate at the end of alcoholic fermentation. A Saccharomyces cerevisiae wine yeast able to ferment grape must sugars to dryness was found to have a high fructose utilization capacity. We investigated the molecular basis of this enhanced fructose utilization capacity by studying the properties of several hexose transporter (HXT) genes. We found that this wine yeast harbored a mutated HXT3 allele. A functional analysis of this mutated allele was performed by examining expression in an hxt1-7Δ strain. Expression of the mutated allele alone was found to be sufficient for producing an increase in fructose utilization during fermentation similar to that observed in the commercial wine yeast. This work provides the first demonstration that the pattern of fructose utilization during wine fermentation can be altered by expression of a mutated hexose transporter in a wine yeast. We also found that the glycolytic flux could be increased by overexpression of the mutant transporter gene, with no effect on fructose utilization. Our data demonstrate that the Hxt3 hexose transporter plays a key role in determining the glucose/fructose utilization ratio during fermentation.

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Molecular basis for resistance to antimycin and diuron, Q-cycle inhibitors acting at the Qi site in the mitochondrial ubiquinol-cytochrome c reductase in Saccharomyces cerevisiae.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)37792-5 ◽

1988 ◽

Vol 263 (25) ◽

pp. 12564-12570 ◽

Cited By ~ 6

Author(s):

J P di Rago ◽

A M Colson

Keyword(s):

Saccharomyces Cerevisiae ◽

Cytochrome C ◽

Molecular Basis ◽

Cytochrome C Reductase ◽

Q Cycle

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Genomic Analysis of Avian Infectious Bronchitis Viruses Recently Isolated in South Korea Reveals Multiple Introductions of GI-19 Lineage (QX Genotype)

Viruses ◽

10.3390/v13061045 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1045

Author(s):

Hyuk-Chae Lee ◽

Sol Jeong ◽

Andrew Y. Cho ◽

Kyu-Jik Kim ◽

Jun-Young Kim ◽

...

Keyword(s):

Phylogenetic Analysis ◽

South Korea ◽

Infectious Bronchitis Virus ◽

Economic Burden ◽

Genomic Analysis ◽

Multiple Introductions ◽

Infectious Bronchitis ◽

South Korean ◽

Phylogeographic Analysis ◽

The Past

Infectious bronchitis virus (IBV) was first identified in the 1930s and it imposes a major economic burden on the poultry industry. In particular, GI-19 lineage has spread globally and has evolved constantly since it was first detected in China. In this study, we analyzed S1 gene sequences from 60 IBVs isolated in South Korea. Two IBV lineages, GI-15 and GI-19, were identified in South Korea. Phylogenetic analysis suggested that there were six distinct subgroups (KM91-like, K40/09-like, and QX-like I to IV) of the South Korean GI-19 IBVs. Among them, QX-type III and IV subgroups, which are phylogenetically different from those reported in South Korea in the past, accounted for more than half of the total. Moreover, the phylogeographic analysis of the QX-like subgroups indicated at least four distinct introductions of GI-19 IBVs into South Korea during 2001–2020. The efficacy of commercialized vaccines against the recently introduced QX-like subgroups should be verified, and continuous international surveillance efforts and quarantine procedures should be enhanced to prevent the incursion of viruses.

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2,2-Dialkylacetic Acids -A New Class of Naturally Occurring Lipid Constituents

Zeitschrift für Naturforschung C ◽

10.1515/znc-1995-1-218 ◽

1995 ◽

Vol 50 (1-2) ◽

pp. 123-126 ◽

Cited By ~ 2

Author(s):

Gottfried Raab ◽

Jürgen Jacob

Keyword(s):

Retention Time ◽

Relative Retention Time ◽

Methyl Esters ◽

South American ◽

Time Data ◽

New Class ◽

The Past ◽

Relative Retention ◽

Naturally Occurring ◽

Acetic Acids

Abstract The uropygial gland waxes of the South American red-legged Seriema (Cariama cristata (L., 1766)) were found to be composed of unbranched alcohols and 2,2′-dialkyl-substituted acetic acids which so far have not been found in skin lipids. When used as a chemosystematic character, the occurrence of this lipid class separates the order Cariamiformes (Seriemas) from all other avian orders hitherto investigated, especially from the Gruiformes (cranes and rails) to which they have been tentatively attributed in the past. From the GC retention time data now available for a series of 2-alkyl-substituted fatty acid methyl esters relative retention time indices for other compounds may be predicted.

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