Evaluation of arterial stiffness in new diagnosed idiopathic pulmonary arterial hypertension patients

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
G Radchenko ◽  
I Zhyvylo ◽  
E Titov ◽  
Y.U Sirenko
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Arterial Stiffness ◽  
Arterial Hypertension ◽  
Linear Regression Analysis ◽  
Control Group ◽  
Funding Source ◽  
Hypertensive Patients ◽  
Artery Stiffness ◽  
Healthy Persons

Abstract Objective This study is the first attempt to use cardio-ankle vascular index (CAVI) for the evaluation of systemic arterial stiffness in patients with IPAH. Methods 112 patients were included in the study: group 1 – 45 patients with new diagnosed IPAH, group 2 – 32 patients with arterial hypertension, control group – 35 healthy persons adjusted by age. Right heart catheterization, ECG, a 6-minute walk test (6 MWT), echocardiography, blood pressure (BP) measurement and ambulatory BP monitoring, pulse wave elastic artery stiffness (PWVe) [segment carotid-femoral arteries] and muscular artery stiffness (PWVm) [segment carotid-radial arteries], CAVI, N-terminal pro-B-type natriuretic peptide (NT-proBNP) level were provided. The Spearman correlation, a linear regression and multivariable binary logistic analysis were performed to indicate the predictors associated with PWV and CAVI. Results The PWVm and PWVe were the highest in hypertensive patients – 10.3±1.5 and 11.42±1.70 m/s. The control group and IPAH did not have significant differences in aorta BP, but PWVm/PWVe values were significantly (P<0.003/0.008) higher in IPAH patients than in the control group - 8.1±1.9/8.49±1.92 vs 6.63±1.34/7.29±0.87 m/s. The CAVIs on both sides were significantly lower in the healthy subjects (5.91±0.99/5.98±0.87 right/left side). Patients with IPAH did not differ from the arterial hypertension patients by CAVIs in comparison with the control group - 7.40±1.32/7.22±1.32 vs 7.19±0.78/7.2±1.1. PWVe did not correlate with any parameters except uric acid. PWVm correlated with uric acid (r=0.58, P<0.001), NT-proBNP (r=0.33, P=0.03) and male gender (r=0.37, P=0.013) at Spearman analysis, but not at multifactorial linear regression analysis. The CAVI correlated with age and parameters characterized functional capacity (6 MWT distance) and right ventricle function (NT-proBNP, TAPSE) at Spearman analysis and with age and TAPSE at multifactorial linear regression analysis. At binary logistic regression analysis CAVI >8.0 at right or/and left side had a correlation with age, 6MWT distance, TAPSE, but an independent correlation was only with age (β=1.104, P=0.008, CI 1.026–1.189) and TAPSE (β=0.66, P=0.016, CI 0.47–0.93). Conclusion In spite of equal and at normal range BP level the age adjusted patients with IPAH had significantly stiffer arteries than the healthy persons and they were comparable with the arterial hypertensive patients. Arterial stiffness evaluated by CAVI correlated with age and TAPSE in IPAH patients. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): National Academy of Medical science of Ukraine

scholarly journals The Association of Circulating MiR-29b and Interleukin-6 with Subclinical Atherosclerosis

2017 ◽  
Vol 44 (4) ◽  
pp. 1537-1544 ◽  
Author(s):  
Yu-qing Huang ◽  
Jie Li ◽  
Ji-yan Chen ◽  
Ying-ling Zhou ◽  
An-ping Cai ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Interleukin 6 ◽  
Subclinical Atherosclerosis ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Control Group ◽  
Study Group ◽  
Circulating Levels

Background/Aims: Although it is widely acknowledged that atherosclerosis is mainly a chronic inflammatory process, in which both miR-29b and interleukin-6 (IL-6) play multifaceted roles, the association between miR-29b and IL-6 remains unknown. The aim of the present study was to explore the relationship between miR-29b and IL-6 and to test whether circulating levels of miR-29b and IL-6 could predict atherosclerosis. Methods: A total of 170 participants were divided into two groups according to carotid intima-media thickness (CIMT): study group (CIMT ≥ 0.9mm) and control group (CIMT < 0.9mm). Levels of circulating miR-29b and IL-6 were measured by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. The association of miR-29b and IL-6 levels with CIMT was assessed using Spearman correlation analysis and multiple linear regression analysis. Results: The study group showed higher miR-29b levels (31.61 ± 3.05 vs. 27.91 ± 1.71 Ct, p < 0.001) and IL-6 levels (3.40 ± 0.67 vs. 2.99 ± 0.37 pg/ml, p < 0.001), compared with the control group. CIMT was positively correlated with miR-29b (r = 0.587, p < 0.001) and IL-6 (r = 0.410, p < 0.001), and miR-29b levels were also correlated with IL-6 (r = 0.242, p = 0.001). Multiple linear regression analysis also showed that CIMT was positively correlated with miR-29b and IL-6. After adjustment for age, body mass index, systolic blood pressure, total cholesterol and C-reactive protein, CIMT was still closely correlated with miR-29b and IL-6. The combination of miR-29b and IL-6 (AUC = 0.901, p < 0.001) offered a better predictive index for atherosclerosis than either miR-29b (AUC = 0.867, p < 0.001) or IL-6 (AUC = 0.747, p < 0.001) alone. Conclusion: Circulating levels of miR-29b and IL-6 may be independently correlated with subclinical atherosclerosis, and may serve as novel biomarkers for the identification of atherosclerosis.

scholarly journals Effect of sex class on the levels of some biochemical variables in thalassemia patients

2019 ◽  
Vol 24 (6) ◽  
pp. 1
Author(s):  
Khalaf N. Mohammed ◽  
Mossa M. Marbut
Keyword(s):  
Regression Analysis ◽  
Growth Factor ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Correlation Coefficients ◽  
Control Group ◽  
Simple Linear Regression ◽  
Positive Direction ◽  
Males And Females ◽  
And Control

The study was conducted at Azadi Teaching Hospital - Thalassemia Center for the period from 1/10/2017 to 1/4/2018. It included 60 patients including 30 males and 30 females, as well as control group which included 20 Healthy people were all 10 to 21 years of age. The following variables were studied: ferritin, GSH, insulin-like growth factor-1 (IGF-1) Malondialdehyde (MDA) Interleukin-6 (IL-6), and Cortisol. The analysis of correlation coefficients and simple linear regression was carried out to determine the effect of the variables among them. The results were as follows: Thalassemia patients recorded the lowest levels of GSH, IGF-1 and cortisol at 2.2 μmol / L and 50.4 ng / ml and 10.11 μg / dL respectively, while the same group recorded the highest levels of ferritin, MDA and IL- 6 was 3083 ng / ml, 941 mmol / L and 368 pg / mol. There were significant effects of both sexes in the group of thalassemia patients in both ferritin, GSH, IGF-1, MDA, and IL-6 with 2573, 3592 μg / dL, 2.821, 1.573 μmol / L, 63.3, 37.47 ng / ml and 1163.1 719.3 mmol / L 300.9 and 435.6 pg / mol for males and females, respectively. The results of the correlation coefficient analysis showed existence of and low correlations in the negative and positive direction between the study variables of the two groups of patients and control. The results of the simple linear regression analysis showed positive and negative regression ratios of IL-6 and IGF-1 growth factor on the rest of the study variables.   http://dx.doi.org/10.25130/tjps.24.2019.101  

Do Aromatase Inhibitors Increase Hemoglobin in Women with Breast Cancer?

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 4575-4575
Author(s):  
Daniel J. Lachant ◽  
Kanu P. Sharan ◽  
Andres Ferber ◽  
Robert Somer ◽  
Generosa Grana ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Regression Analysis ◽  
Linear Regression ◽  
Postmenopausal Women ◽  
Aromatase Inhibitors ◽  
Linear Regression Analysis ◽  
Estrogen Therapy ◽  
Stage I ◽  
Control Group ◽  
The Mean

Abstract Aromatase inhibitors (AI) block the conversion of testosterone and androstenedione to the estrogen estrone by inhibiting the aromatase enzyme complex. AI are used to treat estrogen receptor positive (ER+) breast cancer in postmenopausal women. With AI therapy, estrogen levels decrease to 85–95% of baseline. In women with metastatic disease, androstenedione levels do not increase. We have evaluated 2 women for polycythemia during AI therapy. Case 1 is 52 years old with stage II breast cancer treated with lumpectomy, TAC × 6 and radiation. Tamoxifen was started 4 months later. The mean hemoglobin during 6 months of tamoxifen was 14.0±0.1 gm/dl. When switched to exemestane, the mean hemoglobin over the next 24 months was 16.1±0.5 gm/dl (Mann-Whitney, p&lt;0.003). Case 2 is an 80 year old with stage I breast cancer treated with lumpectomy followed by radiation. Her baseline hemoglobin was 13.8 gm/dl. 26 months after starting exemestane, her hemoglobin reached 18.0 gm/dl. After extensive evaluation, neither patient met the criteria for polycythemia vera and no etiology for secondary polycythemia was found. The presumption was that the temporal increase in hemoglobin may be due to AI therapy. Previous clinical trials have not reported an increase in hemoglobin in women receiving AI therapy for breast cancer. However, given the dramatic increase in hemoglobin in our 2 patients, we wished to test the hypothesis that inhibition of aromatase may lead to an increase in hemoglobin in postmenopausal women receiving AI therapy for breast cancer. The Cooper University Hospital Tumor Registry was used as a source of potential subjects. Women over the age of 50 years, diagnosed with ER+ nonmetastatic breast cancer between 2002 and 2006 were identified. Women included for study were postmenopausal, and treated with breast surgery +/− local radiation. Women receiving chemotherapy were excluded because of the potential effect of chemotherapy or therapeutic erythropoietin on the hemoglobin level. In order to be included for study, women needed to have a hemoglobin prior to surgery or prior to starting anti-estrogen therapy and at least 3 hemoglobin measurements over a minimum of 12 months after starting anti-estrogen therapy. AI included anastrozole and exemestane. Of 123 charts available for review, 82 had inadequate data for analysis. 27 evaluable women received only an AI. The mean age was 67±8 years and 67% were stage I. The mean hemoglobin before and during AI therapy was 13.7±0.4 and 13.2±1.1 gm/dl, respectively (Mann Whitney, p&lt;0.09). 3/27 had an increase in hemoglobin after starting AI therapy by linear regression analysis (r ≥ 0.60). The increase in hemoglobin ranged from 0.9 to 1.1 gm/dl. As a control group, 11 women received tamoxifen rather than an AI. Mean age was 59±8 years and 54% were stage I. The mean hemoglobin before and during tamoxifen therapy was 13.0±1.0 and 12.8±0.8 gm/dl, respectively (Mann Whitney, p=0.53). 0/11 had an increase in hemoglobin by linear regression analysis (r &gt; 0.60). 2 additional women received tamoxifen which was subsequently changed to an AI, 1 of whom had a mean hemoglobin of 12.9±0.3 gm/dl on tamoxifen which increased to 14.9±0.4 gm/dl on exemestane (Mann Whitney, p&lt;0.05). 1 additional woman had a rise in hemoglobin of &gt; 1 gm/dl while on AI therapy which decreased back to baseline when switched to tamoxifen. In conclusion, although the numbers are small and the data retrospective, these data suggest that AI therapy may be associated with an increase in hemoglobin in a subgroup of women treated with AI therapy for localized breast cancer. Given that AI have not been shown to significantly increase the systemic androgen level, the mechanism for the increase in hemoglobin remains unclear. A well designed, prospective study is needed to determine if AI have an effect on hemoglobin in women being treated for breast cancer.

scholarly journals 1033 Prominent longitudinal strain involvement of left ventricular basal segments in native hypertensive patients without clear-cut hypertrophy

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
M Lembo ◽  
R Esposito ◽  
C Santoro ◽  
R Sorrentino ◽  
F Luciano ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Longitudinal Strain ◽  
Linear Regression Analysis ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Control Group ◽  
Hypertensive Patients ◽  
Clear Cut ◽  
Lv Mass ◽  
Significant Difference

Abstract Background Left ventricular (LV) global longitudinal strain (GLS) is able to detect an early subclinical dysfunction and it has been demonstrated to be a prognosticator in arterial hypertension. Information of regional longitudinal strain (LS) pattern has not been investigated in this clinical setting. Purpose We analyzed regional LV patterns of LS and base-to-apex behaviour of LS in newly diagnosed and never-treated hypertensive patients (HTN) without clear-cut LV hypertrophy (LVH). Methods 166 HTN (M/F = 107/59; age 43.9 ± 14.3 years, blood pressure [BP] = 146.5± 10.7/90.1 ± 7.5 mmHg) and a control group of 94 healthy subjects (M/F = 58/36; age 41.2 ± 15.0 years) underwent standard echo-Doppler exam, including speckle tracking quantification of regional LS and GLS (considered in absolute values). The average LS of six basal (BLS), six middle (MLS), and six apical (ALS) segments and relative regional strain ratio - RRSR = [ALS/(BLS + MLS)] - were also computed. Exclusion criteria were LVH (LV mass index ≥45 g/m^2.7 in females and ≥49 g/m^2.7 in males), diabetes mellitus, coronary artery disease, overt heart failure, hemodynamically significant valve heart disease, primary cardiomyopathies, atrial fibrillation and inadequate echo imaging. Results The two groups were comparable for sex, age, heart rate and LV ejection fraction (EF). Body mass index (BMI), systolic (SBP), diastolic (DBP) and mean BP (MBP) (all p &lt; 0.0001), LV mass index (p = 0.03), relative wall thickness (RWT) (p &lt; 0.02) and E/e’ ratio (p &lt; 0.01) were higher, and GLS lower (21.6 ± 2.0 vs. 22.2 ± 2.1%, p &lt; 0.02) in HTN. By analyzing regional LS, BLS (18.2 ± 2.1% vs. 19.2 ± 2.1%, p &lt; 0.0001) and MLS (20.7 ± 2.0 vs. 21.4 ± 2.1%, p = 0.007) resulted significantly lower in HTN, without significant difference in ALS (26.0 ± 3.6 vs. 25.9 ± 3.8%, p = 0.98). Accordingly, RRSR was higher in HTN (0.67 ± 0.09 vs. 0.64 ± 0.09, p &lt; 0.01). Even after excluding patients with LV concentric remodeling (RWT &gt; 0.42) (n = 34), BLS (p &lt; 0.0001) and MLS (p &lt; 0.002) were again lower and RRSR (p &lt; 0.01) higher in HTN than in controls. In the pooled population, BLS negatively correlated with SBP (r=-0.22), DBP (r=-0.25) and MBP (r=-0.26) (Figure) (all p &lt; 0.0001). By a multiple linear regression analysis, after adjusting for age, sex, BMI and RWT, the association between BLS and MBP remained significant (β coefficient=-0.23, p &lt; 0.0001), with an additional significant impact of male sex (β=-0.33, p &lt; 0.0001) (cumulative R²=0.18, SEE = 1.9%, p &lt; 0.0001). Conclusions Besides normal LV EF, GLS is lower in HTN. LS dysfunction involves basal and, with a lower extent, middle myocardial segments, with a compensation of apical segments. RRSR appears to be significantly higher in HTN. These results are even confirmed in hypertensive patients with normal LV geometry. The association of BLS and BP appears to be independent on several confounders. Regional LS pattern might be useful to detect very early LV systolic abnormalities in arterial hypertension. Abstract 1033 Figure. Relation between MBP and BLS

scholarly journals Gender is a determinant of carotid artery stiffness independent of age and blood pressure

2021 ◽  
Vol 94 (1119) ◽  
pp. 20200796
Author(s):  
Zhenzhen Wang ◽  
Wei Li ◽  
Wei Liu ◽  
Jiawei Tian
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Carotid Artery ◽  
Linear Regression ◽  
Arterial Stiffness ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Stiffness Index ◽  
Males And Females

Objective: To identify the gender-specific differences in carotid artery structural and stiffening parameters by radiofrequency ultrasound (RFU) with an automatic arterial stiffness analyzing system. Methods: Seventy-two consecutive individuals (32 males and 40 females, age range from 36 to 62 years) with no history of significant cardiovascular diseases or carotid artery plaques were enrolled between September and December 2017. Quality intima-media thickness (QIMT) and quality arterial stiffness (QAS) parameters were automatically computed, including pulse wave velocity (PWV), vascular distension, compliance coefficient (CC), distensibility coefficient (DC), stiffness index α and β, augmentation pressure (AP), and augmentation index (AIx). Those parameters were compared between males and females. Multiple linear regression analysis was performed to assess the independent association between gender and RFU parameters. Results: The mean age had no difference between males and females (47.8 ± 3.3 vs 50.0 ± 8.5 years, p = 0.19). Females had higher systolic blood pressure (134.53 ± 9.65 vs 127.78 ± 6.12 mm Hg) and diastolic blood pressure (85.83 ± 3.94 vs 78.03 ± 5.22 mm Hg), greater carotid QIMT (598.73 ± 72.16 vs 550.84 ± 29.37 µm), advanced PWV (8.08 ± 1.60 vs 6.24 ± 0.70 m/s), higher stiffness index α (6.21 ± 1.94 vs 3.95 ± 0.78) and β (9.43 ± 3.17 vs 6.38 ± 0.78), higher AP (6.68 ± 2.24 vs 3.64 ± 1.22 mm Hg) and AIx (7.42 ± 2.08 vs 4.69 ± 1.26%), all p < 0.001. Multiple linear regression analysis demonstrated gender was independently associated with carotid structural and elastic parameters. Conclusion: Gender independently impacts carotid structure and function, with females more vulnerable to the progression of arterial aging. Awareness of the gender differences on the risk stratification of carotid artery disease will benefit reliable assessments and specific management recommendations in clinical practice. Advances in knowledge: (1) RFU provides an μm-unit quality IMT measurement and multiple quality arterial stiffness parameters. (2) Gender is an independent determinant in both the arterial structural and elastic aspects, with females of stiffer arteries in low CVD risk individuals.

P0235LOW SERUM 3-METHYL HISTIDINE LEVEL IS ASSOCIATED WITH AORTIC STIFFNESS IN HEMODIALYSIS PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Yu-Chi Chang ◽  
Chi-Chong Tang ◽  
Bang-Gee Hsu
Keyword(s):  
Regression Analysis ◽  
Arterial Stiffness ◽  
Aortic Stiffness ◽  
High Performance ◽  
Independent Predictor ◽  
Linear Regression Analysis ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Control Group ◽  
Multivariable Logistic Regression Analysis

Abstract Background and Aims 3-methyl histidine (3MH) is a non-proteinogenic amino acid and an index of muscle breakdown. Subclinical protein malnutrition is an independent association with arterial stiffness. The aim of this study was to evaluate the relationship between serum 3MH levels and carotid-femoral pulse wave velocity (cfPWV) values in chronic hemodialysis patients. Method Fasting blood samples and baseline characteristics were obtained from 136 chronic hemodialysis patients. Serum 3MH was performed with high-performance liquid chromatography and mass spectrometry. Aortic arterial stiffness was defined as cfPWV values &gt;10 m/s according to the ESH-ESC 2013 guidelines. Results Among 110 chronic hemodialysis patients, 45 patients (40.9%) were in the aortic arterial stiffness group. When compared to those in the control group, the aortic arterial stiffness group had high prevalence of diabetes mellitus (p &lt; 0.001), hypertension (p = 0.006), older age (p = 0.002), higher systolic blood pressure (p = 0.016), and lower serum 3MH level (p = 0.001). Multivariable logistic regression analysis of the factors significantly associated with aortic arterial stiffness revealed that serum 3MH levels (odds ratio (OR): 0.791, 95% confidence interval (CI): 0.691–0.906, p = 0.001) was the independent predictor of aortic arterial stiffness in chronic hemodialysis patients. Multivariable forward stepwise linear regression analysis also showed that logarithmically transformed 3MH level (log-3MH, β = -0.322, adjusted R2 change = 0.127, p &lt; 0.001) was an independent predictor of cfPWV values in chronic hemodialysis patients. The area under the receiver-operating characteristic (ROC) curve indicates the diagnostic power of 3MH at predicting aortic stiffness of chronic hemodialysis patients was 0.691 (95% CI: 0.595-0.775, p = 0.0002). Conclusion Serum-free 3MH level is negatively associated with aortic arterial stiffness in chronic hemodialysis patients.

scholarly journals The status of medication literacy and associated factors of hypertensive patients in China: a cross-sectional study

2019 ◽  
Vol 15 (3) ◽  
pp. 409-419 ◽  
Author(s):  
Guiyue Ma ◽  
Aijing Luo ◽  
Zhiying Shen ◽  
Yinglong Duan ◽  
Shuangjiao Shi ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Literacy Level

Abstract The adverse consequence of low medication literacy is a major problem that threatens patients' health. The number of people with hypertension is increasing in China. We described the current situation of medication literacy of patients with hypertension in China and its related influencing factor. We conducted a cross-sectional study, which contains 590 hypertensive patients. Stratified sampling was adopted according to the hospital level in China. To determine the factors related to medication literacy, multiple linear regression analysis was used to determine associations between medication literacy of hypertensive patients and other factors. Among 590 respondents, results showed that they have poor medication literacy. Multiple linear regression analysis showed that level of education, annual income, occupation status, and type of medical insurance were significantly associated with medication literacy level of hypertensive patients. In addition, our study also demonstrates that we can identify the medication literacy level of hypertensive patients using the Chinese version Medication Literacy Scale for Hypertensive Patients. High medication literacy is an important factor for hypertensive patients to improve medication adherence, so as to better control blood pressure. We should pay attention to the improvement of medication literacy and take corresponding measures.

scholarly journals Factors Associated with RANTES Concentration in Cardiovascular Disease Patients

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Olga M. Koper-Lenkiewicz ◽  
Joanna Kamińska ◽  
Anna Lisowska ◽  
Anna Milewska ◽  
Tomasz Hirnle ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Atherosclerotic Lesion ◽  
Control Group ◽  
Model Parameters ◽  
Coronary Risk Factors ◽  
Monocyte Count ◽  
The Mean

Objective.The aim of the study was to establish, by means of linear regressions analysis, whether RANTES and CCL2 have a relationship with age, sex, heart rate, ejection fraction, white blood cells count, monocyte count, platelet count, mean platelet volume, hsCRP concentration, creatinine and eGFR value, applied treatments, and coronary risk factors in polish cardiovascular disease patients.Methods.Plasma chemokines concentrations were measured by ELISA method (R&D Systems Europe Ltd., Abingdon, England) in 115 cardiovascular disease patients (83 myocardial infarction/AMI and 32 stable angina/SA) and in the control group (N=25).Results.Univariate linear regression analysis found that (1) for men mean RANTES plasma level is 1.56 times higher as compared to women; (2) if patient’s age increases by 1 year, the mean RANTES concentration value increases by 1.4%; (3) if CCL2 concentration increases by 10 pg/mL, the mean RANTES concentration value increases by 3.3%; (4) if hsCRP concentration increases by 1 mg/L, the mean RANTES concentration value increases by 1.0%. By means of multiple linear regression analysis we found that (1) for men the mean plasma RANTES concentration value increases 1.89 times as compared to women; (2) if CCL2 concentration increases by 10 pg/mL, the mean RANTES concentration value increases by 3.4%; (3) if MPV increases by 1 fL, the mean RANTES concentration value increases by 12%, if other model parameters are fixed. For CCL2 we did not obtain statistically significant linear regression models.Conclusion.Due to high variability of obtained CCL2 concentrations, it seems that RANTES better reflects the presence of the atherosclerotic lesion than CCL2. RANTES as a marker of atherosclerotic process may be an important therapeutic target, and the assessment of RANTES concentration should be interpreted depending on patient’s sex, age, platelet hyperactivity state, hsCRP, and CCL2 concentration.

scholarly journals Relationship between Serum Bactericidal Activity and Serogroup-Specific Immunoglobulin G Concentration for Adults, Toddlers, and Infants Immunized with Neisseria meningitidis Serogroup C Vaccines

2000 ◽  
Vol 7 (5) ◽  
pp. 764-768 ◽  
Author(s):  
Daniel J. Sikkema ◽  
Keith E. Friedman ◽  
Bartholomew Corsaro ◽  
Alan Kimura ◽  
Stephen W. Hildreth ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Conjugate Vaccine ◽  
Bactericidal Activity ◽  
Immunoglobulin G ◽  
Linear Regression Analysis ◽  
Control Group ◽  
Serum Bactericidal Activity ◽  
Specific Immunoglobulin ◽  
Specific Igg

ABSTRACT A new meningococcal group C-CRM197 conjugate vaccine (MnCC; Meningitec) has been evaluated in multiple clinical trials in the United States and most recently has been approved for routine administration in the United Kingdom. Meningococcal serogroup C (MnC)-specific immunoglobulin G (IgG) antibodies in pre- and postimmunization sera obtained from healthy U.S. adults, toddlers, and infants were quantitated by enzyme-linked immunosorbent assay (ELISA) and by an antibody-dependent, complement-mediated serum bactericidal assay (SBA). Serogroup-specific IgG antibody (micrograms per milliliter) in adults immunized either with the quadrivalent polysaccharide (A, C, Y, and W-135) vaccine or with MnCC showed a strong correlation (r = 0.848 and 0.934, respectively) by linear regression analysis with SBA. Sera from infants immunized with the MnCC (n = 30) and an age-matched unimmunized control group (n = 15) were also analyzed. Linear regression analysis of serum bactericidal and IgG ELISA data from sera obtained at 2 months of age (preimmunization) showed no correlation; however, a high degree of correlation was observed at time points after two (r = 0.877) and three (r = 0.951) immunizations, where significant rises in anti-MnC polysaccharide antibodies occurred relative to the age-matched control group. Infants previously primed with 3 doses of MnCC were given a booster dose of conjugate vaccine at 12 to 15 months of age. The correlation coefficient of ELISA to SBA for combined pre- and postbooster data wasr = 0.836 (n = 48 pairs). In conclusion, increases in serum bactericidal activity in immunized adult, toddler, and infant populations were found to correlate very well with increases in serogroup-specific IgG concentrations, whereas the correlation between these two assays in nonimmunized 2-month-old infants was poor. Characterizing the relationship between these methods is important for understanding the significance of antigen-specific antibody concentrations relative to vaccine performance and protection from disease.

scholarly journals A Retrospective Cohort Study of the Association between Serum Osteopontin Levels and Aortic Stiffness in Hypertensive Patients

2022 ◽  
Vol 19 (1) ◽  
pp. 477
Author(s):  
Yuan-Chieh Chang ◽  
Jen-Pi Tsai ◽  
Ji-Hung Wang ◽  
Bang-Gee Hsu
Keyword(s):  
Regression Analysis ◽  
Aortic Stiffness ◽  
Linear Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
High Serum ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
High Systolic Blood Pressure ◽  
Hypertensive Patients ◽  
Potential Biomarker

By suppressing mineralization and preventing ectopic calcium deposits, osteopontin (OPN) has an inhibitory effect on vascular calcification. Also, there is an association between OPN and aortic stiffness (AS). We aimed to investigate the association between serum OPN levels and AS measured by carotid–femoral pulse wave velocity (cfPWV) in hypertensive patients. Baseline characteristics and fasting blood sampling of 120 participants with hypertension and 120 participants without hypertension were acquired. Serum OPN concentrations were determined by enzyme-linked immunosorbent assay. In total, 43 (35.9%) participants were assigned to the AS group with cfPWV of >10 m/s in hypertensive patients. There were more patients with diabetes mellitus, old age, high systolic blood pressure, high serum intact parathyroid hormone (iPTH), elevated C-reactive protein, and high OPN levels in the AS group compared with the control group in hypertensive participants. A multivariate logistic regression analysis discloses that age, SBP, serum OPN, and iPTH levels were independently associated with AS in hypertensive patients. Moreover, according to a multivariate forward stepwise linear regression analysis, OPN level is positively associated with cfPWV. In conclusion, serum OPN level is assumed to be a potential biomarker to predict AS and is positively associated with cfPWV in patients with hypertension.

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