scholarly journals Typhoid Conjugate Vaccines and Enteric Fever Control: Where to Next?

2020 ◽  
Vol 71 (Supplement_2) ◽  
pp. S185-S190
Author(s):  
A Duncan Steele ◽  
Megan E Carey ◽  
Supriya Kumar ◽  
Calman A MacLennan ◽  
Lyou-Fu Ma ◽  
...  
Keyword(s):  
Health Impact ◽  
World Health ◽  
Surveillance Systems ◽  
Conjugate Vaccines ◽  
Immunization Strategies ◽  
Global Demand ◽  
Health Organization ◽  
Global Agenda ◽  
Potential Use

Abstract After the unprecedented success and acceleration of the global agenda towards typhoid fever control with a strong World Health Organization recommendation and the approval of funding from Gavi, the Vaccine Alliance (Gavi), for the use of a new typhoid conjugate vaccine (TCV), we should turn our minds to the challenges that remain ahead. Despite the evidence showing the safety and clinical efficacy of TCV in endemic populations in developing countries, we should remain vigilant and explore hurdles for the full public health impact of TCV, including vaccine supply for the potential global demand, immunization strategies to optimize the effectiveness and long-term protection provided by the vaccines, potential use of TCV in outbreak settings, and scenarios for addressing chronic carriers. Finally, challenges face endemic countries with poor surveillance systems concerning awareness of the need for TCV and the extent of the issue across their populations, and how to target immunization strategies appropriately.

Addressing the importance of Stem cell-based therapy: a Perspective in the treatment of COVID-19’

2020 ◽  
Vol 20 ◽  
Author(s):  
Christine Ibrahim ◽  
Hanna Semaan ◽  
Marwan El-Sabban ◽  
Fadia Najjar ◽  
Aline Hamade
Keyword(s):  
Stem Cell ◽  
Drug Repositioning ◽  
World Health ◽  
Unknown Etiology ◽  
Cell Based Therapy ◽  
Pathogenic Virus ◽  
Lung Injuries ◽  
Healthcare Crisis ◽  
Health Organization ◽  
Potential Use

: Severe acute respiratory syndrome-associated corona virus 2 (SARS-CoV-2), is an extremely pathogenic virus belonging to the family of Coronaviridae. First identified in Wuhan China in December 2019 after an epidemiological investigation of an emerging cluster of pneumonia of unknown etiology, SARS-CoV-2 was declared the cause of a pandemic on March 11 by the World Health Organization (WHO) pointing to the over 118000 cases of Coronavirus disease 2019 (COVID- 19) in over 110 countries. Despite the promising results of drug repositioning studies in the treatment of COVID-19, the evidence of their safety and efficacy remains inconclusive. Cell based therapy has been proven safe and possibly effective in treating multiple lung injuries and diseases but its potential use in the treatment of COVID-19 has not been yet elucidated. Our aim in this review is to provide an overview on the immunomodulatory effect and the regenerative capacity of stem cells and their secretome in the treatment of many diseases including lung injuries. Those findings may contribute to a better understanding of the potential of stem cell therapy in SARS-CoV-2 infection and its potential use in order to find a solution for this healthcare crisis.

scholarly journals Psychometric validation of the Chinese version of the PaArticular Scales among elderly residents in long-term care facilities with joint contractures

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yi-chang Chen ◽  
Keh-chung Lin ◽  
Chen-Jung Chen ◽  
Shu-Hui Yeh ◽  
Ay-Woan Pan ◽  
...  
Keyword(s):  
World Health Organization ◽  
Long Term Care ◽  
Chinese Version ◽  
World Health ◽  
Term Care ◽  
Joint Contractures ◽  
The World ◽  
Health Organization

Abstract Background Joint contractures, which affect activity, participation, and quality of life, are common complications of neurological conditions among elderly residents in long-term care facilities. This study examined the reliability and validity of the Chinese version of the PaArticular Scales in a population with joint contractures. Methods A cross-sectional study design was used. The sample included elderly residents older than 64 years with joint contractures in an important joint who had lived at one of 12 long-term care facilities in Taiwan for more than 6 months (N = 243). The Chinese version of the PaArticular Scales for joint contractures was generated from the English version through five stages: translation, review, back-translation, review by a panel of specialists, and a pretest. Test-retest reliability, internal consistency reliability, construct validity, and criterion validity were evaluated, and the results were compared with those for the World Health Organization Quality of Life scale and the World Health Organization Disability Assessment Schedule. Results The Chinese version of the PaArticular Scales had excellent reliability, with a Cronbach α coefficient of 0.975 (mean score, 28.98; standard deviation, 17.34). An exploratory factor analysis showed three factors and one factor with an eigenvalue > 1 that explained 75.176 and 62.83 % of the total variance in the Activity subscale and Participation subscale, respectively. The subscale-to-total scale correlation analysis showed Pearson correlation coefficients of 0.881 for the Activity subscale and 0.843 for the Participation subscale. Pearson’s product-moment correlation revealed that the correlation coefficient (r) between the Chinese version of the PaArticular Scales and the World Health Organization Disability Assessment Schedule was 0.770, whereas that for the World Health Organization Quality of Life scale was − 0.553; these values were interpreted as large coefficients. Conclusions The underlying theoretical model of the Chinese version of the PaArticular Scales functions well in Taiwan and has acceptable levels of reliability and validity. However, the Chinese version must be further tested for applicability and generalizability in future studies, preferably with a larger sample and in different clinical domains.

AVALIAÇÃO DA RELAÇÃO DO NÚMERO DE SINTOMÁTICOS RESPIRATÓRIOS E OS CASOS CONFIRMADOS DE TUBERCULOSE EM PALMAS-TO NO PERÍODO DE 2015-2016

2018 ◽  
Vol 5 (2) ◽  
pp. 29-33
Author(s):  
Robson de Sousa ◽  
Maria do Socorro Rocha Sarmento Nobre
Keyword(s):  
Early Identification ◽  
World Health ◽  
Epidemiological Surveillance ◽  
Cross Sectional ◽  
Public Health Activity ◽  
Transmission Chain ◽  
Keywords Tuberculosis ◽  
Health Organization ◽  
Term Objective

RESUMO Estratégia usada internacionalmente a busca ativa de sintomáticos respiratórios permite identificar precocemente pessoas com tosse por tempo igual ou superior a três semanas consideradas com suspeita de tuberculose pulmonar visando à descoberta dos casos bacilíferos. É uma atividade de saúde pública e deve ser realizada por todos os serviços de saúde de forma permanente. Com o objetivo de identificar os casos, interromper a cadeia de transmissão e reduzir a incidência da doença a longo prazo.  Objetivo: Conhecer os números de casos notificados de tuberculose e realizar um comparativo com os indicadores de sintomático respiratório no município de Palmas/TO entre os anos de 2015 e 2016. Método: O estudo é do tipo descritivo, de corte transversal e documental direta. Conclusão: Verifica-se que o número confirmado de TB da pesquisa do SR tanto para o ano de 2015 quanto para o ano de 2016 está muito aquém dos casos novos notificados, foi possível perceber a descontinuidade dos pacientes que são encaminhados para avaliação e que não há segmentos principalmente em relação ao resultado dos exames.   Palavras-chave: Tuberculose. Vigilância Epidemiológica. Organização Mundial da Saúde. ABSTRACT A strategy used internationally for the active search of respiratory symptomatic patients allows early identification of people with cough for a time equal to or greater than three weeks considered with suspicion of pulmonary tuberculosis in order to discover the bacilliferous cases. It is a public health activity and must be performed by all health services on an ongoing basis. In order to identify the cases, interrupt the transmission chain and reduce the incidence of the disease in the long term. Objective: To know the numbers of reported cases of tuberculosis and to carry out a comparison with the indicators of respiratory symptomatology in the municipality of Palmas / TO between the years 2015 and 2016. Method: The study is descriptive, cross-sectional and direct documentary. Conclusion: It is verified that the confirmed number of TB of the RS research for both the year 2015 and the year 2016 is well below the new cases reported, it was possible to perceive the discontinuity of the patients that are referred for evaluation and which are not mainly related to the results of the exams. Keywords: Tuberculosis. Epidemiological surveillance. World Health Organization.

scholarly journals World Health Organization Sub-Types, Initial Treatment Outcome and Prognostic Study of Unselected Adult Patients with Acute Myeloid Leukaemia in Shanghai: An Analysis of 623 Cases

2009 ◽  
Vol 37 (4) ◽  
pp. 1191-1201 ◽  
Author(s):  
Y Ma ◽  
X Wang ◽  
X Xu ◽  
G Lin
Keyword(s):  
Prognostic Factor ◽  
Acute Myeloid Leukaemia ◽  
World Health Organization ◽  
Myeloid Leukaemia ◽  
Treatment Effect ◽  
Developed Countries ◽  
World Health ◽  
Health Organization ◽  
Acute Myeloid

This study investigated the complete remission (CR) rate and survival of 623 newly diagnosed patients with acute myeloid leukaemia (AML) in Shanghai, China, classified according to World Health Organization and French–American–British criteria, and compared the differences in treatment effect with those reported in developed countries and those reported in Shanghai from 1984 to 1994. Total CR rate was 66.5%, median survival was 18 months and estimated survival at 3 years was 30.8%. The 3-year relapse rate was 55.1%. These data showed that the CR rate was similar to that achieved in studies from developed countries, but long-term survival was worse. The CR rate and survival were increased markedly compared with data previously collected in Shanghai (1984-1994). Induction chemotherapeutic regimens based on idarubicin, daunorubicin or homoharringtonine all had similar CR rates and survivals. Karyotype was the most important prognostic factor. Multilineage dysplasia in de novo AML was not an independent prognostic factor. Improvement in the long-term treatment effect in China is an important challenge for the future.

scholarly journals Health and Economic Impacts Assessment of O3 Exposure in Mexico

2021 ◽  
Vol 18 (21) ◽  
pp. 11646
Author(s):  
José Texcalac-Sangrador ◽  
Magali Hurtado-Díaz ◽  
Eunice Félix-Arellano ◽  
Carlos Guerrero-López ◽  
Horacio Riojas-Rodríguez
Keyword(s):  
Air Pollution ◽  
Economic Valuation ◽  
Ambient Air ◽  
Health Impact ◽  
Ambient Air Pollution ◽  
World Health ◽  
Health Impacts ◽  
Uncertainty Interval ◽  
Avoidable Deaths

Health effects related to exposure to air pollution such as ozone (O3) have been documented. The World Health Organization has recommended the use of the Sum of O3 Means Over 35 ppb (SOMO35) to perform Health Impact Assessments (HIA) for long-term exposure to O3. We estimated the avoidable mortality associated with long-term exposure to tropospheric O3 in 14 cities in Mexico using information for 2015. The economic valuation of avoidable deaths related to SOMO35 exposure was performed using the willingness to pay (WTP) and human capital (HC) approaches. We estimated that 627 deaths (95% uncertainty interval (UI): 227–1051) from respiratory diseases associated with the exposure to O3 would have been avoided in people over 30 years in the study area, which confirms the public health impacts of ambient air pollution. The avoidable deaths account for almost 1400 million USD under the WTP approach, whilst the HC method yielded a lost productivity estimate of 29.7 million USD due to premature deaths. Our findings represent the first evidence of the health impacts of O3 exposure in Mexico, using SOMO35 metrics.

scholarly journals Coronavirus Pandemic: Coping with the Psychological Outcomes, Mental Changes, and the “New Normal” During and After COVID-19

2020 ◽  
pp. 07-19
Author(s):  
Hiba Takieddine ◽  
Samaa AL Tabbah
Keyword(s):  
Healthcare Providers ◽  
Well Being ◽  
World Health ◽  
Vulnerable Groups ◽  
Public Health Response ◽  
New Normal ◽  
The World ◽  
Health Organization ◽  
The Impact

Coronavirus disease 2019 (COVID-19) is a highly infectious disease that has rapidly swept across the world, inducing a considerable degree of fear, worry and concern in the population at large and among certain groups in particular, such as older adults, healthcare providers and people with underlying health conditions. Authorities around the world tried to prevent the virus spread by imposing social distancing measures, quarantining citizens and isolating infected persons. Apart from its physical impact, COVID-19 pandemic has brought numerous changes to people’s lives. It changed daily routines, caused worldwide economic crisis, increased unemployment, and placed people under emotional and financial pressures. It affected people psychologically and mentally especially in terms of emotions and cognition. During the acute crisis, everyone to varying degrees experienced fear of infection, somatic concerns, worries about the pandemic’s consequences, loneliness, depression, stress, as well as increased alcohol and drug use. As part of its public health response, the World Health Organization (WHO) has worked with partners to develop a set of new guidelines and messages that can be used to prevent, manage, and support mental and psychological well-being in different vulnerable target groups during the outbreak. Whether people like it or not, the psychological sequela of this pandemic will emerge and persist for months and years to come leading to long-term consequences. New lifestyles and “New Normals” will surely emerge. The main purpose of this review is to summarize the impact of coronavirus pandemic on the psychological and mental health of people around the world especially vulnerable groups. It also presents the relevant intervention actions and recommendations to cope efficiently and effectively with the psychological short-term and long-term outcomes, mental changes, and the “New Normal” during and after COVID-19. Keywords: COVID-19; Coronavirus, Psychological; Mental; New Normal

scholarly journals A review of post infectious pulmonary fibrosis in the era of COVID-19 and potential treatment options

2021 ◽  
Vol 9 (40) ◽  
pp. 37-46
Author(s):  
Medha Ghose ◽  
Maehali Patel
Keyword(s):  
Risk Factors ◽  
Pulmonary Fibrosis ◽  
Treatment Options ◽  
World Health ◽  
Potential Treatment ◽  
Pulmonary Injury ◽  
The World ◽  
Health Organization ◽  
Post Infectious

On March 11, 2020, the World Health Organization (WHO) released a statement characterizing COVID-19 as a pandemic that has, as of October 2020, caused almost 36 million confirmed global cases and over 1 million deaths. One of the long-term complications suggested by researchers is fibrosis. It has been hypothesized that the combination of ongoing pulmonary injury caused by COVID-19 and the inability to promptly repair damage results in interstitial matrix widening and eventual compression and destruction of alveoli and capillaries. Here we focus on pathogenesis, risk factors, different infectious causes of fibrosis along with COVID-19, and potential treatment options that might reduce its effects. Key words: COVID-19, pulmonary fibrosis, mechanism, treatment

scholarly journals Developing WHO guidelines: Time to formally include evidence from mathematical modelling studies

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1584 ◽  
Author(s):  
Matthias Egger ◽  
Leigh Johnson ◽  
Christian Althaus ◽  
Anna Schöni ◽  
Georgia Salanti ◽  
...  
Keyword(s):  
Mathematical Modelling ◽  
The Body ◽  
World Health ◽  
Who Guidelines ◽  
Problem Model ◽  
Assessment Development ◽  
Modelling Studies ◽  
Health Organization

In recent years, the number of mathematical modelling studies has increased steeply. Many of the questions addressed in these studies are relevant to the development of World Health Organization (WHO) guidelines, but modelling studies are rarely formally included as part of the body of evidence. An expert consultation hosted by WHO, a survey of modellers and users of modelling studies, and literature reviews informed the development of recommendations on when and how to incorporate the results of modelling studies into WHO guidelines. In this article, we argue that modelling studies should routinely be considered in the process of developing WHO guidelines, but particularly in the evaluation of public health programmes, long-term effectiveness or comparative effectiveness.  There should be a systematic and transparent approach to identifying relevant published models, and to commissioning new models.  We believe that the inclusion of evidence from modelling studies into the Grading of Recommendations Assessment, Development and Evaluation (GRADE) process is possible and desirable, with relatively few adaptations.  No single “one-size-fits-all” approach is appropriate to assess the quality of modelling studies. The concept of the ‘credibility’ of the model, which takes the conceptualization of the problem, model structure, input data, different dimensions of uncertainty, as well as transparency and validation into account, is more appropriate than ‘risk of bias’.

scholarly journals Australian National Enterovirus Reference Laboratory annual report, 2017

2020 ◽  
Vol 44 ◽  
Author(s):  
Jason A Roberts ◽  
Linda K Hobday ◽  
Aishah Ibrahim ◽  
Bruce R Thorley
Keyword(s):  
Surveillance System ◽  
Disease Surveillance ◽  
Performance Criterion ◽  
World Health ◽  
Reference Laboratory ◽  
Surveillance Systems ◽  
Disease Surveillance System ◽  
Enterovirus A71 ◽  
Clinical Surveillance ◽  
Health Organization

Australia monitors its polio-free status by conducting surveillance for cases of acute flaccid paralysis (AFP) in children less than 15 years of age, as recommended by the World Health Organization (WHO). Cases of AFP in children are notified to the Australian Paediatric Surveillance Unit or the Paediatric Active Enhanced Disease Surveillance System and faecal specimens are referred for virological investigation to the National Enterovirus Reference Laboratory. In 2017, no cases of poliomyelitis were reported from clinical surveillance and Australia reported 1.33 non-polio AFP cases per 100,000 children, meeting the WHO performance criterion for a sensitive surveillance system. Three non-polio enteroviruses, coxsackievirus B1, echovirus 11 and enterovirus A71, were identified from clinical specimens collected from AFP cases. Australia established enterovirus and environmental surveillance systems to complement the clinical system focussed on children and an ambiguous vaccine-derived poliovirus type 2 was isolated from sewage in Melbourne. In 2017, 22 cases of wild polio were reported with three countries remaining endemic: Afghanistan, Nigeria and Pakistan.

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