scholarly journals C-Reactive Protein Mediates the Association Between Subjective Aging and Incident Heart Disease

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 605-605
Author(s):  
Hanamori Skoblow ◽  
Christine Proulx
Keyword(s):  
Cardiovascular Disease ◽  
Sex Education ◽  
Indirect Effect ◽  
Repeated Measures ◽  
Cardiovascular Health ◽  
Subjective Age ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Incident Cardiovascular Disease ◽  
Subjective Aging

Abstract Recent studies have shown that negative perceptions of subjective aging are associated with a heightened risk of cardiovascular events (Stephan et al., 2020) and increased C-reactive protein (CRP), a biomarker associated with inflammation (Stephan et al., 2014). Because inflammation is deleterious to cardiovascular health, CRP might mediate the association between subjective aging and cardiovascular disease. The purpose of this study was to examine the association between subjective aging (i.e., negative self-perceptions of aging [SPA] and subjective age) and incident cardiovascular disease (e.g., heart attack, angina, congestive heart failure), and to determine whether CRP mediates this relation. We used up to five waves of repeated measures data from the Health and Retirement Study (HRS, 2008 - 2016) with adults aged 50 to 101 (n = 9,531). Two separate models were conducted in MPlus with bias-corrected bootstrap confidence intervals and controls for respondent age, sex, education, race, ethnicity, body mass index (BMI), diabetes, hypertension, depressive symptoms, and physical inactivity. There were significant indirect effects of both SPA and subjective age on incident cardiovascular disease through CRP (indirect effect SPA model = .02, CIs [.01, .03], p < .05; indirect effect subjective age model = .05, CIs [.02, .10], p < .05). In both models, CRP fully mediated the association between subjective aging and incident cardiovascular disease. Taken together, these findings underscore the importance of considering older adults’ views of aging for understanding physical health and suggest that interventions aimed at improving views on aging may reduce inflammation and promote cardiovascular health.

scholarly journals Cardiovascular health and cognitive functioning among centenarians: a comparison between the Tokyo and Georgia centenarian studies

2019 ◽  
Vol 31 (04) ◽  
pp. 455-465 ◽  
Author(s):  
Peter Martin ◽  
Yasuyuki Gondo ◽  
Yasumichi Arai ◽  
Yoshiko Ishioka ◽  
Mary Ann Johnson ◽  
...  
Keyword(s):  
United States ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Cognitive Functioning ◽  
Cardiovascular Health ◽  
The United States ◽  
C Reactive Protein ◽  
Differential Effects ◽  
Reactive Protein ◽  
Positive Effects

ABSTRACTObjectives:Centenarians have survived into very late life, but whether they reach very old age in good health remains unclear. The purpose of this study was to compare the cardiovascular health status and cognitive functioning of centenarians in the United States with centenarians in Japan.Design, Setting, and Participants:This cross-national design compared centenarians from the United States and Japan. The sample of U.S. centenarians was recruited from the Georgia Centenarian Study and included 287 centenarians. The sample of Japanese centenarians was recruited from the Tokyo Centenarian Study and included 304 centenarians.Measurements:Cognitive functioning was assessed with a mental status questionnaire, and cardiovascular disease by a health history assessment, blood pressure, and selected blood parameters.Results:The results suggest that Tokyo centenarians had lower disease experiences and BMI values, when compared to Georgia centenarians, but blood pressure was higher among Japanese centenarians. Lower levels of hemoglobin in Japanese centenarians and higher levels of C-reactive protein in Georgia were also found. The positive association of hypertension and albumin levels with cognitive functioning and the negative association of stroke occurrence with cognitive functioning were replicated in both countries. Differential effects were obtained for heart problems, BMI, and C-reactive protein (with positive effects for Tokyo centenarians, except for C-reactive protein).Conclusion:For extremely old individuals, some markers of cardiovascular disease are replicable across countries, whereas differential effects for cardiovascular health also need to be considered in cardiovascular health.

scholarly journals GlycA, a Pro-Inflammatory Glycoprotein Biomarker, and Incident Cardiovascular Disease: Relationship with C-Reactive Protein and Renal Function

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0139057 ◽  
Author(s):  
Eke G. Gruppen ◽  
Ineke J. Riphagen ◽  
Margery A. Connelly ◽  
James D. Otvos ◽  
Stephan J. L. Bakker ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Renal Function ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Incident Cardiovascular Disease

scholarly journals Serum Alkaline Phosphatase and Risk of Incident Cardiovascular Disease: Interrelationship with High Sensitivity C-Reactive Protein

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132822 ◽  
Author(s):  
Setor K. Kunutsor ◽  
Stephan J. L. Bakker ◽  
Jenny E. Kootstra-Ros ◽  
Ronald T. Gansevoort ◽  
John Gregson ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Alkaline Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Incident Cardiovascular Disease

Complementary Effects of Multivitamin and Omega-3 Fatty Acid Supplementation on Indices of Cardiovascular Health in Individuals with Elevated Homocysteine

2012 ◽  
Vol 82 (1) ◽  
pp. 41-52 ◽  
Author(s):  
P. Earnest ◽  
S. Kupper ◽  
M. Thompson ◽  
Guo ◽  
S. Church
Keyword(s):  
Risk Factors ◽  
Cardiovascular Health ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
C Reactive Protein ◽  
Fatty Acid Supplementation ◽  
Omega 3 Fatty Acid ◽  
Reactive Protein ◽  
Daily Ingestion

Homocysteine (HCY), C-reactive protein (hsCRP), and triglycerides (TG) are risk factors for cardiovascular disease (CVD). While multivitamins (MVit) may reduce HCY and hsCRP, omega-3 fatty acids (N3) reduce TG; yet, they are seldom studied simultaneously. We randomly assigned 100 participants with baseline HCY (> 8.0 umol/L) to the daily ingestion of: (1) placebo, (2) MVit (VitC: 200 mg; VitE: 400 IU; VitB6: 25 mg; Folic Acid: 400 ug; VitB12: 400 ug) + placebo, (3) N3 (2 g N3, 760 mg EPA, 440 mg DHA)+placebo, or (4) MVit + N3 for 12 weeks. At follow-up, we observed significant reductions in HCY (umol/L) for the MVit (- 1.43, 95 %CI, - 2.39, - 0.47) and MVit + N3 groups (- 1.01, 95 %CI, - 1.98, - 0.04) groups, both being significant (p < 0.05) vs. placebo (- 0.57, 95 %CI, - 1.49, 0.35) and N3 (1.11, 95 % CI, 0.07, 2.17). hsCRP (nmol/L) was significantly reduced in the MVit (- 6.00, 95 %CI, - 1.04, - 0.15) and MVit + N3 (- 0.98, 95 %CI, - 1.51, - 0.46) groups, but not vs. placebo (- 0.15, 95 %CI, - 0.74, 0.43) or N3 (- 0.53, 95 %CI, - 1.18, 0.12). Lastly, we observed significant reductions in TG for the N3 (- 0.41, 95 %CI, - 0.69, - 0.13) and MVit + N3 (- 0.71, 95 %CI, - 0.93, - 0.46) groups, both significant vs. placebo (- 0.10, 95 %CI, - 0.36, 0.17) and MVit groups (0.15, 95 %CI, - 12, 0.42). The co-ingestion of MVit + N3 provides synergistic affects on HCY, hsCRP, and plasma TG.

Relationship of C-Reactive Protein to Risk of Cardiovascular Disease in the Elderly

1997 ◽  
Vol 17 (6) ◽  
pp. 1121-1127 ◽  
Author(s):  
Russell P. Tracy ◽  
Rozenn N. Lemaitre ◽  
Bruce M. Psaty ◽  
Diane G. Ives ◽  
Rhobert W. Evans ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
The Elderly ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Relationship Of
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