PS01.058: OLDER AGE AND DEMENTIA MIGHT BE CONSIDERED BACKGROUND FACTORS OF BLEEDING FROM EROSIVE REFLUX ESOPHAGITIS WITH ESOPHAGEAL ULCER

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 66-66
Author(s):  
Tomohiro Kato ◽  
Yukari Uno ◽  
Hironao Ichikawa ◽  
Yuhei Iwasa ◽  
Chiemi Nakayama ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Cognitive Decline ◽  
Hiatal Hernia ◽  
Logistic Regression Analysis ◽  
Reflux Esophagitis ◽  
Older Age ◽  
Esophageal Ulcer ◽  
Background Factors ◽  
Esophageal Hiatal Hernia

Abstract Background Hematemesis is one of the most eventful complications in patients with reflux esophagitis (RE). But bleeding is not observed in all patients who have RE with esophageal ulcer. We retrospectively studied the association of bleeding with background factors in patients with RE with esophageal ulcer. Methods Between January 2013 and January 2018, 30 patients were endoscopically diagnosed as RE with Los Angeles classification D (LA-D). These 30 patients were enrolled in our study. Fifteen of them were suddenly admitted to our hospital because the RE exhibited bleeding (B-group). Patients with Mallory-Weiss syndrome, peptic ulcers, and any malignancies were excluded as possible sources of the bleeding. Bleeding was not observed in the remaining 15 RE patients (NB-group). In these 30 patients, we retrospectively studied the relations between the bleeding and the following background factors: age, gender, body mass index (BMI), esophageal hiatal hernia, endoscopical atrophy of the gastric mucosa which is related to the secretion of gastric juice, cognitive decline (so called dementia), diabetes mellitus, and drugs (NSAIDs, PPI). Results The B-group included 5 males and 10 females. The NB-group also included 5 males and 10 females. The mean age of the B-group was 81.7 ± 8.2 (M ± SD) yrs, which was statistically (P < 0.05) greater than that of the NB-group, which was 71.5 ± 11.0 yrs. Older age, larger esophageal hiatal hernia, and cognitive decline (so-called dementia) were significantly (P < 0.05) associated with bleeding on logistic regression analysis. Multiple logistic regression analysis showed that older age and dementia were significantly (P < 0.05) associated with bleeding. Conclusion It is well known that esophageal hiatal hernia is a major factor in erosive RE, such as RE with LA-D. On the other hand, it was speculated that older RE patients and those with cognitive decline could not easily explain their RE complaints, and their condition might be left unattended for long periods. This lack of attention may result in sudden bleeding in patients with non-treated RE. Further studies are needed. Disclosure All authors have declared no conflicts of interest.

scholarly journals Study on the relationship of depression, anxiety, lifestyle and eating habits with the severity of reflux esophagitis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Rongxin Wang ◽  
Jing Wang ◽  
Shuiqing Hu
Keyword(s):  
Quality Of Life ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Reflux Esophagitis ◽  
Eating Habits ◽  
Positive Correlation ◽  
Relationship Of ◽  
The Relationship

Abstract Background The etiology of reflux esophagitis (RE) is multi-factorial. This study analyzed the relationship of depression, anxiety, lifestyle and eating habits with RE and its severity and further explored the impact of anxiety and depression on patients’ symptoms and quality of life. Methods From September 2016 to February 2018, a total of 689 subjects at Xuanwu Hospital Capital Medical University participated in this survey. They were divided into the RE group (patients diagnosed with RE on gastroscopy, n = 361) and the control group (healthy individuals without heartburn, regurgitation and other gastrointestinal symptoms, n = 328). The survey included general demographic information, lifestyle habits, eating habits, comorbidities, current medications, the gastroesophageal reflux disease (GERD) questionnaire (GerdQ), the Patient Health Questionnaire-9 depression scale and the General Anxiety Disorder-7 anxiety scale. Results The mean age and sex ratio of the two groups were similar. Multivariate logistic regression analysis identified the following factors as related to the onset of RE (p < 0.05): low education level; drinking strong tea; preferences for sweets, noodles and acidic foods; sleeping on a low pillow; overeating; a short interval between dinner and sleep; anxiety; depression; constipation; history of hypertension; and use of oral calcium channel blockers. Ordinal logistic regression analysis revealed a positive correlation between sleeping on a low pillow and RE severity (p = 0.025). Depression had a positive correlation with the severity of symptoms (rs = 0.375, p < 0.001) and patients’ quality of life (rs = 0.306, p < 0.001), whereas anxiety showed no such association. Conclusions Many lifestyle factors and eating habits were correlated with the onset of RE. Notably, sleeping on a low pillow was positively correlated with RE severity, and depression was positively related to the severity of symptoms and patients’ quality of life.

scholarly journals Prevalence and Associated Metabolic Factors of Gallstone Disease in the Elderly Agricultural and Fishing Population of Taiwan

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Hsi-Che Shen ◽  
Yi-Chun Hu ◽  
Yu-Fen Chen ◽  
Tao-Hsin Tung
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Gallstone Disease ◽  
Multiple Logistic Regression Analysis ◽  
Older Age ◽  
Multiple Logistic Regression ◽  
Metabolic Factors ◽  
Female Sex ◽  
Study Population

Purpose. To evaluate sex-related differences in the prevalence of and cardiovascular risk factors related to gallstone disease (GSD) in an elderly agricultural and fishing population of Taipei, Taiwan.Methods. The study sample consisted of 6511 healthy elderly participants (3971 men and 2540 women) who were voluntarily admitted to a teaching hospital for a physical checkup in 2010. The participants’ blood samples and real-time ultrasound fatty liver results were collected.Results. The prevalence of GSD in the study population was 13.2%, which increased significantly with population age (P<.0001). Women were associated with significantly higher GSD prevalence than men (14.8% versus 12.2%; for the chi-square test,P=.003). In a multiple logistic regression analysis, female sex, older age, and metabolic syndrome (MetS) were significantly associated with GSD. Multiple logistic regression analysis also revealed that obesity (odds ratioOR=1.26, 95% confidence interval (CI): 1.09–1.44) and metabolic factors (one or 2 versus none,OR=1.48, 95% CI: 1.08–1.76) were significantly associated with GSD in women but not in men.Conclusion. In the study population, female sex, older age, and MetS were associated with higher GSD prevalence. The population exhibited other sex-related differences.

Is rising BMI associated with an increased rate of clinically relevant pancreatic fistula after distal pancreatectomy for pancreatic adenocarcinoma?

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 360-360
Author(s):  
Evan Scott Glazer ◽  
Yixuan Zhou ◽  
Justin Drake ◽  
Jeremiah Lee Deneve ◽  
Stephen W Behrman ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Pancreatic Fistula ◽  
Distal Pancreatectomy ◽  
Logistic Regression Analysis ◽  
Older Age ◽  
Ductal Adenocarcinoma ◽  
Multivariable Logistic Regression Analysis ◽  
Term Survival ◽  
Increased Risk

360 Background: Clinically relevant pancreatic fistula (CR-POPF), following distal pancreatectomy (DP) remains a clinical challenge. Prior studies investigating the relationship between body mass index (BMI) and CR-POPF have yielded conflicting results. We examined this relationship utilizing our institutional database and hypothesized that BMI is associated with CR-POPF in patients having DP for pancreatic ductal adenocarcinoma (PDAC). Methods: Patients who underwent DP for PDAC at a single institution from 2007 to 2018 were retrospectively reviewed. A CR-POPF was defined as ISGPS grade B or C fistula. Uni- and multi-variable logistic regression analysis to assess factors associated with CR-POPF following DP was performed, controlling for factors such as gland texture, operative drain placement, gender, and smoking status. Results: 78 patients met the inclusion criteria. 51% were female, 51% were Caucasian, and the average age was 59 ± 15 years. The median BMI was 26 (interquartile range 24 to 29). Overall, 19% (n = 15) of patients had a CR-POPF. With a mean follow up 2.8 ± 2.5 years, the presence of a CR-POPF was not associated with long-term survival (P = 0.17). On univariable logistic regression, older age was associated with a decreased risk of CR-POPF (OR = 0.95, P = 0.015) while increasing BMI was associated with an increased risk of CR-POPF (OR = 1.1, P = 0.044). After controlling for multiple factors on multivariable logistic regression analysis, BMI (OR = 1.12, P = 0.035) was the only factor associated with development of a CR-POPF while older age (OR = 0.94, P < 0.001) was slightly protective of CR-POPF development. Conclusions: For patients undergoing DP for PDAC, increasing BMI is associated with an increased risk of CR-POPF, independent of other factors. These findings should be considered during preoperative counseling. Although there is no specific cut-off for the association between BMI and CR-POPF, efforts to diminish the risk of CR-POPF should be focused on patients with higher BMI based on this data.

scholarly journals Factors associated with prolonged viral shedding and impact of Lopinavir/Ritonavir treatment in patients with SARS-CoV-2 infection

2020 ◽  
Author(s):  
Dan Yan ◽  
Xiao-Yan Liu ◽  
Ya-nan Zhu ◽  
Li Huang ◽  
Bi-tang Dan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Treatment Group ◽  
Logistic Regression Analysis ◽  
Median Duration ◽  
Symptom Onset ◽  
Older Age ◽  
Factors Associated ◽  
Viral Shedding

AbstractBackgroundThe duration of viral shedding is central to guide decisions around isolation precautions and antiviral treatment. However, studies about risk factors associated with prolonged SARS-CoV-2 shedding and the potential impact of Lopinavir/Ritonavir (LPV/r) treatment remain scarce.MethodsIn this retrospective study, data were collected from all SARS-CoV-2 infected patients who were admitted to isolation wards and had RT-PCR conversion at the NO.3 People’s hospital of Hubei province between 31 January and 09 March 2020. We compared clinical features and SARS-CoV-2 RNA shedding between patients with LPV/r treatment and those without. Logistic regression analysis was employed to evaluate risk factors associated with prolonged viral shedding.ResultsOf 120 patients, the median age was 52 years, 54 (45%) were male and 78 (65%) received LPV/r treatment. The median duration of SARS-CoV-2 RNA detection from symptom onset was 23 days (IQR, 18-32 days). Older age (odd ratio [OR] 1.03, 95% confidence interval [CI] 1.00-1.05, p=0.03) and lack of LPV/r treatment (OR 2.42, 95% CI 1.10-5.36, p=0.029) were independent risk factors for prolonged SARS-CoV-2 RNA shedding in multivariate logistic regression analysis. The median duration of viral shedding was shorter in the LPV/r treatment group (n=78) than that in no LPV/r treatment group (n=42) (median, 22 days vs. 28.5 days, p=0.02). Only earlier administration of LPV/r treatment (≤10 days from symptom onset) could shorten the duration of viral shedding.ConclusionsOlder age and lack of LPV/r treatment were independently associated with prolonged SARS-CoV-2 RNA shedding in patients with COVID-19. Earlier administration of LPV/r treatment could shorten viral shedding.Take home messageRisk factors for prolonged SARS-CoV-2 shedding included older age and lack of Lopinavir/Ritonavir treatment. Earlier administration of Lopinavir/Ritonavir treatment could shorten the duration of SARS-CoV-2 RNA shedding.

scholarly journals Prevalence of Type of Removable Dentures in Elderly Citizens in the Northern India

2015 ◽  
Vol 5 (2) ◽  
pp. 76-79
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Clinical Examination ◽  
Logistic Regression Analysis ◽  
Uttar Pradesh ◽  
Complete Dentures ◽  
Background Factors ◽  
Northern India ◽  
Age Range

ABSTRACT Aims and objectives The aim of this study was to evaluate the prevalence of removable partial dentures (RPD), conventional complete dentures (CCD) in elderly citizens in northern India and to identify factors that might be associated with the findings. Materials and Methods The survey was carried out in the nearby villages under the aegis of Saraswati Dental College, Lucknow, Uttar Pradesh, India (n = 1,050) from the period March 2013 to March 2014. The age range of the subjects was 55 to 70 years. In addition to a clinical examination, data on background factors were obtained using questionnaires and/or interviews. Results Overall, 12.4% of men and 12.1% of women had RPD, while 8% of men and 4.8% of women had CCD. Among the dentate subjects, 18.8% have posterior RPDs and 9.9% have anterior RPDs. Conclusion A logistic regression analysis showed that the prevalence of dentures in the form of removable dentures and complete dentures were relatively low in elderly citizens in the northern India. How to cite this article Kar S, Tripathi A. Prevalence of Type of Removable Dentures in Elderly Citizens in the Northern India. J Contemp Dent 2015;5(2):76-79.

scholarly journals Prevalence and correlates of hazardous, harmful or dependent alcohol use and drug use amongst persons 15 years and older in South Africa: Results of a national survey in 2017

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Supa Pengpid ◽  
Karl Peltzer ◽  
Shandir Ramlagan
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Psychological Distress ◽  
Drug Use ◽  
Logistic Regression Analysis ◽  
Middle Age ◽  
Mixed Race ◽  
Older Age ◽  
Negatively Associated ◽  
Adjusted Logistic Regression

Background: Harmful alcohol and illicit drug use significantly contribute the burden of disease.Aim: This study aimed to assess the prevalence and correlates of hazardous, harmful or dependent alcohol (HHDA) use and drug use amongst persons 15 years and older in South Africa.Setting: Population-based survey.Method: In a national cross-sectional 2017 survey, 39 210 persons 15 years and older (Median = 34 years) responded to a questionnaire on substance and health variables. The prevalence of HHDA use was 10.3% and past 3-month drug use 8.6%.Results: In adjusted logistic regression analysis, men of middle age (25–34 year olds) with higher education, urban residence, drug use and psychological distress were positively associated and Indian or Asian and white population groups were negatively associated with HHDA. Women of middle age (25–34 year old) and mixed race, residing on rural farms and urban areas, with drug use and psychological distress were positively associated and older age (55 years and older) and Indians or Asians were negatively associated with HHDA. In adjusted logistic regression analysis, men, having Grade 8–11 education, mixed race, being unemployed, and the HHDA used were positively associated and middle and older age (25 years and older) and being a student or learner were negatively associated with past 3-month any drug use. Women, who were mixed race, Indians or Asians, with the HHDA use were positively associated and older age (45 years and older) were negatively associated with the past 3-month drug use.Conclusion: About one in 10 participants with several sociodemographic and health indicators was identified to be associated with HHDA and any drug use.

scholarly journals Disrupted Dynamic Functional Connectivity in Distinguishing Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment Based on the Triple-Network Model

2021 ◽  
Author(s):  
Chen Xue ◽  
Wenzhang Qi ◽  
Qianqian Yuan ◽  
Guanjie Hu ◽  
Honglin Ge ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Cognitive Decline ◽  
Network Model ◽  
Logistic Regression Analysis ◽  
Amnestic Mild Cognitive Impairment ◽  
Subjective Cognitive Decline

Abstract Aberrant static functional connectivity (FC) within the triple networks involving the default mode network (DMN), the salience network (SN), and the executive control network (ECN) was found in subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI). However, dynamic FC (DFC) analysis within triple networks of SCD and aMCI was absent. We collected resting-state functional magnetic resonance imaging data from 44 SCD, 49 aMCI, and 58 controls (HC). DFC analysis were used to analyze the DFC variability within the triple networks among three groups. Then the correlation analysis was conducted to reveal the relationship between the altered DFC variability within the triple networks and the declined cognitive function. Furthermore, the logistic regression analysis was used to assess the diagnostic accuracy of altered DFC variability within the triple networks in SCD and aMCI. Compared to HC, SCD and aMCI both showed altered DFC variability within the triple networks. The DFC variability in the right middle temporal gyrus and left inferior frontal gyrus (IFG) within ECN were significantly different between SCD and aMCI. Moreover, the altered DFC variability in the left IFG within ECN was obviously associated with the decline in episodic memory and executive function. Lastly, the logistic regression analysis showed multivariable analysis had high sensitivity and specificity in the diagnosis of SCD and aMCI. The altered DFC variability and triple-network model proved to be an important biomarker to diagnosis and identification of preclinical AD spectrum.

Association Between Cognitive Decline and Oral Health Status in the Aging Population

GeroPsych ◽  
2021 ◽  
Author(s):  
Swapnil Sunil Bumb ◽  
Charu Chitra Govindan ◽  
Safalya S. Kadtane ◽  
Roshani Chawla ◽  
Ruchika Gupta ◽  
...  
Keyword(s):  
Older Adults ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Health Status ◽  
Oral Health ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Logistic Regression Analysis ◽  
Oral Health Status ◽  
Health Examination

Abstract. Background: To date, no longitudinal prospective study has investigated the association between oral health status and cognitive decline in the geriatric Indian population, possibly because past studies differed in their target groups and methodologies. We investigated the association between tooth loss, as evaluated through clinical oral examinations, and the development of cognitive decline in older adults while considering baseline cognitive function. Objectives: This study served to find an association between oral health status and the subsequent development of cognitive decline in older adults of Maharashtra state while considering baseline cognitive function. Material and Methods: This 5-year prospective cohort study followed 140 participants without cognitive impairment aged ≥ 65 years (mean age: 70.9 ± 4.3 years) living in the Dhule region of Maharashtra, India. Cognitive function was evaluated with the Mini-Mental State Examination (MMSE) in baseline and follow-up surveys, while oral health examination was carried out using Oral Hygiene Index. To investigate the association between oral health status and cognitive decline, we applied a multiple logistic regression analysis adjusted for age, sex, hypertension, diabetes, cerebrovascular/cardiovascular disease, hypercholesterolemia, depressive symptoms, body mass index, smoking status, drinking status, duration of education, and baseline MMSE score. Results: In the 5 years after the baseline survey, we obtained an overall incidence of 20.71% in the population that developed cognitive decline (i.e., MMSE scores of ≤ 24). A multivariable logistic regression analysis indicated that participants with compromised oral health were more likely to develop cognitive decline than those with mild to moderate oral health were (odds ratio: 3.31; 95% confidence interval: 1.07–10.2). Age, male sex, and baseline MMSE scores were also significantly associated with cognitive decline. Conclusion: Among the geriatric population of India, poor oral health status was independently associated with the development of cognitive decline within 5 years. This finding corroborates the hypothesis that oral health may be a predictor or risk factor for cognitive decline.

scholarly journals Transepithelial photorefractive keratectomy for myopia: effect of age and keratometric values

2021 ◽  
Vol 14 (5) ◽  
pp. 744-749
Author(s):  
Amanda Nur Shinta Pertiwi ◽  
◽  
Agus Supartoto ◽  
Wasisdi Goenawan ◽  
Suhardjo Suhardjo ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Older Age ◽  
Photorefractive Keratectomy ◽  
Bivariate Logistic Regression ◽  
Myopic Astigmatism ◽  
Effect Of Age ◽  
Preoperative Factors

AIM: To investigate demographic and preoperative factors increasing the risk of ametropia following transepithelial photorefractive keratectomy (transPRK) in myopia and myopic astigmatism. METHODS: This retrospective cohort study included myopic eyes (-0.50 to -8.75 D) with or without astigmatism (up to 3.50 D) enrolled at Dr. Yap Eye Hospital Yogyakarta. TransPRK was performed using Technolaz 217z100 excimer laser. Subjects were clustered into ametropia and emmetropia group based on uncorrected distance visual acuities (UDVA) 3mo post-operatively. Multiple preoperative and intraoperative parameters were analyzed using Logistic regression to obtain their effect on ametropia risk following transPRK. RESULTS: A total of 140 eyes of 87 consecutive subjects were studied. Prevalence of ametropia following transPRK was 20 (14.29%) eyes. Subjects in ametropia group were significantly older than the emmetropia group (31.80±14.23 vs 18.88±2.41, respectively; P&#x003C;0.001). Bivariate Logistic regression analysis showed that older age (OR=1.23), higher preoperative spherical equivalent (&#x003E;-6 D; OR=12.78), steeper anterior keratometric readings (Kmax&#x003E;45 D and mean K&#x003E;44 D; OR=4.28 and 4.35, respectively) increased the risk of ametropia following transPRK. Adjusted multivariate Logistic regression analysis showed that age was the strongest predictor for the incidence of ametropia following transPRK. Complications of transPRK were overcorrection, suspected posterior keratoectasia and accommodation insuffiency. CONCLUSION: Older age can be the strongest factor for increasing ametropia risk following transPRK. Cut-off points of Kmax and mean K at 45 and 44 D respectively are proposed as the predictors for ametropia following transPRK.

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