PSV-8 Glucocorticoid receptor agonist (GRA): what is the best delivery method to newly weaned pigs?

Abstract We previously found that i.m. injection of GRA, similar to in-feed antibiotics, improves measures of intestinal integrity, nutrient digestibility, and overall growth performance in nursery pigs. In addition, we have demonstrated that the mitigating effects of GRA on the stress of weaning is predominantly done by subsiding the inflammatory response that often accompanies early weaning. The objective of the current study was to explore the most practical methods for delivering GRA to newly weaned pigs. One-hundred and sixty-seven PIC pigs were weaned at 25 ±1.0 days of age (BW 7 ±1.2 kg), and assigned to fourteen treatments (3-4 pigs /pen; 3 pens/treatment). Seven treatments were tested within two sexes (gilts vs. barrows). The treatments were: 1) i.m. injection of GRA (two injections, 0.2 mg/kg BW at -1 and 3 d post-weaning), 2) two levels of in-water GRA (0.8 and 1.6 ppm), 3) in-feed GRA (2.5 and 5.0 ppm), 4) in-feed antibiotic (ANT, 100 ppm tylosin), and 5) control. Dexamethasone was used as GRA. Pigs had free access to in-feed or in-water GRA or ANT during the 1st-week post-weaning. Parameters of growth performance were measured weekly until the end of the nursery phase. A completely randomized design and repeated measurement ANOVA (PROC MIXED) in SAS were used for statistical analyses. In-water, in-feed, and i.m. GRA treatments resulted in growth performance outcomes comparable to that of in-feed ANT. Relative to CON pigs, both ANT and GRA improved ADG and G: F during the nursery phase (P < 0.05). Among the delivery methods tested, 2.5 ppm of in-feed GRA resulted in superior ADG (GRA vs. CON; 0.29 vs. 0.20 kg/d) and G: F (0.63 vs. 0.40 ± 0.05), compared to the control group (P < 0.02). Collectively, these results suggested that in-feed treatment is the best method for delivering GRA to newly weaned pigs.

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Performance and nutrient digestibility of broiler chickens fed graded levels of fermented and toasted seed meal

Nigerian Journal of Animal Production ◽

10.51791/njap.v45i2.458 ◽

2020 ◽

Vol 45 (2) ◽

pp. 150-156

Author(s):

D. N. Tsado ◽

A. H. Dikko ◽

O. J. Alabi ◽

T. N. Kperun ◽

B. K. Jiya ◽

...

Keyword(s):

Growth Performance ◽

Feed Intake ◽

Broiler Chickens ◽

Nutrient Digestibility ◽

Seed Meal ◽

Control Group ◽

Albizia Lebbeck ◽

Final Body Weight ◽

Randomized Design ◽

Better Than

This study was conducted to investigate the effects of fermented and toasted Albizia lebbeck seed meal (FTALSM), on the growth performance and nutrient digestibility of broiler chickens at the starter and finisher phases. One hundred and fifty (150) day old chicks (Abo acres) were used for this study and were divided into five treatments (with three replicate each containing 10 birds) using a completely randomized design (CRD) for eight weeks. The treatments were five diets containing 0% (control), 5%, 10%, 15% and 20% of fermented and toasted Albizia lebbeck seed meal (FTALSM), respectively and were tagged Diet 1, 2, 3, 4 and 5. The diets were formulated to be isocaloric and isonitrogenous. The feed intake at the starter phase was significantly higher (p<0.05) in Diets 3 and 4 which had 10 and 15% inclusion of FTALSM, respectively. Diets 2, 3 and 4 also differ significantly (p<0.05) in final body weight and total weight gained from the control diets. The results at the finisher phase indicated that, there were significant differences (P<0.05) in all the parameters measured except for mortality. Birds fed Diet 2 performed significantly better in weight gain (1453g) and feed intake (3087.25g) compared to the control group. Birds on the control and Diet 2 had similar feed efficiency, the values were however, better than those on the other treatments. The results of nutrient digestibility showed birds fed Diet 5 (20% FTALSM) recorded significantly (P<0.05) low digestibility values in all parameters measured. The results showed that fermentation and toasting reduced phytase, oxalate and cyanide by 41.87, 26.67 and 99.94 % respectively. It can be concluded therefore, that FTALSM can be included up to 15 % in broiler chickens starter diets and 5 % in the finisher diet for optimum growth performance.

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The Effects of a Glucocorticoid Receptor Agonist (GRA) on the Immune Function, Nutrient Digestibility, and Wean-to-Finish Growth Performance of Early-Weaned Pigs

Animals ◽

10.3390/ani10060953 ◽

2020 ◽

Vol 10 (6) ◽

pp. 953 ◽

Cited By ~ 1

Author(s):

Hailey Wooten ◽

Hwanhee Kim ◽

Amanda R. Rakhshandeh ◽

Anoosh Rakhshandeh

Keyword(s):

Glucocorticoid Receptor ◽

Growth Performance ◽

Receptor Agonist ◽

Nutrient Digestibility ◽

Feed Ratio ◽

Control Group ◽

Blood Collection ◽

Weaned Pigs ◽

Weaning Stress ◽

Dietary Nutrient

This study assessed the viability of glucocorticoid receptor agonist (GRA) treatment as an alternative to in-feed antibiotics (ANT) in wean-to-finish pigs. A total of 209 piglets were assigned to eight treatments based on a factorial arrangement, with GRA (+ vs. −; dexamethasone, 0.2 mg/kg body weight, BW), ANT (+ vs. −; 110 mg/kg in-feed Tylosin) and sex (gilt vs. barrow) as the main factors. The serial slaughter technique and serial blood collection were performed on 115 pigs during the first week post-weaning to collect blood, tissue and ileal digesta samples. Fecal samples were collected to determine energy digestibility. In comparison to ANT, GRA more effectively improved the measures of systemic inflammation, protein utilization and recovery-associated biomarkers (p ≤ 0.05). Relative to the control group, GRA treatment improved (p ≤ 0.03) dietary nutrient digestibility relative to control pigs, which was comparable to ANT effects. Relative to the control group, all groups had a higher ADG and BW during the starter phase (p < 0.01). Similar to the ANT group, GRA improved the gain-to-feed ratio relative to the control group during the starter phase. Relative to control pigs, overall BW was higher in GRA and ANT pigs during the grow-to-finish phase (p < 0.01). Collectively, these results suggest that GRA injection improves the growth performance of newly weaned pigs by reducing weaning-induced inflammation and improving nutrient digestibility. GRA can be used as an alternative to in-feed ANT to mitigate the effects of weaning stress on pigs.

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Effect of carbohydrase supplementation of wheat- and canola-meal-based diets on growth performance and nutrient digestibility in group-housed weaned pigs

Canadian Journal of Animal Science ◽

10.4141/a03-127 ◽

2004 ◽

Vol 84 (4) ◽

pp. 689-695 ◽

Cited By ~ 22

Author(s):

R. T. Zijlstra ◽

S. Li ◽

A. Owusu-Asiedu ◽

P. H. Simmins ◽

J. F. Patience

Keyword(s):

Small Intestine ◽

Growth Performance ◽

Feed Intake ◽

Feed Efficiency ◽

Control Diet ◽

Nutrient Digestibility ◽

Canola Meal ◽

Free Access ◽

Weaned Pigs ◽

Digesta Viscosity

Fibrous components in canola meal and wheat limit their effective use in diets for weaned pigs. Effects of supplementing a carbohydrase (845 and 327 Units g-1 xylanase and β-glucanase) to a wheat-canola meal diet on growth performance, small intestine nutrient digestibility and digesta viscosity were investigated. Ninety-six weaned pigs (7.2 ± 1.2 kg) had free access to control diet [65% wheat, 25% canola meal; 3.15 Mcal digestible energy (DE) kg-1, 10.6 g digestible lysine kg-1] or control diet supplemented with carbohydrase at three inclusion rates (1, 2, or 4 g kg-1) for 28 d. Four pigs were housed per pen for six pens per diet. On days 19 to 21, six pigs per diet were euthanised to collect small intestine digesta. Carbohydrase increased average daily feed intake (ADFI) and average daily gain (ADG) quadratically (P < 0.01) for days 1 to 28, resulting in 16% higher ADFI and 13% higher ADG for 2 g kg-1 carbohydrase compared to control. Carbohydrase did not affect feed efficiency (P > 0.10). The ADG was positively correlated to ADFI (r = 0.94; P < 0.01), but not to feed efficiency (P > 0.10). Carbohydrase did not affect digestibility of dry matter (DM) and energy (P > 0.10). Carbohydrase at 4 g kg-1 only reduced digesta viscosity 30% in the distal small intestine compared to control (P < 0.05). Carbohydrase supplementation increased ADFI and thereby ADG, but not feed efficiency and nutrient digestibility, suggesting that reduction of dietary fibrous components using carbohydrase may stimulate voluntary feed intake of pigs fed diets limiting in DE. Key words: Carbohydrase, canola meal, wheat, pig, feed intake, digestibility

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82 Glucocorticoid receptor agonist (GRA): an alternative to in-feed antibiotics (ANT) for newly weaned pigs

Journal of Animal Science ◽

10.1093/jas/skz122.084 ◽

2019 ◽

Vol 97 (Supplement_2) ◽

pp. 46-47 ◽

Cited By ~ 1

Author(s):

Hailey Wooten ◽

John J McGlone ◽

Arlene Garcia ◽

Amanda R Rakhshandeh ◽

Anoosh Rakhshandeh

Keyword(s):

Growth Performance ◽

Repeated Measures ◽

Blood Chemistry ◽

Feed Ratio ◽

Free Access ◽

Weaned Pigs ◽

Nursery Pigs ◽

Weaning Stress ◽

Feeding Program ◽

Main Effects

Abstract Previously we found that GRA reduces systemic inflammation in newly weaned pigs. Therefore, we evaluated the effects of GRA on growth performance and blood chemistry in newly weaned pigs, since inflammation impacts growth. A total of 209 pigs (BW 7.4 ±1.27 kg) were weaned at 26 ±1.5-d of age and assigned to a factorial CRD, with sex and treatment as main effects. Treatments included control (CON), GRA, ANT, and ANT+GRA (ANGA). Dexamethasone (0.2 mg/kg BW; i.m. injections) and Tylan 40 (0.12% of diet) were used as GRA and ANT, respectively. Pigs had free access to conventional corn-soybean diets according to a phase-feeding program. Feed intake, BW, ADG, measures of blood chemistry and hematocrit were determined over the 28-d post-weaning period. The repeated measures ANOVA (PROC MIXED) in SAS was used for statistical analysis. Interaction effects of sex and treatments were observed on BW and ADG (P = 0.03), but not on the gain-to-feed ratio (G:F). BW (kg) was higher in GRA gilts (10 ±0.08) than ANT gilts (9.7 ±0.06) and barrows (9.6 ±0.05), and CON barrows (9.4 ±0.09; P = 0.01). GRA gilts tended to be heavier than CON gilts (9.8 ±0.10; P = 0.06). ADG (kg) was higher in GRA gilts (0.40 ±0.014) than ANT gilts (0.34 ±0.019), CON barrows (0.29 ±0.016) and ANT barrows (0.36 ±0.012; P = 0.05). Overall G:F was higher in GRA pigs than CON pigs (0.63 vs. 0.56 ±0.020; P = 0.01) and tended to be higher than ANT pigs (P = 0.09). Creatinine levels tended to be lower in GRA pigs than ANT pigs (1.18 vs. 1.30 ±0.046 mg/dl; P = 0.07). Treatments had no effects on other measures of blood chemistry. Collectively, treatment with GRA effectively improves the growth performance of nursery pigs, especially gilts, during the nursery phase. GRA can be considered as an alternative to in-feed antibiotics for mitigating the adverse effects of weaning stress. USDA-NIFA-2017-68008-26304.

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Effects of Rocket Seed Oil, Wheat Germ Oil, and Their Mixture on Growth Performance, Feed Utilization, Digestibility, Redox Status, and Meat Fatty Acid Profile of Growing Rabbits

Agriculture ◽

10.3390/agriculture11070662 ◽

2021 ◽

Vol 11 (7) ◽

pp. 662

Author(s):

Sabrin Abdelrahman Morshedy ◽

Ahmed M. Abdelmodather ◽

Mohamed M. Basyony ◽

Soliman A. Zahran ◽

Mohamed A. Hassan

Keyword(s):

Immune Response ◽

Fatty Acid ◽

Growth Performance ◽

Wheat Germ ◽

Seed Oil ◽

Average Daily Gain ◽

Feed Utilization ◽

Nutrient Digestibility ◽

Control Group ◽

Wheat Germ Oil

Vegetable oils are a source of natural antioxidants, including tocopherols, sterols, phenolic compounds, coenzymes, and polyunsaturated fatty acids that provide nutritional value, organoleptic properties, and significantly delay or prevent lipid oxidation. Eighty-four V-line rabbits at 5 weeks of age with an initial body weight (BW) of 535.60 ± 13.48 g were assigned randomly to four experimental groups (seven replicates in each group with three rabbits each). The first group served as a control and received 0.3 mL/kg BW of distilled water (CON), while the second and third groups received 0.3 mL/kg BW of rocket seed oil (RSO) and wheat germ oil (WGO), respectively. The fourth group received a mixture of oils consisting of 0.15 mL of RSO and 0.15 mL of WGO/kg BW (MOs). The experiment lasted 7 weeks. The study investigated the effects of RSO, WGO, and their mixture on growth performance, feed utilization, antioxidant status, and immune response of growing rabbits. The results indicated that the rabbits that were administered orally with RSO and WGO or their mixture had higher (p ≤ 0.05) final BW, weight gain, and average daily gain when compared to the control group. In addition, the feed conversion ratio improved significantly with RSO, WGO, and MOs treatments. Different oil treatments improved nutrient digestibility, nutritive value, and nitrogen balance. Moreover, the rabbits that received RSO, WGO, and their mixture had an improvement the meat fatty acid composition compared to the control rabbits. Oral administration of RSO, WGO, and their mixture significantly improved serum protein fractions, decreased blood urea nitrogen, and had a positive effect on serum total lipids, HDL-c, and LDL-c. Furthermore, the treatments of RSO, WGO, and MOs had a significant improvement in the antioxidative status and immune response.

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268 In-feed Antibiotics Elicit Intestinal Integrity Modifications Early in Post-weaning Life

Journal of Animal Science ◽

10.1093/jas/skab054.158 ◽

2021 ◽

Vol 99 (Supplement_1) ◽

pp. 99-99

Author(s):

Jessica M Johnson ◽

Emma T Helm ◽

Nicholas K Gabler ◽

Eric R Burrough ◽

Carson M De Mille

Keyword(s):

Growth Performance ◽

Fixed Effects ◽

Ex Vivo ◽

Phase 1 ◽

Physiological Mechanisms ◽

Nursery Pigs ◽

Ussing Chambers ◽

Intestinal Integrity ◽

And Function ◽

Dietary Treatments

Abstract The physiological mechanisms by which in-feed antibiotics improve pig growth performance are largely unknown. One proposed mode of action is improvements in intestinal integrity and function. Therefore, the objective of this study was to test the hypothesis that in-feed therapeutic and sub-therapeutic antibiotics would improve intestinal integrity and function in nursery pigs. Twenty-four weaned pigs (6.1±1.1 kg BW) were randomly allotted to individual pens and assigned one of three dietary treatments as follows (n = 8 pigs/trt): 1) control, no antibiotics (CON), 2) CON + sub-therapeutic chlortetracycline [40 ppm in feed (sCTC)], and 3) CON + chlortetracycline-tiamulin [400 ppm + 35 ppm, respectively (CTCDen)]. The study consisted of two consecutive 14 d phases. Chlortetracycline-tiamulin was only fed in phase 1, sCTC was fed in both phases. Phase 1 and 2 ADG, ADFI, and G:F were determined. After 28 d, ileal and colonic ex vivo intestinal integrity was assessed via transepithelial resistance (TER) and macromolecule flux (FD4) in modified Ussing chambers. All data were analyzed for the fixed effects of treatment and start BW as a covariate. In phase 1, compared with CON and sCTC, CTCDen tended to have greater ADG (0.28, 0.31, and 0.33 kg/d, respectively, P = 0.10) and ADFI (0.28, 0.30, and 0.35 kg/d, respectively, P = 0.09). No differences in phase 1 G:F were observed (P = 0.11). Phase 2 ADG, ADFI, and G:F did not differ (P > 0.10). Further, ileal TER and FD4 did not differ (P > 0.10). Colonic TER tended to be increased in sCTC compared with CON and CTCDen (78, 56, and 59 Ω/cm2, respectively, P = 0.07). Compared with CON, colonic FD4 flux was decreased in sCTC and CTCDen by 35–40% (P = 0.03). Altogether, these data indicate that in-feed antibiotics improve colon integrity early in production which may contribute to improved growth performance.

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Effects of Defatted Rice Bran Inclusion Level on Nutrient Digestibility and Growth Performance of Different Body Weight Pigs

Animals ◽

10.3390/ani11051374 ◽

2021 ◽

Vol 11 (5) ◽

pp. 1374

Author(s):

Bingbing Huang ◽

Huangwei Shi ◽

Li Wang ◽

Lu Wang ◽

Zhiqian Lyu ◽

...

Keyword(s):

Body Weight ◽

Growth Performance ◽

Rice Bran ◽

Nutrient Digestibility ◽

Growing Pigs ◽

Neutral Detergent Fiber ◽

Control Group ◽

Defatted Rice Bran ◽

Gross Energy ◽

Stage 1

This study was conducted to determine the effects of low-protein diet prepared with different levels of defatted rice bran (DFRB) and weight stages on growth performance and nutrient digestibility of growing–finishing pigs. The animal experiment included three stages. A total of 240 growing pigs with an initial body weight of 28.06 ± 8.56 kg for stage 1 were allocated to five diets including one control group and four DFRB diets supplemented with 2.5%, 5%, 7.5% and 10% DFRB, respectively. The 192 crossbred pigs with initial body weights of 55.03 ± 7.31 kg and 74.55 ± 9.10 kg were selected for stage 2 and stage 3, respectively. Pigs were allocated to four diets including one control group and three DFRB diets supplemented with 10%, 15% and 20% DFRB, respectively. The results showed that with the increase in DFEB intake, the gain: feed was linearly increased (p < 0.05), and the average daily feed intake tended to linearly decrease (p = 0.06) in stage 1. Except for the apparent total tract digestibility (ATTD) of acid detergent fiber (ADF) in stage 3, levels of DFRB had significant effects on the ATTD of gross energy (GE), dry matter (DM), ash, neutral detergent fiber (NDF) and ADF in three weight stages. In stage 1, with the increase in levels of DFRB, the ATTD of NDF and hemicellulose were firstly increased and then decreased (p < 0.01). In stage 2, with the increasing levels of DFRB, the ATTD of DM, ash and cellulose were firstly increased and then decreased (p < 0.01). In stage 3, the ATTD of GE, DM, ash, NDF and hemicellulose decreased linearly with the increase in levels of DFRB (p < 0.01). Collectively, DFRB could be used as a replacement for corns and soybean meal, and weight stage is important to consider when adjusting the additive proportion.

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Wheat bran fermented by mixed fungal strains improves the digestibility of crude fiber and may benefit the gut health without impacting the growth performance in weaned pigs

Food & Function ◽

10.1039/d1fo00273b ◽

2021 ◽

Vol 12 (7) ◽

pp. 2962-2971

Author(s):

Yuheng Luo ◽

Jun He ◽

Hua Li ◽

Cong Lan ◽

Jingyi Cai ◽

...

Keyword(s):

Growth Performance ◽

Wheat Bran ◽

Nutrient Digestibility ◽

Crude Fiber ◽

Gut Health ◽

Intestinal Health ◽

Weaned Piglets ◽

Weaned Pigs ◽

Fungal Strains

This study was conducted to compare the effect of raw (WB) or mixed fungi-fermented wheat bran (FWB) on the growth, nutrient digestibility and intestinal health in weaned piglets.

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129 Effects of a multi-strain Bacillus subtilis-based direct-fed microbial on growth performance, nutrient digestibility, and colonic pH in diets fed to weanling pigs

Journal of Animal Science ◽

10.1093/jas/skaa278.185 ◽

2020 ◽

Vol 98 (Supplement_4) ◽

pp. 101-102

Author(s):

Jaron R Lewton ◽

Adrienne Woodward ◽

Ronny Moser ◽

Kyan M Thelen ◽

Adam J Moeser ◽

...

Keyword(s):

Amino Acids ◽

Bacillus Subtilis ◽

Growth Performance ◽

Distal Colon ◽

Nutrient Digestibility ◽

Nursery Pigs ◽

Fiber Digestion ◽

Males And Females ◽

Dietary Treatments ◽

The Impact

Abstract A study was conducted to evaluate the effects of a multi-strain Bacillus subtilis-based direct-fed microbial (DFM) on apparent digestibility and colonic pH of nursery pigs. Eighty pigs, of equal number of barrows and gilts (initial BW: 6.99 ± 1.67 kg), were weaned at 21 ± 1 d and randomly allotted to sixteen pens, with five pigs per pen. Two dietary treatments were implemented, a basal control (CON) and a control plus DFM (DFM). Both diets were corn, soybean meal, and distillers dried grains based, formulated to meet all or exceed all nutritional requirements, and manufactured on site. Diets were fed for 42 days. Performance measures were recorded weekly. On d 21 and 42 of the experiment, one pig per pen was randomly selected and euthanized, with equal number of males and females represented. Digestibility of specific nutrients was evaluated within the duodenum, jejunum, ileum, ascending and distal colon. There were no overall differences in growth performance. Overall means ± SD were 0.51 ± 0.05 kg/d, 0.79 ± 0.05 kg/d and 0.66 ± 0.05 for ADG, ADFI, and G:F, respectively. Digestibility of tryptophan within the jejunum tended (P = 0.06) to increase with addition of DFM, as did cysteine (P = 0.12) and methionine (P = 0.10). The analysis also suggested that the impact of the DFM on the digestibility of amino acids may be early in the nursery phase. The pH of contents in ascending colon, a possible indicator of varied fiber digestion, did not differ. Likewise, no differences were observed between treatment in apparent total tract nitrogen and energy digestibility (analysis of distal colon contents). The addition of a multi-strain Bacillus subtilis-based DFM appears to impact digestibility of select amino acids depending upon location in the gastrointestinal tract.

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173 Lysed Corynebacterium glutamicum cell mass from lysine production as a novel feed additive to enhance gut health and growth of newly-weaned pigs

Journal of Animal Science ◽

10.1093/jas/skaa054.139 ◽

2020 ◽

Vol 98 (Supplement_3) ◽

pp. 77-78

Author(s):

Yi-Chi Cheng ◽

Marcos E Duarte ◽

Sung Woo Kim

Keyword(s):

Growth Performance ◽

Corynebacterium Glutamicum ◽

Block Design ◽

Cell Mass ◽

Nutrient Digestibility ◽

Feed Additive ◽

Jejunal Mucosa ◽

Gut Health ◽

Weaned Pigs ◽

Dietary Treatments

Abstract The objective was to determine the functional and nutritional values of Corynebacterium glutamicum Cell Mass (CGCM) on growth performance and gut health of newly-weaned pigs. Forty newly-weaned pigs (21 d of age; initial BW 7.1 ± 0.4 kg) were allotted to 5 dietary treatments based on randomized complete block design with sex and BW as blocks. The lysine broth of CGCM (CJ Bio, Fort Dodge, IA) was homogenized by using French press and dried to obtain lysed CGCM. Dietary treatments were: basal diet with lysed CGCM at 0, 0.7, 1.4, 2.1%, and with 1.4% intact CGCM. Experimental diets were formulated based on nutrient requirements (NRC, 2012) and pigs were fed based on 2 phases (10 and 11 d for each phase). Titanium dioxide (0.4%) was added to phase 2 diets as an indigestible external marker to calculate nutrient digestibility. Feed intake and BW were measured at d 0, 10, and 21. Pigs were euthanized on d 21 to collect proximal and distal jejunal mucosa to measure TNF-α, IL-8, MDA, IgA, and IgG concentrations. Diets and ileal digesta were collected to measure AID. Data were analyzed by SAS using MIXED, REG, and GLM procedures. Overall, increasing daily lysed CGCM intake increased (P < 0.05) ADG (211 to 296 g) and ADFI (432 to 501 g). Increasing levels of lysed CGCM decreased (P < 0.05) MDA and changed (quadratic, P < 0.05) IgA (max: 4.90 ng/mg at 1.13%) and IgG (max: 3.37 ng/mg at 1.04%) in the proximal jejunal mucosa. Increasing daily lysed CGCM intake had quadratic effect (P< 0.05) of protein carbonyl (max: 6.3 μmol/mg at 4.9 g/d). Lysed CGCM potentially benefits growth performance and gut health of newly-weaned pigs by reducing oxidative stress and increasing immune response.

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