Factors Associated with RANTES Concentration in Cardiovascular Disease Patients

Objective.The aim of the study was to establish, by means of linear regressions analysis, whether RANTES and CCL2 have a relationship with age, sex, heart rate, ejection fraction, white blood cells count, monocyte count, platelet count, mean platelet volume, hsCRP concentration, creatinine and eGFR value, applied treatments, and coronary risk factors in polish cardiovascular disease patients.Methods.Plasma chemokines concentrations were measured by ELISA method (R&D Systems Europe Ltd., Abingdon, England) in 115 cardiovascular disease patients (83 myocardial infarction/AMI and 32 stable angina/SA) and in the control group (N=25).Results.Univariate linear regression analysis found that (1) for men mean RANTES plasma level is 1.56 times higher as compared to women; (2) if patient’s age increases by 1 year, the mean RANTES concentration value increases by 1.4%; (3) if CCL2 concentration increases by 10 pg/mL, the mean RANTES concentration value increases by 3.3%; (4) if hsCRP concentration increases by 1 mg/L, the mean RANTES concentration value increases by 1.0%. By means of multiple linear regression analysis we found that (1) for men the mean plasma RANTES concentration value increases 1.89 times as compared to women; (2) if CCL2 concentration increases by 10 pg/mL, the mean RANTES concentration value increases by 3.4%; (3) if MPV increases by 1 fL, the mean RANTES concentration value increases by 12%, if other model parameters are fixed. For CCL2 we did not obtain statistically significant linear regression models.Conclusion.Due to high variability of obtained CCL2 concentrations, it seems that RANTES better reflects the presence of the atherosclerotic lesion than CCL2. RANTES as a marker of atherosclerotic process may be an important therapeutic target, and the assessment of RANTES concentration should be interpreted depending on patient’s sex, age, platelet hyperactivity state, hsCRP, and CCL2 concentration.

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Do Aromatase Inhibitors Increase Hemoglobin in Women with Breast Cancer?

Blood ◽

10.1182/blood.v112.11.4575.4575 ◽

2008 ◽

Vol 112 (11) ◽

pp. 4575-4575

Author(s):

Daniel J. Lachant ◽

Kanu P. Sharan ◽

Andres Ferber ◽

Robert Somer ◽

Generosa Grana ◽

...

Keyword(s):

Breast Cancer ◽

Regression Analysis ◽

Linear Regression ◽

Postmenopausal Women ◽

Aromatase Inhibitors ◽

Linear Regression Analysis ◽

Estrogen Therapy ◽

Stage I ◽

Control Group ◽

The Mean

Abstract Aromatase inhibitors (AI) block the conversion of testosterone and androstenedione to the estrogen estrone by inhibiting the aromatase enzyme complex. AI are used to treat estrogen receptor positive (ER+) breast cancer in postmenopausal women. With AI therapy, estrogen levels decrease to 85–95% of baseline. In women with metastatic disease, androstenedione levels do not increase. We have evaluated 2 women for polycythemia during AI therapy. Case 1 is 52 years old with stage II breast cancer treated with lumpectomy, TAC × 6 and radiation. Tamoxifen was started 4 months later. The mean hemoglobin during 6 months of tamoxifen was 14.0±0.1 gm/dl. When switched to exemestane, the mean hemoglobin over the next 24 months was 16.1±0.5 gm/dl (Mann-Whitney, p<0.003). Case 2 is an 80 year old with stage I breast cancer treated with lumpectomy followed by radiation. Her baseline hemoglobin was 13.8 gm/dl. 26 months after starting exemestane, her hemoglobin reached 18.0 gm/dl. After extensive evaluation, neither patient met the criteria for polycythemia vera and no etiology for secondary polycythemia was found. The presumption was that the temporal increase in hemoglobin may be due to AI therapy. Previous clinical trials have not reported an increase in hemoglobin in women receiving AI therapy for breast cancer. However, given the dramatic increase in hemoglobin in our 2 patients, we wished to test the hypothesis that inhibition of aromatase may lead to an increase in hemoglobin in postmenopausal women receiving AI therapy for breast cancer. The Cooper University Hospital Tumor Registry was used as a source of potential subjects. Women over the age of 50 years, diagnosed with ER+ nonmetastatic breast cancer between 2002 and 2006 were identified. Women included for study were postmenopausal, and treated with breast surgery +/− local radiation. Women receiving chemotherapy were excluded because of the potential effect of chemotherapy or therapeutic erythropoietin on the hemoglobin level. In order to be included for study, women needed to have a hemoglobin prior to surgery or prior to starting anti-estrogen therapy and at least 3 hemoglobin measurements over a minimum of 12 months after starting anti-estrogen therapy. AI included anastrozole and exemestane. Of 123 charts available for review, 82 had inadequate data for analysis. 27 evaluable women received only an AI. The mean age was 67±8 years and 67% were stage I. The mean hemoglobin before and during AI therapy was 13.7±0.4 and 13.2±1.1 gm/dl, respectively (Mann Whitney, p<0.09). 3/27 had an increase in hemoglobin after starting AI therapy by linear regression analysis (r ≥ 0.60). The increase in hemoglobin ranged from 0.9 to 1.1 gm/dl. As a control group, 11 women received tamoxifen rather than an AI. Mean age was 59±8 years and 54% were stage I. The mean hemoglobin before and during tamoxifen therapy was 13.0±1.0 and 12.8±0.8 gm/dl, respectively (Mann Whitney, p=0.53). 0/11 had an increase in hemoglobin by linear regression analysis (r > 0.60). 2 additional women received tamoxifen which was subsequently changed to an AI, 1 of whom had a mean hemoglobin of 12.9±0.3 gm/dl on tamoxifen which increased to 14.9±0.4 gm/dl on exemestane (Mann Whitney, p<0.05). 1 additional woman had a rise in hemoglobin of > 1 gm/dl while on AI therapy which decreased back to baseline when switched to tamoxifen. In conclusion, although the numbers are small and the data retrospective, these data suggest that AI therapy may be associated with an increase in hemoglobin in a subgroup of women treated with AI therapy for localized breast cancer. Given that AI have not been shown to significantly increase the systemic androgen level, the mechanism for the increase in hemoglobin remains unclear. A well designed, prospective study is needed to determine if AI have an effect on hemoglobin in women being treated for breast cancer.

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The impact of legs fat mass and legs lean fat mass on thigh circumference according cardiovascular risk: a population-based study

European Journal of Preventive Cardiology ◽

10.1093/eurjpc/zwab061.252 ◽

2021 ◽

Vol 28 (Supplement_1) ◽

Author(s):

M Chlabicz ◽

M Paniczko ◽

J Jamolkowski ◽

P Sowa ◽

M Lapinska ◽

...

Keyword(s):

Adipose Tissue ◽

Regression Analysis ◽

Linear Regression ◽

Muscle Tissue ◽

Fat Mass ◽

Linear Regression Analysis ◽

Population Based ◽

Thigh Circumference ◽

Tissue Model ◽

The Mean

Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Medical University of Bialystok, Poland Introduction A low thigh circumference is associated with an increased risk of high blood pressure, diabetes, cardiovascular diseases, and total mortality. Objectives The aim of the study was to investigate the relationship between the thigh circumference and cardiovascular (CV) risk classes, and to assess what type of tissue, adipose tissue or muscle tissue affects the thigh circumference. Methods The longitudinal, population-based, Polish study was conducted in 2017-2020. A total of 931 individuals aged 20-79 were analyzed. Pol-SCORE system was used to assess the 10-year risk of fatal CV based on the following risk factors: age, gender, smoking, systolic blood pressure, and total cholesterol for individuals aged 40-70. Then, CV risk classes were assessed using the 2019 ESC/EAS guidelines. The measurement of thigh circumference were performed directly below the gluteal fold of the thigh. Both thighs were measured and the mean value was calculated as the final thigh circumference. Body composition was assessed using Dual Energy X-ray Absorptiometry (DEXA). Results The mean age was 49.1 ± 15.5 years and 43.2% male. The mean thigh circumference was 58.2 ± 5.9 cm, the mean legs fat mass was 7.7 ± 2.8kg, and the mean legs lean mass was 16.9 ± 4.0kg. Lower thigh circumference was associated with higher CV risk classes in univariate linear regression analysis (β -0.516, p = 0.002), as well adjusted by age and sex (β -0.839, p = 0.008), adjusted by age, sex, BMI (β -0.886, p <0.001), and age, sex, WHR (β -0.988, p <0.001). In linear regression analysis legs adipose tissue and muscle tissue were related to the thigh circumference independently of CV risk classes (Model 1) and Pol-SCORE value (Model 2). However, fatty tissue (Model 1: β 0.746, p < 0.001; Model 2: β 0.749, p < 0.001) affects the thigh circumference more than the muscle tissue (Model 1: β 0.479, p < 0.001; Model 2: β 0.442, p < 0.001) (Fig. 1). Conclusion Smaller thigh circumference was associated with higher CV risk classes. Thigh circumference was more influenced by adipose tissue than by muscle tissue, regardless of the Pol-SCORE or CV risk classes. Table 1. Variable Model 1 Model 2 Beta p R2 Beta p R2 Legs fat mass 0.746 <0.001 0.785 0.749 <0.001 0.760 Legs lean mass 0.479 <0.001 0.785 0.442 <0.001 0.760 Model 1: adjusted for Cardiovascular risk classesModel 2: adjusted for Pol-SCOREResults of the linear regression analysis thigh circumference in the general population Abstract Figure 1.

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The Association of Circulating MiR-29b and Interleukin-6 with Subclinical Atherosclerosis

Cellular Physiology and Biochemistry ◽

10.1159/000485649 ◽

2017 ◽

Vol 44 (4) ◽

pp. 1537-1544 ◽

Cited By ~ 13

Author(s):

Yu-qing Huang ◽

Jie Li ◽

Ji-yan Chen ◽

Ying-ling Zhou ◽

An-ping Cai ◽

...

Keyword(s):

Regression Analysis ◽

Linear Regression ◽

Multiple Linear Regression ◽

Interleukin 6 ◽

Subclinical Atherosclerosis ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Control Group ◽

Study Group ◽

Circulating Levels

Background/Aims: Although it is widely acknowledged that atherosclerosis is mainly a chronic inflammatory process, in which both miR-29b and interleukin-6 (IL-6) play multifaceted roles, the association between miR-29b and IL-6 remains unknown. The aim of the present study was to explore the relationship between miR-29b and IL-6 and to test whether circulating levels of miR-29b and IL-6 could predict atherosclerosis. Methods: A total of 170 participants were divided into two groups according to carotid intima-media thickness (CIMT): study group (CIMT ≥ 0.9mm) and control group (CIMT < 0.9mm). Levels of circulating miR-29b and IL-6 were measured by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. The association of miR-29b and IL-6 levels with CIMT was assessed using Spearman correlation analysis and multiple linear regression analysis. Results: The study group showed higher miR-29b levels (31.61 ± 3.05 vs. 27.91 ± 1.71 Ct, p < 0.001) and IL-6 levels (3.40 ± 0.67 vs. 2.99 ± 0.37 pg/ml, p < 0.001), compared with the control group. CIMT was positively correlated with miR-29b (r = 0.587, p < 0.001) and IL-6 (r = 0.410, p < 0.001), and miR-29b levels were also correlated with IL-6 (r = 0.242, p = 0.001). Multiple linear regression analysis also showed that CIMT was positively correlated with miR-29b and IL-6. After adjustment for age, body mass index, systolic blood pressure, total cholesterol and C-reactive protein, CIMT was still closely correlated with miR-29b and IL-6. The combination of miR-29b and IL-6 (AUC = 0.901, p < 0.001) offered a better predictive index for atherosclerosis than either miR-29b (AUC = 0.867, p < 0.001) or IL-6 (AUC = 0.747, p < 0.001) alone. Conclusion: Circulating levels of miR-29b and IL-6 may be independently correlated with subclinical atherosclerosis, and may serve as novel biomarkers for the identification of atherosclerosis.

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Chemical prediction of water activity in processed cheese

Journal of Dairy Research ◽

10.1017/s0022029900029198 ◽

1989 ◽

Vol 56 (4) ◽

pp. 665-668 ◽

Cited By ~ 10

Author(s):

María A. Esteban ◽

Andrés Marcos

Keyword(s):

Regression Analysis ◽

Linear Regression ◽

Water Activity ◽

Negative Correlation ◽

Linear Regression Analysis ◽

Significant Negative Correlation ◽

Regression Equation ◽

Low Fat ◽

Two Samples ◽

The Mean

SummaryBy linear regression analysis, a highly significant negative correlation (r = −0·96) was found between the mean ash concentration values (g/100 g moisture) and water activity (aw) of six types of processed cheeses (low-fat, semi-fat, fat, extra-fat, double fat and special). The regression equation aw = 0·9951 − 0·0032* (ash), applied to 40 cheese samples, yielded aw values which differed by < 0·005 aw units from those measured experimentally in 75% of the samples. The maximum differences between the calculated and experimental aw values (found in only two samples) were ±0·01 aw units.

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Effect of sex class on the levels of some biochemical variables in thalassemia patients

Tikrit Journal of Pure Science ◽

10.25130/j.v24i6.879 ◽

2019 ◽

Vol 24 (6) ◽

pp. 1

Author(s):

Khalaf N. Mohammed ◽

Mossa M. Marbut

Keyword(s):

Regression Analysis ◽

Growth Factor ◽

Linear Regression ◽

Linear Regression Analysis ◽

Correlation Coefficients ◽

Control Group ◽

Simple Linear Regression ◽

Positive Direction ◽

Males And Females ◽

And Control

The study was conducted at Azadi Teaching Hospital - Thalassemia Center for the period from 1/10/2017 to 1/4/2018. It included 60 patients including 30 males and 30 females, as well as control group which included 20 Healthy people were all 10 to 21 years of age. The following variables were studied: ferritin, GSH, insulin-like growth factor-1 (IGF-1) Malondialdehyde (MDA) Interleukin-6 (IL-6), and Cortisol. The analysis of correlation coefficients and simple linear regression was carried out to determine the effect of the variables among them. The results were as follows: Thalassemia patients recorded the lowest levels of GSH, IGF-1 and cortisol at 2.2 μmol / L and 50.4 ng / ml and 10.11 μg / dL respectively, while the same group recorded the highest levels of ferritin, MDA and IL- 6 was 3083 ng / ml, 941 mmol / L and 368 pg / mol. There were significant effects of both sexes in the group of thalassemia patients in both ferritin, GSH, IGF-1, MDA, and IL-6 with 2573, 3592 μg / dL, 2.821, 1.573 μmol / L, 63.3, 37.47 ng / ml and 1163.1 719.3 mmol / L 300.9 and 435.6 pg / mol for males and females, respectively. The results of the correlation coefficient analysis showed existence of and low correlations in the negative and positive direction between the study variables of the two groups of patients and control. The results of the simple linear regression analysis showed positive and negative regression ratios of IL-6 and IGF-1 growth factor on the rest of the study variables. http://dx.doi.org/10.25130/tjps.24.2019.101

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Four methods for determining uric acid compared with a candidate reference method.

Clinical Chemistry ◽

10.1093/clinchem/28.10.2098 ◽

1982 ◽

Vol 28 (10) ◽

pp. 2098-2100 ◽

Cited By ~ 8

Author(s):

R J Elin ◽

E Johnson ◽

R Chesler

Keyword(s):

Uric Acid ◽

Regression Analysis ◽

Linear Regression ◽

Phosphotungstic Acid ◽

Linear Regression Analysis ◽

Reference Method ◽

Mean Difference ◽

Acid Method ◽

The Mean ◽

Smac Method

Abstract Uric acid as measured in serum by three different uricase (EC 1.7.3.3) methods (aca, Ektachem, and SMAC) and by the SMAC method with phosphotungstic acid was compared with a candidate Reference Method for uric acid. Serum specimens from 83 patients (uric acid concentrations, 19 to 141 mg/L) were analyzed by all five methods. Results were compared by using linear regression analysis, and the mean difference between results by the candidate Reference Method and the four other methods was calculated. Compared with the candidate Reference Method, the aca method gave the smallest deviation from zero for the intercept and the smallest mean difference, and the SMAC phosphotungstic acid method showed a slope closest to unity. The SMAC uricase method had the largest intercept and greatest deviation of the slope from unity.

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Correlation of CA-125 with different stages of endometriosis

Bangabandhu Sheikh Mujib Medical University Journal ◽

10.3329/bsmmuj.v11i1.35807 ◽

2018 ◽

Vol 11 (1) ◽

pp. 41

Author(s):

Runa Laila ◽

Begum Nasrin ◽

Shayela Shamim ◽

Md. Mozammel Hoque

Keyword(s):

Regression Analysis ◽

Linear Regression ◽

Significant Positive Correlation ◽

Linear Regression Analysis ◽

Stage Iv ◽

Ca 125 ◽

Pelvic Endometriosis ◽

Cancer Antigen ◽

Cutoff Value ◽

The Mean

<p class="Abstract">This study was conducted to evaluate the association of serum cancer antigen (CA-125) level with the severity of pelvic endometriosis. Seventy diagnosed cases of pelvic endometriosis were included in this study. The CA-125 level was estimated in all these patients, cutoff value of the serum CA-125 level was considered 35.0 U/mL. The correlations between serum CA-125 and different stages of endometriosis were evaluated by linear regression analysis. In Stage I of endometriosis, the mean serum CA-125 level was 21.8 ± 15.1 U/mL, in Stage II 26.0 ± 17.3 U/mL, in Stage III 83.2 ± 48.9 U/mL and in Stage IV 117.0 ± 41.6 U/mL. A significant positive correlation (r=0.729; p=0.001) was found between the serum CA-125 and different stages of endometriosis.</p>

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Involvement of Inner Choroidal Layer in Choroidal Thinning during Regression of Multiple Evanescent White Dot Syndrome

Journal of Ophthalmology ◽

10.1155/2019/6816925 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Yuki Hashimoto ◽

Wataru Saito ◽

Yuka Hasegawa ◽

Kousuke Noda ◽

Susumu Ishida

Keyword(s):

Regression Analysis ◽

Linear Regression ◽

Choroidal Thickness ◽

Linear Regression Analysis ◽

Case Series ◽

Enhanced Depth Imaging ◽

Initial Visit ◽

White Dot Syndrome ◽

The Mean ◽

Fellow Eyes

Purpose. To investigate relationships between total thickness and the thickness of inner and outer layers in the choroid during regression in patients with multiple evanescent white dot syndrome (MEWDS). Methods. This retrospective observational case series included 15 unilaterally affected eyes and 13 unaffected fellow eyes from 15 MEWDS patients (4 men and 11 women; mean age, 37.6 ± 17.6 years). Using enhanced depth imaging optical coherence tomography, whole, inner, and outer choroidal layer thicknesses at the fovea and perifovea were manually measured at the initial visit and at 1 and 3 months after the initial visit. The mean thickness values of the layers were compared at each stage. Results. With regression of MEWDS, the mean subfoveal whole and inner choroidal layer thicknesses significantly decreased at 1 and 3 months compared to baseline values in MEWDS eyes (P=0.01 and P<0.0001, respectively), but not in fellow eyes. The outer layer in MEWDS eyes tended to thin. Changes in the inner and outer layers at the perifovea in MEWDS eyes also showed the same trends. Simple linear regression analysis revealed significant positive correlations in choroidal thickness changes between the whole and inner layers (R = 0.53, P=0.04) and between the whole and outer layers (R = 0.91, P<0.0001) from baseline to 3 months. Multiple linear regression analysis revealed that choroidal thickness changes in the whole layer were significantly correlated with those in the inner (β = 0.51, P<0.0001) and outer (β = 0.73, P<0.0001) layers. Conclusion. The inner choroidal layer significantly thinned with regression of MEWDS, correlating with the thinning of total choroidal thickness. These results suggest that MEWDS lesions in the choroid are likely to lie mainly in the inner layer.

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Fib4 index is a more relevant marker for pulse wave velocity but not for carotid intima-media thickness in a men population

European Heart Journal ◽

10.1093/ehjci/ehaa946.2896 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

S Ojima ◽

T Kubozono ◽

S Kawasoe ◽

T Kawabata ◽

H Miyahara ◽

...

Keyword(s):

Cardiovascular Disease ◽

Regression Analysis ◽

Linear Regression ◽

Pulse Wave Velocity ◽

Roc Analysis ◽

Pulse Wave ◽

Linear Regression Analysis ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

The Other

Abstract Background Carotid intima-media thickness (IMT) and pulse wave velocity (PWV) are useful markers for predicting cardiovascular disease not only in patients with cardiovascular disease but also in the general population. On the other hand, liver disease due to obesity has become a problem and has been reported to be associated with the progression of atherosclerosis. Recently, an indicator of liver stiffness, the Fibrosis-4 index (Fib4 index), has been used to detect the pre-stage liver diseases. However, there is no report to investigate the association between atherosclerotic parameters such as IMT and PWV, and Fib4 index. The Fib4 index is a simple index calculated from age and three blood sample data, and it will be useful for screening for an early stage of atherosclerosis if we can show the association between Fib4 index and these parameters. Purpose To investigate the association between atherosclerotic parameters such as IMT or PWV and Fib4 index Methods We recruited 3, 128 men participants who underwent health checkup. IMT was evaluated by carotid ultrasonography, and branchial-ankle PWV (baPWV) was measured by an automatic device. We analysed the association of IMT or baPWV with Fib4 index and atherosclerotic risk factors such as age, systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C) and fasting blood sugar (FBS). baPWV ≥1,600 cm/s was defined high baPWV and we performed the receiver operating characteristics (ROC) analysis to demonstrate the significance of Fib4 index for baPWV. Results Mean Fib4 index was 1.39±0.68. In the univariate linear regression analysis, all factors such as age, SBP, LDL-C, FBS, Fib4 index were significantly associated with IMT or baPWV. On the other hand, in the multivariate linear regression analysis, Fib4 index was an independent factor for baPWV but not for IMT (IMT, p=0.498; baPWV, p=0.023). Figure 1 showed the result of ROC analysis to predict the high baPWV by Fib4 index. The area under curve (AUC) was 0.73, with the highest discriminating sensitivity and specificity at 0.71 and 0.65, respectively at Fib4 index = 1.27. Conclusions Fib4 index was significantly related to baPWV and could be the useful screening marker for arterial stiffness in a general men population. Figure 1. ROC curve analysis Funding Acknowledgement Type of funding source: None

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Change of Retinal Vessel Density After Lowering Intraocular Pressure in Ocular Hypertension

Frontiers in Medicine ◽

10.3389/fmed.2021.730327 ◽

2021 ◽

Vol 8 ◽

Author(s):

Xuhao Chen ◽

Ying Hong ◽

Haohao Di ◽

Qianru Wu ◽

Di Zhang ◽

...

Keyword(s):

Regression Analysis ◽

Intraocular Pressure ◽

Linear Regression ◽

Ocular Hypertension ◽

Linear Regression Analysis ◽

Vessel Density ◽

Factors Associated ◽

Rnfl Thickness ◽

Deep Layers ◽

The Mean

Purpose: To investigate the relationship between retinal microvasculature changes and intraocular pressure (IOP) for ocular hypertension (OHT) patients and further assess the factors associated with retinal microcirculation changes.Methods: This was a single-center prospective study designed for OHT patients, which consisted of two visits. After collecting baseline data of those who met the eligibility criteria, these patients were treated with latanoprost 0.005% ophthalmic solution for 4 weeks. Peripapillary vessel density (VD) of radial peripapillary capillaries (RPC) layer, macular VD in both superficial and deep layers, and foveal avascular zone (FAZ) area were measured by optical coherence tomography angiography (OCTA) before and after the treatment. We compared the changes in IOP and VD among the two visits by paired-sample t-test. Bonferroni correction was applied. Factors associated with VD changes were analyzed by linear regression analysis.Results: Thirty-four eyes of thirty-four patients were included. The mean IOP decreased by 6.5 ± 2.2 mmHg (p < 0.001). The peripapillary RPC VD increased significantly from 51.8 ± 2.5 to 53.0 ± 3.1% (Adjusted-p = 0.012). We found no significant difference in detailed sectors of the peripapillary region after correction. In the macular area, both the superficial and deep layers in foveal (superficial: 0.2 ± 1.9%, p = 0.523; deep: 0.0 ± 2.3%, p = 0.969) and parafoveal (superficial: 0.3 ± 3.0%, p = 0.565; deep: 0.5 ± 3.1%, p = 0.423) VD remained unchanged. The decrease of the mean FAZ area was insignificant (p = 0.295). The percentage of IOP reduction (β = 0.330, p = 0.031) and the baseline RNFL thickness (β = 0.450, p = 0.004) significantly correlated with the percentage of peripapillary RPC VD improvement in the multivariate linear regression analysis.Conclusion: The peripapillary VD in OHT patients increased after the reduction of IOP. The mild change of IOP did not alter the microcirculation in the macula. In addition, the percentage of IOP change and the baseline RNFL thickness were independent factors for the peripapillary RPC VD improvement.

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