scholarly journals 1305Early chronic inflammation and behavioural problems in children at age two: a longitudinal study

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Cindy Pham ◽  
Siroon Bekkering ◽  
Martin O'Hely ◽  
Sarah Thomson ◽  
Fiona Collier ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Chronic Inflammation ◽  
Inflammatory Biomarkers ◽  
Behavioural Problems ◽  
Low Grade ◽  
Sampling Frame ◽  
Time Points ◽  
T Score ◽  
Externalising Behaviours ◽  
Internalising Behaviours

Abstract Background Inflammation has been suggested to contribute to the pathogenesis of adult mental illness and been implicated mechanistically in childhood behavioural problems like internalising and externalising symptoms. High-sensitive C-reactive protein (hsCRP) and glycoprotein acetyls (GlycA) are biomarkers of chronic low-grade inflammation. We aimed to investigate whether hsCRP and GlycA, and environmental factors that influence these inflammatory biomarkers, were associated with internalising and externalising behaviours in early childhood. Methods The Barwon Infant Study is a population-derived birth cohort recruited using an unselected antenatal sampling frame in Victoria, Australia. Infant bloods collected at birth and 12-month were analysed for hsCRP by ELISA and GlycA by NMR. Environmental factors were derived from questionnaires undertaken antenatally to four years postnatally. Internalising and externalising behaviours at age two were measured by the Child Behaviour Checklist. Associations between inflammatory biomarkers and behavioural outcomes were assessed by multivariable regression analyses adjusted for relevant factors. Results Increased GlycA levels at birth (GlycAbirth)(β = 5.22 T-score units; 95% confidence interval (CI)(1.22, 9.21; P=0.01) and decreased GlycA levels at 12 months (GlycA12months)(β=-6.47 T-score units; 95% CI(-11.44, -1.50); P=0.01) were associated with increased internalising behaviours at age two. Association persisted for GlycAbirth, but not for GlycA12months when adjusted for GlycA at both time points within the same model. Weak associations were observed for hsCRP at both time points and externalising behaviours at age two. Conclusions Our findings document an association between increased GlycAbirth and greater internalising behaviours in children aged two years. Elevated early chronic inflammation may be an important pathway in adverse behavioural development in children. Key messages Increased GlycA levels at birth is associated with greater internalising behaviours in children at age two years.

scholarly journals NLRP3 Inflammasome: A Possible Link Between Obesity-Associated Low-Grade Chronic Inflammation and Colorectal Cancer Development

2018 ◽  
Vol 9 ◽  
Author(s):  
Patricia Ahechu ◽  
Gabriel Zozaya ◽  
Pablo Martí ◽  
José Luis Hernández-Lizoáin ◽  
Jorge Baixauli ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Chronic Inflammation ◽  
Nlrp3 Inflammasome ◽  
Cancer Development ◽  
Low Grade

scholarly journals DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Abdelkrim Khadir ◽  
Sina Kavalakatt ◽  
Mohammed Dehbi ◽  
Monira Alarouj ◽  
Abdullah Bennakhi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Inflammation ◽  
Plasma Levels ◽  
Recurrent Events ◽  
Multivariate Logistic Regression Analysis ◽  
Least Square ◽  
Enzyme Linked Immunosorbent Assay ◽  
Low Grade ◽  
Potential Marker ◽  
Diabetes Status

Background. Cardiovascular disease (CVD) risks persist in patients despite the use of conventional treatments. This might be due to chronic inflammation as reflected in epidemiological studies associating circulating low-grade inflammatory markers with CVD recurrent events. Here, we explored this potential link by assessing plasma dual-specificity phosphatase 1 (DUSP1) levels and comparing them to high-sensitivity CRP (hsCRP) and oxidized low-density lipoprotein (oxLDL) levels and their associations to conventional CVD risk factors in confirmed CVD patients. Methods. Human adults with reported CVD (n=207) and controls (n=70) living in Kuwait were used in this study. Anthropometric and classical biochemical parameters were determined. Plasma levels of DUSP1, oxLDL, and hsCRP were measured using human enzyme-linked immunosorbent assay kits. Results. DUSP1 and hsCRP plasma levels and their least square means were higher in CVD cases, while oxLDL plasma levels were lower (p<0.05). Multivariate logistic regression analysis showed that DUSP1 and hsCRP are independently associated with CVD in the studied population, as reflected by 2-fold and 1.5-fold increased risks with increased levels of DUSP1 and hsCRP, respectively. In our study, DUSP1 levels were found to be associated with CVD despite statin treatment and diabetes status (p<0.05), whereas hsCRP mainly correlated with obesity markers. Conclusions. Circulating DUSP1 might be a predictor of chronic subclinical inflammation and residual risk in CVD patients, whereas our data suggest that the association between hsCRP and CVD is largely accounted for adiposity risk factors.

Abstract P283: Association of Cardiorespiratory Fitness and Adiposity with Inflammatory Biomarkers in Young Adults

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Eunduck Park ◽  
Janet C Meininger ◽  
Duck-Hee Kang ◽  
Kelley P Gabriel
Keyword(s):  
Young Adults ◽  
Cardiorespiratory Fitness ◽  
Significant Interaction ◽  
Inflammatory Biomarkers ◽  
Low Grade ◽  
Central Adiposity ◽  
Negatively Associated ◽  
Inflammatory Biomarker ◽  
Tnf Α ◽  
Hs Crp

Introduction: Low grade systemic inflammation plays a key role in the pathogenesis of atherosclerosis. There is evidence that higher cardiorespiratory fitness (CRF) is associated with lower levels of inflammatory biomarkers. However, it remains uncertain whether the negative association between CRF and inflammatory biomarkers is due to CRF itself or results from lower levels of adiposity. Moreover, adiposity, including central adiposity, has not been examined as a moderator of the association between CRF and inflammatory biomarkers in young adults. Hypotheses: 1. Higher level of CRF will be associated with lower levels of inflammatory biomarkers after adjusting for levels of adiposity and confounders. 2. Adjusting for confounders, there will be a significant interaction effect between adiposity (BMI, waist circumference (WC)) and CRF in relation to inflammatory biomarker levels. Methods: A cross-sectional study was conducted in Houston, TX. A sample of 88 asymptomatic young adults aged 20-34 years without diagnosed diseases was accessed. CRF was assessed by a submaximal treadmill walking test. Adiposity was measured using BMI and WC. The inflammatory biomarkers (hs-CRP, IL-6 and TNF-α) were assayed and were log 10 -transformed. A separate multiple regression analysis was conducted with each of inflammatory biomarker as dependent variables for hypothesis one. Analysis of covariance was used for hypothesis two. Confounding variables tested were sex, ethnicity, oral contraceptive use, and education level. Results: Hypothesis 1: CRF was not associated with log 10 hs-CRP after adjustment for BMI (or WC) and confounders. CRF was not associated with log 10 IL-6 after adjustment for BMI and confounders. However, CRF was negatively associated with log 10 IL-6 after adjustment for WC and confounders (Model adjusted R 2 =.273, p < .0001; β = -.341, t = -1.995, p =.049). Hypothesis 2: CRF х BMI (or WC) interaction was not associated with log 10 hs-CRP after adjustment for confounders. CRF х BMI interaction was not associated with log 10 IL-6 after adjustment for confounders. However, CRF х WC interaction was negatively associated with log 10 IL-6 after adjustment for confounders (Model adjusted R 2 = .258, p < .0001; partial eta 2 =.056, F = 4.730, p = .033). There were no associations of CRF, adiposity, and log 10 TNF-α. Conclusions: In young adults, higher level of CRF is associated with lower level of IL-6 after adjustment for central adiposity and confounders. Further, there is a significant interaction between CRF and WC in relation to IL-6 after adjustment for confounders. Higher levels of CRF may play an important role for lowering some inflammatory biomarkers in central adiposity.

Circulating Fibrinogen to Pre-albumin Ratio for Chemotherapy Efficacy Prediction and Prognosis of Colorectal Cancer Patients

2020 ◽  
Author(s):  
Hou-Qun Ying ◽  
Fan Sun ◽  
Wei Wang ◽  
Dan Cai ◽  
Ying Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factor ◽  
Chronic Inflammation ◽  
Clinical Outcomes ◽  
Cox Regression ◽  
Independent Prognostic Factor ◽  
Low Grade ◽  
Albumin Ratio ◽  
Response To Chemotherapy ◽  
Chemotherapy Efficacy

Abstract Background Evaluating chronic inflammation in colorectal cancer (CRC) may aid in identifying patients at the highest risk of recurrence or progression, and help inform clinical treatment decisions. Here, we report the effect of fibrinogen to pre-albumin ratio (FPR) in determining response to chemotherapy and reveal outcomes in CRC patients. Methods A total of 2917 eligible CRC patients from multiple-centers were enrolled, and the outcome of these patients was obtained by three years’ follow-up. Circulating fibrinogen, albumin, pre-albumin, CEA, CA199 and FPR were detected and calculated in these patients. Kaplan-Meier curves, Cox regression, time-dependent ROC, Harrell’s concordance index, calibration and decision curves were used to investigate the role of FPR in clinical outcome of CRC patients. Results Our results reveal significantly inferior outcomes in right- than left-sided patients with advanced CRC (stage III and IV), with preoperative FPR found to be a robust and independent prognostic factor for CRC at each stage. Moreover, prognostic nomograms, including FPR, effectively predicted clinical outcomes of the patients. Furthermore, preoperative FPR was significantly associated with chemotherapy efficacy. Specifically, low-grade (FPR < 15) and medium-grade (15 ≤ FPR < 20) FPR patients exhibited complete response to chemotherapy and attenuated chemosensitivity, respectively, whereas high-grade inflammation (FPR ≥ 20) conferred resistance to the treatment. Conclusion CRC-related inflammation affects response to chemotherapy and the resultant clinical outcomes. Circulating FPR is a simple, economically-friendly and robust independent prognostic factor for effectively predicting outcomes of CRC patients. Targeting chronic inflammation and its corresponding signaling pathway, coupled with measuring FPR, presents a novel approach for clinical management of CRC.

Bioptic intraprostatic chronic inflammation predicts adverse pathology at radical prostatectomy in patients with low-grade prostate cancer

2020 ◽  
Vol 38 (10) ◽  
pp. 793.e19-793.e25 ◽  
Author(s):  
Francesca Sanguedolce ◽  
Ugo Giovanni Falagario ◽  
Pietro Castellan ◽  
Michele Di Nauta ◽  
Giovanni Silecchia ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Chronic Inflammation ◽  
Low Grade

scholarly journals Patient-derived xenografts of low-grade B-cell lymphomas demonstrate roles of the tumor microenvironment

2017 ◽  
Vol 1 (16) ◽  
pp. 1263-1273 ◽  
Author(s):  
W. Richard Burack ◽  
Janice M. Spence ◽  
John P. Spence ◽  
Stephen A. Spence ◽  
Philip J. Rock ◽  
...  
Keyword(s):  
B Cells ◽  
Tumor Microenvironment ◽  
Environmental Factors ◽  
B Cell ◽  
Relative Survival ◽  
Low Grade ◽  
B Cell Lymphomas ◽  
Key Points ◽  
Tumor Environment

Key Points The relative survival/proliferation advantage of lymphoma B cells compared with nonneoplastic B cells is dependent on environmental factors. The tumor environment can dictate the differentiation of neoplastic B cells.

scholarly journals M176. INTESTINAL PERMEABILITY AND LOW-GRADE CHRONIC INFLAMMATION IN SCHIZOPHRENIA: DO THEY INFLUENCE COGNITION AND COGNITIVE RESERVE?

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S203-S204
Author(s):  
Gerard Anmella ◽  
Silvia Amoretti ◽  
Miqueu Alfonso ◽  
Oriol Cuñat ◽  
Gemma Safont ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Mediterranean Diet ◽  
Intestinal Permeability ◽  
Cognitive Reserve ◽  
Psychotic Disorders ◽  
Verbal Learning ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Low Grade ◽  
Cross Sectional

Abstract Background Higher intestinal-permeability is known to cause low-grade chronic inflammation, which seems to participate in the development and worsening of psychotic disorders both in first-episode psychosis (FEP) and schizophrenia (SCZ) patients. Moreover, in psychotic disorders, inflammation has been linked to cognition and cognitive reserve (CR). The aim of this study is to assess the relation between intestinal-permeability, low-grade chronic inflammation, cognition and cognitive reserve in psychotic disorders. Methods Observational, cross-sectional and multisite study including four centers in Spain (Grant from Fondo de Investigación Sanitaria, PI17/00246). A total of 500 adult patients with DSM-5 SCZ-spectrum disorder at any stage of the disease were recruited. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). Disease severity was assessed using the Clinical Global Impression (CGI) scale and functioning was assessed using the Global Assessment of Functioning (GAF) scale. The intestinal-permeability was estimated with the “Permeable-Intestine-syndrome questionnaire”. The diet was assessed with the “Mediterranean-diet-adherence questionnaire”. Exercise was measured with the “International Physical Activity Questionnaire (IPAQ)”. Cognition was measured with the SCIP-S scale. CR was assessed with the Cognitive Reserve Assessment Scale in Health (CRASH), which is a scale developed to measure CR specifically for patients with severe mental illness. Correlations between CRASH scores and the remainder variables were performed. Results For the present study we included only the subjects who had CRASH score, a total of 112 patients, 42.7% female, aged 40.61±12.4 (mean±SD). Substance use was present in 44.3%. The CRASH score was 33.30±15.72 (mean±SD) and was associated with negative (but not positive) psychotic symptoms assessed by PANSS (PANSS negative; rp=-3.98; p=0.001, PANSS general; rp=-2.13; p=0.038, GAF; rp=0.410; p&lt;0.0001, CGI; rp=-0.30; p=0.002, IPAQ; rs=0.224; p=0.025 and the permeability-scale; rs=-0.266; p=0.008. All cognitive domains (assessed by SCIP-S) were associated to CRASH: verbal learning immediate (rp=0.584; p&lt;0.0001) and differed (rp=0.515; p&lt;0.0001), working memory (rp=0.539; p&lt;0.0001), verbal fluency (rs=0.485; p&lt;0.0001) and processing speed (rp=0.584; p&lt;0.0001). No significant associations were found with Mediterranean-diet scale (rs=0.195; p=0.056), IMC (rs=-0.192; p=0.063), C-reactive protein (rs=-0.104; p=0.278) and the IPAQ-resting scale and permeability-scale (rs=0.119; p=0.244). Discussion

Sign in / Sign up

Export Citation Format

Share Document