4328Short-term effects of dapagliflozin versus canagliflozin on acute decompensated heart failure in patients with type 2 diabetes

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M Nakagaito ◽  
S Joho ◽  
R Ushijima ◽  
M Nakamura ◽  
T Hirai ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Glucose ◽  
Repeated Measures ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Fasting Blood Glucose ◽  
Urine Volume ◽  
P Value ◽  
Urine Glucose

Abstract Background The CANVAS program and DECLERE-TIMI 58 reported that SGLT2i had been demonstrated to reduce hospitalization for heart failure (HF) in type 2 diabetic mellitus (T2DM) patients with high cardiovascular disease risk. However, it remains unclear whether the effectiveness of SGLT2i on acute decompensated HF is also observed in T2DM patients irrespective of acting types of SGLT2i. Methods In this single center, open-label, prospective study, fifty-eight T2DM patients hospitalized due to decompensated HF were enrolled (mean age 73 years, HbA1c 7.2%). After treatment for HF, 5mg/day of dapagliflozin (n=24, from February 2016 to February 2017) or 100mg/day of canagliflozin (n=34, from March 2017 to July 2018) was administered and clinical parameters about HF and T2DM were followed for 7 days. Statistical comparison of parameters between groups taking dapagliflozin or canagliflozin was performed using the two-way repeated measures analysis of variance (MANOVA). Results In both groups, urine glucose excretion increased significantly after administration of SGLT2i. Fasting blood glucose level tended to be decreased in both groups. Urine volume increased significantly one day after administration of SGLT2i, and returned to the baseline after one week in both groups. Interestingly, urine volume one day after administration of SGLT2i tended to increase more in the group taking canagliflozin than in the group taking dapagliflozin (interaction P value = 0.088). Importantly, plasma BNP levels and Nt-proBNP levels were decreased significantly in both groups. Parameters before and after treatment Baseline Day 7 (Day 1) P value Interaction P value Fasting blood glucose, mg/dL All 137±57 122±51 0.013 0.900 Dapa 144±64 133±53 0.089 Cana 128±64 118±40 0.069 log BNP All 5.31±1.11 4.91±1.09 <0.001 0.102 Dapa 5.48±1.04 4.94±1.00 <0.001 Cana 5.20±1.15 4.89±1.16 <0.001 log Nt-proBNP All 7.25±1.35 6.96±1.41 <0.001 0.735 Dapa 7.54±1.16 7.22±1.25 0.048 Cana 7.04±1.45 6.79±1.50 0.005 Urine volume (Day 1), mL/24h All 1218±523 1584±614 <0.001 0.088 Dapa 1261±564 1486±568 0.038 Cana 1186±498 1654±644 <0.001 Urine volume (Day 7), mL/24h All 1218±523 1305±408 0.128 0.428 Dapa 1261±564 1295±468 0.700 Cana 1186±498 1313±367 0.097 Urine glucose, g/24h All 1.6±5.5 23.7±23.5 <0.001 0.330 Dapa 1.7±6.8 20.3±21.7 <0.001 Cana 1.5±4.6 26.0±24.7 <0.001 Conclusion SGLT2i are useful for correcting volume overload and recovering from the decompensated state in HF patients with T2DM irrespective of acting types of SGLT2i.

scholarly journals Comparison and Effectiveness of Complementary and Alternative Medicine as against Conventional Medicine in the Treatment and Management of Type 2 Diabetes

2019 ◽  
pp. 1-8
Author(s):  
Cecil Boston ◽  
Natasha Wong ◽  
Teshawattie Ganga ◽  
Khaimwattie Chandradatt ◽  
Judith Rosales ◽  
...  
Keyword(s):  
Disease Risk ◽  
Conventional Medicine ◽  
Statistical Significance ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Laboratory Data ◽  
Controlled Study ◽  
P Value ◽  
Diabetic Patients

Aim: The main objective of the study was to compare, using laboratory data, the efficacy of herbal medicines against conventional drugs in treating and managing diabetes mellitus (DM) among type 2 diabetic (T2DM) patients. Methodology: The study recruited 80 patients from a private Herbal Clinic and the Georgetown Public Hospital Diabetic and Medical Outpatient Clinic after giving their consent and satisfying the inclusion criteria. Laboratory tests and analysis were done using conventional scientific methods and data analyzed using SPSS version 20 with a p-value of 0.05 being used to determine statistical significance.  Results: The results showed that age, religion, ethnicity, education, marital status and monthly income have significant associations with the use of herbs. Persons using herbal medicine alone had normal lipid profile, renal function and liver function test, in addition to hemoglobin (Hb), white blood cell count (WBC), glycosylated hemoglobin (HBA1c) and fasting blood glucose (FBS). The most common herbs used were Momordica charantia (local name- karela) and Azadirachta indica (local name- neem), which were used in combination or alone. Results showed a positive effect on coronary heart disease risk. Conclusion: The information generated from the study indicated that a significant number of diabetic patients using herbs alone for their treatment had normal results. However, a more controlled study is required to validate these results.

scholarly journals Comparing Glycemic Indices among Different Ethnic Groups Residing in Yenegoa, Bayelsa State, Nigeria

2021 ◽  
pp. 38-41
Author(s):  
Jonathan Nyebuchi ◽  
Victor Tuanwii ◽  
Felix Eedee Konne ◽  
Fyneface Chikadibia Amadi ◽  
Friday Ogidigba
Keyword(s):  
Blood Glucose ◽  
Ethnic Groups ◽  
Fasting Blood Glucose ◽  
Glycated Haemoglobin ◽  
Incidence Rates ◽  
P Value ◽  
Significant Difference ◽  
Glycemic Indices ◽  
Study Population

Increased prevalence and incidence rates within ethnic minorities have been reported by numerous studies on tribal differences in type 2 diabetes patients, sharing a western setting. This study was aimed at comparing glycemic indices among different ethnic groups residing in Yenegoa, Bayelsa State. The study population consisted of apparently150 healthy male and female subjects; 116 Ijaws, 21 Igbos and 13 Yorubas residing in Yenagoa Local Government Area, Bayelsa State of Nigeria. All subjects were aged between 16 and 48 years. 4 mls of Blood samples was collected from each subject. 2mls of the blood was withdrawn into EDTA for HbA1c estimation while the other 2mls was withdrawn into fluoride oxalate for fasting blood glucose. Glycated haemoglobin (HbA1c) was determined using the automated CLOVER A1c Analyser while FBG was assayed using Glucose Oxidase Method. Results revealed that there was a significant difference in the mean levels of FBG among the studied groups (P-value < 0.05) but there was no significant difference in the HbA1c mean levels (P-value > 0.05). This study has revealed that ethnic differences may cause significant changes on fasting blood glucose but may not in HbA1c.

scholarly journals Hubungan Antara Tingkat Stres Dan Kadar Glukosa Darah Puasa Penderita Diabetes Melitus Tipe 2 Di Kecamatan Maos

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Esti Oktaviani Purwasih
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Stress Level ◽  
Fasting Blood Glucose ◽  
P Value ◽  
Cross Sectional ◽  
Diabetes Melitus

ABSTRAKDiabetes melitus (DM) tipe 2 yaitu penyakit gangguan metabolik ditandai kenaikan gula darah karena penurunan sekresi insulin oleh sel beta pankreas dan atau ganguan resistensi insulin.Penelitian ini bertujuan untuk mengidentifikasi hubungan antara kadar glukosa darah puasa dengan tingkat stres pada penderita diabetes melitus (DM) tipe 2. Jenis penelitian adalah deskriptif korelasi dengan pendekatan cross sectional. Variabel independen dalam penelitian ini yaitu tingkat stres. Sedangkan variabel dependen dalam penelitian ini yaitu kadar glukosa darah puasa. Penelitian dilakukan di Puskesmas Maos dan Klinik Graha Amanah Maos bulan Maret 2017. Sampel diambil dengan total sampling, berjumlah  60 responden yang menderita DM tipe 2 minimal 1 tahun, memiliki kadar GDP 130 mg/dl, dan tidak memiliki penyakit komplikasi seperti gagal ginjal kronis, dan kanker.Hasil analisis data menggunakan spearman rho didapatkan tidak terdapat hubungan antara kadar glukosa darah puasa dan tingkat stres (p value = 0,137). Kata Kunci: Diabetes Mellitus Tipe 2, Glukosa Darah Puasa, Tingkat Stres. ABSTRACTType 2 diabetes mellitus (DM ) is a metabolic disease that characterized by an increasing of  blood  glucose because of decreasing insulin secretion by pancreatic beta cells and or insulin resistance disorders.This research aimed to identify the relationship between fasting blood glucose (FBG) level and stress level in patients with  type 2 diabetes mellitus (DM). The research design was descriptive correlation with cross sectional approach. The independent variable in this study was stress level. The dependent variable in this study was fasting blood glucose level. The study was at Maos Community Health Center and Graha Amanah Clinic in March 2017.The sample was total sampling. These were 60 respondents who diagnosed  type 2 diabetes mellitus at least 1 year, had FBG level 130 mg / dl, and did not have complications such as chronic kidney failure , and cancer.The results of data analysis by using spearman rho found that there was no correlation between fasting blood glucose level and stress level (p value = 0.137). Keywords: Type 2 Diabetes Mellitus, Fasting Blood Glucose, Stress Level.

scholarly journals Association of vaspin rs2236242 gene polymorphism with serum vaspin level, insulin resistance and diabetes in an Iranian diabetic/ pre-diabetic population

2020 ◽  
Author(s):  
Maria Hosseini ◽  
Masoumeh Nezhadali ◽  
Mehdi Hedayati
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
P Value ◽  
Insulin Sensitizer ◽  
Insulin Resistant ◽  
Amplification System ◽  
Diabetic Population

  Abstract Background/aim: In recent years the role of vaspin as an insulin- sensitizer has been studied widely. This is the investigation that studied the association of vaspin polymorphism rs2236242 on vaspin level and the risk of type 2 diabetes and insulin resistant on pre-diabetic/ diabetic population. Material and method: A case-control study is conducted on 160 participants includes eighty participants holding (FBG) fasting blood glucose 70-100 (mg/dl) in normal group and eighty participants holding FBG≥100 (mg/dl) in diabetic/pre-diabetic group. The serum vaspin and insulin was determined with ELISA and biochemical variables by standard method.  Tetra arms amplification system for vaspin gene was performed. Statistical analysis was done using SPSS software version 20. Results: The means of age, BMI, WC, HC, FBS and vaspin was significantly different between normal and T2DM/IFG group (P-value<0.05). rs2236242 showed association with Hip circumference (P-value<0.05). A significant association between allele A of rs2236242 with type 2 diabetes was seen (P-value<0.001). The vaspin level showed negative correlation with fasting blood glucose (FBG). Conclusions: Allele A of rs2236242 is a protective risk for type 2 diabetes but no association of rs2236242 with insulin resistant was seen. Lower level of vaspin is a predictor for progression of type 2 diabetes.

scholarly journals Correlation between Plasma Osteopontin and Alkaline Phosphatase in Type 2 Diabetes Mellitus Patients

2020 ◽  
Vol 26 (2) ◽  
Author(s):  
Josua TH Sinambela ◽  
M.I Diah Pramudianti ◽  
Dian Ariningrum
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Alkaline Phosphatase ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Postprandial Blood Glucose ◽  
P Value ◽  
Healthy Controls ◽  
Type 2 Dm

Diabetes Mellitus (DM) is a chronic disease caused by pancreas the inability to produce insulin or ineffectively insulin use.Fracture risk in type 2 DM patients increases even though the bone density is normal. This study aimed to examine thecorrelation of osteopontin (OPN) and alkaline phosphatase (ALP) in type 2 DM patients. An observational analytical studywas conducted in 73 type 2 DM patients in Dr. Moewardi Hospital, Surakarta from October to November 2018. The subjectswere examined for blood pressure, fasting blood glucose, two hours postprandial blood glucose, HbA1c, OPN, and ALPlevels. P-value <0.05 was statistically significant with a 95% confidence interval. Poorly controlled type 2 DM had higher OPNlevels than well-controlled (20.5±2.8 vs. 14.8±3.1 ng/mL, p <0.001). The ALP concentration was also higher in poorlycontrolled type 2 DM patients (79.9±31.7 vs. 61.1±25 U/L, p=0.003). The levels of OPN and ALP were significantly correlatedin type 2 diabetes (r=0.273; p=0.020) and in well-controlled patients (r=0.353; p=0.047) but no correlation was found inpoorly controlled type 2 DM patients (r= -0.073; p= 0.652). In this study, a significant correlation was found between OPNand ALP in patients with type 2 DM and well-controlled. Further study involving healthy controls and bone ALPmeasurement is needed.

scholarly journals 0137 Self-Reported Sleep Quality is Associated with Central Hemodynamics in Healthy Individuals

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A54-A54
Author(s):  
M N Culver ◽  
A A Flatt ◽  
G J Grosicki
Keyword(s):  
Cardiovascular Disease ◽  
Blood Glucose ◽  
Arterial Stiffness ◽  
Sleep Quality ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Fasting Blood Glucose ◽  
Healthy Individuals ◽  
Central Hemodynamics ◽  
Central Hemodynamic

Abstract Introduction Insufficient sleep is associated with arterial stiffness and elevated cardiovascular disease risk. Central hemodynamics are influenced by arterial stiffness, yet independently predict cardiovascular risk. Relationships between sleep characteristics and central hemodynamic parameters are largely unexplored. We aimed to characterize the relationship between self-reported sleep quality and central hemodynamics in healthy individuals. To explore the hypothesis that impairments in glucose metabolism, resulting from lack of sleep, may underlie relationships between sleep and central hemodynamic variables, we also examined associations between self-reported sleep quality and fasting blood glucose values. Methods Thirty-one healthy subjects (14 females /17 males; 20–69 years) that were free from metabolic or cardiovascular disease, and that did not take sleep medication were included in the study. Relationships between self-reported sleep quality, obtained using the Pittsburgh Sleep Quality Index (PSQI), with central hemodynamic profiles(systolic and diastolic blood pressures, pulse and augmentation pressures, augmentation index) estimated from oscillometric pulse wave analysis, and fasting blood glucose values were assessed. Results Central pulse pressure was significantly elevated (P&lt;0.05) in poor (PSQIscore &gt;5) compared to normal (PSQI score 0–5) self-reported sleepers. Linear regression models, adjusted for age, gender, and body mass index, demonstrated PSQI score to be an independent predictor (P&lt;0.05) of both central pulse (β=0.469) and augmentation (β=0.364) pressures. Global PSQI scores were not related to fasting blood glucose values (r=0.045; P&gt;0.05). Conclusion Significant relationships between central pulse and augmentationpressures and self-reported sleep quality highlight the importance of considering sleep when examining lifestyle contributors to central hemodynamics. Support No funding.

scholarly journals TYPE 2 DIABETES MELLITUS;

2019 ◽  
Vol 26 (04) ◽  
Author(s):  
Doctor Dilshad Muhammad ◽  
Masood Javed ◽  
Muzzammal Iftikhar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
P Value ◽  
Group A ◽  
Group B ◽  
New Onset

Background: Diabetic complications are related to impaired glycemic control. The UK Prospective Diabetes Study (UKPDS) showed that metformin therapy in overweight and obese patients with type 2 diabetes mellitus (T2DM) could reduce HbA1c and complications. So, metformin has been suggested to be the drug of choice after life style modifications in patients with T2DM. Repaglinide, short-acting insulin secretagogues, has excellent anti-hyperglycemic effect and a lower risk of hypoglycemia. However, whether repaglinide can be used as an initial therapy in patients with newly diagnosed T2DM is still unconfirmed. Objectives: The objective of this study was: To compare efficacy of Repaglinide and Metformin in the Treatment of New Onset Type 2 Diabetes Mellitus. Study Design: Randomized Controlled Trial. Setting: District headquarter Hospital, Faisalabad. Period: 6 Months (Jan 2018 to June 2018). Methodology: Patients were randomly divided into two groups (A & B) by using computer generated random number table. Group A was given repaglinide 0.75-1.5 mg/day while group B received metformin 750-1500mg/day. The doses of metformin and repaglinide were adjusted according to blood glucose level. For HbA1C and FBS, blood samples were sent to pathology laboratory at the start of study and after 3 months. Follow up was ensured by reaching the patients through telephonic contact. Data was collected through self-conducted interviews using a standardized Performa. Results: In our study, mean+sd was calculated as 44.54+5.92 years in Group-A and 45.31+6.13 years in Group-B, 42.86%(n=15) in Group-A and 40%(n=14) in Group-B were male whereas 57.14%(n=20) in Group-A and 60%(n=21) in Group-B were females. Baseline mean HbA1c levels of the patients were calculated as 7.51+0.50 mmol/L in Group-A and 7.54+0.52 mmol/L in Group B, p value was 0.81. After treatment, these findings were reduced to 5.57+0.65 in Group-A and 6.4+0.49 in Group-B, p value was 0.0001, At baseline mean fasting blood glucose levels of the patients were calculated as 7.43+0.56 mmol/L in Group-A and 7.46+0.50 mmol/L in Group B, p value was 0.82. After treatment, these findings were reduced to 5.83+0.71 in Group-A and 6.29+0.67 in Group-B, p value was 0.007. Conclusion: We concluded that on comparison of Metformin and Repaglinide monotherapy in the Treatment of New Onset Type 2 Diabetes Mellitus in terms of mean fasting blood glucose and mean HbA1c, both drugs reduced HbA1c and fasting blood sugar but Repaglinide was found significantly better for reduction of HbA1c and fasting blood sugar when compared to Metformin.

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