scholarly journals Maggot Therapy: The Science and Implication for CAM Part I—History and Bacterial Resistance

2006 ◽  
Vol 3 (2) ◽  
pp. 223-227 ◽  
Author(s):  
Yamni Nigam ◽  
Alyson Bexfield ◽  
Stephen Thomas ◽  
Norman Arthur Ratcliffe
Keyword(s):  
Bacterial Resistance ◽  
Clinical Situation ◽  
Review Article ◽  
Wound Debridement ◽  
Beneficial Effects ◽  
Infected Wounds ◽  
Green Bottle ◽  
The Common ◽  
Maggot Therapy

It is now a universally acknowledged fact that maggot therapy can be used successfully to treat chronic, long-standing, infected wounds, which have previously failed to respond to conventional treatment. Such wounds are typically characterized by the presence of necrotic tissue, underlying infection and poor healing. Maggot therapy employs the use of freshly emerged, sterile larvae of the common green-bottle fly,Phaenicia(Lucilia)sericata, and is a form of artificially induced myiasis in a controlled clinical situation. In this review article, we will discuss the role of maggots and their preparation for clinical use. Maggot therapy has the following three core beneficial effects on a wound: debridement, disinfection and enhanced healing. In part I we explore our current understanding of the mechanisms underlying these effects.

scholarly journals Maggot Therapy: The Science and Implication for CAM Part II—Maggots Combat Infection

2006 ◽  
Vol 3 (3) ◽  
pp. 303-308 ◽  
Author(s):  
Yamni Nigam ◽  
Alyson Bexfield ◽  
Stephen Thomas ◽  
Norman Arthur Ratcliffe
Keyword(s):  
Wound Healing ◽  
Alternative Treatment ◽  
Clinical Situation ◽  
Review Article ◽  
Antibacterial Action ◽  
Wound Debridement ◽  
Beneficial Effects ◽  
Green Bottle ◽  
The Common ◽  
Maggot Therapy

Maggot therapy employs the use of freshly emerged, sterile larvae of the common green-bottle fly,Phaenicia(Lucilia)sericata, and is a form of artificially induced myiasis in a controlled clinical situation. Maggot therapy has the following three core beneficial effects on a wound: debridement, disinfection and enhanced healing. In part II of this review article, we discuss clinical infections and the evidence supporting the potent antibacterial action of maggot secretions. Enhancement of wound healing by maggots is discussed along with the future of this highly successful, often controversial, alternative treatment.

scholarly journals Impact of Micronutrients on Hypertension: Evidence from Clinical Trials with a Special Focus on Meta-Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 588
Author(s):  
Hui-Fang Chiu ◽  
Kamesh Venkatakrishnan ◽  
Oksana Golovinskaia ◽  
Chin-Kun Wang
Keyword(s):  
Clinical Trials ◽  
Meta Analysis ◽  
Review Article ◽  
Special Focus ◽  
Recommended Daily Allowance ◽  
Beneficial Effects ◽  
Daily Allowance ◽  
Regulation Of Blood Pressure ◽  
Morbid Conditions

Hypertension (HT) is one of the pivotal risk factors for various detrimental diseases like cardiovascular diseases (CVDs), cerebrovascular disease, and renal dysfunction. Currently, many researchers are paying immense attention to various diet formula (dietary approach) with a special focus on micro and macronutrients along with modified lifestyle and standard anti-hypertensive drugs. Micronutrients (minerals/vitamins) play a central role in the regulation of blood pressure (BP) as they aid the function of macronutrients and also improve the anti-hypertensive functions of some anti-hypertensive agents. Even though several studies have demonstrated the beneficial effects of micronutrients on controlling BP, still some ambiguity exists among the nutritionists/doctors, which combination or individual mineral (dietary approach) contributes to better BP regulation. Therefore, this critical review article was attempted to delineate the underlying role of micronutrients (minerals and vitamins) for the management and prevention or delaying of HT and their related complications with strong affirmation from clinical trials as well as its mechanism of controlling BP. Moreover, the major source and recommended daily allowance (RDA) of various micronutrients are included in this review for guiding common readers (especially HT subjects) and dieticians to choose/recommend a better micronutrient and their combinations (other nutrients and standard anti-hypertensive drugs) for lowering the risk of HT and its related co-morbid conditions like CVDs.

scholarly journals Promoting the Use of Reference Management Tools An Opportunity for Librarians to Promote Scientific Tradition

2021 ◽  
Vol 42 (1) ◽  
pp. 64-70
Author(s):  
Vishal D. Bapte ◽  
Supriya A. Bejalwar
Keyword(s):  
Academic Writing ◽  
Research Work ◽  
Scientific Work ◽  
Review Article ◽  
Review Of The Literature ◽  
Management Tools ◽  
Research Activities ◽  
The Common ◽  
Library Professionals

The scientific tradition entails that any scientific work needs to be cited if it is responsible for the development of further another research work. This review article discusses the role of library professionals in promoting Reference Management Tools (RMTs) amongst the teachers, students, and researchers to maintain the scientific tradition of citation management. Among the various citation management tools available, four exemplary tools have been discussed briefly. The review of the literature revealed that the users have mixed responses pertaining to the use of RMTs. Especially; the common experience in respect of quality usage is very low. The users seemed to have limited themselves to make use of RMTs for reference management instead of exploring all the options associated with it. An attempt has been made to highlight why and how librarians should promote RMTs in the academic environment. Since librarians are considered experts in the field of reference management, they must grab this opportunity to strengthen the profession. The article urges the library professionals to get expertise in using RMTs so as to promote them successfully for academic writing and research activities.

scholarly journals Role of nutrients regulation in the immune system in preventing COVID-19 infection: A brief review

2021 ◽  
Vol 13 (2) ◽  
pp. 760-765
Author(s):  
Anamika Chauhan
Keyword(s):  
Immune System ◽  
Age Groups ◽  
World Health ◽  
The Novel ◽  
Beneficial Effects ◽  
Coronavirus Infection ◽  
The Common ◽  
Novel Coronavirus ◽  
Health Organization

This review aimed to focus on using foods to boost immunity against COVID-19 in all age groups. In human, coronavirus causes the common cold, severe acute respiratory syndrome (SARS), and a major threat to public health. The novel coronavirus was declared a pandemic by the World Health Organization due to its rapid infectivity. COVID-19 infection is most probably reported in people with low immunity response. The nutrients, which show beneficial effects on the immune system, are called immune nutrients and diet is called immune diet. A healthy diet can reduce the risk of infection of COVID-19 and can prevent disease. Nutritional food intake is also necessary for people with chronic illness, obese persons, diabetes, cardiovascular disease, cognitive dysfunction like anxiety and depression. All nutrients are essential for maintaining immunity and providing appropriate amounts of protein, fat, carbohydrate, vitamins, and minerals for the surveillance mode of keeping us from getting sick. The use of plenty of water, minerals such as micronutrients, zinc, copper, selenium, iron, magnesium, food rich in vitamins, and a good lifestyle can promote health and overwhelm this coronavirus infection.

Procalcitonin

2015 ◽  
Vol 68 (9) ◽  
pp. 675-679 ◽  
Author(s):  
Julie Davies
Keyword(s):  
Primary Care ◽  
Intensive Care Unit ◽  
Antibiotic Resistance ◽  
Bacterial Resistance ◽  
Clinical Situation ◽  
C Cells ◽  
Amino Acid Precursor ◽  
Potential Impact ◽  
Acid Precursor

Procalcitonin (PCT) is the 116 amino acid precursor of the hormone calcitonin, produced by the C cells of the thyroid. Its synthesis is upregulated in bacterial infection and downregulated by viral infection. Consequently, with the increasing development of antibiotic resistance, interest has focused on the ability of this marker to not only diagnose infection but to tailor antibiotic treatment and help reduce the development of antibiotic resistance. The value of PCT depends on the specific clinical situation and pretest probability of disease. This article discusses the role of PCT in these different situations, namely primary care, the emergency department and the intensive care unit. The true cost effectiveness of this test remains difficult to prove as evidence for the potential impact of using PCT on slowing the development of bacterial resistance remains largely circumstantial.

Oxyprenylated Secondary Metabolites as Modulators of Lipid and Sugar Metabolism

2021 ◽  
Vol 21 ◽  
Author(s):  
Serena Fiorito ◽  
Francesco Epifano ◽  
Lorenzo Marchetti ◽  
Lucia Palumbo ◽  
Ilkay Erdogan Orhan ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Metabolic Disorders ◽  
Sugar Metabolism ◽  
Review Article ◽  
Food Plants ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Beneficial Effects ◽  
Related Compounds

: O-Prenylcoumarins (3,3-dimethylallyl, geranyl-, farnesyl- and related biosynthetic derivatives) represent a class of rarely occurring natural compounds. The most part of these secondary metabolites have been obtained from plant species belonging to the Rutaceae, Apiaceae, andFabaceae families, and from fungi, and bacteria. In the last two decades prenyloxycoumarinshave been found to possess a great potential in terms of pharmacological activities. The aim of this comprehensive review is to make a survey of the in so far reported literature citations about these valuable phytochemicals and structurally related compounds about their modulatory properties of lipid and sugar metabolism. Literature data have been acquired from the main Internet database. Several oxyprenylated secondary metabolites have been surveyed. Among these prenyloxycoumarins represented the main group exerting displayed valuable effects as modulators of lipid and sugar metabolism. The title phytochemicals have been found in common edible and fruits vegetables already known to have beneficial effects to this concern, thus enforcing the nutraceutical role of these food plants. All compounds outlined in the present review article have a great potential for the next future for the prevention and management of acute and chronic metabolic disorders

The Myiases

2011 ◽  
Author(s):  
Mahmoud N. Abo-Shehada
Keyword(s):  
Molecular Techniques ◽  
Cochliomyia Hominivorax ◽  
Relative Importance ◽  
Wound Debridement ◽  
Caribbean Islands ◽  
Infected Wounds ◽  
The Usa ◽  
The Caribbean ◽  
The Uk ◽  
Maggot Therapy

Human myiases can be caused by over 50 species of dipteran larvae. The numbers of human clinical myiasis reports, reflect their relative importance in the following order; cutaneous, ophthalmomyiases, nasal, oral, intestinal, ear, urogenital, and cerebral myiases. Myiasis producing flies are distributed worldwide, but most reported cases are from warm and developing countries. Molecular techniques have been applied to myiasis fly identification and classification, especially ostrids and calliphorines. Successful elimination programs have been carried out against Hypoderma spp. in the UK and Cochliomyia hominivorax in the USA, Mexico, Central America, Libya and the Caribbean Islands and another is ongoing against Crysomya bezziana in the Middle East. A beneficial myissis “Biosurgery or maggot therapy” is the intentional use of Lucilia sericata larvae applied in specially designed dressings to chronic and MRSA infected wounds. The growing larvae execration/secretion facilitate wound debridement and successfully treated leg and pressure ulcers, wounds associated with diabetes, and many other types of infected wounds in a shorter time compared to conventional treatment. Now knowledge of myiases producing flies is accepted in many countries as a forensic tool.

scholarly journals Revisiting the Spleen—An Imaging Review of the Common and Uncommon Splenic Pathology

2021 ◽  
Author(s):  
Meshaal Nadeem ◽  
Hina Arif Tiwari ◽  
Kedar Jambhekar ◽  
Hemendra Shah ◽  
Roopa Ram
Keyword(s):  
Magnetic Resonance Imaging ◽  
Review Article ◽  
Resonance Imaging ◽  
Inflammatory Conditions ◽  
Lymphatic Organ ◽  
Malignant Lesions ◽  
The Common ◽  
Magnetic Resonance Imaging Mri ◽  
Developmental Variants

AbstractThe spleen is the largest lymphatic organ and is responsible for both hematological and immunological functions. Several common etiologies such as trauma, developmental variants, infectious/inflammatory conditions, and benign and malignant lesions can occur in the spleen. The role of imaging modalities such as ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI) in diagnosing these conditions continues to evolve. The main objective of this review article is to illustrate the role of imaging in identifying the common and uncommon pathology of the spleen.

scholarly journals Investigation the role of mutations M182T and Q39K in structure of beta-lactamase TEM-72 by molecular dynamics method

2016 ◽  
Vol 62 (5) ◽  
pp. 527-534
Author(s):  
D.S. Shcherbinin ◽  
M.Yu. Rubtsova ◽  
V.G. Grigorenko ◽  
I.V. Uporov ◽  
A.V. Veselovsky ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Enzyme Activity ◽  
High Temperature ◽  
Active Site ◽  
Bacterial Resistance ◽  
Beta Lactamase ◽  
Amino Acid Residues ◽  
The Common ◽  
Dynamics Method

Synthesis of b-lactamases is one of the common mechanisms of bacterial resistance to b-lactam antibiotics including penicillins and cephalosporins. The widespread use of antibiotics results in appearance of numerous extended-spectrum b-lactamase variants or resistance to inhibitors. Mutations of 92 residues of TEM type were found. Several mutations are the key mutations that determine the extension of spectrum of substrates. However, roles of the most associated mutations, located far from active site, remain unknown. We have investigated the role of associated mutations in structure of b-lactamase TEM-72, which contain two key mutation (G238S, E240K) and two associated mutations (Q39K, M182T) by means of simulation of molecular dynamics. The key mutation lead to destabilization of the protein globule, characterized by increased mobility of amino acid residues at high temperature of modelling. Mutation M182T lead to stabilization protein, whereas mutation Q39K is destabilizing mutation. It seems that the last mutation serves for optimization of conformational mobility of b-lactamase and may influence on enzyme activity.

scholarly journals PHYSICAL ACTIVITY DURING PREGNANCY AND AFTER DELIVERY

2019 ◽  
pp. 277
Author(s):  
Dragan Đurđević ◽  
Sanja Mazić ◽  
Goran Janković ◽  
Aleksandra Isaković
Keyword(s):  
Physical Activity ◽  
Body Weight ◽  
Review Article ◽  
Psychological State ◽  
Health Improvement ◽  
Moderate Physical Activity ◽  
Special Period ◽  
Beneficial Effects ◽  
Exercise During Pregnancy

It is well known that physical activity and proper diet can have beneficial effects on health improvement, as a prevention and as a therapy of chronic non-communicable diseases. Pregnancy is a special period in the life of every woman. Therefore, you often ask yourself whether it is advisable to exercise during pregnancy, when and how much? This review article, by analyzing the available literature data, has tried to explain what form of physical activity is recommended during pregnancy, depending on the period of pregnancy, under what conditions pregnant women should exercise, what forms of physical activity they should avoid and when they should not to practice it. In addition, we analyzed the role of physical activity in the prevention of gestational diabetes, the most common metabolic disorder that occurs during pregnancy. Following the recommendations of the FITT principle outlined in this paper, controlled exercise conditions with a specialized trainer and nutritionist, regular moderate physical activity adapted to different periods of pregnancy, undoubtedly contributes to the maintenance and improvement of the musculoskeletal and cardiovascular system of the pregnant woman, better control of her body weight and improvement of her psychological state.

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