scholarly journals P761 Illness cognition of Saudi patients with Crohn’s disease

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S606-S606
Author(s):  
M H A Mosli ◽  
A Saeedi ◽  
M ALNEFAIE ◽  
N Bawahab ◽  
L Abdu ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Considerable Proportion ◽  
Illness Cognition ◽  
Wide Range ◽  
The Mean ◽  
Saudi Patients

Abstract Background The prevalence of Crohn’s disease (CD) has markedly increased in Saudi Arabia over the past 3 decades.Patients’ awareness of the chronic recurrent course and potential risk of disease complications can lead to a wide range of psychological and interpersonal concerns. Patients’ cognition about the disease and treatment are important mediators as they explain the occurrence of individual differences in the individuals’ adjustment to chronic diseases. The aim of this study is to assess illness cognition of Saudi patients diagnosed with CD and to identify clinical predictors. Methods Consecutive patients with confirmed CD seen in the adult outpatient gastroenterology clinic at King Abdulaziz university hospital were recruited between January and December of 2019. Data was collected from interviews conducted with the patients and from the hospitals’ electronic medical records.The primary endpoint of the study was patients’ illness cognition according to the illness cognition questionnaire (ICQ), which can be used to assess three cognitive functions that patients attribute to disease: helplessness (6 items), acceptance (6 items), and perceived benefits (6 items). Each item is scored from 1 to 4, with 1 corresponding to ‘Not’, and 4 corresponding to ‘Totally. Descriptive statistics were used to summarise patient characteristics and linear regression analysis was used to identify predictors of the ICQ score. Results A total of 88 patients were surveyed, of which 55.8% were females, 18% were smokers and 11.5% had undergone CD-related surgery. The mean age was 26.9 ± 7.7 years and the mean duration of disease was 54.7 ± 60.5 months. Perianal disease was reported by 16.1% of the cohort. Twenty eight percent of patients reported that they ‘completely’ missed things that they like to do the most because of their illness and 35% responded by ‘not at all’ when asked if they had learned to live with their disease. Forty one percent of patients reported that the illness ‘completely’ controls their life and 30% responded by ‘not at all’ when asked if they can accept their illness. Mean ICQ score was 44.3 ( ± 6.6). On linear regression analysis, duration of the disease in months (coef = −0.04, p = 0.008) and fatigue (coef = −1.40, p = 0.04) were predictive of the ICQ score. Conclusion A considerable proportion of Saudi patients diagnosed with CD report negative perception of their disease. Duration of illness and presence of fatigue appear to be predictive of the ICQ score.

The impact of legs fat mass and legs lean fat mass on thigh circumference according cardiovascular risk: a population-based study

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
M Chlabicz ◽  
M Paniczko ◽  
J Jamolkowski ◽  
P Sowa ◽  
M Lapinska ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Regression Analysis ◽  
Linear Regression ◽  
Muscle Tissue ◽  
Fat Mass ◽  
Linear Regression Analysis ◽  
Population Based ◽  
Thigh Circumference ◽  
Tissue Model ◽  
The Mean

Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Medical University of Bialystok, Poland Introduction A low thigh circumference is associated with an increased risk of high blood pressure, diabetes, cardiovascular diseases, and total mortality. Objectives The aim of the study was to investigate the relationship between the thigh circumference and cardiovascular (CV) risk classes, and to assess what type of tissue, adipose tissue or muscle tissue affects the thigh circumference. Methods The longitudinal, population-based, Polish study was conducted in 2017-2020. A total of 931 individuals aged 20-79 were analyzed. Pol-SCORE system was used to assess the 10-year risk of fatal CV based on the following risk factors: age, gender, smoking, systolic blood pressure, and total cholesterol for individuals aged 40-70.  Then, CV risk classes were assessed using the 2019 ESC/EAS guidelines. The measurement of thigh circumference were performed directly below the gluteal fold of the thigh. Both thighs were measured and the mean value was calculated as the final thigh circumference. Body composition was assessed using Dual Energy X-ray Absorptiometry (DEXA). Results The mean age was 49.1 ± 15.5 years and 43.2% male. The mean thigh circumference was 58.2 ± 5.9 cm, the mean legs fat mass was 7.7 ± 2.8kg, and the mean legs lean mass was 16.9 ± 4.0kg. Lower thigh circumference was associated with higher CV risk classes in univariate linear regression analysis (β -0.516, p = 0.002), as well adjusted by age and sex (β -0.839, p = 0.008), adjusted by age, sex, BMI (β -0.886, p <0.001), and age, sex, WHR (β -0.988, p <0.001). In linear regression analysis legs adipose tissue and muscle tissue were related to the thigh circumference independently of CV risk classes (Model 1) and Pol-SCORE value (Model 2). However, fatty tissue (Model 1: β 0.746, p < 0.001; Model 2: β 0.749, p < 0.001) affects the thigh circumference more than the muscle tissue (Model 1: β 0.479, p < 0.001; Model 2: β 0.442, p < 0.001) (Fig. 1). Conclusion Smaller thigh circumference was associated with higher CV risk classes. Thigh circumference was more influenced by adipose tissue than by muscle tissue, regardless of the Pol-SCORE  or CV risk classes. Table 1. Variable Model 1 Model 2 Beta p R2 Beta p R2 Legs fat mass 0.746 <0.001 0.785 0.749 <0.001 0.760 Legs lean mass 0.479 <0.001 0.785 0.442 <0.001 0.760 Model 1: adjusted for Cardiovascular risk classesModel 2: adjusted for Pol-SCOREResults of the linear regression analysis thigh circumference in the general population Abstract Figure 1.

scholarly journals Reliability of Nitrogen Content (%N) and Carbon:Nitrogen Atomic Ratios (C:N) as Indicators of Collagen Preservation Suitable for Radiocarbon Dating

Radiocarbon ◽  
2012 ◽  
Vol 54 (3-4) ◽  
pp. 879-886 ◽  
Author(s):  
Fiona Brock ◽  
Rachel Wood ◽  
Thomas F G Higham ◽  
Peter Ditchfield ◽  
Alex Bayliss ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Radiocarbon Dating ◽  
Linear Regression Analysis ◽  
Atomic Weight ◽  
Animal Bones ◽  
Bone Powder ◽  
Wide Range ◽  
Pass Through ◽  
Percent Nitrogen

A recent study into prescreening techniques to identify bones suitable for radiocarbon dating from sites known for poor or variable preservation (Brock et al. 2007, 2010a) found that the percent nitrogen (%N) content of whole bone powder was the most reliable indicator of collagen preservation. Measurement of %N is rapid, requires little preparation or material, and is relatively cheap. The technique reduces the risk of needlessly sampling valuable archaeological objects, as well as saving time and money on their unsuccessful pretreatment prior to dating. This method of prescreening is now regularly used at the Oxford Radiocarbon Accelerator Unit (ORAU). In the original study, linear regression analysis of data from 100 bones from 12 Holocene sites across southern England showed that when 0.76% N was chosen as a threshold, 84% of bones were successfully identified as containing sufficient (i.e. >1%) or insufficient (i.e. <1%) collagen for dating. However, it has been observed that for older, Pleistocene bones the failure rate may be higher, possibly due to the presence of more degraded, short-chain proteins that pass through the ultrafilters used in pretreatment, resulting in lower yields. Here, we present linear regression analysis of data from nearly 600 human and animal bones, antlers, and teeth, from a wide range of contexts and ages, to determine whether the 0.76% threshold identified in the previous study is still applicable. The potential of carbon:nitrogen atomic weight ratios (C:N) of whole bone to predict collagen preservation is also discussed.

Chemical prediction of water activity in processed cheese

1989 ◽  
Vol 56 (4) ◽  
pp. 665-668 ◽  
Author(s):  
María A. Esteban ◽  
Andrés Marcos
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Water Activity ◽  
Negative Correlation ◽  
Linear Regression Analysis ◽  
Significant Negative Correlation ◽  
Regression Equation ◽  
Low Fat ◽  
Two Samples ◽  
The Mean

SummaryBy linear regression analysis, a highly significant negative correlation (r = −0·96) was found between the mean ash concentration values (g/100 g moisture) and water activity (aw) of six types of processed cheeses (low-fat, semi-fat, fat, extra-fat, double fat and special). The regression equation aw = 0·9951 − 0·0032* (ash), applied to 40 cheese samples, yielded aw values which differed by < 0·005 aw units from those measured experimentally in 75% of the samples. The maximum differences between the calculated and experimental aw values (found in only two samples) were ±0·01 aw units.

scholarly journals P232 In suspected small bowel Crohn’s disease: Clinical impact of using capsule endoscopy to make decisions

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S258-S259
Author(s):  
R A Gonzalez ◽  
E J Gómez ◽  
L Pereyra ◽  
J M Mella ◽  
G N Panigadi ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Logistic Regression Analysis ◽  
Capsule Endoscopy ◽  
Clinical Impact ◽  
Therapeutic Decisions ◽  
The Mean

Abstract Background Capsule endoscopy (CE) can detect small bowel (SB) lesions compatible of Crohn’s disease (CD) in patients with suggestive symptoms but with inconclusive results for the diagnostic workup. However, the clinical impact of CE in helping physicians to make decisions about patients with suspected CD is not currently well established. The aim of the study was to investigate the clinical impact of CE to confirm diagnosis of CD and also to evaluate whether the results of CE modify therapeutic decisions. Methods We conducted a single-centre retrospective cohort study. All consecutive adult’s patients submitted to CE for clinical suspected of CD, on period November 2012 to November 2018, were included. Data on demography, previous research, medications for IBD, CE procedures and follow-up were analysed. Multivariate logistic regression analysis was carried out to identify predictors of CD. Results A total of 329 CE protocols in adult’s patients were performed over the study period. Ninety were in IBD patients and were included in the analysis 63 CEs submitted for suspected of CD: Clinical suspected CD 54(86%) and colitis unclassified 9 (14%). The mean age was 41 years (range 17–77 years) and 54% were males. The CE reached the caecum in 58 cases (92%) and retention was observed in 5 (8%) with only one patient (1.6%) requiring surgical removal. Overall, 28 of 63 patients (44%) had CE findings consistent with the diagnosis of CD. The lesions identified by CE included ulcers 24 (86%), erythema and villous oedema 17(61%), aphthas and mucosal erosions 5 (18%), stenosis 2 (7%) and were distributed mainly in the distal part of the SB (third tertile) in 23 (82%), but in 14 (50%) cases the proximal SB (first and second tertiles) was also affected. The mean Lewis Score (LS) was 903 (112–4356). Significant inflammatory activity (LS ≥ 135) was detected in 17 (27%) and was moderate or severe (LS &gt; 790) in 7 (11%). CE visualise normal SB mucosa in 34 (54%) of patient’s, which rules out CD. Therapeutic started in 23 (36%) of patients, initiating a new IBD medication in most cases in the 3 months after the CE. On logistic regression analysis, male (p = 0.02) and findings in ileocolonoscopy (p = 0.004) were independents predictors of CD. Conclusion In our cohort, CE in suspected CD confirm diagnosis in 44% of cases. Male gender and findings in ileocolonoscopy appear to be independents predictors of CD. CE is a useful tool in suspected CD, since it adds relevant information for diagnosis and had a great impact on therapeutic decisions.

Four methods for determining uric acid compared with a candidate reference method.

1982 ◽  
Vol 28 (10) ◽  
pp. 2098-2100 ◽  
Author(s):  
R J Elin ◽  
E Johnson ◽  
R Chesler
Keyword(s):  
Uric Acid ◽  
Regression Analysis ◽  
Linear Regression ◽  
Phosphotungstic Acid ◽  
Linear Regression Analysis ◽  
Reference Method ◽  
Mean Difference ◽  
Acid Method ◽  
The Mean ◽  
Smac Method

Abstract Uric acid as measured in serum by three different uricase (EC 1.7.3.3) methods (aca, Ektachem, and SMAC) and by the SMAC method with phosphotungstic acid was compared with a candidate Reference Method for uric acid. Serum specimens from 83 patients (uric acid concentrations, 19 to 141 mg/L) were analyzed by all five methods. Results were compared by using linear regression analysis, and the mean difference between results by the candidate Reference Method and the four other methods was calculated. Compared with the candidate Reference Method, the aca method gave the smallest deviation from zero for the intercept and the smallest mean difference, and the SMAC phosphotungstic acid method showed a slope closest to unity. The SMAC uricase method had the largest intercept and greatest deviation of the slope from unity.

scholarly journals Correlation of CA-125 with different stages of endometriosis

2018 ◽  
Vol 11 (1) ◽  
pp. 41
Author(s):  
Runa Laila ◽  
Begum Nasrin ◽  
Shayela Shamim ◽  
Md. Mozammel Hoque
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Significant Positive Correlation ◽  
Linear Regression Analysis ◽  
Stage Iv ◽  
Ca 125 ◽  
Pelvic Endometriosis ◽  
Cancer Antigen ◽  
Cutoff Value ◽  
The Mean

<p class="Abstract">This study was conducted to evaluate the association of serum cancer antigen (CA-125) level with the severity of pelvic endometriosis. Seventy diagnosed cases of pelvic endometriosis were included in this study. The CA-125 level was estimated in all these patients, cutoff value of the serum CA-125 level was considered 35.0 U/mL. The correlations between serum CA-125 and different stages of endometriosis were evaluated by linear regression analysis. In Stage I of endometriosis, the mean serum CA-125 level was 21.8 ± 15.1 U/mL, in Stage II 26.0 ± 17.3 U/mL, in Stage III 83.2 ± 48.9 U/mL and in Stage IV 117.0 ± 41.6 U/mL. A significant positive correlation (r=0.729; p=0.001) was found between the serum CA-125 and different stages of endometriosis.</p>

scholarly journals Involvement of Inner Choroidal Layer in Choroidal Thinning during Regression of Multiple Evanescent White Dot Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Yuki Hashimoto ◽  
Wataru Saito ◽  
Yuka Hasegawa ◽  
Kousuke Noda ◽  
Susumu Ishida
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Choroidal Thickness ◽  
Linear Regression Analysis ◽  
Case Series ◽  
Enhanced Depth Imaging ◽  
Initial Visit ◽  
White Dot Syndrome ◽  
The Mean ◽  
Fellow Eyes

Purpose. To investigate relationships between total thickness and the thickness of inner and outer layers in the choroid during regression in patients with multiple evanescent white dot syndrome (MEWDS). Methods. This retrospective observational case series included 15 unilaterally affected eyes and 13 unaffected fellow eyes from 15 MEWDS patients (4 men and 11 women; mean age, 37.6 ± 17.6 years). Using enhanced depth imaging optical coherence tomography, whole, inner, and outer choroidal layer thicknesses at the fovea and perifovea were manually measured at the initial visit and at 1 and 3 months after the initial visit. The mean thickness values of the layers were compared at each stage. Results. With regression of MEWDS, the mean subfoveal whole and inner choroidal layer thicknesses significantly decreased at 1 and 3 months compared to baseline values in MEWDS eyes (P=0.01 and P<0.0001, respectively), but not in fellow eyes. The outer layer in MEWDS eyes tended to thin. Changes in the inner and outer layers at the perifovea in MEWDS eyes also showed the same trends. Simple linear regression analysis revealed significant positive correlations in choroidal thickness changes between the whole and inner layers (R = 0.53, P=0.04) and between the whole and outer layers (R = 0.91, P<0.0001) from baseline to 3 months. Multiple linear regression analysis revealed that choroidal thickness changes in the whole layer were significantly correlated with those in the inner (β = 0.51, P<0.0001) and outer (β = 0.73, P<0.0001) layers. Conclusion. The inner choroidal layer significantly thinned with regression of MEWDS, correlating with the thinning of total choroidal thickness. These results suggest that MEWDS lesions in the choroid are likely to lie mainly in the inner layer.

Evaluation and comparison of a radiative energy attenuation method for determining cholesterol in serum.

1985 ◽  
Vol 31 (4) ◽  
pp. 605-608 ◽  
Author(s):  
P L Cary ◽  
C A Johnson ◽  
P D Whitter ◽  
J W Parker
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
High Performance ◽  
Linear Regression Analysis ◽  
Radiative Energy ◽  
Comparison Methods ◽  
Analytical Recovery ◽  
Wide Range

Abstract Determination of cholesterol by a radiative energy attenuation (REA) technique was evaluated and compared with results obtained by the Boehringer Mannheim High Performance Cholesterol Assay and the Du Pont aca. Within-assay and between-assay CVs for the REA method, for two sets of controls, were both less than 5%. We observed no interference with lipemic samples. Analytical recovery averaged 102.8%. We used all three methods for parallel determinations of 217 patients' samples containing a wide range of cholesterol concentrations. Linear regression analysis of the REA results vs those of the comparison methods were as follows: REA = 1.03 Boehringer - 0.072 (r = 0.993) and REA = 1.02 aca - 0.048 (r = 0.995). We also discuss bilirubin interference with the REA method for cholesterol.

scholarly journals Change of Retinal Vessel Density After Lowering Intraocular Pressure in Ocular Hypertension

2021 ◽  
Vol 8 ◽  
Author(s):  
Xuhao Chen ◽  
Ying Hong ◽  
Haohao Di ◽  
Qianru Wu ◽  
Di Zhang ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Intraocular Pressure ◽  
Linear Regression ◽  
Ocular Hypertension ◽  
Linear Regression Analysis ◽  
Vessel Density ◽  
Factors Associated ◽  
Rnfl Thickness ◽  
Deep Layers ◽  
The Mean

Purpose: To investigate the relationship between retinal microvasculature changes and intraocular pressure (IOP) for ocular hypertension (OHT) patients and further assess the factors associated with retinal microcirculation changes.Methods: This was a single-center prospective study designed for OHT patients, which consisted of two visits. After collecting baseline data of those who met the eligibility criteria, these patients were treated with latanoprost 0.005% ophthalmic solution for 4 weeks. Peripapillary vessel density (VD) of radial peripapillary capillaries (RPC) layer, macular VD in both superficial and deep layers, and foveal avascular zone (FAZ) area were measured by optical coherence tomography angiography (OCTA) before and after the treatment. We compared the changes in IOP and VD among the two visits by paired-sample t-test. Bonferroni correction was applied. Factors associated with VD changes were analyzed by linear regression analysis.Results: Thirty-four eyes of thirty-four patients were included. The mean IOP decreased by 6.5 ± 2.2 mmHg (p &lt; 0.001). The peripapillary RPC VD increased significantly from 51.8 ± 2.5 to 53.0 ± 3.1% (Adjusted-p = 0.012). We found no significant difference in detailed sectors of the peripapillary region after correction. In the macular area, both the superficial and deep layers in foveal (superficial: 0.2 ± 1.9%, p = 0.523; deep: 0.0 ± 2.3%, p = 0.969) and parafoveal (superficial: 0.3 ± 3.0%, p = 0.565; deep: 0.5 ± 3.1%, p = 0.423) VD remained unchanged. The decrease of the mean FAZ area was insignificant (p = 0.295). The percentage of IOP reduction (β = 0.330, p = 0.031) and the baseline RNFL thickness (β = 0.450, p = 0.004) significantly correlated with the percentage of peripapillary RPC VD improvement in the multivariate linear regression analysis.Conclusion: The peripapillary VD in OHT patients increased after the reduction of IOP. The mild change of IOP did not alter the microcirculation in the macula. In addition, the percentage of IOP change and the baseline RNFL thickness were independent factors for the peripapillary RPC VD improvement.

scholarly journals Nutritional status and weight gain in pregnant women

2012 ◽  
Vol 20 (3) ◽  
pp. 462-468 ◽  
Author(s):  
Ana Paula Sayuri Sato ◽  
Elizabeth Fujimori
Keyword(s):  
Regression Analysis ◽  
Weight Gain ◽  
Birth Weight ◽  
Linear Regression ◽  
Nutritional Status ◽  
Pregnant Women ◽  
Infant Health ◽  
Linear Regression Analysis ◽  
Total Weight Gain ◽  
The Mean

This study described the nutritional status of 228 pregnant women and the influence of this on birth weight. This is a retrospective study, developed in a health center in the municipality of São Paulo, with data obtained from medical records. Linear regression analysis was carried out. An association was verified between the initial and final nutritional status (p<0.001). The mean of total weight gain in the pregnant women who began the pregnancy underweight was higher compared those who started overweight/obese (p=0.005). Weight gain was insufficient for 43.4% of the pregnant women with adequate initial weight and for 36.4% of all the pregnant women studied. However, 37.1% of those who began the pregnancy overweight/obese finished with excessive weight gain, a condition that ultimately affected almost a quarter of the pregnant women. Anemia and low birth weight were uncommon, however, in the linear regression analysis, birth weight was associated with weight gain (p<0.05). The study highlights the importance of nutritional care before and during pregnancy to promote maternal-infant health.

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