scholarly journals Awareness, Treatment, and Control Rates of Hypertension in Adults Aged 35–75 Years in Three Provinces of Central China

2020 ◽  
Vol 33 (5) ◽  
pp. 471-471
Author(s):  
Jia-li Song ◽  
Jing-wei Yang ◽  
Dan-wei Zhang ◽  
Jian-lan Cui ◽  
Chao-qun Wu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Drug Use ◽  
Antihypertensive Drug ◽  
Mixed Model ◽  
Family Income ◽  
Antihypertensive Drugs ◽  
Individual Characteristics ◽  
Central China ◽  
Combination Drug ◽  
And Control

Abstract Background To describe the status of hypertension awareness, treatment, and control rates and their relationships with individual characteristics in Henan, Hubei, and Hunan provinces in central China, and to describe the patterns of antihypertensive drug use in this region. Methods The awareness, treatment, and control rates of hypertension in this area were identified through analysis of the data from China Patient-Centered Evaluative Assessment of Cardiac Events (PEACE) Million Persons Project in three provinces (Henan, Hubei, and Hunan) of central China. The patterns of antihypertensive drug use were also examined. The mixed model was used to analyze the relationship between the awareness, treatment, and control rates and individual characteristics at the patient level. Results A total of 268,461 subjects were enrolled with 37.9% male and an average age of (56.3 ± 9.7) years. Among them, 129,099 (48.1%) had hypertension, of which 49.5% were aware of hypertension, 42.9% received antihypertensive drugs, and 11.5% had blood pressure under control. Calcium channel antagonists (54.6%) were the most widely used among all antihypertensive drugs. Of the patients whose blood pressure were not controlled, 25,482 patients (86.4%) took only one antihypertensive drug. In addition, the rate of awareness, treatment, and control of hypertension varied significantly among different populations: the rates were higher among the older, as well as among subjects with higher annual family income, higher educational status, and history of myocardial infarction, stroke, and diabetes (all P < 0.05). Conclusions The awareness, treatment, and control rates of hypertension in adult patients of central China require further improvement. Meanwhile the proportion of combination drug therapy is low.

Sex differences in antihypertensive drug use and blood pressure control

2019 ◽  
Vol 95 (1124) ◽  
pp. 295-299
Author(s):  
Junwen Wang ◽  
Weihong Jiang ◽  
Manju Sharma ◽  
Yuyan Wu ◽  
Jiayin Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sex Differences ◽  
Drug Use ◽  
Antihypertensive Drug ◽  
Antihypertensive Drugs ◽  
Age Groups ◽  
Channel Blockers ◽  
Elderly Age ◽  
Converting Enzyme Inhibitors ◽  
Males And Females

BackgroundHypertension is the most important modifiable cardiovascular risk factor. Epidemiological studies have shown the benefits of lowering blood pressure (BP), but BP control is a major challenge. Furthermore, there are significant sex differences in antihypertensive drug use and BP control. This study examined sex differences in antihypertensive drug use and BP control, with the aim of reducing the complications of hypertension and improving quality of life.MethodsThe study was performed in our outpatient hypertension clinic, and included 1529 patients without secondary hypertension or comorbidities. The study, investigated BP control rates and patterns of antihypertensive drug use in male and female. All data were collected using structured questionnaires and patient measurements.ResultsThe study included 713 males and 816 females in this study. Fewer females had hypertension in the younger age group (16.2% vs 11.6%; p>0.05), but this difference disappeared in middle-aged (47.8% vs 49.9 %; p<0.05) and elderly age groups (36.0% vs 38.5%; p<0.05). BP control rates differed between males and females (35.6% in male, 31.9% in female, p<0.01). There was an overall difference in BP control rates between males and females (35.6% in males, 31.9% in females, p<0.01). In this aged 18–44 years, angiotensin converting enzyme inhibitors (ACEIs) showed the best control rate in males, while calcium channel blockers (CCBs) were least effective (61.5% with ACEIs, 28.6% with CCBs; p<0.05). In this aged 45–64 years, diuretics (DUs) showed the best control rate in females, while CCBs were least effective (47.5% with DUs, 28.3% with CCBs; p<0.05).ConclusionsSex plays an important role in BP control. In those aged 18–44 years, males using ACEIs showed best control rates. In those aged 45–64 years, females using DUs showed best control rates. Our study provides a basis with the selection of antihypertensive drugs according to sex and age.

scholarly journals The Prevalence of Arterial Hypertension in Romanian Adult Population: Results from the Predatorr Study

2018 ◽  
Vol 25 (3) ◽  
pp. 303-312 ◽  
Author(s):  
Maria-Magdalena Roșu ◽  
Maria Moța
Keyword(s):  
Blood Pressure ◽  
Drug Therapy ◽  
Antihypertensive Drug ◽  
Antihypertensive Drugs ◽  
Adult Population ◽  
Antihypertensive Drug Therapy ◽  
National Study ◽  
Age Group ◽  
Unhealthy Lifestyle ◽  
And Control

Abstract Background and aims: PREDATORR is a national study designed to estimate the prevalence of diabetes mellitus, prediabetes, overweight, obesity, dyslipidemia, hyperuricemia and chronic kidney disease in Romanian adult population. The aim of present study was to estimate the prevalence, incidence, treatment and control in subjects from PREDATORR study. Material and methods: This study included 2727 adults aged 20 – 79 years. Subjects were examined, and three measurements were performed at a time of at least one minute and the mean of blood pressure readings was recorded. Hypertension was defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg and/or antihypertensive drug therapy. Results: The prevalence of hypertension in Romanian adult population aged 20 – 79 years was 47.38% and was higher in men: 48.62% than women: 46.23%. The incidence of hypertension was: 10.7% in 20 – 39 years age group, 43.1% in 40 – 59 years age group and 75.1% in subjects aged ≥ 60 years. Among subjects with hypertension, 18.7% did not receive antihypertensive drug therapy, 27.7% received antihypertensive treatment in monotherapy, 34.7% were under double antihypertensive drugs and most of them (37.6%) received three or more antihypertensive drugs. Conclusions: The prevalence of hypertension in Romania is high, possible explanations of this might be the unhealthy lifestyle and diet.

scholarly journals The longitudinal association between the use of antihypertensive drugs and 24-hour sleep in nursing homes. Results from the randomized controlled COSMOS trial

2020 ◽  
Author(s):  
Elisabeth Flo-Groeneboom ◽  
Tony Elvegaard ◽  
Christine Gulla ◽  
Bettina Sandgate Husebo
Keyword(s):  
Blood Pressure ◽  
Nursing Home ◽  
Drug Use ◽  
Antihypertensive Drug ◽  
Sleep Problems ◽  
Antihypertensive Drugs ◽  
Control Group ◽  
Randomized Controlled ◽  
Nursing Home Patients ◽  
Longitudinal Association

Abstract BackgroundAntihypertensive drug use and sleep problems are highly prevalent in nursing home patients. While it is hypothesized that blood pressure and antihypertensive drug use can affect sleep, this has not been investigated in depth in this population. We aimed to investigate the longitudinal association between antihypertensive drug use, blood pressure and day- and night-time sleep over 4 months.MethodsThis study was based on secondary analyses from the multicomponent randomized controlled COSMOS trial, in which the acronym denotes the intervention: COmmuncation, Systematic pain assessment and treatment, Medication review, Organization of activities and Safety. We included baseline and 4-month follow-up data from a subgroup of nursing home patients who wore actigraphs (n = 107). The subgroup had different levels of blood pressure, from low (< 120) to high (≥ 141). Assessments included blood pressure, antihypertensive drug use, and sleep parameters as assessed by actigraphy.ResultsWe found a significant reduction in total sleep time at month four in the intervention group compared to the control group. When analyzing the control group alone, we found a significant association between antihypertensive use and increased daytime sleep. We also found negative associations between blood pressure, antihypertensive drug use and sleep onset latency in the control group.ConclusionOur results suggest a correlation between excessive daytime sleep and hypertensive drug use. These findings have clinical urgency, as antihypertensive drugs are frequently used in nursing homes, and sleep problems may be especially detrimental for this population.The trial is registered at clinicaltrials.gov (NCT02238652).

scholarly journals A Japan nationwide web-based survey of patient preference for renal denervation for hypertension treatment

2021 ◽  
Author(s):  
Kazuomi Kario ◽  
Hideaki Kagitani ◽  
Shoko Hayashi ◽  
Satsuki Hanamura ◽  
Keisuke Ozawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Drug Therapy ◽  
Side Effects ◽  
Antihypertensive Drug ◽  
Patient Preference ◽  
Renal Denervation ◽  
Antihypertensive Drugs ◽  
Japanese Patients ◽  
Home Blood Pressure ◽  
Antihypertensive Drug Therapy

AbstractRenal denervation is a potential alternative to antihypertensive drug therapy. However, data on patient preference for this treatment option are limited and there are no data specifically from Asian patients. This study evaluated patient preference for renal denervation in patients with hypertension from Japan. Patients were a subset of those who participated in a March 2020 online electronic survey of patients with hypertension who had regularly visited medical institutions for treatment, were receiving antihypertensive drug therapy and had home blood pressure recordings available. The survey included a question about patient preference for treatment with renal denervation. A total of 2,392 patients were included (66% male, mean age 59.8 ± 11.6 years, mean duration of hypertension 11.4 ± 9.5 years). Preference for renal denervation was expressed by 755 patients (31.6%), and was higher in males than in females, in younger compared with older patients, in those with higher versus lower blood pressure, in patients who were less adherent versus more adherent to antihypertensive drug therapy, and in those who did rather than did not have antihypertensive drug-related side effects. Significant predictors of preference for renal denervation on logistic regression analysis were younger patient age, male sex, higher home or office systolic blood pressure, poor antihypertensive drug adherence, the presence of heart failure, and the presence of side effects during treatment with antihypertensive drugs. Overall, a relevant proportion of Japanese patients with hypertension expressed a preference for renal denervation. This should be taken into account when making shared decisions about antihypertensive drug therapy.

scholarly journals Drug utilization study of antihypertensive drugs and prevalence of blood pressure control in adult hypertensive patients based on JNC VIII guidelines in a tertiary care hospital: a cross sectional study

2019 ◽  
Vol 8 (2) ◽  
pp. 245
Author(s):  
Saumya Ramadas ◽  
M. B. Sujatha ◽  
M. A. Andrews ◽  
Sanalkumar K. B.
Keyword(s):  
Blood Pressure ◽  
Combination Therapy ◽  
Drug Utilization ◽  
Antihypertensive Drug ◽  
Blood Pressure Control ◽  
Antihypertensive Drugs ◽  
Pressure Control ◽  
Antihypertensive Drug Therapy ◽  
Care Hospital ◽  
Drug Utilization Study

Background: Hypertension is a major independent risk factor for coronary artery disease, congestive heart failure, stroke, chronic kidney disease and peripheral vascular diseases if left untreated. Drug utilization study of antihypertensive drugs and the study on prevalence of blood pressure control would help in reducing the burden of the disease and health expenditure.Methods: The study was conducted in the Outpatient Department of Medicine in Government Medical College, Thrissur. Patients aged 18yrs or above diagnosed with hypertension, on antihypertensive drugs were enrolled in the study. Patients suffering from secondary hypertension and acutely ill were excluded. Patients were enrolled after taking an informed consent. Demographic data, present treatment for hypertension, associated co- morbid conditions if any, and treatment of the same were recorded. BP was recorded, and cost of treatment was calculated using CIMS.Results: A total of 250 patients were included in the study. Mono therapy was used in 64.8% patients and combination therapy in 35.2%. Overall drug utilization pattern showed that CCBs (42.8%) were most commonly prescribed, followed by ACEIs (32.4%) and ARBs (29.2%). Most commonly prescribed combination therapy was ACE I + BB (29.3%), followed by ARB + CCB (21.3%). Mean cost of antihypertensive drug therapy was 3057.8 Rs / yr. Recommended target BP was achieved in 49.6% of patients.Conclusions: The prescription pattern of antihypertensive drug was in accordance to the JNC-VIII guidelines. The blood pressure target was achieved only in less than 50% of patients.

scholarly journals Effects of Angiotensin-Converting Enzyme Inhibitors on Arterial Stiffness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Xiuli Li ◽  
Peng Chang ◽  
Qiongying Wang ◽  
Hao Hu ◽  
Feng Bai ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Randomized Controlled Trials ◽  
Antihypertensive Drugs ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Controlled Trials ◽  
High Quality ◽  
Randomized Controlled ◽  
And Control

To determine the effects of ACEIs on arterial stiffness, a meta-analysis of randomized controlled trials was conducted. Relevant articles that investigated the effects of ACEIs on arterial stiffness from PubMed, Embase, and the Cochrane library from inception to September 2018 were systematically retrieved. The investigated outcomes included brachial-ankle pulse wave velocity (ba-PWV) and carotid-femoral PWV (cf-PWV) by using weighted mean differences (WMDs) and 95% confidence intervals (CIs) with the random-effects model. A total of 17 RCTs including 1,458 individuals were included. The summary results indicated no significant differences between ACEIs and control for ba-PWV and cf-PWV. Also, no significant differences between ACEI and control for ba-PWV and cf-PWV were observed in hypertensive patients, while the therapeutic effects of ACEI versus placebo showed statistically significant difference. Moreover, subgroup analysis indicated that the levels of ba-PWV were significantly associated if the study was conducted in Western countries, mean age <60.0 years, percentage male ≥60.0%, compared with ARBs, baseline PWV <10.0, and high-quality study. Furthermore, the significant levels of cf-PWV in patients who received ACEIs were observed when percentage male was ≥60.0% and the studies were of high-quality. Finally, no significant differences were observed between ACEIs and other antihypertensive drugs regarding the changes of systolic blood pressure (SBP) and diastolic blood pressure (DBP). The overall analysis suggested no significant differences between ACEIs and other antihypertensive drugs for ba-PWV and cf-PWV levels, whereas ACEIs versus placebo showed lower levels of ba-PWV and cf-PWV.

First-Choice Antihypertensive Drug Use in the Glasgow Blood Pressure Clinic

1990 ◽  
Vol 16 ◽  
pp. S120-S122
Author(s):  
David W. J. Clark ◽  
Joan L. Curzio ◽  
Catherine A. Howie ◽  
John L. Reid
Keyword(s):  
Blood Pressure ◽  
Drug Use ◽  
Antihypertensive Drug ◽  
First Choice

Combined effects of APOE genotype, blood pressure, and antihypertensive drug use on incident AD

Neurology ◽  
2003 ◽  
Vol 61 (5) ◽  
pp. 655-660 ◽  
Author(s):  
C. Qiu ◽  
B. Winblad ◽  
J. Fastbom ◽  
L. Fratiglioni
Keyword(s):  
Blood Pressure ◽  
Drug Use ◽  
Antihypertensive Drug ◽  
Apoe Genotype ◽  
Combined Effects

scholarly journals Association between Antihypertensive Drug Use and the Incidence of Cognitive Decline and Dementia: A Meta-Analysis of Prospective Cohort Studies

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Guangli Xu ◽  
Feng Bai ◽  
Xin Lin ◽  
Qiongying Wang ◽  
Qiang Wu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Drug Use ◽  
Cohort Studies ◽  
Cognitive Decline ◽  
Antihypertensive Drug ◽  
Prospective Cohort ◽  
Antihypertensive Drugs ◽  
Prospective Cohort Studies

Background.Antihypertensive drug use is inconsistently associated with the risk of dementia, Alzheimer’s disease, cognitive impairment, and cognitive decline. Therefore, we conducted a meta-analysis of available prospective cohort studies to summarize the evidence on the strength of these relationships.Methods.Three electronic databases including MedLine, Embase, and the Cochrane Library were searched to identify studies from inception to April 2017. Only prospective cohort studies that reported effect estimates with corresponding 95% confidence intervals (CIs) of dementia, Alzheimer’s disease, cognitive impairment, and cognitive decline for antihypertensive drug use versus not using antihypertensive drugs were included.Results.We included 10 prospective cohort studies reporting data on 30,895 individuals. Overall, participants who received antihypertensive drugs had lower incidence of dementia (relative risk [RR]: 0.86; 95% CI: 0.75–0.99;p=0.033), while there was no significant effect on the incidence of Alzheimer’s disease (RR: 0.83; 95% CI: 0.64–1.09;p=0.154), cognitive impairment (RR: 0.89; 95% CI: 0.57–1.38;p=0.596), and cognitive decline (RR: 1.11; 95% CI: 0.86–1.43;p=0.415). Further, the incidence of Alzheimer’s disease might be affected by antihypertensive drug use in participants with specific characteristics.Conclusions.Antihypertensive drug use was associated with a significantly reduced risk of dementia, but not with the risk of Alzheimer’s disease, cognitive impairment, and cognitive decline.

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