scholarly journals Does Anxiety Affect the Clock-Drawing Task in Patients in a Memory Clinic? A Clinical Correlation Study

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 284-284
Author(s):  
Hamed Khachan ◽  
Mahak Kanjolia ◽  
Anil Nair

Abstract Background: It is unknown if anxiety levels affect performance on clock drawing test (CDT) in memory clinic patients. Method: We performed a retrospective analysis of memory clinic patients in the south shore of Boston from 2010 to 2019. We correlated anxiety screen data (GAD7) to CDT scores, based on contour, numbers, and hands placement. Univariate analyses used Spearman correlation. A multivariate regression model analzed GAD7 to covariates of CDT, age, sex, and race. Hypothesis : We hypothesized a positive correlation between anxiety levels scored by the GAD7 and CDT. Results: 994 patients in the memory clinic between 2010-2020 had analyzable data. Patients were 58.6% female, 84.6 % White. Mean age was 70.1±14.4, CDT 1.84±1.04. CDT score correlated significantly to race (⍴=-0.16, p< 0.001), age (⍴=-0.28, p<0.001), gender (⍴=0.05, p=0.16), but not GAD7 (⍴=0.05, p=0.27). Multivariate model confirmed the lack of association of anxiety scores to CDT (□= 0.08, p=0.78). GAD7 scores correlated to female gender (□= -1.16, p=0.04). Conclusions: CDT scores were not affected by anxiety as measured on GAD7 scores. However, a positive correlation was shown on anxiety scores in females to CDT completion.

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 284-285
Author(s):  
Hamed Khachan ◽  
Anil Nair ◽  
Fioralba Andrea ◽  
Mahak Kanjolia

Abstract Background: It is unknown if anxiety affects performance on immediate recall testing (IR) in memory clinic patients. Method: We performed a retrospective analysis of memory clinic patients in the south shore of Boston from 2010 to 2019. We correlated anxiety screen data (GAD7) to IR scores. Univariate analyses used Spearman correlation. A multivariate regression model analyzed GAD7 to covariates of IR, age, sex, and race. Hypothesis: We hypothesized a positive correlation between anxiety levels scored by GAD7 and IR. Results: 994 patients in the memory clinic between 2010-2020 had analyzable data. Patients were 58.6% female, 84.6 % White. The mean age was 70.1±14.4, IR 6.62 ± 5.4, GAD7 5.5±5.71. On univariate analysis, IR correlated significantly to age (⍴ = 0.08, p = 0.01), gender (⍴ = 0.06, p = 0.046), and race (⍴= - 0.25, p <0.001), but not to GAD7 (⍴=-0.07, p=0.14). The multivariate model confirmed the lack of association of anxiety scores to (□=-0.05, p=0.41) to GAD7 scores. IR task performance was significantly associated only to age (□= -0.04, p=0.03) and gender (□= -1.18, p=0.04) in the regression model. Conclusions: Immediate recall task performance was not significantly affected by anxiety measured by GAD7 scores in a memory clinic population. However, a negative correlation was shown on immediate recall scores in males and older subjects.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 878-878
Author(s):  
Rima Patel ◽  
Anil Nair

Abstract It is unknown if anxiety affects performance on Digit span forward (DSF) in memory clinic patients. We performed a retrospective chart review of memory clinic patients in the south shore of Boston from 2010 to 2020. We correlated anxiety screen data (GAD7) to Digit Span Forward (DSF) scores obtained from the MoCA. As the data were not normal, we performed univariate analyses with Spearman correlation. A multivariate regression model estimated the relationship of DSF to covariates of GAD7, age, sex, and race. We hypothesized a negative correlation between anxiety levels scored by GAD7 and DSF. H0: Digit span forward DSF ~ GAD7+Age+Sex+Race. A chart review found 965 patients attending the memory clinic between 2010 to 2020 had analyzable data. 433 patients with available DSF and 737 had available GAD7. The patients were 58.7% female and 84.7% caucasian. The mean age was 70.1±14.4, DSF 0.8±0.4 and GAD 5.6±5.7. DSF correlated significantly to race (⍴=-0.25, p=<0.001), but not to gender (⍴=0.05, p=0.149), age (⍴=-0.04, p=0.3), or GAD7 (⍴=-0.018, p=0.71). There was no significant association of DSF to race, age, gender or GAD7 on the multivariate model. In memory clinic subjects there exists no correlation between anxiety levels scored by GAD7 and DSF performance.


2002 ◽  
Vol 17 (5) ◽  
pp. 480-485 ◽  
Author(s):  
Jeremia Heinik ◽  
Isaac Solomesh ◽  
Victoria Shein ◽  
Daniel Becker

2012 ◽  
Vol 25 (1) ◽  
pp. 96-104 ◽  
Author(s):  
Monika Milian ◽  
Anna-Maria Leiherr ◽  
Guido Straten ◽  
Stephan Müller ◽  
Thomas Leyhe ◽  
...  

ABSTRACTBackground: The aim of this study was to assess the specificities of the Mini-Cog, the Clock Drawing Test (CDT), and the Mini-Mental State Examination (MMSE) against depression and healthy controls in a German Memory Clinic. Furthermore, we analyzed the specificities of all three screening instruments in dependence of actual depression severity.Methods: Data from 142 depressed elderly, 438 dementia patients, and 64 healthy controls were retrospectively analyzed. The CDT and an extraction of the three-item recall of the MMSE were used to constitute the Mini-Cog algorithm. Depression severity was rated by either the Beck Depression Inventory (BDI) or the Geriatric Depression Scale (GDS) depending on the age of the patients.Results: The Mini-Cog achieved a specificity of 79.6% against depressed elderly and 100.0% against healthy subjects (p < 0.001). Similarly, the specificities of the CDT (83.8%) and MMSE (92.3% at a cut-off ≤24 and 90.8% at ≤25, respectively) against healthy subjects were significantly higher than the specificities against depressed patients (each p < 0.05). Concerning the depressed patients, the MMSE demonstrated significant higher specificity than the Mini-Cog and the CDT, but also showed the lowest sensitivity for the detection of dementia. Surprisingly, the depression severity had no effect on the specificity of the Mini-Cog and the CDT, only the MMSE was susceptible for the depression severity.Conclusion: Although the MMSE showed higher specificities, the weighting between the sensitivities and specificities in all tests prove again the Mini-Cog as a short, valid, and sensitive screening tool.


2012 ◽  
Vol 24 (11) ◽  
pp. 1738-1748 ◽  
Author(s):  
Alexandra Jouk ◽  
Holly Tuokko

ABSTRACTBackground: Many scoring systems exist for clock drawing task variants, which are common dementia screening measures, but all have been derived from clinical samples. This study evaluates and combines errors from two published scoring systems for the Clock Drawing Test (CDT), the Lessig and Tuokko methods, in order to create a simple yet optimal scoring procedure to screen for dementia using a Canadian population-based sample.Methods: Clock-drawings from 356 participants (80 with dementia, 276 healthy controls) from the Canadian Study on Health and Aging were analyzed using logistic regression and Receiver Operating Characteristic curves to determine a new, simplified, population-based CDT scoring system. The new Jouk scoring method was then compared to other commonly used systems (e.g. Shulman, Tuokko, Watson, Wolf-Klein).Results: The Jouk scoring system reduced the Lessig system even further to include five critical errors: missing numbers, repeated numbers, number orientation, extra marks, and number distance, and produced a sensitivity of 81% and a specificity of 68% with a cut-off score of one error. With regard to other traditionally used scoring methods, the Jouk procedure had one of the most balanced sensitivities/specificities when using a population-based sample.Conclusions: The results from this study improve our current state of knowledge concerning the CDT by validating the simplified scoring system proposed by Lessig and her colleagues in a more representative sample to mimic conditions a general clinician or researcher will encounter when working among a wide-ranging population and not a dementia/memory clinic. The Jouk CDT scoring system provides further evidence in support of a simple and reliable dementia-screening tool that can be used by clinicians and researchers alike.


2011 ◽  
Vol 24 (5) ◽  
pp. 766-774 ◽  
Author(s):  
Monika Milian ◽  
Anna-Maria Leiherr ◽  
Guido Straten ◽  
Stephan Müller ◽  
Thomas Leyhe ◽  
...  

ABSTRACTBackground: The aim of this study was to compare the screening value of the Mini-Cog, Clock Drawing Test (CDT), Mini-Mental State Examination (MMSE) and the algorithm MMSE and/or CDT to separate elderly people with dementia from healthy depending on test time, type and severity of dementia, and demographic variables in a German Memory Clinic.Methods: Data from a heterogeneous patient sample and healthy participants (n = 502) were retrospectively analyzed. Of the 438 patients with dementia, 49.1% of the dementia diagnoses were Alzheimer's dementia and 50.9% were non-Alzheimer's dementia. Sixty-four participants were classified as cognitively unimpaired. The CDT and an extraction of the 3-item recall of the MMSE were used to constitute the Mini-Cog algorithm.Results: Overall, the Mini-Cog showed significantly higher discriminatory power (86.8%) than the MMSE (72.6% at a cut-off ≤ 24 and 79.2% at ≤ 25, respectively) and CDT (78.1%) (each p < 0.01) and did not perform worse than the algorithm MMSE and/or CDT (each p > 0.05). The specificity of the Mini-Cog (100.0%) was similar to that of the MMSE (100.0% for both cut-offs) and CDT (96.9%) (p = 0.154). For all age and educational groups the Mini-Cog outmatched the CDT and MMSE, and was less affected by education than MMSE and less susceptible for the dementia stage than the CDT.Conclusion: The Mini-Cog proved to have superior discriminatory power than either CDT or MMSE and is demonstrated to be a valid “short” screening instrument taking 3 to 4 minutes to administer in the geriatric setting.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 877-877
Author(s):  
Neil Tangal ◽  
Neeraj Tangal ◽  
Anil Nair ◽  
Malini Nair

Abstract Tau protein levels in cerebrospinal fluid are a biomarker of Alzheimer’s disease. We correlated MMSE severity to CSF tau levels in a large memory clinic sample. We retrospectively analyzed data from patients attending a memory clinic in the south shore of Boston from 2010 to 2020, and had a lumbar puncture to obtain CSF Tau levels. We compiled cognitive screen data from MMSE scores. Univariate analyses used Spearman correlation as data were non-normal. A multivariate model was created including covariates of age, sex, and race. 965 patients attended the memory clinic from 2010 to 2020. 711 had available MMSE scores. 129 subjects had lumbar punctures and available CSF tau levels. Univariate analyses showed that cognition as measured by MMSE total was not correlated to total tau levels in the CSF (rho=-0.07, p&gt;0.05), but caucasian race was inversely associated with CSF tau levels (rho= -0.217, p&lt;0.05). In a multivariate model, tau levels in the CSF were not associated with MMSE, race, gender, or age. In a large memory clinic sample, CSF tau levels did not correlate to MMSE scores, age, race or gender.


2018 ◽  
Vol 3 (3) ◽  
pp. 467
Author(s):  
Diah Merdekawati ◽  
Dasuki Dasuki

<p><em>Pre-school age is particularly vulnerable to the effects of stress and fear during hospitalization. Children under the age of 6 are less able to think about an event as a whole, have not been able to determine behavior that can overcome the fear based on experience ever experienced and coping strategies ever done. The aims of this research to know correlation family support with child anxious response during infusion. This study was a quantitative with correlation study using cross sectional method. There were 51 respondents participated in this research. Data were collected through observation with purposive sampling technique. Then, data were analysed through univariate and bivariate. The result of univariate statistic test revealed that as much as 64.7% had good family support and 56.9% experienced an anxious response during infusion. The result of  bivariate statistic test showed that there was a positive correlation with moderate strength between family support and child's anxious response during infusion. This riset showed that families should provide support when children experience fear, anxiety and pain during infusion.</em></p><p><em><br /></em></p><p>Usia pra sekolah sangat rentan terhadap efek stress dan ketakutan selama rawat inap. Anak- anak dibawah usia 6 tahun kurang mampu berpikir tentang suatu peristiwa secara keseluruhan, belum bisa menentukan perilaku yang dapat mengatasi ketakutan berdasarkan pengalaman yang pernah dialami dan strategi koping yang pernah dilakukan. Tujuan penelitian ini adalah untuk mengetahui korelasi dukungan keluarga dengan respon cemas anak saat pemasangan infus. Penelitian ini merupakan penelitian kuantitatif studi korelatif dengan metode <em>cross secsional</em>. Sebanyak 51 responden terlibat dalam penelitian ini. Pengumpulan data melalui observasi. Pengambilan sampel dilakukan secara <em>purposive sampling. </em>Analisis data dilakukan secara <em>univariat </em>dan<em> bivariat. </em>Dari hasil uji statistik univariat diketahui sebanyak 64,7% memiliki dukungan keluarga baik dan 56,9% mengalami respon cemas saat pemasangan infus. Hasil uji statistik bivariat menunjukkan ada korelasi positif dengan kekuatan sedang antara dukungan keluarga dengan respon cemas anak saat pemasangan infus. Penelitian ini menunjukkan bahwa keluarga sebaiknya memberikan dukungannya pada saat anak mengalami ketakutan, kecemasan dan rasa nyeri pada saat pemasangan infus.</p><p><em><br /></em></p>


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