scholarly journals Endothelial dysfunction in cancer patients before and after chemotherapy: focus on biomarkers

2021 ◽  
Vol 20 (Supplement_1) ◽  
Author(s):  
A Emelianov ◽  
YU Kirichenko ◽  
I Ilgisonis ◽  
YU Belenkov ◽  
E Privalova ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Endothelial Dysfunction ◽  
Cancer Patients ◽  
Basic Research ◽  
Vascular Wall ◽  
Platinum Compound ◽  
Normal Ranges ◽  
Endothelin System ◽  
Wall Stiffness ◽  
Before And After

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): The reported study was funded by Russian Foundation for Basic Research (RFBR) project number 19-315-90034 Background. Nowadays gastric cancer is one of the leading causes of world cancer mortality. Modern chemotherapy (CT) significantly improves survival and quality of life among these patients. Unfortunately, anticancer drugs induce some biomolecular disorders, which influence endothelial dysfunction and microcirculation lesions, subsequently leading to vasculo- and cardiotoxicity. The aim To study the dynamics of endothelial dysfunction’s (ED) biomarkers (endothelin-1 (ET-1), von Willebrand factor (VWF)) in patients with gastric cancer before and after CT. Material and methods The study included 25 patients with histologically confirmed gastric cancer (adenocarcinoma) stage II - IV, who have been treated by CT including platinum compound (oxaliplatin, cisplatin) and fluoropyrimidine group (5-fluorouracil, capecitabine) and are proven to be cardiovasculotoxic. All patients underwent blood tests, computer nailfold capillaroscopy and finger photoplethysmography (non-invasive assessment of vascular wall stiffness and endothelial function), electrocardiography (ECG), 24-hour ECG, echocardiography before CT and within a month after the last course. Results The median patients’ age was 64 ± 13 years; 68% were male; 52% had a prior cardiac illness: arterial hypertension (n = 12, 48%), coronary artery disease (n = 7, 28%), chronic heart failure (n = 3, 12%). The data obtained showed that ET-1 median levels were below normal values and did not change during CT: 0,95pg/ml (0,6;1,4) vs. 0,94pg/ml (0,7;1,4), р<0,9 (N = 1–3pg/ml), before and after CT respectively. The level of VWF remained within normal ranges and did not significantly differ in cancer patients before and after treatment 0,75IU/ml (0,7;0,9) vs. 0,8IU/ml (0,74;0,9), р<0,6 (N = 0,5–1,5IU/ml). Even before CT, endothelial dysfunction was detected, which significantly worsened after the treatment (occlusion index (IO) before and after CT 1.7 (1.38; 1.9) vs. 1.3 (1.2; 1.5), p < 0.0002, respectively). During data analysis, significant correlations were found: between ET-1 level and IO (r = 0.554, p = 0,006), ET-1 and percentage of capillary recovery (r= -0.7, p = 0,029) [both parameters characterize functional abnormalities of the microvasculature], ET-1 and the quantity of supraventricular extrasystoles (r=-0.48, p = 0,032). Conclusion In this study, the dynamics of ED biomarkers in patients with gastric cancer were studied. Even though reliable changes were not proven for the assessed molecular parameters ET-1 and VWF during CT (supposing depletion of endothelin system, small patient cohort), the above parameters may be used for identifying early signs of close and long-term cardio/vasculotoxicity due to significant positive correlations with microvasculature lesions. Further bigger trials for identification of other accurate and effective laboratory methods of detecting early features of vasculotoxicity are required.

scholarly journals The effect of chemotherapy on endothelial function and microcirculation in patients with gastric cancer

Kardiologiia ◽  
2020 ◽  
Vol 60 (2) ◽  
pp. 89-95
Author(s):  
Yu. Yu. Kirichenko ◽  
I. S. Ilgisonis ◽  
Yu. N. Belenkov ◽  
E. V. Privalova ◽  
Yu. I. Naymann ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Endothelial Dysfunction ◽  
Healthy Volunteers ◽  
Cancer Patients ◽  
Vascular Diseases ◽  
Vascular Wall ◽  
Capillary Network ◽  
Wall Stiffness ◽  
Before And After ◽  
Cardio Vascular

Objective. To evaluate and study the dynamics of endothelial dysfunction instrumental indicators, vascular wall stiffness and microcirculation state in patients with gastric cancer (adenocarcinoma) before and after chemotherapy; compare it with the results obtained from healthy volunteers and patients with cardio-vascular diseases.Materials and Methods. The study included 65 people: 25 healthy volunteers, 15 patients with known cardio-vascular diseases (CVD) and 25 patients with histologically confirmed gastric cancer (adenocarcinoma) stage 2—4 who underwent surgical treatment followed by chemotherapy according to the FOLFOX, XELOX, and XP regimes. For non-invasive assessment of the vascular wall’s state of large vessels and microcirculation, all patients in the main group underwent computer nailfold capillaroscopy and finger photoplethysmography before chemotherapy and within a month after the completion of the last course. For healthy volunteers and patients with CVD, the above studies were performed once during the examination.Results. The data obtained indicate a significant increase in the reflection index of small muscle arteries (RI) and the stiffness index of large conducting arteries (aSI) during chemotherapy. In cancer patients, even before the treatment, endothelial dysfunction was detected, which significantly worsened after treatment (occlusion index (IO) before and after chemotherapy 1.7 (1.38; 1.9) vs. 1.3 (1.2; 1.5), p<0.0002, respectively). Significant differences in the compared indices in cancer patients and CVD group were revealed only after chemotherapy. Significant structural and functional disorders of capillaries were noted in the studied groups, which also worsened during chemotherapy in the main group (density of the capillary network at rest 43.23cap/mm2 vs. 42.19cap/mm2, p <0.01, respectively; density of the capillary network after the reactive hyperemia test 46.77cap/mm2 vs. 44.11cap/mm2, p<0,02, respectively).Conclusion. In this study, for the first time, the dynamics of endothelial dysfunction indicators, vascular wall stiffness and microcirculation state in patients with gastric cancer were studied, and a reliable increasing of these changes was proved during chemotherapy. The results indicate the need for a further search for accurate and effective methods of identifying early signs of close and distant vasculotoxicity, the development of individual prevention programs in order to significantly reduce the risk of cardiovascular events during and after chemotherapy.

scholarly journals Tu1325 – Comparison of Gastric Cancer Patients Before and After the Age of 40 : Treatment Modality and Pathologic Findings

2019 ◽  
Vol 156 (6) ◽  
pp. S-1027
Author(s):  
Yo Han Kim ◽  
Yong Eun Park ◽  
Yumun Jeong ◽  
Tae Young Park ◽  
Su Jin Jeong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Treatment Modality ◽  
Pathologic Findings ◽  
Before And After ◽  
Gastric Cancer Patients

Detection of genes related to peritoneal metastasis of primary gastric cancer based on large-panel Next Generation Sequencing.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e16026-e16026
Author(s):  
Si Tao ◽  
Xin Liu ◽  
Chunhui Jin ◽  
Rongrong Chen
Keyword(s):  
Gastric Cancer ◽  
Next Generation Sequencing ◽  
Cancer Patients ◽  
Peritoneal Metastasis ◽  
Genetic Alterations ◽  
Next Generation ◽  
Large Panel ◽  
Before And After ◽  
Gastric Cancer Patients ◽  
Generation Sequencing

e16026 Background: Peritoneum is a common site of recurrence and metastasis of gastric cancer. The traditional clinical methods have poor sensitivity for the diagnosis of peritoneal metastasis, and there is no effective marker for predicting peritoneal metastasis of gastric cancer. In this study, the genetic profiles of primary tumors in gastric cancer patients with and without peritoneal metastasis, as well as the genetic alterations before and after metastasis in the same patient were analyzed to explore the genetic alterations associated with peritoneal metastasis. Methods: 232 patients with stage Ⅳ gastric cancer were divided into PM group and non-PM group according to whether there was peritoneal metastasis, DNA based Next Generation Sequencing (NGS) with a 1021 gene panel was performed on their samples. Clinical information was obtained synchronously from physicians and surgeons. Results: There was no significant difference in baseline clinical characteristics between patients in PM and non-PM groups. Molecular analysis revealed that in the PM group, the incidence of CDH1, CDH23, HDAC1, IDH1, KRAS, MED12, RHOA, NOTCH2, TGFBR1 mutations was significantly higher in PM group than that in non-PM group, and these mutated genes were mostly located in wnt/β- catenin and MAPK signaling pathway. On the contrary, the incidence of ERBB2 and CCNE1 amplification was significantly higher in non-PM group than in the other group. Further analysis of samples before and after peritoneal metastasis of 13 patients did not find significant differences in genetic alterations. Conclusions: Compared with other sites, the primary tumor of gastric cancer patients with peritoneal metastasis seems to have its unique molecular characteristics, and large-panel NGS can help us identify this part of patients. Future research may need to clarify whether more radical treatment strategies are needed for these patients.

scholarly journals Dynamic Changes in the Systemic Inflammation Response Index Predict the Outcome of Resectable Gastric Cancer Patients

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhenhua Liu ◽  
Haijue Ge ◽  
Zhilong Miao ◽  
Shoupeng Shao ◽  
Hongtai Shi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Systemic Inflammation ◽  
Dynamic Change ◽  
Clinicopathological Parameters ◽  
Original Cohort ◽  
Inflammation Response ◽  
Response Index ◽  
Before And After ◽  
Gastric Cancer Patients

The systemic inflammation response index (SIRI) has been revealed to be closely related to the prognosis of a variety of tumors. Whether the dynamic change in SIRI before and after surgery can be used to judge the prognosis of patients after radical gastrectomy has not yet been studied. In this study, the predictive ability of preoperative SIRI and changes in SIRI before and after surgery for the survival rate of gastric cancer patients was evaluated in two independent cohorts. It was found that SIRI was closely related to TNM staging. The higher the TNM stage, the higher the proportion of patients with a high SIRI. However, SIRI was not related to any other clinicopathological parameters. Kaplan-Meier survival analysis showed that a high SIRI was associated with poor prognosis in gastric cancer patients in the original cohort and in the validation cohort. SIRI, NLR, PLR, and MLR could be used to judge the prognosis of patients with operable gastric cancer. However, multivariate analysis suggested that only SIRI was an independent prognostic factor for patients with operable gastric cancer. In addition, the change in SIRI at 4 to 6 weeks after surgery compared with SIRI before surgery was closely related to the survival of gastric cancer patients. Compared with the unchanged group (absolute variation &lt;50%), gastric cancer patients with a SIRI increase &gt;50% had a worse OS, while patients with a SIRI decrease &gt;50% had a better prognosis. In conclusion, SIRI can be used as a reliable index to evaluate the prognosis of patients with operable gastric cancer, and the dynamic change in SIRI before and after surgery is significantly related to the prognosis of patients with gastric cancer.

scholarly journals THE IMPACT OF ANTI B-CELL THERAPY ON ARTERIAL STIFFNESS IN SYSTEMIC SCLERODERMA

2013 ◽  
Vol 19 (3) ◽  
pp. 212-220 ◽  
Author(s):  
A. L. Maslyanskiy ◽  
E. P. Kolesovа ◽  
I. N. Penin ◽  
M. D. Cheshuina ◽  
S. V. Lapin ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Immunosuppressive Therapy ◽  
Arterial Wall ◽  
Independent Predictor ◽  
Vascular Wall ◽  
Wall Stiffness ◽  
Before And After ◽  
Diffuse Form ◽  
Design And Methods ◽  
The Impact

Background.Arterial wall stiffness is an independent predictor of cardiovascular mortality in different patient populations. Currently, there are several studies that show an increase of arterial wall stiffness in systemic sclerosis (SSc). The effect of immunosuppressive therapy on vascular wall stiffness in SSc patients is not investigated. The authors of this paper attempted to study the effect of rituximab and cyclophosphamide combination therapy on vascular stiffness in 5 patients with diffuse form of SSc.Design and methods.We assessed arterial stiffness in 5 patients with diffuse form of SSc before and after 6 months after combined immunosuppressive therapy.Conclusion.The parameters of arterial stiffness decreased in all patients with the moderate effect of the therapy.

M1640 Helicobacter pylori Infection and Plasma Ghrelin and Gastrin Levels in Gastric Cancer Patients Before and After Gastrectomy

2009 ◽  
Vol 136 (5) ◽  
pp. A-400
Author(s):  
Anna Zub ◽  
Kazimierz Rembiasz ◽  
Stanislaw Konturek ◽  
Bartosz Jenner ◽  
Peter C. Konturek
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Cancer Patients ◽  
Helicobacter Pylori Infection ◽  
Before And After ◽  
Gastric Cancer Patients

scholarly journals Markers of endothelial dysfunction in adolescent and young patients with hypothalamic syndrome

2020 ◽  
Vol 17 (3) ◽  
pp. 257-268
Author(s):  
Lana K. Tsertsvadze ◽  
Marina V. Avdeeva ◽  
Larisa V. Scheglova ◽  
Vladimir S. Vasilenko
Keyword(s):  
Endothelial Dysfunction ◽  
Functional State ◽  
Clinical Laboratory ◽  
Young Patients ◽  
Vascular Wall ◽  
Control Group ◽  
Functional Changes ◽  
Hypothalamic Syndrome ◽  
Wall Stiffness ◽  
Group 2

Background: Endothelial dysfunction is the first but reversible stage of atherosclerosis. A change in the functional state of the vascular endothelium, especially of a growing organism, can be the basis for the development of many diseases in adulthood. The study of the structural and functional state of peripheral vessels of adolescents with hypothalamic syndrome is extremely important for understanding of the mechanisms of formation of cardiometabolic risks.Aims: to compare the structural and functional state of the vascular wall of young men with hypothalamic syndrome and constitutionally exogenous obesity.Methods: During the study 360 males were examined (average age 21.27±2.44 years) and divided into 3 groups: group 1 -with hypothalamic syndrome (n=242); group 2 - with constitutionally exogenous obesity (n=98); control group - practically healthy individuals (n=20). Hypothalamic syndrome was verified in the presence of a symptom complex, including obesity and pink striae. Cross-group comparative analysis of results of clinical, laboratory and instrumental examination was carried out.Results: In the group of patients with hypothalamic syndrome, endothelium-dependent vasodilatation (9.44±1.26 versus 10.37±1.21%; p=0.001) and endothelium-independent vasodilatation (10.29±1.28 versus 11.29±1.14%; p=0.001) is worse than in the group of patients with constitutionally exogenous obesity, and the rate of endothelium-dependent vasodilatation is lower than the generally accepted norm. In addition, among patients with hypothalamic syndrome, the stiffness of the vascular wall is higher than among patients with constitutionally exogenous obesity (15.47±2.58 versus 13.24±3.84%; p=0.001). Statistically significant correlations were revealed between the structural and functional state of peripheral arteries and hemodynamic, hormonal, metabolic changes, and the level of C-reactive protein (p<0.05).Conclusions: The obtained data indicate a deterioration of endothelial function and an increase in vascular wall stiffness in obese patients, regardless of its etiology. The patients with hypothalamic syndrome have more pronounced structural and functional changes in the vascular wall are observed than patients with constitutionally exogenous obesity.

Sign in / Sign up

Export Citation Format

Share Document