scholarly journals Predictors of cardiac implantable electronic device infection in the United States

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
K Shah ◽  
V Modi ◽  
H Gandhi ◽  
H Thyagaturu ◽  
A Walker ◽  
...  

Abstract Background Cardiac implantable electronic devices (CIED) are important tools for managing arrhythmias, improving hemodynamics, and preventing sudden cardiac death. Device infection (DI) remains a significant complication of CIED and is associated with high morbidity, mortality, and healthcare cost. Purpose To analyze predictors of DI and its in-hospital outcomes. Methods National Inpatient Sample 2011–2018 database was analyzed for admissions for CIED implantation or DI. Baseline and hospital level characteristics were derived. The Chi-square test and student t-test were used for comparison of categorical and continuous variables respectively. Variables with p<0.20 from univariate analysis were included in the multivariate logistic regression to identify independent predictors of DI. Results A total of 1,604,173 admissions for CIED implantations and 71,007 (4.4%) admissions for DI were reported during 2011–2018. There was no significant change in annual admissions for DI (range 8550 to 9307, p for trend=0.98). Those with DI were more likely to be male (69.3 vs 57%, p<0.001) and had higher Charlson comorbidity index score ≥3 (46.6%-vs-36.8%, p<0.001). Multivariate analysis identified post-procedural hematoma (odds ratio (OR)=3.96; 95% Confidence Interval (CI)=3.46–4.54), congestive heart failure (CHF; OR=2.80, 95% CI=2.66–2.96), age group 45–60 years (OR=2.46, 95% CI=2.30–2.63), malnutrition (OR=1.99, 95% CI=1.85–2.15), coagulopathy (OR=1.75, 95% CI=1.64–1.86), end-stage renal disease (OR=1.65, 95% CI=1.53–1.78), atrial fibrillation (OR=1.42; 95% CI=1.35–1.49), non-Hispanic race (OR=1.25; 95% CI=1.16–1.36), coronary artery disease (OR=1.21; 95% CI=1.15–1.26), and thyroid disease (OR=1.15; 95% CI=1.09–1.12) [all p<0.001] as independent predictors of DI. Prevalence of CHF, malnutrition, and atrial fibrillation increased in those admitted with DI over the observation period as shown in Figure 1 (p for trend <0.001). Prevalence of diabetes mellitus also increased during the observation period although it was not an independent predictor of DI (p for trend <0.001). Pulmonary embolism and deep vein thrombosis were most common complications in those with DI (4.1 and 3.6% respectively). Annual in-hospital mortality ranged from 3.9 to 5.7% (mean 4.4%, p for trend=0.07). Conclusion DI is relatively common and continues to be associated with high morbidity and mortality. Prevalence of DI has not changed significantly despite technical and technological advances in device implantation. Evaluation of risk factors for DI and management of modifiable comorbidities may be needed to reduce the incidence of this important complication of CIED implantation. FUNDunding Acknowledgement Type of funding sources: None.

2021 ◽  
pp. 000313482094525
Author(s):  
Jessica K. Friedman ◽  
Elizabeth Mytty ◽  
Scott Ninokawa ◽  
Tara Reza ◽  
Elinore Kaufman ◽  
...  

Introduction Per police data, the case fatality rate (CFR) of firearm assault in New Orleans (NO) over the last several years ranged between 27% and 35%, compared with 18%-22% in Philadelphia. The reasons for this disparity are unknown, and potentially reflect important system differences with broader implications for the reduction of firearm mortality. Methods A retrospective analysis of police and city-specific trauma databases between 2012 and 2017 was performed. Victims of firearm assaults within city limits were included. Univariate analysis was performed using chi-square for categorical and t-test for continuous variables. Bivariate analysis was conducted using logistic regression. Results Per police data, the CFR of firearm assault was 31% in NO and 20% in Philadelphia. However, per trauma registry data, the CFR of firearm assault was 14% in NO and 25% in Philadelphia. Patients in Philadelphia were older, had higher injury severity score, and lower blood pressure. Patients in NO had higher rates of head injury. 51% of patients in Philadelphia arrived via police compared to <1% in NO. There was no mortality difference between police and emergency medical service (EMS) transport. Longer EMS prehospital times were associated with increased mortality in NO but not Philadelphia. A much larger percentage of patients died on-scene in NO than Philadelphia. Conclusions Our findings suggest that the major driver of increased mortality following firearm assault in NO compared with Philadelphia is death prior to the arrival of first responders. Interventions that shorten prehospital time will likely have the greatest impact on mortality in NO. This should include the consideration of police transport.


2021 ◽  
Author(s):  
Yan Luo ◽  
Xuewen Tang ◽  
Lingling Ding ◽  
Zhujun Shao ◽  
Jianxing Yu ◽  
...  

Abstract Background Non-prescription antibiotic use at community is a main driver of antimicrobial resistance. Cough is a common condition and prevalent in all communities, including China. This study aims to investigate the non-prescription antibiotic use for cough in China and explore to which extent antibiotic use knowledge was correctly instructed in communities.Methods A probability-proportionate-to-size (PPS) sampling method was adopted to survey from all 14 communities in Yiwu city, China. All participants were investigated by face-to-face interview on Portable Android Devices (PADs). The continuous variables were presented by mean and standard deviation (SD) or medium and inter-quartile range (IQR). The categorical variables were presented using percentage or constituent ratio. Chi-square test for univariate analysis and logistic regression for multivariate analysis were conducted to assess the odds ratios (ORs) and 95% confidence intervals (CIs), respectively.Results A total of 3034 respondents across the 14 communities and the 50 natural villages/streets completed all key items of the questionnaire. Of 2400 (79.10%) respondents stated that they experienced cough in the past 12 months with the medium age of 36.5 (IQR: 26-49) and 12.21% (293/2400) respondents had the non-prescription antibiotic use behavior. Among those 293 respondents, the proportion of non-prescription antibiotic use for cough peaked at around 16% among people aged 30-39 years old. The major sources of antibiotics were pharmacy (77.70%) and/or family storage (43.92%). As for antibiotic knowledge in 3034 participants, 61.8% participants had minimal knowledge on broad-spectrum antibiotic and 53.76% were not familiar about the effects of joint use.Conclusions Non-prescription antibiotics use for cough is prevalent in the community, especially among people in their thirties. Strengthened drug purchase regulation and well-trained professional pharmacists would be promising alternatives to ameliorate AMR. Moreover, penetrating antibiotics knowledge to common citizens and is an urgent task to alleviate antimicrobial resistance. Therefore, proactive policies and regulations should be made to improve current situations.


2018 ◽  
Vol 6 (1) ◽  
pp. 5-14
Author(s):  
Sajan Kumar Thakur ◽  
Pramod Kattel

Background and Objectives: Acute febrile illness is common presentation in children. Thrombocytosis can be used as a predictor of febrile illness in children. The objectives of this study were to find out the prevalence and causes of thrombocytosis among febrile children and to access the utility of platelet count as a potential predictor of serious bacterial infection alone or in association with other predictors.Material and Methods: A cross-sectional descriptive study was done in 290 febrile children following convenience sampling method. Statistical analysis was done using SPSS. Univariate analysis using chi-square test for categorical and independent samples and “t” test for continuous variables were done.Results: Thrombocytosis was present in 13.1% of cases. Most cases had mild thrombocytosis (10%) whereas moderate thrombocytosis was present in 2.8% of cases and 0.3% cases had severe thrombocytosis. Lymphocyte level, erythrocyte sedimentation rate and C-reactive protein also showed a significant association with thrombocytosis (p<0.05). Serious bacterial infection was present in 209 cases out of which 30 children had thrombocytosis but was not significant compared to children with non serious bacterial infection with thrombocytosis (p=0.171).Conclusion: Thrombocytosis was found to have an association with febrile illnesses. More so, it indicated a fair discriminate ability to diagnose infectious cause of disease. However there was no statistical significance between thrombocytosis and serious bacterial infection.


2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
H Thyagaturu ◽  
K Shah ◽  
S Li ◽  
S Thangjui ◽  
B Shrestha

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Atrial fibrillation is a common disorder in the elderly population and a known risk factor for stroke and dementia. Purpose  To study the burden of dementia in Afib hospitalizations and identify the predictors of in-hospital mortality in Afib with dementia hospitalizations. Methods We queried January 2016 to December 2018 National Inpatient Sample (NIS) to identify adult (≥18 yrs) hospitalizations with a primary diagnosis of Afib. Hospitalizations of Afib with dementia was compared with Afib without dementia. We used the Chi-square test for differences between categorical variables, and Student’s t-test for continuous variables. Multivariate logistic regression was used in outcomes analysis to adjust for potential hospital and patient-level confounders. Results  We identified 1,236,540 weighted Afib hospitalizations across three years. Of which, 79,405 (6.4%) of them were associated with dementia. Afib with dementia hospitalizations were associated with older age (mean age 83.2 vs 70.0 yrs; P &lt; 0.01), higher rate of chronic Afib (15.3% vs 7.5%; P &lt; 0.01), higher rate of comorbidity (% of &gt;3 Elixhauser comorbidity score 91.8% vs 83.6%; P &lt; 0.01). After adjusting for patient and hospital-level characteristics, we observed that Afib with dementia hospitalizations was associated with higher odds of in-hospital mortality compared to Afib without dementia [Odds Ratio (OR): 1.6 (1.4 – 1.9); P &lt; 0.01]. We also observed statistically significant association with increased LOS [4.7 vs 3.2 days; P &lt; 0.01], repeated falls [OR: 2.8 (2.5 – 3.1); P &lt; 0.01] and protein calorie malnutrition [OR: 1.9 (1.7 – 2.0); P &lt; 0.01] in Afib with dementia group. Conclusion Afib with dementia hospitalizations are not only associated with higher mortality, but they are also associated with higher repeated fall rates, and skilled nursing facility discharge dispositions. Co-morbidities like hypertension, CKD, obesity, HFrEF, HFpEF, OSA are associated with higher in-hospital mortality. Our study findings emphasize the burden of dementia in Afib hospitalizations and the need for prevention of poor outcomes in this population.


2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Kam Kalantar-Zadeh ◽  
Christine Baker ◽  
J Brian Copley ◽  
Daniel Levy ◽  
Stephen Berasi ◽  
...  

Abstract Background and Aims The burden of disease associated with FSGS has not been well characterized, especially with regard to health care resource utilization (HCRU) and related costs. The aim of this study was to evaluate all-cause HCRU and estimate associated costs in patients with FSGS compared with a matched non-FSGS cohort; a secondary aim was to evaluate the impact of nephrotic range proteinuria on these outcomes. Method Data were from the Optum Clinformatics® Data Mart Database. Patients with ≥ 1 claim (1st claim = index event) for FSGS between April 2016 and December 2018 were identified based on ICD-10-CM codes and matched 1:2 (FSGS:controls) on index date, age, sex, and race to non-FSGS controls; continuous enrollment 6 months pre- and 12 months post-index was required. FSGS nephrotic range (either UPCR &gt;3000 mg/g or ACR &gt;2000 mg/g) and non-nephrotic subpopulations were also identified. Quan-Charlson Comorbidity Index (CCI) and individual comorbidities at baseline, and 12-month post-index all-cause HCRU and associated costs (per patient per year [PPPY]) as well as medication prescriptions related to FSGS treatment were compared between the matched cohorts and between the FSGS subpopulations; t-tests were used for continuous variables and chi-square tests for categorical variables. Results 844 patients with FSGS were matched with 1688 non-FSGS controls; 57.4% male, 56.9% white, mean (SD) age 54.7 (18.4) years. Mean (SD) CCI was higher in the FSGS cohort relative to matched controls (2.72 [2.12] vs 0.55 [1.29]; P &lt; .0001), with prevalence of most individual comorbidities higher in the FSGS cohort. Only 308 FSGS patients (36.5%) had UPCR or ACR tests with available results during the review period; 112 (36.4%) were in the nephrotic range and 196 were non- nephrotic (63.6%). The FSGS cohort was characterized by higher rates of all-cause HCRU across resource categories (all P &lt; .0001) (Table 1); outpatient visits was the most frequently used category (99.1% vs 69.0%), followed by prescription medications. Among patients who used these resources, units of use were significantly higher in FSGS vs matched controls except for length of stay (Table 1). Readmission rates following 1st post-index hospitalization were higher in the FSGS cohort vs matched controls at 30 days (16.1% vs 6.0%; P &lt; .05) and 365 days (39.1% vs 22.9%; P &lt; .05). Glucocorticoids were the most frequently prescribed FSGS-related medication in both cohorts, with a higher rate in FSGS vs matched controls (50.6% vs 23.3%; P &lt; .0001); other FSGS-related medications were infrequently prescribed (&lt; 14%). Inpatient, outpatient, and prescription costs were higher in the FSGS cohort vs matched controls (all P &lt; .0001) resulting in mean total annual medical costs of $59,753 vs $8,431 PPPY (P &lt; .0001) that were driven by outpatient costs (Fig. 1A). Nephrotic range proteinuria was associated with higher all-cause inpatient, outpatient, and prescription costs vs non-nephrotic patients (all P &lt; .0001; Fig. 1B), resulting in higher total costs ($70,481 vs $36,099 PPPY; P &lt; .0001). A higher proportion of nephrotic range patients were prescribed FSGS-modifying medications (73.2% vs 54.1%; P = 0.001), with glucocorticoids the most frequent medication. However, 26.8% of nephrotic range patients were not prescribed any FSGS-related medications. Conclusion FSGS is associated with significant clinical and economic burdens with total annual medical costs &gt; 7-fold higher than matched controls that were driven by outpatient costs. The presence of nephrotic range proteinuria substantially and significantly increased the economic burden. New treatment modalities leading to lower rates of proteinuria may help improve patient outcomes while reducing HCRU and their associated costs.


2021 ◽  
Author(s):  
David Zekan ◽  
Robert Scott King ◽  
Ali Hajiran ◽  
Apexa Patel ◽  
Samuel Deem ◽  
...  

Abstract Introduction/Background Adrenal incidentalomas (AIs) are masses >1 cm found incidentally during radiographic imaging. They are present in up to 4.4% of patients undergoing CT scan, and incidence is increasing with usage and sensitivity of cross-sectional imaging. Most result in diagnosis of adrenal cortical adenoma, questioning guidelines recommending removal of all AIs with negative functional workup. This retrospective study analyzes histological outcome based on size of non-functional adrenal masses. Material and Methods 10 years of data was analyzed from two academic institutions. Exclusion criteria included patients with positive functional workups, those who underwent adrenalectomy during nephrectomy, <18 years, and incomplete records. AI radiologic and histologic size, histologic outcome, laterality, imaging modality, gender, and age were collected. T-test was used for comparison of continuous variables, and the two-sided Fisher’s exact or chi-square test were used to determine differences for categorical variables. Univariate analysis of each independent variable was performed using simple logistic regression. Results 73 adrenalectomies met the above inclusion criteria. 60 were detected on CT scan, 12 on MRI, and one on ultrasound. Eight of 73 cases resulted in malignant pathology, 3 of which were adrenocortical carcinoma (ACC). Each ACC measured >6 cm, with mean radiologic and pathologic sizes of 11.2 cm and 11.3 cm. Both radiologic and pathologic size were significant predictors of malignancy (p=0.008 and 0.011). Conclusions Our results question the generally-accepted 4 cm cutoff for excision of metabolically-silent AIs. They suggest a 6 cm threshold would suffice to avoid removal of benign lesions while maintaining sensitivity for ACC.


2018 ◽  
Vol 11 (1) ◽  
pp. 31
Author(s):  
Sri Adeyana ◽  
Haryadi Haryadi ◽  
Chandra Wijaya

Atrial Fibrillationis a kind of arrhythmia which has the most incidence. Based on its Etiology, atrial fibrillationcouldbe divided in to two, valvular and nonvalvular atrial fibrillation. This study was aimed toknow the correlation ofatrial fibrillation incidence between valvular and nonvalvular with its left atrium diameter in Arifin Achmad ProvinsiRiau’s General Hospital. This study was analytical and done by cross sectional approach with 185 patient. The datawere processing with computerize to univariate analysis and chi-square for bivarite analysis. From this study it can beconcluded that the most occurrence of atrial fibrillation was non valvular atrial fibrillation which was 76,8% with theetiology mostly of hypertension which was 41,5%. Valvular atrial fibrillation was mostly caused by mitral stenosiswhich was 37,2% and there were no correlation between the diameter of left atrium to the occurrence of valvular andnon valvular atrial fibrillation (p=0,273.)


Author(s):  
Yan Luo ◽  
Xuewen Tang ◽  
Linling Ding ◽  
Zhujun Shao ◽  
Jianxing Yu ◽  
...  

Abstract Background Non-prescription antibiotic use at community is a main driver of antimicrobial resistance. Cough is a common condition and prevalent in all townships, including China. This study aims to investigate the non-prescription antibiotic use for cough in China and explore to which extent antibiotic use knowledge was correctly instructed in communities. Methods A probability-proportionate-to-size sampling method was adopted to survey from all 14 townships in Yiwu city, China. All participants were investigated by face-to-face interview on Portable Android Devices. The continuous variables were presented by mean and standard deviation or medium and inter-quartile range (IQR). The categorical variables were presented using percentage or constituent ratio. Chi-square test for univariate analysis and logistic regression for multivariate analysis were conducted to assess the odds ratios and 95% confidence intervals, respectively. Results A total of 3034 respondents across all the 14 townships and the 50 natural villages/streets completed all key items of the questionnaire. Of 2400 (79.10%) respondents stated that they experienced cough in the past 12 months with the medium age of 36.5 (IQR: 26–49) and 12.21% (293/2400) respondents had the non-prescription antibiotic use behavior. Among those 293 respondents, the proportion of non-prescription antibiotic use for cough peaked at around 16% among people aged 30–39 years old. The major sources of antibiotics were pharmacy (77.70%) and/or family storage (43.92%). Conclusions Non-prescription antibiotics use for cough is prevalent in the community, especially among people in their thirties. Strengthened drug purchase regulation and well-trained professional pharmacists would be promising alternatives to ameliorate AMR. Moreover, penetrating antibiotics knowledge to common citizens and is an urgent task to alleviate antimicrobial resistance. Therefore, proactive policies and regulations should be made to improve current situations.


2021 ◽  
pp. 000313482110257
Author(s):  
John Kepros ◽  
Susan Haag ◽  
Karen Lewandowski ◽  
Frank Bauer ◽  
Hirra Ali ◽  
...  

Background Work hour restrictions have been imposed by the Accreditation Council for Graduate Medical Education since 2003 for medical trainees. Many acute care surgeons currently work longer shifts but their preferred shift length is not known. Methods The purpose of this study was to characterize the distribution of the current shift length among trauma and acute care surgeons and to identify the surgeons’ preference for shift length. Data collection included a questionnaire with a national administration. Frequencies and percentages are reported for categorical variables and medians and means with SDs are reported for continuous variables. A chi-square test of independence was performed to examine the relation between call shift choice and trauma center level (level 1 and level II), age, and gender. Results Data from 301 surgeons in 42 states included high-level trauma centers. Assuming the number of trauma surgeons in the United States is 4129, a sample of 301 gives the survey a 5% margin of error. The median age was 43 years (M = 46, SD = 9.44) and 33% were female. Currently, only 23.3% of acute care surgeons work a 12-hour shift, although 72% prefer the shorter shift. The preference for shorter shifts was statistically significant. There was no significant difference between call shift length preference and trauma center level, age, or gender. Conclusion Most surgeons currently work longer than 12-hour shifts. Yet, there was a preference for 12-hour shifts indicating there is a gap between current and preferred shift length. These findings have the potential to substantially impact staffing models.


2020 ◽  
Vol 1 (2) ◽  
pp. 1
Author(s):  
Asrul Asrul Asrul ◽  
Debby Pratiwi

ASI merupakan gizi sangat ideal dengan komposisi seimbang akantetapi, pemberian ASI tidak selamanya dapat berjalan normal salah satunya karena bendungan air susu yaitu pembengkakan pada payudara karena peningkatan aliran vena dan limfe menurut data WHO tahun 2013 di Amerika Serikat sebanyak 87,05%. perempuan menyusui mengalami bendungan asi data SDKI tahun 2015 sebanyak 37,12% ibu nifas mengalami bendungan asi. Dari data survey awal  didapat, dari 10 orang ibu nifas  bahwa 6 orang mengalami bendungan asi. Tujuan penelitian untuk mengetahui Faktor-Faktor Yang Berhubungan Dengan Kejadian Bendungan ASI Di Klinik Kasih Ibu Deli Serdang  Tahun 2017. Jenis penelitian survei analitik dengan desain cross sectional. Lokasi penelitia Klinik Kasih Ibu Deli Serdang. Teknik pengambilan sampel adalah total population sebanyak 34 orang. Teknik pengumpulan data menggunakan kuesioner. Data dianalisis menggunakan uji Chi-Square yaitu analisis univariat dan analisis Bivariat. Hasil penelitian menunjukkan Hasil uji statistik menggunakan uji chi square, diperoleh hasil perhitungan  pendidikan (p value = 0,004 < α = 0,05), pengetahuan (p value = 0,002 < α = 0,05), paritas (p value = 0,003 < α = 0,05), maka Ho ditolak dan Ha diterima. Kesimpulannya terdapat Pengaruh yang Berhubungan Dengan Kejadian Bendungan ASI Di Klinik Kasih Ibu Deli Serdang  Tahun 2017. Disarankan  tenaga kesehatan untuk memberikan penyuluhan tentang kejadian bendungan ASI melalui kerjasama lintas program dengan lembaga terkait. ABSTRACTBreast milk is not always able to walk normally one of them because milk dams that is swelling in the breast due to increased venous flow and lymph velopes according to WHO data 2013 in the United States as much as 87.05%. of breastfeeding women suffered from data damages of ICI data in 2015 as much as 37.12% of postpartum women suffered dams. From preliminary survey data obtained, from 10 postpartum mothers that 6 people suffered dam ation. The purpose of research to determine Factors Associated With Breastfeeding Incidence At Deli Serdang Ibu Bersih Clinic Year 2017. Type of research analytic survey with cross sectional design. Location researcher Klinik Kasih Ibu Deli Serdang. Sampling technique is total population of 34 people. Data collection techniques using questionnaires. Data were analyzed using Chi-Square test that is univariate analysis and Bivariat analysis. The result of the research shows that the result of statistical test using chi square test, obtained the calculation of education (p value = 0,004 <α = 0,05), knowledge (p value = 0,002 <α = 0,05), parity (p value = 0,003 < = 0,05), then Ho is rejected and Ha accepted. In conclusion there is Influence Associated with Breastfeeding Incidence At Deli Serdang Deli Health Clinic Year 2017. Suggested health workers to provide counseling about the incidence of milk dam through cross-program cooperation with related institutions. 


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