Dietary omega-3 fatty acid supplementation does not impair vitamin E status or promote lipid peroxidation in growing horses

2021 ◽  
Author(s):  
Sarah H White-Springer ◽  
Kelly R Vineyard ◽  
Jan Kivipelto ◽  
Lori K Warren
Keyword(s):  
Lipid Peroxidation ◽  
Body Weight ◽  
Vitamin E ◽  
Repeated Measures ◽  
Antioxidant Status ◽  
Serum Vitamin ◽  
Omega 3 ◽  
Potential Health ◽  
Increased Risk ◽  
Vitamin E Status

Abstract Omega-3 (n-3; ω-3) fatty acids (FA) are often included in the diet for their potential health benefits. However, because oxidative potential is increased with the degree of unsaturation in vitro, polyunsaturated FA such as eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) may be at increased risk of lipid peroxidation. We aimed to determine the effects of dietary n-3 FA supplementation on antioxidant status and lipid peroxidation in yearling horses. Quarter Horses (mean ± SEM; 14.6 ± 0.2 mo) were randomly assigned to receive no n-3 FA supplementation (CON; n = 6) or 60 mg n-3/kg body weight from milled flaxseed (FLAX; n = 6) or encapsulated fish oil (FISH; n = 6). All horses received a basal diet of mixed grain concentrate fed individually at 1.5% body weight (dry matter basis) and ad libitum bahiagrass pasture forage. Blood samples were obtained before and after 70 d of supplementation to evaluate vitamin E, selenium, lipids, antioxidant status, and oxidative stress. Data were analyzed using a mixed model ANOVA with repeated measures. Supplementation with n-3 FA did not reduce serum vitamin E or Se and, in fact, elevated (P ≤ 0.0003) vitamin E status in FISH horses. At d 70, serum triglycerides were lower in FISH and FLAX horses than CON horses (P ≤ 0.02) and F2-isoprostanes were lower in FISH than CON horses (P = 0.0002). Dietary n-3 FA had no effect on cholesterol, reduced and oxidized glutathione, glutathione peroxidase, and thiobarbituric acid-reactive substances. In growing horses fed to meet their vitamin E requirements, supplementation with 60 mg n-3/kg body weight did not negatively affect vitamin E status or promote lipid peroxidation. Elevated vitamin E status in horses fed FISH, coupled with lower serum F2-isoprostanes, further suggest that the longer-chain, highly unsaturated n-3 FA, EPA and DHA, may actually attenuate lipid peroxidation.

scholarly journals A Prospective Study of Serum Vitamin E and 28-Year Risk of Lung Cancer

2019 ◽  
Vol 112 (2) ◽  
pp. 191-199 ◽  
Author(s):  
Jiaqi Huang ◽  
Stephanie J Weinstein ◽  
Kai Yu ◽  
Satu Männistö ◽  
Demetrius Albanes
Keyword(s):  
Lung Cancer ◽  
Vitamin E ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Statistical Tests ◽  
Serum Vitamin ◽  
Alpha Tocopherol ◽  
Lower Lung ◽  
Trial Intervention ◽  
Vitamin E Status

Abstract Background Epidemiologic data are inconsistent regarding the vitamin E-lung cancer association, and no study to our knowledge has examined serologic changes in vitamin E status in relation to subsequent risk. Methods In a cohort of 22 781 male smokers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, we ascertained 3184 lung cancer cases during up to 28 years of observation. Cox proportional hazards models examined whether higher serum alpha-tocopherol concentrations at baseline, 3 years, or the interval change were associated with lower lung cancer risk. All statistical tests were two-sided. Results After adjustment for age, body mass index, smoking intensity and duration, serum total cholesterol, and trial intervention group, we found lower lung cancer risk in men with high baseline alpha-tocopherol (fifth quintile [Q5] vs Q1, hazard ratio [HR] = 0.76, 95% confidence interval [CI] = 0.66 to 0.87, Ptrend < .001). A similar reduction in risk was seen for serum alpha-tocopherol at 3 years (Q5 vs Q1, HR = 0.78, 95% CI = 0.67 to 0.91, Ptrend = .004). The inverse risk association appeared stronger for younger men and those who had smoked fewer years but was similar across trial intervention groups. We also found reduced risk among men not supplemented with vitamin E who had a lower serum alpha-tocopherol at baseline and greater increases in concentrations at 3 years (third tertile vs first tertile of serum alpha-tocopherol change, HR = 0.74, 95% CI = 0.59 to 0.91, P = .005). Conclusions Higher vitamin E status, as measured by serum alpha-tocopherol concentration, as well as repletion of a low vitamin E state, was related to decreased lung cancer risk during a 28-year period. Our findings provide evidence supporting the importance of adequate physiological vitamin E status for lung cancer risk reduction.

Effect of Prolonged Marginal Ascorbic Acid Deficiency on Lenticular Levels of Antioxidants and Lipid Peroxide in Guinea Pigs

2001 ◽  
Vol 71 (2) ◽  
pp. 103-109 ◽  
Author(s):  
Yoshiji Ohta ◽  
Takafumi Niwa ◽  
Takashi Yamasaki
Keyword(s):  
Ascorbic Acid ◽  
Vitamin E ◽  
Guinea Pigs ◽  
Antioxidant Status ◽  
Serum Vitamin ◽  
Lipid Peroxide ◽  
Ascorbic Acid Content ◽  
Ascorbic Acid Deficiency ◽  
Acid Deficiency ◽  
Deficient Group

We examined the effect of prolonged marginal ascorbic acid deficiency of the levels of antioxidants and lipid peroxide in lenses of guinea pigs in order to clarify lenticular antioxidant status under ascorbic acid deficiency. Male guinea pigs aged 4 weeks were given a scorbutic diet (20 g/animal per day) with either marginally deficient ascorbic acid (0.5 mg/animal per day) or sufficient ascorbic acid (1 g/animal per day) in drinking water for 3 and 6 months. The deficient group showed no lens opacity during the administration period. The deficient group had 62.3 and 53.9% of lenticular ascorbic acid content in the sufficient group at 3 and 6 months of ascorbic acid deficiency, respectively. There were no differences in lenticular contents of reduced glutathione and thiobarbituric acid reactive substances, an index of lipid peroxidation, between both groups at 3 and 6 months of ascorbic acid deficiency, while the deficient group tended to have higher lenticular vitamin E content than the sufficient group. The deficient group had higher serum vitamin E concentration than the sufficient group at 3 and 6 months of ascorbic acid deficiency. These results indicate that lenticular antioxidant status is maintained well in guinea pigs with prolonged marginal ascorbic acid deficiency, which may result in no cataract formation.

scholarly journals Increased Oxidative Stress in Prepubertal Children Born Small for Gestational Age

2007 ◽  
Vol 92 (4) ◽  
pp. 1372-1378 ◽  
Author(s):  
Angelika Mohn ◽  
Valentina Chiavaroli ◽  
Marina Cerruto ◽  
Annalisa Blasetti ◽  
Cosimo Giannini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Antioxidant Status ◽  
Lag Phase ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Prepubertal Children ◽  
Increased Risk

Abstract Context: Low birth weight is associated with an increased risk of metabolic and cardiovascular diseases in adulthood. The development of insulin resistance (IR) seems to play a pivotal role; no data on the oxidant-antioxidant status are available in this risk group. Objective: This study is an assessment of oxidant-antioxidant status in prepubertal children born small for gestational age (SGA) in comparison to healthy controls and the relationship to IR. Design: This cross-sectional study compares indexes of IR and oxidant-antioxidant status in three different groups (SGA+, SGA−, controls), with analysis by post hoc and Pearson correlation. Setting: The study was conducted in the Academic Department of Pediatrics. Participants: A total of 19 SGA+ and 16 SGA− children were compared with 13 controls. Intervention: No intervention was used. Main Outcome Measures: Indexes of IR (glucose to insulin ratio, homeostasis model assessment of IR) were evaluated, and markers of oxidative stress (lag phase, malonildialdehyde, vitamin E) were measured. Results: Homeostasis model assessment of IR was significantly higher in SGA+ than SGA− children (1.32 ± 0.9 vs. 0.69 ± 0.47; P = 0.03) and controls (0.71 ± 0.37; P = 0.04). Glucose to insulin ratio was significantly lower in SGA+ than SGA− children (12.41 ± 5.01 vs. 26.54 ± 17.18; P = 0.02) and controls (26.96 ± 20.70; P = 0.04). Lag phase was significantly shorter in SGA+ than SGA− children (24.3 ± 4.38 vs. 35.59 ± 11.29 min; P = 0.003) and controls (45.28 ± 7.69 min; P = 0.0001) and in SGA− than controls (P = 0.01). Malonildialdehyde was significantly higher in SGA+ than SGA− children (0.79 ± 0.3 vs. 0.6 ± 0.1 nmol/mg; P = 0.03) and controls (0.36 ± 0.04 nmol/mg; P = 0.0001) and in SGA− children than controls (P = 0.02). Vitamin E was significantly reduced in SGA+ children than controls (27.54 ± 7.9 vs. 43.23 ± 11.32 μmol/liter; P = 0.002). Conclusion: Oxidative stress is present in both SGA+ and SGA− children, with a continuous alteration in relation to IR. Therefore, catch-up growth might exert the greatest influence in the development of future diseases.

Pre-eclampsia and eclampsia associated with increased lipid peroxidation and decreased serum vitamin E levels

1999 ◽  
Vol 64 (1) ◽  
pp. 27-33 ◽  
Author(s):  
F.F Yanik ◽  
R Amanvermez ◽  
A Yanik ◽  
C Çelik ◽  
A Kökçü
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Serum Vitamin

scholarly journals Dehydroepiandrosterone alters vitamin E status and prevents lipid peroxidation in vitamin E-deficient rats

2016 ◽  
Vol 58 (3) ◽  
pp. 223-231 ◽  
Author(s):  
Hiroshi Miyazaki ◽  
Kimitaka Takitani ◽  
Maki Koh ◽  
Akiko Inoue ◽  
Hiroshi Tamai
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Vitamin E Status

Lipid peroxidation and vitamin E status in gestational diabetes mellitus

2003 ◽  
Vol 29 (5) ◽  
pp. 300-304 ◽  
Author(s):  
Debjyoti Santra ◽  
Harjit Sawhney ◽  
Neelam Aggarwal ◽  
Siddarth Majumdar ◽  
Kala Vasishta
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Peroxidation ◽  
Vitamin E ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vitamin E Status

Effect of Long-Term Fish Oil Supplementation on Vitamin E Status and Lipid Peroxidation in Women

1991 ◽  
Vol 121 (4) ◽  
pp. 484-491 ◽  
Author(s):  
Mohsen Meydani ◽  
Felicia Natiello ◽  
Barry Goldin ◽  
Nancy Free ◽  
Margo Woods ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Fish Oil ◽  
Fish Oil Supplementation ◽  
Vitamin E Status

scholarly journals The Association Between Vitamin E Deficiency and Critically Ill Children With Sepsis and Septic Shock

2021 ◽  
Vol 8 ◽  
Author(s):  
Hongxing Dang ◽  
Jing Li ◽  
Chengjun Liu ◽  
Feng Xu
Keyword(s):  
Septic Shock ◽  
Vitamin E ◽  
Critically Ill ◽  
Serum Vitamin ◽  
Independent Effect ◽  
Critically Ill Children ◽  
Vitamin E Deficiency ◽  
Suspected Infection ◽  
Sepsis And Septic Shock ◽  
Vitamin E Status

Background: Literature is scarce on the assessment of vitamin E status in septic children. We aim to investigate the prevalence of vitamin E deficiency in critically ill children with sepsis and septic shock and its association with clinical features and outcomes.Methods: We compared serum vitamin E status between the confirmed or suspected infection and no infection groups, the sepsis shock and no sepsis shock groups upon pediatric intensive care unit admission. Clinical characteristics were compared in subgroup patients with and without vitamin E deficiency. The association between vitamin E deficiency and septic shock were evaluated using univariate and multivariable methods.Results: 182 critically ill children with confirmed or suspected infection and 114 without infection were enrolled. The incidence of vitamin E deficiency was 30.2% in the infection group and 61.9% in the septic shock subgroup (P < 0.001). Thirty-days mortality in critically ill children with vitamin E deficiency was significantly higher than that without vitamin E deficiency (27.3 vs. 14.2%, P < 0.05). Vitamin E levels were inversely associated with higher pediatric risk of mortality (r = − 0.238, P = 0.001) and cardiovascular sequential organ failure assessment (r = −0.249, p < 0.001) scores in critically ill children with infection. In multivariable logistic regression, vitamin E deficiency showed an independent effect on septic shock (adjusted OR: 6.749, 95%CI: 2.449–18.60, P < 0.001).Conclusion: Vitamin E deficiency is highly prevalent in critically ill children with sepsis and contributed to the septic shock.

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