Feasibility of Pure Silk for the Treatment of Large Superficial Burn Wounds Covering Over 10% of the Total Body Surface

2019 ◽  
Vol 41 (1) ◽  
pp. 131-140
Author(s):  
Jennifer Lynn Schiefer ◽  
Marc Daniels ◽  
Daniel Grigutsch ◽  
Paul Christian Fuchs ◽  
Alexandra Schulz
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Control Group ◽  
Natural Silk ◽  
Burn Wounds ◽  
Nylon Mesh ◽  
Time Treatment ◽  
High Satisfaction ◽  
Total Body ◽  
And Control

Abstract Large, superficial burn wounds require many painful dressing changes and, thus, dressings that can stay on the wound and peel off during re-epithelization such as Biobrane® and Suprathel® are preferred, but they are costly. Natural silk has shown good outcomes with respect to wound healing, scarring, and patient satisfaction. This study aimed to evaluate the efficacy of natural silk compared with that of initially used dressings for the treatment of superficial burn wounds greater than 10% of the TBSA. Patients with superficial burns covering >10% of the TBSA were treated with pure silk for the first time (treatment group). Complications during wound healing with respect to the need for further surgery and scarring were compared with those of patients with similar burns of more than 10% TBSA and treated with nylon mesh and collagen instead of silk (treatment group). The treatment and control group comprised 25 and 13 patients, respectively. In total, 88% of patients in the treatment group did not require further treatment, while two patients with chemical burns needed further surgeries. Moreover, patients reported high satisfaction with respect to scarring and aesthetic outcome. Meanwhile, 85% of patients in the control group healed without further surgery and showed higher median hypopigmentation and hyperpigmentation after 12 months. Silk is an effective wound dressing for the treatment of large superficial burn wounds. It avoids painful dressing changes and yields satisfactory aesthetic outcomes. However, especially in large burns, careful initial wound depth assessment is crucial to prevent infection and reoperations.

scholarly journals The application of moist dressing in treating burn wound

Open Medicine ◽  
2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Liu Wei
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Healing Time ◽  
Control Group ◽  
Burn Wound ◽  
Burn Wounds ◽  
Wound Pain ◽  
The Difference ◽  
And Control ◽  
The Impact

AbstractBasic experiments have demonstrated that the effect of wound healing in moist environments is better than that in dry environments; therefore, research on moist dressing is the focus of wound healing research. 42 burn patients receiving treatment in Jiangsu Provincial People’s Hospital were selected as experimental cases. Wound surface is divided into treatment group and control group using a self-contrasted method. The treatment group received a moist dressing in the treatment of burn wounds and the control group adopted iodine gauze or Vaseline gauze coverage. Wound healing effect and the impact on the degree of pain of in the two different treatment methods were observed after treatment. The results of 42 patients were included in the analysis. The average healing time of patients’ burn wounds in treatment group is (10.9 3.3) d, and the average healing time in control group is (13.8 3.6) d, so, the difference is significant (P<0.01). Wound pain in the treatment group is significantly lower than that in the control group (P<0.01). Using moist dressing (Mepitel and Mepilex, etc.) in the treatment of burn wounds, woundhealing time can be shortened and wound pain can be reduced significantly.

scholarly journals PERAN BATATA (Ipomea batatas L) TERHADAP PENYEMBUHAN LUKA BAKAR

2015 ◽  
Vol 3 (3) ◽  
Author(s):  
Channesya Sampetoding ◽  
Taufiq F. Pasiak ◽  
George Tanudjaja
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Skin Inflammation ◽  
Control Group ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Ipomea Batatas ◽  
And Control ◽  
Ipomea Batata

Abstract: Theoretically, batata, Ipomea batata L (Lam) theoritically can be used in wound healing since it acts as antiseptic, antibiotic, and anti-inflammatory agents. Batata ingredients can also stimulate epithelialization in wound bed. This study aimed to obtain the role of batata juice in burn wound healing noticed from the inflammatory response aspect. This was an experimental study conducted in the research laboratory of Faculty of Medicine Univeristy of Sam Ratulangi. Samples were six rabbits divided into 2 groups: treatment group with batata juice, and control group without treatment. The histological examination showed that the quality of inflammatory tissue of the treatment group was denser, settled, and associated with edema expansion compared to the control group with diminished inflammatory components, edema, and vasodilatation, meanwhile, there were angiogenesis, improvement of dermis, and regrowth of epidermis. Conclusion: Batata juice was not superior in healing burns than the natural responses.Keywords: batata (Ipomeas batata L), burns, skin, inflammation, wound healingAbstrak: Batata, Ipomea batata L (Lam) secara teoritik berfaedah untuk penyembuhan luka, yang bekerja sebagai antiseptik, antibiotik, dan anti inflamatorik. Batata berkhasiat dalam penyembuhan luka karena kandungannya yang secara bermakna merangsang pembentukan epitel jaringan luka. Penelitian ini bertujuan untuk mendapatkan peran batata terhadap penyembuhan luka bakar dilihat dari kualitas komponen radang pada jaringan luka. Sampel terdiri dari 6 ekor kelinci yang dibagi atas 2 kelompok: kelompok perlakuan dan kontrol. Kelompok perlakuan diberi jus batata pada luka bakar sedangkan kelompok kontrol tanpa perlakuan. Penelitian ini dilakukan di Laboratorium Riset Fakultas Kedokteran Universitas Sam Ratulangi dengan menggunakan metode eksperimental. Hasil identifikasi mikroskopik menunjukkan bahwa pada kelompok perlakuan kualitas komponen radang jaringan luka bakar lebih padat dan menetap disertai perluasan sembab kolagen dibandingkan kelompok kontrol dimana komponen radang dan sembab berkurang, dilatasi pembuluh darah berkurang, pertumbuhan kapiler baru, jaringan dermis yang membaik, dan epidermis yang mulai tumbuh kembali. Simpulan: Jus batata tidak memperlihatkan penyembuhan luka bakar yang lebih baik dibandingkan dengan penyembuhan luka oleh tubuh sendiri.Kata kunci: batata (Ipomeas batata L), luka bakar, kulit, radang, penyembuhan luka

scholarly journals Clinical Study of MEBO Combined with Jinhuang Powder for Diabetic Foot with Infection

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Hong-Bo Zhan ◽  
Qing-Qing Sun ◽  
Lei Yan ◽  
Jia Cai
Keyword(s):  
Wound Healing ◽  
Clinical Study ◽  
Treatment Group ◽  
Diabetic Foot ◽  
Effective Rate ◽  
Control Group ◽  
Efficacy And Safety ◽  
Wound Pain ◽  
The Difference ◽  
And Control

Background. To investigate the efficacy and safety of MEBO combined with Jinhuang powder for the treatment of diabetic foot with infection. Methods. From August 2015 to August 2019, patients with diabetic foot in our hospital were divided into the treatment group and control group. The treatment group was treated with moist exposed burn ointment (MEBO) combined with Jinhuang powder, while the control group was treated with MEBO only. Results. After one week of treatment, the effective rate in the treatment group was 100%, and the effective rate in the control group was only 76%. The difference between the two groups was statistically significant ( P < 0.05 ). The wound pain score was 2.40 ± 1.38 in the treatment group and 3.76 ± 1.85 in the control group. The difference was statistically significant ( P < 0.01 ). After one month of treatment, the effective rate of wound healing was 92.0% in the treatment group and 68% in the control group. The difference between the two groups was statistically significant ( P < 0.05 ). Conclusion. MEBO combined with Jinhuang powder is effective in treating diabetic foot with infection wound.

scholarly journals Healing Effects of Iranian Dwarf Elder on Full-thickness Epidermal Thermal Injury in Wistar Rats

2022 ◽  
Vol 19 (4) ◽  
Author(s):  
Hosein Mohamadi haftador ◽  
Parisa Ramhormozi ◽  
Mitra Yousefpour ◽  
Ali Sobhanizadeh ◽  
Laya Ghahari
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Wistar Rats ◽  
Thermal Injury ◽  
Herbal Medicines ◽  
Vehicle Group ◽  
Control Group ◽  
Full Thickness ◽  
Wound Area ◽  
Burn Wounds

Background: Wound healing is a physiologic process that cells and tissues react when the skin is exposed to thermal injury. The inflammatory process has ‎essential effects on wound healing that includes coordination between immunological and biological responses. Chemical and herbal medicines are locally or systemically administrated to help wound healing. Herbal medicines have become more prevalent in recent years due to fewer side effects. Dwarf elder is used to treating inflammation and has been reported to possess antibacterial and antioxidant activities. This plant is also effective against burns, wounds, eczema, and infection. Objectives: In this study, we evaluated the topical application of dwarf elder on full-thickness epidermal thermal wounds in Wistar rats. Methods: Thirty adult male Wistar rats of about 300 g were used. The rats were randomly divided into three groups: Control group, vehicle group treated with an ointment base, and treatment group treated with elder ointment 10%. The animals were anesthetized and were created burn wounds with an area of 1 cm2 using the Meyer method. After 21 days, the wounds were photographed with a Canon camera. The wound area and healing degree were calculated. Slides were stained with H&E and examined by light microscopy and GraphPad Prism software. Data were analyzed by SPSS software using ANOVA and Tukey’s test. The significance level was considered at P < 0.05. Results: The wound area on the 21st day was significantly lower in the treatment group than in the control and vehicle groups. The epithelium thickness (μm) was significantly higher in the treatment group than in the control and vehicle groups. The blood vessels were significantly higher in the treatment group than in the other groups. Conclusions: The study showed that elder extract could be an effective remedy to repair and heal thermal injury and burn wounds.

Perbandingan Efek Suplementasi Tablet Tambah Darah Dengan Dan Tanpa Vitamin C Terhadap Kadar Hemoglobin Pada Ibu Hamil Dengan Usiakehamilan 16-32 Minggu Di Desa Keniten Kecamatan Mojo Kabupaten Kediri

2017 ◽  
Vol 3 (1) ◽  
pp. 76
Author(s):  
Siti Asiyah ◽  
Dwi Estuning Rahayu ◽  
Wiranti Dwi Novita Isnaeni
Keyword(s):  
Treatment Group ◽  
Vitamin C ◽  
Gestational Age ◽  
Group Treatment ◽  
Sampling Technique ◽  
Hemoglobin Level ◽  
The Body ◽  
Control Group ◽  
Fetal Organ ◽  
And Control

The needed of Iron Tablet in pregnancy was increase than mother who not pregnant.  That  cause of  high metabolism at the pregnancy for formed of  fetal organ and energy. One of effort for prevent anemia in mother pregnant with giving the Iron tablet and vitamin c. The reason of  this research in 4 June – 11 July 2014 is for compare the effect of  iron tablet suplementation with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks In Desa Keniten Kecamatan Mojo Kabupaten Kediri. This research method using comparative analytical.  Research design type of Quasy Eksperiment that have treatment group and control group. Treatment group will giving by Iron tablet and 100 mg vitamin C, and control group just giving by iron tablet during 21 days. Population in this research are all of mother pregnant with Gestational Age Of 16-32 Weeks with Sampling technique is  cluster random sampling is 29 mother pregnant. Comparison analysis of  iron tablet suplementation effect with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks, data analysis using Mann Whitney U-test and the calculated U value (44,5) less than U-table (51). So there was difference of iron tablet suplementation effect with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks Therefore, the addition of vitamin C on iron intake is needed to increase the uptake of iron tablets. When the amount of iron uptake increases, the reserves of iron in the body will also increase, so as to prevent anemia in pregnant women; Keywords : Iron Tablet (Fe), Vitamin C, Hemoglobin level, Mother Pregnant

PENGGUNAAN SELAPUT AMNION SEGAR PADA INSISI LUKA OPERASI SEKSIO SESAREA

2019 ◽  
Vol 1 (2) ◽  
pp. 47-55
Author(s):  
Syahredi Syaiful Adnani ◽  
Hafni Bachtiar
Keyword(s):  
Wound Healing ◽  
Caesarean Section ◽  
Amniotic Membrane ◽  
Healing Time ◽  
Cost Of Care ◽  
Control Group ◽  
P Value ◽  
Control Groups ◽  
And Control ◽  
Wound Healing Time

In the last few decades, the incidence of caesarean section is increasing in the world, especially in Indonesia. One of the way to treat tissue scar is through biologic and synthetic dressing where nowadays, amnion has been used as biologic dressing frequently. This study was conducted to determine the effect of the use of fresh amniotic membrane on wound incision Caesarean section compared with Caesarean section incision wound covered using regular gauze bandages and fixated with plaster in RS. Dr. Reksodiwiryo Padang. The design of this study is an experimen-tal study with Post test design with control group design. Sampling was done using a formula consecutive sampling two different test samples obtained an average of 72 people for each group. The analysis used include univariate and bivariate analyzes. The average wound healing time the difference was statistically significant (p value <0.05) in the treatment and control groups. There was highly significant difference in the proportion of local infection on day 3 between the treatment and control groups (p value <0.05). There were very significant differences in the proportion of local allergic reactions at day 3, and 5 between the treatment and control group (p <0.05). There are significant differences in terms of the cost of care per day between treatment and control groups (p <0.05). From this study, the average wound healing time has a very significant difference.Keywords: Fresh Amniotic Membrane, Wound Cesarean Section, Wound Healing

RNA Sequencing Reveals the Wound Repair Mechanism of Cuyuxunxi Prescription in Surgical Patients with Anal Fistulas

2021 ◽  
Vol 24 ◽  
Author(s):  
Yin Qu ◽  
Zhijun Zhang ◽  
Yafeng Lu ◽  
De Zheng ◽  
Wei Yang
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Rna Sequencing ◽  
Anal Fistula ◽  
Wound Repair ◽  
Inflammatory Responses ◽  
Control Group ◽  
Surgical Wound ◽  
Anal Fistulas ◽  
Skin Development

Background: Anal fistula is one of the most common colorectal and perirectal diseases in the world. Cuyuxunxi (CYXX) prescription is an efficient herbal fumigant used to promote the surgical wound healing of anal fistulas. Objective: This study aimed to explore the underlying molecular mechanism of CYXX prescription on surgical wound healing of anal fistulas. Methods: Ten patients with anal fistula were randomized into a control group or treatment group. The wound surface of patients in the control group was rinsed by normal saline, while that in the treatment group was rinsed by CYXX prescription. The wound tissues of patients with anal fistulas seven days after the surgery were collected for hematoxylin-eosin (HE) staining and RNA sequencing. The expressions of differentially expressed genes (DEGs) were validated by real-time quantitative PCR (RT-qPCR). Results: HE staining showed that CYXX treatment reduced the infiltration of inflammatory cells. A total of 472 DEGs, including 141 up-regulated genes and 331 down-regulated genes, were identified. These genes were significantly related to skin development, xenobiotic stimulus, and inflammation. In addition, the consistency rate of RT-qPCR and sequencing results was 83.33%, which showed a high relative reliability of the sequencing results. Conclusion: CYXX prescription could improve epidermis repair and reduce inflammatory responses.

673 Effect of Subcutaneous Topical Ozone Therapy on Second Degree Burn Wounds in Rats: An Experimental Study

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S193-S193
Author(s):  
Emre Karakaya ◽  
Aydincan Akdur ◽  
H Ebru ◽  
Ayvazoglu Soy ◽  
Alev Ok Atilgan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Male Rats ◽  
Control Group ◽  
Ozone Therapy ◽  
Burn Wounds ◽  
Degree Burn ◽  
Significant Difference ◽  
Second Degree

Abstract Introduction Burn is one of the most severe traumas that causes coagulative destruction of the skin. The use of various products that accelerate wound healing in patients with burn may affect the patient’s survival and reduce the complications that may be seen. In the present study we aimed effects of subcutaneous ozone injection on second degree burn wound. Methods A total of 72 Sprague-Dawley male rats included in the study were divided randomly into three groups (control group (CG), silver sulfadiazine group (SG), ozone group (OG)) and each group was divided randomly two subgroups (as sacrificed on d7 and on d14).A deep second degree scald burns were created on the lower back. In CG subcutaneous 0.9% serum saline was injected daily into the burn area. In SG, burns were dressed with silver sulfadiazine daily and in OG subcutaneous ozone was injected daily into the burn area. Tissue hydroxyproline level measurement and histopathological evaluation were done. Results When the groups were compared in terms of weight change, no significant difference was found on the 7th and 14th days. In the evaluation made in terms of tissue hydroxyproline, tissue hydroxyproline level in OG was found to be significantly higher on both the 7th and 14th days (p &lt; 0.001). In histopathological evaluations, it was determined that wound healing in OG was significantly higher than in the other groups. Conclusions According to the results, subcutaneous ozone therapy is more effective than silver sulphadiazine in the healing process of second-degree burn wounds and it can be safely used in the treatment of burn wounds.

Comparison of Early Implant Failure Rates Between Subjects With and Without Orthodontic Treatment Before Dental Implantation

2019 ◽  
Vol 45 (1) ◽  
pp. 29-34
Author(s):  
Li-ching Chang ◽  
I-ming Tsai
Keyword(s):  
Treatment Group ◽  
Failure Rate ◽  
Orthodontic Treatment ◽  
Implant Failure ◽  
Control Group ◽  
Failure Rates ◽  
Implant Surgery ◽  
Dental Implantation ◽  
And Control

The present study compared early dental implant failure rates between patients with and without orthodontic treatment before dental implantation. The data of adults who had undergone dental implantation between January 2007 and December 2016 were analyzed retrospectively. A total of 124 subjects with 255 implants were divided into a treatment group (46 subjects, 85 teeth) consisting of patients who had undergone implant surgery after orthodontic treatment and a control group of patients who had not undergone preimplant orthodontic treatment. Implants that failed before permanent crown fabrication were defined as failures. No significant differences in gender or age were found between the treatment group and controls. No significant differences were found in implant failure rates in either jaw between the treatment and control groups. However, the failure rate was still higher in the treatment group (14.81%) than in the control group (3.28%) for the maxilla. Results of this study demonstrate an increased implant failure rate only in the maxilla of patients who underwent orthodontic treatment before dental implantation, especially implant surgery combined with a sinus lift procedure. Further study with a larger sample size and longer follow-up period is necessary to confirm results of the present study and identify other confounding factors.

Dropout Prevention for Youth with Disabilities: Efficacy of a Sustained School Engagement Procedure

1998 ◽  
Vol 65 (1) ◽  
pp. 7-21 ◽  
Author(s):  
Mary F. Sinclair ◽  
Sandra L. Christenson ◽  
David L. Evelo ◽  
Christine M. Hurley
Keyword(s):  
Treatment Group ◽  
Dropout Prevention ◽  
School Engagement ◽  
Behavioral Disabilities ◽  
Control Group ◽  
Youth With Disabilities ◽  
Engagement Strategies ◽  
Overall Performance ◽  
And Control ◽  
To Receive

The purpose of this study was to examine the efficacy of a sustained dropout prevention procedure that incorporated monitoring and school engagement strategies. Ninety-four students with learning and emotional/behavioral disabilities received interventions in Grades 7 and 8; half of the students (treatment group) continued to receive intervention through Grade 9. Results of this experimental study indicated that, for two of three measures, students in the treatment group were significantly more likely to be engaged in school than were control group students. The overall performance of both treatment and control students, however, points to the need for early and sustained support for students with learning and behavioral disabilities to attain academic and behavioral standards.

Sign in / Sign up

Export Citation Format

Share Document