Night sleep duration and sleep initiation time with hypertension in Chinese rural population: the Henan Rural Cohort

2019 ◽  
Author(s):  
Haiqing Zhang ◽  
Xinyu Zhao ◽  
Yuqian Li ◽  
Zhenxing Mao ◽  
Wenqian Huo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Clinical Trial ◽  
Sleep Duration ◽  
Combined Effect ◽  
Initiation Time ◽  
Night Sleep ◽  
Clinical Trial Registration ◽  
Registration Number ◽  
Adjusted Model ◽  
Clinical Trial Register

Abstract Background The study was conducted to evaluate the independent dose-response of the night sleep duration and sleep initiation time on hypertension, and to explore their combined effect with hypertension. Methods Participants from the Henan Rural Cohort were enrolled in this study. Information on sleep was collected using the Pittsburgh Sleep Quality Index. Hypertension was defined as systolic blood pressure/diastolic blood pressure ≥140/90 mmHg or self-reported hypertension and current use of anti-hypertensive medicines. Logistic regression and restricted cubic spline were conducted to evaluate the association of night sleep duration and sleep initiation time with hypertension. Results Of the 37 317 included participants, 12 333 suffered from hypertension. 14 474 (38.79%) were men and 22 843 (61.21%) were women, the mean age were 57.18 ± 12.10 and 55.24 ± 11.98 in men and women. Compared to reference (7–h), fully adjusted odd ratios (ORs) and 95% confidence interval (CI) of hypertension were 0.91 (0.66–1.25) in <5 h group and 1.74 (1.41–2.16) in ≥10 h among men, respectively. Fully adjusted ORs (95% CIs) for hypertension compared with reference (21:00–22:00) were 1.05 (95% CI 0.78–1.41) in the <20:00 group, 1.52 (1.25–1.85) in ≥24:00 in men. The combined effect of sleep duration and sleep initiation time on hypertension were statistically significant in the category of (≥8 h)/night and ≥24:00 (OR 1.87, 95% CI 1.07–3.25) compared to reference in fully adjusted model among men. Conclusions Long night sleep duration and late sleep initiation time were associated with the higher odds of hypertension, and the sleep duration and sleep initiation time might cumulatively increase the prevalence of hypertension in men. Clinical trial registration The Henan Rural Cohort Study has been registered at the Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). http://www.chictr.org.cn/showproj.aspx? proj=11375.

scholarly journals Combined Effect of Vitamin D Supplementation and Physiotherapy on Reducing Pain Among Adult Patients With Musculoskeletal Disorders: A Quasi-Experimental Clinical Trial

2021 ◽  
Vol 8 ◽  
Author(s):  
Mohammad Ali ◽  
Zakir Uddin ◽  
Ahmed Hossain
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Musculoskeletal Disorders ◽  
Multivariable Analysis ◽  
Vitamin D Supplementation ◽  
Combined Effect ◽  
Clinical Trial Registration ◽  
Physiotherapy Intervention ◽  
Vitamin D Levels ◽  
Combined Intervention

Background: The prevalence of musculoskeletal disorders (MSD) and vitamin D insufficiency is high. Past research indicating vitamin D supplementation and physiotherapy are useful for the treatment of MSDs. However, to the best of our knowledge, the combined benefits of vitamin D and physiotherapy are not yet evaluated in MSD. We hypothesized that combined intervention of vitamin D supplementation and physiotherapy would be more effective in relieving the pain of MSD compared to only physiotherapy intervention.Objective: This study aimed to examine whether combined effect of vitamin D supplementation and physiotherapy was better than physiotherapy alone in reducing pain-related outcomes (e.g., pain severity, affective interference, and physical interference) in patients with MSD.Methods: A quasi-clinical experiment was conducted between May 2020 and April 2021. Vitamin D level in the blood was measured at the start of the study. Patients with vitamin D levels &lt;20 ng/mL were assigned to the combined physiotherapy and vitamin D group. The physiotherapy group consisted of the patients with vitamin D levels more than 20 ng/mL. The Brief Pain Inventory scale was utilized to measure pain at baseline and after 12 weeks of interventions. We used the paired t-tests for unadjusted analysis. Further, a linear regression model was used to identify the combined effect of physiotherapy and vitamin D on reducing pain scores after adjusting potential confounders.Results: Combined intervention of vitamin D and physiotherapy showed significantly better results than only physiotherapy intervention in the reduction of three pain-related outcomes (p &lt; 0.001). The multivariable analysis indicated that the combination of physiotherapy and vitamin D treatment reduced pain score by 1.126 (slope = −1.126, p = 0.035) compared to physiotherapy alone.Conclusion: Combined intervention (vitamin D with physiotherapy) had a better pain-relieving effect than physiotherapy alone. To confirm these findings, more research is needed with randomized control trials.Clinical Trial Registration: [http://ctri.nic.in/Clinicaltrials/advancesearchmain.php], identifier [CTRI/2020/04/024845].

Compression sutures combined with intracameral air injection versus thermokeratoplasty for acute corneal hydrops: a prospective-randomised trial

2020 ◽  
pp. bjophthalmol-2020-316414
Author(s):  
Zelin Zhao ◽  
Siteng Wu ◽  
Weina Ren ◽  
Qinxiang Zheng ◽  
Cong Ye ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomised Trial ◽  
Randomised Clinical Trial ◽  
Air Injection ◽  
Clinical Trial Registration ◽  
Duration Of Symptoms ◽  
Prospective Randomised Trial ◽  
Registration Number ◽  
Corneal Hydrops

AimsTo compare the efficacy of compression sutures combined with intracameral air injection (CSAI) and thermokeratoplasty (TKP) for the management of acute corneal hydrops in keratoconus.MethodsIn this multi-centre randomised clinical trial, 20 patients with keratoconus (20 eyes) with acute corneal hydrops were enrolled and randomised to receive either CSAI or TKP and followed-up for a period of 6 months.ResultsThere were no significant differences in patient demographics, severity of corneal hydrops and preoperative duration of symptoms between the two groups. In both groups, corneal oedema resolved within 2 weeks. The maximum thickness of the corneal scars following CSAI and TKP was not significantly different. Best spectacle-corrected visual acuity was superior in the CSAI group at 6-month follow-up (CSAI vs TKP, 0.52 (0.37, 0.85) vs 0.96 (0.70, 1.34) LogMAR, p=0.042). CSAI resulted in greater corneal endothelial cell density (CSAI vs TKP, 2677.8±326.7 vs 1955.3±298.1 cells/mm2, p<0.001) and flatter corneal curvature (CSAI vs TKP: mean keratometry value, 52.13±4.92 vs 63.51±5.83D, p<0.001; maximum keratometry value, 65.21±7.42 vs 77.13±12.01D, p=0.016) at the 6-month follow-up.ConclusionAlthough both CSAI and TKP resulted in resolution of acute corneal hydrops in keratoconus, CSAI was associated with superior clinical outcomes in this study.Chinese Clinical trial registration numberChiCTR-IOR-17013764

scholarly journals A Randomized Comparison of Delivered Energy in Cardioversion of Atrial Fibrillation: Biphasic Truncated Exponential versus Pulsed Biphasic Waveforms

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1107
Author(s):  
Elina Trendafilova ◽  
Elena Dimitrova ◽  
Jean-Philippe Didon ◽  
Vessela Krasteva
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Trial ◽  
High Energy ◽  
Success Rates ◽  
Clinical Trial Registration ◽  
Fixed Energy ◽  
St Segment ◽  
Registration Number ◽  
Post Shock ◽  
Baseline Characteristics

A few randomized trials have compared impedance-compensated biphasic defibrillators in clinical use. We aim to compare pulsed biphasic (PB) and biphasic truncated exponential (BTE) waveforms in a non-inferiority cardioversion (CVS) study. This was a prospective monocentric randomized clinical trial. Eligible patients admitted for elective CVS of atrial fibrillation (AF) between February 2019 and March 2020 were alternately randomized to treatment with either a PB defibrillator (DEFIGARD TOUCH7, Schiller Médical, Wissembourg, France) or a BTE high-energy (BTE-HE) defibrillator (LIFEPAK15, Physio-Control Inc., Redmond, WA, USA). Fixed-energy protocol (200–200–200 J) was administered. CVS success was accepted if sinus rhythm was restored at 1 min post-shock. The study design considered non-inferiority testing of the primary outcome: cumulative delivered energy (CDE). Seventy-three out of 78 randomized patients received allocated intervention: 38 BTE-HE (52%), 35 PB (48%). Baseline characteristics were well-balanced between groups (p > 0.05). Both waveforms had similar CDE (mean ± standard deviation, 95% confidence interval): BTE-HE (253.9 ± 120.2 J, 214–293 J) vs. PB (226.0 ± 109.8 J, 188–264 J), p = 0.31. Indeed, effective PB shocks delivered significantly lower energies by mean of 25.6 J (95% CI 24–27.1 J, p < 0.001). Success rates were similar (BTE-HE vs. PB): 1 min first-shock (84.2% vs. 82.9%), 1 min CVS (97.4% vs. 94.3%), 2 h CVS (94.7% vs. 94.3%), 24 h CVS (92.1% vs. 94.3%), p > 0.05. Safety analysis did not find CVS hazards, reporting insignificant changes of myocardial-specific biomarkers, transient and rare ST-segment deviations, and no case of harmful tachyarrhythmias and apnea. Cardioversion of AF with fixed-energy protocol 200–200–200 J was highly efficient and safe for both PB and BTE-HE waveforms. These similar performances were achieved despite differences in the waveforms’ technical design, associated with significantly lower delivered energy for the effective PB shocks. Clinical Trial Registration: Registration number: NCT04032678, trial register: ClinicalTrials.gov.

scholarly journals Randomized clinical trial to assess pain and bruising in medicines administered by means of subcutaneous and intramuscular needle injection: Is it necessary to have needles changed?

2011 ◽  
Vol 19 (5) ◽  
pp. 1063-1071 ◽  
Author(s):  
Luiz Carlos Ribeiro Lamblet ◽  
Edilson Sant'Anna Meira ◽  
Silvana Torres ◽  
Barbara Carvalho Ferreira ◽  
Sergio Dias Martucchi
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Public Hospital ◽  
Pain Scale ◽  
Clinical Trial Registration ◽  
Test Power ◽  
Subcutaneous Injections ◽  
Intramuscular Injections ◽  
Registration Number ◽  
Needle Injection

This clinical trial aimed at comparing the intensity of pain and bruising by subcutaneous and intramuscular injections using and retractable fixed syringes and needles and syringes with no needles combined, at a public hospital in Sao Paulo, for six months. We evaluated the perception of pain in case of intramuscular (n=1000) and subcutaneous injections (n=240). In subcutaneous application, bruise formation was also verified. Pain and bruising scores were higher in the group with no needles combined (p<0.001) and (p<0.029), respectively. The test power in relation to the pain scale of was 0.98. The use of retractable fixed needles is recommended in the application of subcutaneous and intramuscular injections. Clinical trial registration number: NCT01271608.

scholarly journals Duration of night sleep and cognitive performance of community older adults

2021 ◽  
Vol 29 ◽  
Author(s):  
Élen dos Santos Alves ◽  
Sofia Cristina Iost Pavarini ◽  
Bruna Moretti Luchesi ◽  
Ana Carolina Ottaviani ◽  
Juliana de Fátima Zacarin Cardoso ◽  
...  
Keyword(s):  
Older Adults ◽  
Sleep Quality ◽  
Cognitive Performance ◽  
Sleep Duration ◽  
Verbal Fluency ◽  
Family Health ◽  
Cognitive Domain ◽  
Night Sleep ◽  
Post Hoc ◽  
Adjusted Model

Objective: to analyze the relationship between the duration of self-reported night sleep and the cognitive performance of older adults. Method: the sample consisted of 156 older adults registered in Family Health Units (FHUs) in a city of São Paulo, divided into quartiles according to the duration of night sleep. Data collection was performed using a characterization questionnaire, Addenbrooke’s Cognitive Exam – Revised (ACE-R) and Pittsburgh Sleep Quality Index (PSQI). Descriptive, comparative and correlational statistical analyses were performed. Results: the older adults obtained a mean of 61.94 points in ACE-R and 55.1% presented good sleep quality. Comparative analyses showed differences between the groups only in the cognitive domain of verbal fluency (p=0.018). The post-hoc analyses showed that older adults who slept more hours, a mean of 8.85 hours (Q1), had lower scores when compared to those who slept a mean of 6.11 hours (Q3) (p=0.004) and of 4.52 hours (Q4) (p=0.045). The adjusted model with application of the stepwise method showed a relationship between the independent variables of schooling and sleep duration and the domain verbal fluency. Conclusion: it is concluded that sleep duration is related to the verbal fluency cognitive domain.

scholarly journals Associations of Snoring, Daytime Napping and Night Sleep Duration With Hyperuricemia in Rural Chinese Adults: the Henan Rural Cohort Study

2020 ◽  
Author(s):  
Xiaokang Dong ◽  
Xiaotian Liu ◽  
Lulu Zhang ◽  
Yan Wang ◽  
Runqi Tu ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid ◽  
Sleep Duration ◽  
Serum Uric Acid Level ◽  
Baseline Survey ◽  
Night Sleep ◽  
Chinese Adults ◽  
Habitual Snoring

Abstract Background. Evidence on the association of snoring, daytime napping or sleep duration with hyperuricemia (HUA) was limited, especially in the resources-poor areas. This study aimed to investigate the independent and joint effect of snoring frequency, daytime napping and sleep duration with prevalence of HUA in rural Chinese adults. Methods. 29,643 participants aged 18-79 years were included from baseline survey of the Henan Rural Cohort Study. Sleep variables were assessed using the Pittsburgh Sleep Quality Index (PSQI). Multivariate logistic regression and linear regression models with HUA and serum uric acid level as dependent variables were conducted, respectively. Results. Of the 29,643 included adults, 3498 suffered from HUA. Compared to never snoring, the adjusted odds ratio (OR) and 95% confidence interval (CI) of HUA for rare snoring, occasional snoring and habitual snoring were 1.35 (1.17, 1.56), 1.30 (1.14, 1.47) and 1.59 (1.47, 1.73), respectively. Compared with no napping, participants who had daytime napping of 61-90 and >91 min were associated with 29% and 30% increase in prevalence of HUA, respectively. But in night sleep duration groups, no significant associations were observed (all P>0.05). The positive associations between snoring and HUA were attenuated in older, female adults and those with chronic disease conditions. The joint of habitual snoring and longer daytime napping (≥61min) increased 63% prevalence on HUA. Conclusion. Snoring or daytime napping may independently increase the prevalence of HUA and serum uric acid (SUA) level. Moreover, habitual snoring and longer daytime napping might be jointly associated with a higher prevalence of HUA.Clinical Trial Registration The Henan Rural Cohort Study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). http://www.chictr.org.cn/showproj.aspx?proj=11375

scholarly journals Effect of mCIMT with and without interval on hand in patient suffering from stroke

2021 ◽  
Vol 20 (1) ◽  
pp. 57-65
Author(s):  
Piyush Bhardwaj ◽  
◽  
Jaspreet Kaur ◽  
Charu Gera ◽  
Manoj Malik ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Test Score ◽  
Control Group ◽  
Stroke Patients ◽  
Post Intervention ◽  
Clinical Trial Registration ◽  
Registration Number ◽  
Hand Evaluation ◽  
Block Test ◽  
And Control

Introduction. Paresis of hand has severe impact on the life of the stroke patients. Modified constrained induced movement therapy (mCIMT) can be used to treat the involved limb of the patient. It involves constraining of functional hand and increasing the activity of paretic hand which overcomes the “learned disuse” that develops following stroke but the constraining also creates difficulties for the patient and reduces his/her compliance to the treatment. Hence this trial aims to study the effect of mCIMT with and without interval to see if providing relaxation in between the treatment would be able to produce similar effect as mCIMT without interval protocol. Matgerial and methods. 44 patients were recruited in the study and were divided in to three groups: mCIMT without interval (n = 18), mCIMT with interval (n = 16) and control group (n = 10). Participants in three groups were examined for pain and functionality of hand through Patient rated wrist hand evaluation score and Box and Block test at pre and post intervention. The intervention was given for 6 days/week for two weeks. Therapy time was 2 hours and constrain was for 6 hours a day. Clinical trial registration number -CTRI/2019/12/022547. Results. No baseline differences were found in between the three groups. There was significant increase in box and block test score and significant decrease in PRWHE score in pre and post treatment readings for with and without interval mCIMT but non-significant changes in PRWHE score and box and block test were seen in control group. Conclusion. Both interval and without interval mCIMT was effective. Interval mCIMT was seen to be more comfortable than without interval mCIMT for the patient.

scholarly journals Copeptin Levels in Patients With Treatment-Resistant Hypertension Before and 6 Months After Renal Denervation

2019 ◽  
Author(s):  
Agnes Bosch ◽  
Axel Schmid ◽  
Christian Ott ◽  
Dennis Kannenkeril ◽  
Marina V Karg ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Clinical Trial ◽  
Renal Artery ◽  
Resistant Hypertension ◽  
Renal Denervation ◽  
Treatment Resistant ◽  
Clinical Trial Registration ◽  
All Cause Mortality ◽  
Stage 1

Abstract BACKGROUND Copeptin, the C-terminal peptide of provasopressin, is released from the neurohypophysis and reflects the activity of the hormone arginine vasopressin in patients with hypertension. Elevated copeptin levels are associated with increased cardiovascular and all-cause mortality. The aim of this study is to compare copeptin levels in patients with treatment-resistant hypertension (TRH) before and 6 months after renal denervation (RDN). METHODS Copeptin was measured in 34 patients with TRH and 30 patients with primary hypertension stage 1 or 2 (HT). In addition, copeptin levels were measured in patients with TRH at 6-month follow-up visit after RDN. RDN was performed by an experienced interventionalist applying at least 4 ablations longitudinally and rotationally within the lengths of each renal artery to cover a full 4-quadrant ablation. RESULTS In patients with TRH 24-hour ambulatory blood pressure (BP) decreased from 154 ± 15/87 ± 12 mm Hg to 146 ± 13/83 ± 7.9 mm Hg after RDN (systolic: P = 0.001, diastolic: P = 0.034). There was no significant change in copeptin levels in these 34 patients with TRH before vs. 6 months after RDN (median 8.4 [interquartile range 3.6–14] vs. 8.5 [4.5–13] pmol/l, P = 0.334). Patients with TRH had higher copeptin levels (P = 0.024) than patients with HT (24-hour ambulatory BP: 142 ± 11/91 ± 8.3 mm Hg, copeptin: 4.2 [2.8–6.3] pmol/l). CONCLUSION Patients with TRH showed 2-fold higher copeptin levels than patients with HT. RDN did not lead to any change of copeptin levels in patients with TRH 6 months after procedure despite significant fall in BP. CLINICAL TRIAL REGISTRATION NCT01318395, NCT01687725

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