Association between malnutrition status and incident heart failure in community population
Abstract Background Malnutrition is commonly prevalent in patients with heart failure (HF) and associated with poor prognosis. However, few studies have explored the association between malnutrition status and incident HF in community population. Method 379,759 participants (46.3% women) without HF at baseline from the UK Biobank were included. Nutritional status was evaluated using the Controlling Nutritional Status (CONUT) score, with higher scores reflecting worse nutritional status. Association between CONUT score and incident HF were investigated using Cox proportional hazard regression models, with adjustment for traditional risk factors. Results During a median follow-up of 8.1 years, 5,520 cases (1.5%) of HF occurred. The hazard ratio for incident HF with 1-point increase of CONUT scores was 1.16 (95% CI, 1.12–1.20, P<0.001), after adjustment for traditional HF risk factors. Compared with good nutritional status, malnutrition was associated with significantly increased risk for incident HF [adjust hazard ratio were 1.25 (95% CI 1.17–1.34, P<0.001) for mild malnutrition and 2.06 (95% CI 1.36–3.12, P=0.001) for moderate or severe malnutrition]. Conclusion Malnutrition status were associated with increased risk of incident HF. Further studies are needed to confirm these findings and evaluate the use of CONUT in community monitoring. FUNDunding Acknowledgement Type of funding sources: None.