Supplementation with organic acids showing different effects on growth performance, gut morphology and microbiota of weaned pigs fed with highly or less digestible diets

This study was conducted to investigate the effects of dietary supplementation with different organic acid (OA) mixtures on growth performance, nutrient digestibility, and gut morphology in weaned pigs. A total of 56 weaned pigs (7.93 ± 1.04 kg body weight) were assigned to four dietary treatments with seven replicates per treatment for a 35-d study conducted over two phases; phase 1 (d 1 to 14) and phase 2 (d 14 to 35). Diets consisted of 1) a corn-soybean meal-basal diet without any additive (negative control, NC); 2) NC + formic and propionic acids (TRT1); 3) NC + butyric, formic, and propionic acids (TRT2); and 4) NC + antibiotic (positive control, PC). During the overall period, the gain to feed ratio of pigs fed the PC and TRT1 diets tended to be higher (P = 0.059) than that of the NC diet. However, OA supplementation had no effects on nutrient digestibility. Jejunal villus height to crypt depth ratio was higher (P < 0.05) in pigs fed the TRT1 diet than those fed the NC diet. In conclusion, dietary OA supplementation tended to increase overall feed efficiency and improved gut morphology in weaned pigs.

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Impact of feeding blends of organic acids and herbal extracts on growth performance, gut microbiota and digestive function in newly weaned pigs

Canadian Journal of Animal Science ◽

10.4141/a04-005 ◽

2004 ◽

Vol 84 (4) ◽

pp. 697-704 ◽

Cited By ~ 107

Author(s):

H. Namkung ◽

M. Li J. Gong ◽

H. Yu ◽

M. Cottrill ◽

C. F. M. de Lange

Keyword(s):

Immune Response ◽

Gut Microbiota ◽

Organic Acids ◽

Growth Performance ◽

Dietary Treatment ◽

Intestinal Morphology ◽

Herbal Extract ◽

Coliform Bacteria ◽

Herbal Extracts ◽

Weaned Pigs

One hundred eighty newly weaned pigs were used to inves tigate effects of feeding organic acids and herbal extracts on growth performance, gut morphology and microbiota, and immune response in newly weaned pigs during a 4-wk period. There were five dietary treatments: control, Acid 1 (acetic, propionic, phosphoric and citric acid; 1.1% inclusion), Acid 2 (Acid 1 + 1.0% lactic acid), herbal extracts (0.75% inclusion; containing cinnamon, thyme and oregano extract), and antibiotic (110 ppm lincomycin). As compared to the control, pigs on antibiotic and Acid 2 showed higher (P < 0.05) ADG only during week 2 post-weaning, whereas pigs on herbal extract showed lower (P < 0.05) ADG only during week 3 post-weaning. Fecal coliform counts were lower (P < 0.08) in pigs on Acid 1 and 2 on day 4 post-weaning and in pigs on antibiotic and herbal extract on day 14 post-weaning. Fecal lactobacilli counts were lower (P < 0.05) in pigs on antibiotic on day 14 post-weaning. Based on PCR-DGGE, treatment influenced the composition of gut microbiota. The pH of the colon was lower (P < 0.05) in pigs on acid treatments and serum IgG was lower (P < 0.05) in pigs on antibiotic. Dietary treatment did not affect (P > 0.10) intestinal morphology. These results show that the inclusion of antibiotic in the diet reduced the proliferation of both potentially harmful coliform bacteria and potentially beneficial lactobacilli in the pig’s gut, while herbal extract and organic acids appeared to reduce the proliferation of coliform bacteria. Blends of organic acids can serve as an alternative to in-feed antibiotics during the first few weeks post-weaning for pigs. Key words: Piglet, organic acids, herb, microbiota, immune response, intestinal morphology

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Effects of Microencapsulated Blends of Organics Acids (OA) and Essential Oils (EO) as a Feed Additive for Broiler Chicken. A Focus on Growth Performance, Gut Morphology and Microbiology

Animals ◽

10.3390/ani10030442 ◽

2020 ◽

Vol 10 (3) ◽

pp. 442 ◽

Cited By ~ 1

Author(s):

Alessandro Stamilla ◽

Antonino Messina ◽

Sabrina Sallemi ◽

Lucia Condorelli ◽

Francesco Antoci ◽

...

Keyword(s):

Organic Acids ◽

Essential Oils ◽

Growth Performance ◽

Clostridium Perfringens ◽

Broiler Chickens ◽

Average Daily Gain ◽

Feed Additive ◽

Feed Conversion ◽

Gut Morphology ◽

Dietary Treatments

The goal of the trial was testing the effects of a blend of organic acids and essential oils dietary supplementation on growth performance and gut healthiness in broiler chickens. In total, 420 male Ross 308 chicks (1-day old) were randomly assigned to two dietary treatments: basal (BD) and organic acids and essential oils (OA&EO) diets (three replicates/treatment; 70 broilers/replicate). BD group received commercial diets whereas OA&EO group basal diets + 5 g/kg of microencapsulated organic acids and essential oils. OA&EO treatment improved the average daily gain (p < 0.01) and feed conversion ratio at 37–47 days compared to BD treatment. OA&EO treatment improved gut morphology mostly at ileum and duodenum levels in terms of villi height, crypt depth, number of villi, mucosa thickness and villi area at 24 and 34 sampling days. A certain selective action against Clostridium perfringens in ileum of OA&EO group was shown at 33 (p = 0.053) and 46 days (p = 0.09) together with lower median values for Enterobacteriaceae, Enterococci, Mesophilic bacteria and Clostridium perfringens at ceca level. Overall, organic acids and essential oils supplementation improved growth performance in the final growth stage and some morphological gut traits and reduced to a certain extent Clostridium perfringens count in ileum.

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Effect of low-protein amino acid-supplemented diets on the growth performance, gut morphology, organ weights and digesta characteristics of weaned pigs

animal ◽

10.1017/s175173110800270x ◽

2008 ◽

Vol 2 (10) ◽

pp. 1457-1464 ◽

Cited By ~ 29

Author(s):

F.O. Opapeju ◽

M. Rademacher ◽

G. Blank ◽

C.M. Nyachoti

Keyword(s):

Amino Acid ◽

Growth Performance ◽

Weaned Pigs ◽

Protein Amino Acid ◽

Gut Morphology ◽

Organ Weights ◽

Low Protein

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PSV-8 Glucocorticoid receptor agonist (GRA): what is the best delivery method to newly weaned pigs?

Journal of Animal Science ◽

10.1093/jas/skaa054.279 ◽

2020 ◽

Vol 98 (Supplement_3) ◽

pp. 158-159

Author(s):

Hailey Wooten ◽

Hwanhee Kim ◽

Amanda Rakhshandeh ◽

Anoosh Rakhshandeh

Keyword(s):

Growth Performance ◽

Performance Outcomes ◽

Nutrient Digestibility ◽

Control Group ◽

Free Access ◽

Weaned Pigs ◽

Delivery Methods ◽

Nursery Pigs ◽

Intestinal Integrity ◽

Randomized Design

Abstract We previously found that i.m. injection of GRA, similar to in-feed antibiotics, improves measures of intestinal integrity, nutrient digestibility, and overall growth performance in nursery pigs. In addition, we have demonstrated that the mitigating effects of GRA on the stress of weaning is predominantly done by subsiding the inflammatory response that often accompanies early weaning. The objective of the current study was to explore the most practical methods for delivering GRA to newly weaned pigs. One-hundred and sixty-seven PIC pigs were weaned at 25 ±1.0 days of age (BW 7 ±1.2 kg), and assigned to fourteen treatments (3-4 pigs /pen; 3 pens/treatment). Seven treatments were tested within two sexes (gilts vs. barrows). The treatments were: 1) i.m. injection of GRA (two injections, 0.2 mg/kg BW at -1 and 3 d post-weaning), 2) two levels of in-water GRA (0.8 and 1.6 ppm), 3) in-feed GRA (2.5 and 5.0 ppm), 4) in-feed antibiotic (ANT, 100 ppm tylosin), and 5) control. Dexamethasone was used as GRA. Pigs had free access to in-feed or in-water GRA or ANT during the 1st-week post-weaning. Parameters of growth performance were measured weekly until the end of the nursery phase. A completely randomized design and repeated measurement ANOVA (PROC MIXED) in SAS were used for statistical analyses. In-water, in-feed, and i.m. GRA treatments resulted in growth performance outcomes comparable to that of in-feed ANT. Relative to CON pigs, both ANT and GRA improved ADG and G: F during the nursery phase (P < 0.05). Among the delivery methods tested, 2.5 ppm of in-feed GRA resulted in superior ADG (GRA vs. CON; 0.29 vs. 0.20 kg/d) and G: F (0.63 vs. 0.40 ± 0.05), compared to the control group (P < 0.02). Collectively, these results suggested that in-feed treatment is the best method for delivering GRA to newly weaned pigs.

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PSIII-16 Growth Performance of Weaned Pigs Fed Barley Differing in Fermentable Starch and Fiber Profile

Journal of Animal Science ◽

10.1093/jas/skab054.296 ◽

2021 ◽

Vol 99 (Supplement_1) ◽

pp. 175-176

Author(s):

Joaquin J Sanchez Zannatta ◽

L F Wang ◽

Eduardo Beltranena ◽

Aaron D Beattie ◽

Rex N Newkirk ◽

...

Keyword(s):

Energy Source ◽

Growth Performance ◽

Steam Explosion ◽

Phase 1 ◽

Average Daily Gain ◽

Barley Grain ◽

Gut Health ◽

Weaned Pigs ◽

Cereal Grain ◽

Hulled Barley

Abstract Barley grain containing more fermentable starch or fiber might be an attractive energy source in weaned pig diets due to benefits on gut health. Barley rapidly-fermentable carbohydrates may serve as prebiotic and slowly-fermentable fiber may decrease diarrhea in weaned pigs. Steam-explosion processing may disrupt the fiber matrix of hulls, increasing slowly-fermentable fiber of barley. To explore, 220 pigs were fed 1 of 5 diets containing 60% cereal grain: 1) low-fermentable hulled barley (LFB); 2) LFB steam-exploded (LFB-E; 1.2 MPa, 120 s); 3) high β-glucan (10% DM) hull-less barley (HFB); 4) high amylose (17% DM) hull-less barley (HFA); or 5) low-fermentable wheat (LFW). Diets were fed starting 1-week post-weaning and formulated to provide 2.4 and 2.3 Mcal net energy (NE)/kg, 5.5 and 5.1 g standardized ileal digestible lysine/Mcal NE for phase 1 (day 1–14) and phase 2 (day 15–35), respectively. For the entire trial (day 1–35), average daily feed intake (ADFI) and average daily gain (ADG) of pigs did not differ among diets. Gain:feed (G:F) did not differ between LFB and LFW diets, but steam-explosion of hulled barley reduced (P < 0.05) G:F. Feces consistency did not differ between LFB and LFW diets, but was better (P < 0.05) for LFB than HFB, HFA and LFB-E diets. For phase 1, G:F of pigs was lower (P < 0.05) for LFB-E diet than LFW diet. For days 22–28, LFB-E diet had greater (P < 0.01) ADFI than HFA diet and tended (P = 0.09) to have a greater ADG than HFB diet. In conclusion, hulled or hull-less barley grain replaced wheat grain without affecting growth performance in weaned pigs. Hulled barley increased feces consistency. Steam-explosion of hulled barley did not increase growth performance of weaned pigs. Barley grain is an attractive energy source for weaned pigs for managing growth and feces consistency.

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PSVIII-16 The effects of adding two organic acid blends with or without high levels of zinc or copper, on post-weaning pig performance

Journal of Animal Science ◽

10.1093/jas/skaa054.362 ◽

2020 ◽

Vol 98 (Supplement_3) ◽

pp. 209-210

Author(s):

Casey L Bradley ◽

Jon Bergstrom ◽

Jeremiah Nemechek ◽

J D Hahn

Keyword(s):

Phosphoric Acid ◽

Benzoic Acid ◽

Organic Acids ◽

Organic Acid ◽

Factorial Design ◽

Sodium Butyrate ◽

Weaned Pigs ◽

Weaning Pig ◽

Pig Performance ◽

Dietary Treatments

Abstract A subset of 720 weaned pigs (6.44 ± 0.1 kg, PIC genetics, approximately 21-d of age) were used in a 42-d trial with a 2x3 factorial design evaluating the effects of adding organic acid (OA) blends [factor 1 = no organic acid (NO), Acid Pak 1 (AP1), Acid Pak 2 (AP2)] to diets with or without higher levels of Zn or Cu [factor 2 = +/-PZC] on pig performance. Pigs were allotted 10 pigs/pen to 12 weight blocks and randomly assigned the six dietary treatments. The +PZC diets contained 3000 ppm Zn (d 0-7), 2000 ppm Zn (d 8-21), and 250 ppm Cu (d 21-42) and -PZC diets contained 95 ppm Zn and 20 ppm Cu (d 0-42). The AP1 and AP2 diets used 0.9% of 2 acid premixes (d 0-21), and 0.45% of the premixes (day 22-42). AP1 provided 0.5% benzoic acid, 0.07% sodium butyrate, and 0.025% phosphoric acid (day 0-21) and half those levels (day 22-42). AP2 included the same acids as AP1 but at half the rate and combined with 7 other organic acids and carvacrol. From d 0-21, ADG, ADFI, and G:F were improved (P< 0.01) by +PZC compared to -PZC and by AP1 or AP2 compared to NO (P< 0.02). Overall (d 0-42), ADG and G:F were improved (P< 0.01) by +PZC compared to -PZC and by AP1 or AP2 compared to NO (P< .010). Data from this trial indicate that performance was improved by the addition of both OA and PZC. However, pigs fed OA and -PZC performed similarly to those fed NO and +PZC in the post-weaning period. In summary, regardless of the acid combination, organic acid supplementation has the potential to improve growth performance in weaned pigs.

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Wheat bran fermented by mixed fungal strains improves the digestibility of crude fiber and may benefit the gut health without impacting the growth performance in weaned pigs

Food & Function ◽

10.1039/d1fo00273b ◽

2021 ◽

Vol 12 (7) ◽

pp. 2962-2971

Author(s):

Yuheng Luo ◽

Jun He ◽

Hua Li ◽

Cong Lan ◽

Jingyi Cai ◽

...

Keyword(s):

Growth Performance ◽

Wheat Bran ◽

Nutrient Digestibility ◽

Crude Fiber ◽

Gut Health ◽

Intestinal Health ◽

Weaned Piglets ◽

Weaned Pigs ◽

Fungal Strains

This study was conducted to compare the effect of raw (WB) or mixed fungi-fermented wheat bran (FWB) on the growth, nutrient digestibility and intestinal health in weaned piglets.

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