scholarly journals 139 Nutrigenetics/Nutrigenomics: Nutrient-gene interactions in humans and animals

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 134-135
Author(s):  
Artemis P Simopoulos
Keyword(s):  
Cardiovascular Disease ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Genetic Variants ◽  
Genetic Variant ◽  
Fatty Acid Desaturase ◽  
Omega 3 Fatty Acids ◽  
Human Beings ◽  
Omega 3 ◽  
Omega 6

Abstract Human beings evolved on a diet that was balanced in the omega-6 and omega-3 essential fatty acids to which their genes were programmed to respond. Studies on gene-nutrient interactions using methods from molecular biology and genetics have clearly shown that there are genetic differences in the population, as well as differences in the frequency of genetic variations that interact with diet and influence the growth and development of humans and animals, as well as overall health and chronic disease. Nutrigenetics refers to studies on the role of genetic variants and their response to diet. For example, persons with genetic variants in the metabolism of omega-6 and omega-3 fatty acids have different levels of arachidonic acid (AA) and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) based on the type of genetic variant in the Fatty Acid Desaturase 1 (FADS1) and Fatty Acid Desaturase 2 (FADS2). At the same level of linoleic acid (LA) and alpha-linolenic acid (ALA) a person with a genetic variant that increases the activity of the FADS1 will have a higher AA in the red cell membrane phospholipids and a higher risk for obesity and cardiovascular disease. Nutrigenomics refers to how nutrients (diets) influence the expression of genes. For example, diets rich in omega-3 fatty acids, EPA and DHA decrease the expression of inflammatory genes and as a result decrease the risk of obesity and cardiovascular disease. Thus, through studies on Nutrigenetics/Nutrigenomics nutritional science stands at its “golden threshold” where personalized nutrition is the future, to improve an individual’s health.

scholarly journals Identification of Novel Acinetobacter baumannii Host Fatty Acid Stress Adaptation Strategies

mBio ◽  
2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Jhih-Hang Jiang ◽  
Karl A. Hassan ◽  
Stephanie L. Begg ◽  
Thusitha W. T. Rupasinghe ◽  
Varsha Naidu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Acinetobacter Baumannii ◽  
Bacterial Membrane ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Efflux System ◽  
Content Type ◽  
Omega 3 Fatty Acid ◽  
Omega 6

ABSTRACT Free fatty acids hold important immune-modulatory roles during infection. However, the host’s long-chain polyunsaturated fatty acids, not commonly found in the membranes of bacterial pathogens, also have significant broad-spectrum antibacterial potential. Of these, the omega-6 fatty acid arachidonic acid (AA) and the omega-3 fatty acid decosahexaenoic acid (DHA) are highly abundant; hence, we investigated their effects on the multidrug-resistant human pathogen Acinetobacter baumannii. Our analyses reveal that AA and DHA incorporate into the A. baumannii bacterial membrane and impact bacterial fitness and membrane integrity, with DHA having a more pronounced effect. Through transcriptional profiling and mutant analyses, we show that the A. baumannii β-oxidation pathway plays a protective role against AA and DHA, by limiting their incorporation into the phospholipids of the bacterial membrane. Furthermore, our study identified a second bacterial membrane protection system mediated by the AdeIJK efflux system, which modulates the lipid content of the membrane via direct efflux of lipids other than AA and DHA, thereby providing a novel function for this major efflux system in A. baumannii. This is the first study to examine the antimicrobial effects of host fatty acids on A. baumannii and highlights the potential of AA and DHA to protect against A. baumannii infections. IMPORTANCE A shift in the Western diet since the industrial revolution has resulted in a dramatic increase in the consumption of omega-6 fatty acids, with a concurrent decrease in the consumption of omega-3 fatty acids. This decrease in omega-3 fatty acid consumption has been associated with significant disease burden, including increased susceptibility to infectious diseases. Here we provide evidence that DHA, an omega-3 fatty acid, has superior antimicrobial effects upon the highly drug-resistant pathogen Acinetobacter baumannii, thereby providing insights into one of the potential health benefits of omega-3 fatty acids. The identification and characterization of two novel bacterial membrane protective mechanisms against host fatty acids provide important insights into A. baumannii adaptation during disease. Furthermore, we describe a novel role for the major multidrug efflux system AdeIJK in A. baumannii membrane maintenance and lipid transport. This core function, beyond drug efflux, increases the appeal of AdeIJK as a therapeutic target.

From Homicide to Happiness – A Commentary on Omega-3 Fatty Acids in Human Society

2007 ◽  
Vol 19 (1-2) ◽  
pp. 9-19 ◽  
Author(s):  
Joseph R. Hibbeln
Keyword(s):  
Risk Factors ◽  
Fatty Acids ◽  
Fatty Acid ◽  
American Psychiatric Association ◽  
Human Society ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Increased Risk ◽  
Omega 6

The field of omega-3 fatty acid deficiencies as reversible risk factors in major psychiatric disorders has flourished in the last decade. Treatment recommendations of the American Psychiatric Association may be considered for application to more normative states of psychiatric health. Considered here is the proposition that an increased risk of personality disorders, and an increased sense of despair in normative populations, might be considered as symptoms of deficiencies of omega-3 fatty acids. The major changes in the essential fatty acid composition of the food supply, including increased availability of the omega-6 linoleic acid, may be correlated not only with increased risks of homicide, but also increased risks of suicide and suboptimal social cohesion.

scholarly journals Effects of Omega-3 Polyunsaturated Fatty Acids and Their Metabolites on Haemostasis—Current Perspectives in Cardiovascular Disease

2021 ◽  
Vol 22 (5) ◽  
pp. 2394
Author(s):  
Jacek Golanski ◽  
Patrycja Szymanska ◽  
Marcin Rozalski
Keyword(s):  
Cardiovascular Disease ◽  
Fatty Acids ◽  
Blood Platelets ◽  
Epidemiological Studies ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Beneficial Effects ◽  
Omega 6 ◽  
Supporting Tool ◽  
Higher Doses

The beneficial effects of long-chain polyunsaturated omega-3 fatty acids (omega-3 PUFAs) in cardioprotection are widely known and generally accepted. In this literature review, we have focused on the known and postulated mechanisms of action of omega-3 PUFAs and their metabolites on various components of the haemostatic system, in particular on blood platelets and endothelium. We have also made an attempt to provide a comprehensive review of epidemiological studies with particular regard to clinical trials. Notably, the results of these studies are contradictory, and some of them failed to report the beneficial effects of taking or supplementing omega-3 PUFAs in the diet. A potential explanation, in our opinion, could be the need to use higher doses of omega-3 PUFAs and a proper ratio of omega-3 and omega-6 PUFAs. An additional problem which is difficult to solve is the use of a proper neutral placebo for interventional studies. Despite some controversies regarding the beneficial effects of supplementation of omega-3 PUFAs in cardiovascular disease, our review suggests that a promising aspect of future studies and applications is to focus on the anti-thrombotic properties of these compounds. An argument supporting this assumption is the recent use of omega-3 PUFAs as a supporting tool for the treatment of COVID-19 complications.

scholarly journals Role of blood plasma fatty acids in pathogenesis of stable anginapectoris

2007 ◽  
Vol 6 (4) ◽  
pp. 41-45
Author(s):  
V. V. Novitsky ◽  
R. S. Karpov ◽  
S. V. Klimenkov ◽  
A. B. Salmina ◽  
M. Yu. Kotlovsky ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Saturated Fatty Acids ◽  
Control Group ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Men And Women ◽  
Number Of Patients ◽  
Omega 6 ◽  
Functional Classes

In men and women suffering from stable angina pectoris of 1-2 functional classes and aged from 35 to 69 years old, decrease of C 23:0 and increase of C 18:1(11) fatty acids was observed regardless of sex, the content of the rest fatty acids changed depending on patients sex. Correlation was found that metabolism of fatty acids in this pathology group depends on patients sex: men in the control group showed decrease in the sum of omega-3 fatty acids as well as in the omega-3/omega-6 fatty acid ratio, while women showed decrease of omega-6 fatty acids at the constant sum of omega-3 fatty acids. Regardless of sex, the presence of this pathology is accompanied with decrease in correlations between fatty acids, as the number of correlations between saturated fatty acids increases and the number of correlations between not saturated and saturated fatty aсids decreases. Change in correlations between not saturated fatty acids depends on sex. In the number of patients having supernormal fatty acid contents, no pronounced differences were found between men and women.

scholarly journals Potensi Pemberian Cod Liver Oil (CLO) pada Pakan Komersial Terhadap Jumlah Total Asam Lemak Omega 3 dan Omega 6 Di Daging Udang Galah (Macrobrachium Rosenbergii) [Potential Of Giving Cod Liver Oil (CLO) Commercial Feed On To The Total Amount of Omega 3 and Omega 6 Fatty Acid in Meat Giant Freshwater Prawn (Macrobrachium Rosenbergii)]

2017 ◽  
Vol 9 (1) ◽  
pp. 65
Author(s):  
Hartik Hartik ◽  
Boedi Setya Rahardja ◽  
Agustono Agustono
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Unsaturated Fatty Acid ◽  
Macrobrachium Rosenbergii ◽  
Cod Liver Oil ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Commercial Feed ◽  
Omega 6 ◽  
Poly Unsaturated Fatty Acid

                                                              AbstrakAsam lemak omega 3 dan omega 6 adalah asam lemak tak jenuh yang termasuk kedalam golongan Poly Unsaturated Fatty Acid (PUFA) dan juga termasuk dalam kelompok asam lemak esensial. Asam lemak omega 3 dan omega 6 tidak dapat disintesis sendiri oleh tubuh, sehingga perlu adanya suplai asam lemak omega 3 dan omega 6 di makanan yang dikonsumsi. Fungsi dari asam lemak omega 3 dan omega 6 secara fisiologis yaitu sebagai sumber penting dalam menunjang pertumbuhan dan kelangsungan hidup krustacea. Penelitian ini bertujuan untuk mengetahui potensi pemberian Cod Liver Oil (CLO) pada pakan komersial terhadap jumlah total asam lemak omega 3 dan omega 6 di daging udang galah (Macrobrachium rosenbergii). Metode penelitian yang digunakan adalah percobaan dengan Rancangan Acak Lengkap sebagai rancangan percobaan. Perlakuan yang digunakan adalah kandungan Cod Liver Oil (CLO) yang berbeda, yaitu P0 (0%), P1 (3%), P2(6%), P3 (9%), P4(12%) masing-masing perlakuan diulang sebanyak 4 kali. Parameter utama yang diamati adalah jumlah total asam lemak omega 3 dan omega 6 di daging udang galah. Parameter penunjang yang diamati adalah parameter kualitas air. Analisis data menggunakan analisis of varian (ANOVA) dan untuk mengetahui perlakuan terbaik dilakukan uji jarak berganda Duncan. Hasil penelitian pemberian Cod Liver Oil (CLO) menunjukkan berbeda nyata (P<0,05) terhadap jumlah total asam lemak omega 3 tetapi tidak berbeda nyata (P>0,05) dengan jumlah total asam lemak omrga 6 di daging udang galah (Macrobrachium rosenbergii). Jumlah total asam lemak omega 3 pada perlakuan P0 (0%) berbeda nyata dengan perlakuan P2 (6%), P3 (9%) dan P4 (12%), tetapi tidak berbeda nyata dengan perlakuan P1. Jumlah total asam lemak omega 6 pada perlakuan P0 (0%) tidak berbeda nyata dengan perlakuan P1 (3%), P2 (6%), P3 (9%) dan P4 (12%).                                                                AbstractFatty acids omega 3 and omega 6 unsaturated fatty acids are included into class Poly Unsaturated Fatty Acid (PUFA) and is also included in a group of essential fatty acids.Fatty acids omega 3 and omega 6 can not be synthesized by the body, so it is necessary to supply fatty acids omega 3 and omega 6 in the food consumed. This study aims to determine the potential for the provision of Cod Liver Oil (CLO) on a commercial feed to the total amount of fatty acids omega 3 and omega 6 in the flesh of giant fresh water prawn (Macrobrachium rosenbergii). The method used is experiment with completely randomized design as the experimental design. The treatment used is the content of Cod Liver Oil (CLO) that is different, that P0 (0%), P1 (3%), P2 (6%), P3 (9%), P4 (12%) of each treatment was repeated 4 times. The main parameters measured were the number of total fatty acids omega 3 and omega 6 in meat prawns. Supporting parameters measured were water quality parameters. Analysis of data using analysis of variance (ANOVA) and to determine the best treatment Duncan's multiple range test. The results of the research granting Cod Liver Oil (CLO) showed significantly (P <0.05) of the total amount of omega 3 fatty acids but not significantly different (P> 0.05) with the total amount of fatty acids omrga 6 in the meat giant fresh water prawn (Macrobrachium rosenbergii). The total amount of omega 3 fatty acids in the treatment of P0 (0%) was significantly different from P2 treatment (6%), P3 (9%) and P4 (12%), but not significantly different from P1 treatment. The total amount of fatty acids in the treatment omega 6 P0 (0%) did not differ significantly with treatment P1 (3%), P2 (6%), P3 (9%) and P4 (12%).

scholarly journals Domestic chicken omega 3 – a product for promoting human health

2021 ◽  
Vol 854 (1) ◽  
pp. 012081
Author(s):  
Dragan Sefer ◽  
Stamen Radulovic ◽  
Dejan Peric ◽  
Matija Sefer ◽  
Lazar Makivic ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Linolenic Acid ◽  
Fatty Acid Profile ◽  
Unsaturated Fatty Acids ◽  
Daily Intake ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Wide Range ◽  
Omega 6

Abstract Literature data show that the relationship between two groups of polyunsaturated fatty acids in diet, omega 3 acids, whose basic representative is a-linolenic acid (C18: 3 n-3), and omega 6 acids, whose basic representative is linoleic acid (C18: 2 n-6), has a significant role in development of cardiovascular diseases in humans. The optimal ratio of omega 6 to omega 3 fatty acids is around 4:1. In monogastric animals, the fatty acids in feed are absorbed in the gastrointestinal tract largely unchanged. This means the fatty acid profile of the animal’s diet directly reflects the fatty acid profile of the tissue. The daily intake of unsaturated fatty acids can be increased by an adequate animal nutrition strategy. Flaxseed contains ten times more unsaturated (32.26%) than saturated (3.66%) fatty acids. The largest amount of unsaturated fatty acids (about 70%) is a-linolenic acid (ALA), which is a precursor of the entire omega 3 series of fatty acids, and which makes flaxseed an ideal raw material for the production of a wide range of omega 3 enriched products. In order to obtain chicken meat rich in omega 3, an experiment was organized with a specific diet for broilers at fattening. Thanks to the designed animal feed, it was possible to get products (meat, breast, drumstick, liver, subcutaneous fat) with significantly higher amounts of omega 3 fatty acids compared to the same products obtained from broilers fed with conventional mixtures, or with almost the ideal ratio between omega 6 and omega 3 fatty acids.

Omega-3 Fatty Acid Supplements for the Prevention of Cardiovascular Disease

2020 ◽  
Vol 35 (7) ◽  
pp. 318-323
Author(s):  
Michelle Lan ◽  
Thanh Nguyen ◽  
Shelly Gray
Keyword(s):  
Cardiovascular Disease ◽  
Fatty Acids ◽  
Clinical Trials ◽  
Fatty Acid ◽  
Primary Prevention ◽  
Older People ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Science Advisory

In the United States, cardiovascular disease (CVD) is the most common cause of death in older people. The use of omega-3 fatty acid supplements (nonprescription) is common in older people, despite the conflicting evidence regarding the benefits of supplements in CVD. The 2017 American Heart Association science advisory on omega-3 fatty acid supplements suggested that it is reasonable to use omega-3 fatty acids for secondary prevention in people with coronary heart disease and heart failure. This article reviewed large meta-analyses and clinical trials published since the science advisory. Two metaanalyses concluded that these supplements were not effective for secondary or primary prevention of CVD. Two large randomized, placebo-controlled clinical trials, one in people with diabetes mellitus, evaluated omega-3 fatty acid supplements for primary prevention and reported no benefit. Taken together, these findings do not support the routine dietary supplementation with omega-3 fatty acids to prevent cardiovascular events.

Effects of Dietary Omega-3 Fatty Acids (DHA/EPA) and Vitamin E on Fatty Acid Profile of Common Carp, Cyprinus carpio Ovaries

2021 ◽  
Vol 5 (1) ◽  
pp. 10-23
Author(s):  
Osamah Salih
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Vitamin E ◽  
Common Carp ◽  
Food Additives ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Common Carp Cyprinus Carpio ◽  
Carp Cyprinus Carpio ◽  
Omega 6

The current study aimed to clarify the fatty acids profile in the breeding stock ovaries of common carp (Cyprinus carpio L.) fed on two food additives. The study was carried out in the Shrimp Hatchery which belonging to the Basrah Agricultural Directorate. Three treatment groups were used, the first treatment (T1) represented as control without any food additives, the second treatment (T2) supplemented with 5 g/kg omega-3 fatty acids, and the third treatment (T3) to which vitamin E was added at a concentration of 200 mg/kg. Fishes were randomly distributed in three replicates for each treatment with six of common carp brood stock per replicate. Nine cages were used which placed in earthen pond. Feeding trail lasted from 29 Oct 2018 to 14 Mar 2019. After feeding fish for 82 days, the oil was extracted from gonads by two methods, the first one by Soxhlet apparatus and the second by Accelerated Solvent Extraction (ASE) method. The fatty acid profiles were analyzed using gas chromatograph by GC/MS (Gas Chromatography Mass spectrometry). Results showed that the content of fatty acids in the ovaries of treated fishes in T1, the presence of saturated and unsaturated omega-3 and omega-6 fatty acids, were monounsaturated fatty acid (C19H36:1) scored the highest percentage (52.55%). Fishes in T2 recorded the presence of saturated and unsaturated omega-3 and omega-6 fatty acids were omega-12 (C18H34:12) recorded the highest percentage (50.02%), while T3 fishes showed the presence of saturated and unsaturated fatty acids from the group of omega-6 fatty acids and the unsaturated fatty acid omega-9 (C18H34:9) record the highest percentage (63.24%).In conclusion this study suggested that the content of fatty acids in fish ovaries reflects the composition of fatty acids in the diet.

Supplementation of dietary long-chain polyunsaturated omega-3 fatty acids high in docosahexaenoic acid (DHA) increases plasma DHA concentration and may increase trot stride lengths in horses

2007 ◽  
Vol 4 (2) ◽  
pp. 71-78 ◽  
Author(s):  
A D Woodward ◽  
B D Nielsen ◽  
C I O'Connor ◽  
C D Skelly ◽  
S K Webel ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Stride Length ◽  
Omega 3 Fatty Acids ◽  
Total Plasma ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Omega 6 ◽  
Long Chain

AbstractTwelve mature and six 2-year-old Arabian horses were used to determine the effect of dietary long-chain polyunsaturated omega-3 fatty acid supplementation on plasma fatty acids and lameness. Lameness scores and stride lengths were measured on day 0. Horses were striated and pair-matched according to age, gender, stride length and, for mature horses, lameness score, and each horse was fed either a treatment diet containing 5.95 g of stabilized omega-3 fatty acids plus a fat carrier (FA), for a total of 19.4 g fat, or a control diet containing 49 g of corn oil (CO) for 75 days. Horses were exercised 5 d week− 1, and blood samples were drawn and body weights recorded on days 0, 25, 50 and 75. Lameness scores and stride lengths were recorded again on day 75. Total plasma omega-3 fatty acid concentrations were higher on all days in FA horses than in CO horses. Total plasma omega-6 fatty acids increased from days 0 to 25, remained elevated through day 50 and returned to baseline on day 75 in all horses. The ratio of plasma omega-6:omega-3 fatty acids was lower in FA horses. Horses on FA had increased plasma docosahexaenoic acid (DHA) on days 25, 50 and 75. No difference in walk stride length was noted; however, FA horses tended to have a longer trot stride after supplementation when compared with CO horses. No differences were seen in prostaglandin E2 (PGE2) metabolite or tumour necrosis factor-α as measured in blood serum. In summary, supplementing omega-3 fatty acids increases plasma DHA, although there was no overall increase in omega-3 in FA horses. While a trend to increase trot stride length was seen, no differences in lameness scores between treatments were noted.

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