Headache

Neurology Clinic ◽

Gender Specific ◽

Insight Into ◽

Migraine is a common disorder that affects women of menstruating age, and it is frequently the chief complaint of women presenting in the neurology clinic. The prevalence of menstrually related migraine can range from 20–60%, while pure menstrual migraine occurs in less than 10% of women. In addition to utilizing non–gender-specific abortive and preventative strategies, understanding migraine and its relationship to hormones, particularly estrogen, can have clinical implications for optimal treatment. This chapter seeks to provide insight into diagnosing menstrually related migraine, the role of decreased estrogen just prior to menstrual cycle onset and migraine, as well as the therapeutic options that are available to treat and possibly prevent menstrual migraine attacks.

Ovarian Epithelial-Stromal Interactions: Role of Interleukins 1 and 6

Obstetrics and Gynecology International ◽

10.1155/2011/358493 ◽

2011 ◽

Vol 2011 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Kamisha T. Woolery ◽

Patricia A. Kruk

Keyword(s):

Physiological Function ◽

Clinical Implications ◽

Epithelial Cancer ◽

Gynecologic Malignancy ◽

Ovarian Epithelial Cancer ◽

Ovarian Surface Epithelial ◽

Ovarian Epithelial Cells ◽

Normal Physiological Function ◽

Ovarian epithelial cancer is the most lethal gynecologic malignancy. The high mortality is attributed to the fact that most cases typically present in late stage when ovarian cancer (OC) has already spread beyond the ovary. Ovarian epithelial cancer cells are shed into intraperitoneal ascites and easily disseminate throughout the peritoneal cavity with preferential metastasis to the omentum, peritoneum, and local organs. Understanding how ovarian epithelial cells interact with and modulate their microenvironment can provide insight into the molecular mechanism(s) involved with malignant transformation and progression which may eventually identify novel diagnostic, prognostic, and therapeutic targets. The objective of this paper is to provide a brief consideration of ovarian surface epithelial-stromal interactions in regard to normal physiological function and tumor progression as influenced by two potentially key interleukins, interleukins-1 (IL-1) and -6 (IL-6), present in the microenvironment. Lastly, we will consider the clinical implications of IL-1 and IL-6 for OC patients.

Rizatriptan Efficacy in ICHD-II Pure Menstrual Migraine and Menstrually Related Migraine

Headache The Journal of Head and Face Pain ◽

10.1111/j.1526-4610.2008.01093.x ◽

2008 ◽

Vol 48 (8) ◽

pp. 1194-1201 ◽

Cited By ~ 17

Author(s):

Robert Nett ◽

Lisa K. Mannix ◽

Loretta Mueller ◽

Anthony Rodgers ◽

Carolyn M. Hustad ◽

...

Keyword(s):

Menstrual Migraine ◽

Menstrual Migraine : How Hormones Impact Migraine

JOURNAL OBGIN EMAS ◽

10.25077/aoj.5.1.9-17.2021 ◽

2021 ◽

Vol 5 (1) ◽

pp. 9-17

Author(s):

Restu Susanti ◽

Syamel Muhammad

Keyword(s):

Menstrual Cycle ◽

Trigeminal Nerve ◽

Menstrual Migraine ◽

Female Hormones

Menstrual Migraine is divided into 2 subtypes: Menstrually Related Migraine (MRM) and Pure Menstrual Migraines (PMM). In PMM symptoms do not occur outside the menstrual cycle while MRM, symptoms can occur at other times apart from the menstrual cycle. The occurrence of menstrual migraines is related to the female hormones cycle in the form of the decrease in estrogen levels which usually occurs a week before the onset of menstruation. The mechanism is unclear, but it is thought that a decrease in estrogen levels can trigger decrease in serotonin levels, causing cranial vasodilation and sensitization of the trigeminal nerve. Keywords: menstrual migraine, hormones

Premenstrual Exacerbation of Life-Threatening Asthma: Effect of Gonadotrophin Releasing Hormone Analogue Therapy

Canadian Respiratory Journal ◽

10.1155/1996/691249 ◽

1996 ◽

Vol 3 (3) ◽

pp. 203-206 ◽

Cited By ~ 2

Author(s):

Alun L Edwards ◽

M Sarah Rose ◽

Lois E Donovan ◽

Gordon T Ford

Keyword(s):

Menstrual Cycle ◽

Gnrh Analogue ◽

Hormonal Changes ◽

Gnrh Analogues ◽

Releasing Hormone ◽

Life Threatening ◽

Gonadotrophin Releasing Hormone ◽

Premenstrual Exacerbation ◽

Variability in the severity of asthma during various phases of the menstrual cycle has been frequently suspected. However, the hormonal changes that might affect mediators of bronchospasm have yet to be elucidated. The case of a 41-year-old woman suffering from longstanding asthma with life-threatening exacerbations is reported. The patient was treated with buserelin, a gonadotropin releasing hormone (GnRH) analogue, which created a temporary chemical menopause and thus permitted diagnosis of a premenstrual exacerbation of asthma and offered insight into potential therapy. GnRH analogues may therefore be of value in assessing women with severe asthma suspected to vary with the menstrual cycle. The addition of estrogens and progestins at the same time as treatment with GnRH analogue may be of value in determining the role of these hormones in the pathogenesis of menstrually related exacerbations of asthma.

Brain structural and functional differences between pure menstrual migraine and menstrually-related migraine

Scientific Reports ◽

10.1038/s41598-020-73399-0 ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 1

Author(s):

Tao Xu ◽

Yutong Zhang ◽

Chen Wang ◽

Huaqiang Liao ◽

Siyuan Zhou ◽

...

Keyword(s):

Prefrontal Cortex ◽

Low Frequency ◽

Menstrual Migraine ◽

Grey Matter Volume ◽

Spontaneous Neural Activity ◽

Dorsolateral Prefrontal ◽

Brain Structure And Function ◽

And Function ◽

Abstract The pathophysiological differences between menstrually-related migraine (MRM) and pure menstrual migraine (PMM) are largely unclear. The aim of this study was to investigate the potential differences in brain structure and function between PMM and MRM. Forty-eight menstrual migraine patients (32 MRM; 16 PMM) were recruited for this study. Voxel-based morphometry (VBM) was applied on structural magnetic resonance imaging (sMRI), and the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) in resting state functional MRI (rsfMRI) were calculated. No significant between-group difference was observed in the grey matter volume (GMV). MRM patients exhibited lower ALFF values at the dorsolateral prefrontal cortex (DLPFC) and medial prefrontal cortex (mPFC) than PMM patients. Moreover, the MRM group showed significantly higher ReHo values in the DLPFC. Higher values in the mPFC were related to higher expression of calcitonin gene-associated peptide (CGRP) in the PMM group (r = 0.5, P = 0.048). Combined ALFF and ReHo analyses revealed significantly different spontaneous neural activity in the DLPFC and mPFC, between MRM and PMM patients, and ALFF values in the mPFC were positively correlated with CGRP expression, in the PMM group. This study enhances our understanding of the relationship between neural abnormalities and CGRP expression in individuals with PMM.

Migraine and Menstruation: A Pilot Study

Cephalalgia ◽

10.1046/j.1468-2982.1990.1006305.x ◽

1990 ◽

Vol 10 (6) ◽

pp. 305-310 ◽

Cited By ~ 116

Author(s):

EA MacGregor ◽

H Chia ◽

RC Vohrah ◽

M Wilkinson

Keyword(s):

Pilot Study ◽

Menstrual Cycle ◽

Hormonal Therapy ◽

Migraine Without Aura ◽

Hormonal Treatment ◽

Menstrual Migraine ◽

Menstrual Cycles ◽

City Of London ◽

The City

Objective: To define the term “menstrual” migraine and to determine the prevalence of “menstrual” migraine in women attending the City of London Migraine Clinic. Design: Women attending the clinic were asked to keep a record of their migraine attacks and menstrual periods for at least 3 complete menstrual cycles. Results: Fifty-five women completed the study. “Menstrual” migraine was defined as “migraine attacks which occur regularly on or between days -2 to +3 of the menstrual cycle and at no other time”. Using this criterion, 4 (7.2%) of the women in our population had “menstrual” migraine. All 4 women had migraine without aura. A further 19 (34.5%) had an increased number of attacks at the time of menstruation in addition to attacks at other times of the cycle. Eighteen (32.7%) had attacks occurring throughout the cycle but with no increase in number at the time of menstruation. Fourteen (25.5%) had no attacks within the defined period during the 3 cycles studied. Discussion: A small percentage of women have attacks only occurring at the time of menstruation, which can he defined as true “menstrual” migraine. This group is most likely to respond to hormonal treatment. The group of 34.5% who have an increased number of attacks at the time of menstruation in addition to attacks at other times of the month could be defined as having “menstrually related” migraine and might well respond to hormonal therapy. The 32.7% who have attacks throughout the menstrual cycle without an increase at menstruation are unlikely to respond to hormonal therapy. The 25.5% who do not have attacks related to menstruation almost certainly will not respond to hormonal therapy.

Perimenstrual headache: Migraine without aura or premenstrual syndrome symptom?

Vojnosanitetski pregled ◽

10.2298/vsp1012969s ◽

2010 ◽

Vol 67 (12) ◽

pp. 969-976 ◽

Cited By ~ 2

Author(s):

Ana Sundic ◽

Jasna Zidverc-Trajkovic ◽

Svetlana Vujovic ◽

Nadezda Sternic

Keyword(s):

Premenstrual Syndrome ◽

Migraine Headache ◽

Migraine Without Aura ◽

Tension Type Headache ◽

Menstrual Migraine ◽

Headache Onset ◽

Perimenstrual Headache ◽

Type Headache ◽

Background/Aim. Definition of menstrual migraine as a specific clinical entity or, maybe, migraine headache with menstrually related occurring, still remains unresolved question. The aim of this study was to investigate if perimenstrual headache in our patients fulfills diagnostic the International Classification of Headache Disorders (ICHD) criteria for migraine without aura or represents a different type of headache which is the symptom of premenstrual syndrome (PMS). Methods. The study included 50 women with headache in perimenstrual period in at least two out of three menstrual cycles, during the last year or longer. Two questionnaires, a questionnaire for headache and a questionnaire for PMS, were used. Results. The majority of all the examined women, 29 of them, had migraine and PMS and 9 women had migraine without PMS. Headache in 38 (76.0%) patients fulfilled diagnostic criteria for menstrual migraine, (26 and 12 women had pure menstrual migraine and menstrually related migraine respectively). Intensity of PMS was not different in a groups of women with different types of headache (p = 0.184): a total number of PMS symptoms was 8.2 ? 4.6 in the group with pure menstrual migraine, 10.8 ? 3.9 in the group with menstrually related migraine and 10.8 ? 6.3 in the group with non-migraine headache. Conclusion. This study shows that headache, occuring in perimenstrual period, is not always migraine, but could fulfill criteria for tension-type headache, as well. Specific characteristics of perimenstrual headache, which could distinguish it as a symptom of PMS, were not found. Expected relation in time of headache onset and menarche was not confirmed.

Plasminogen Activation In Vivo upon Intravenous Infusion of DDAVP

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648390 ◽

1992 ◽

Vol 67 (01) ◽

pp. 111-116 ◽

Cited By ~ 64

Author(s):

Marcel Levi ◽

Jan Paul de Boer ◽

Dorina Roem ◽

Jan Wouter ten Cate ◽

C Erik Hack

Keyword(s):

Monoclonal Antibodies ◽

Plasminogen Activator ◽

Plasma Levels ◽

Fold Increase ◽

Fibrinolytic System ◽

Plasminogen Activation ◽

Plasminogen Activator Activity ◽

SummaryInfusion of desamino-d-arginine vasopressin (DDAVP) results in an increase in plasma plasminogen activator activity. Whether this increase results in the generation of plasmin in vivo has never been established.A novel sensitive radioimmunoassay (RIA) for the measurement of the complex between plasmin and its main inhibitor α2 antiplasmin (PAP complex) was developed using monoclonal antibodies preferentially reacting with complexed and inactivated α2-antiplasmin and monoclonal antibodies against plasmin. The assay was validated in healthy volunteers and in patients with an activated fibrinolytic system.Infusion of DDAVP in a randomized placebo controlled crossover study resulted in all volunteers in a 6.6-fold increase in PAP complex, which was maximal between 15 and 30 min after the start of the infusion. Hereafter, plasma levels of PAP complex decreased with an apparent half-life of disappearance of about 120 min. Infusion of DDAVP did not induce generation of thrombin, as measured by plasma levels of prothrombin fragment F1+2 and thrombin-antithrombin III (TAT) complex.We conclude that the increase in plasminogen activator activity upon the infusion of DDAVP results in the in vivo generation of plasmin, in the absence of coagulation activation. Studying the DDAVP induced increase in PAP complex of patients with thromboembolic disease and a defective plasminogen activator response upon DDAVP may provide more insight into the role of the fibrinolytic system in the pathogenesis of thrombosis.

Fibrinolytic Activity of Cerebro-Spinal Fluid and the Development of Artificial Cerebral Haematomas in Dogs

Thrombosis and Haemostasis ◽

10.1055/s-0038-1653538 ◽

1969 ◽

Vol 21 (02) ◽

pp. 294-303 ◽

Cited By ~ 3

Author(s):

H Mihara ◽

T Fujii ◽

S Okamoto

Keyword(s):

Cerebrospinal Fluid ◽

Carboxylic Acid ◽

Fibrinolytic Activity ◽

Clinical Implications ◽

Trans Form ◽

Plate Method ◽

Blood Samples ◽

Fibrin Plate ◽

The Brain

SummaryBlood was injected into the brains of dogs to produce artificial haematomas, and paraffin injected to produce intracerebral paraffin masses. Cerebrospinal fluid (CSF) and peripheral blood samples were withdrawn at regular intervals and their fibrinolytic activities estimated by the fibrin plate method. Trans-form aminomethylcyclohexane-carboxylic acid (t-AMCHA) was administered to some individuals. Genera] relationships were found between changes in CSF fibrinolytic activity, area of tissue damage and survival time. t-AMCHA was clearly beneficial to those animals given a programme of administration. Tissue activator was extracted from the brain tissue after death or sacrifice for haematoma examination. The possible role of tissue activator in relation to haematoma development, and clinical implications of the results, are discussed.

On Metaphysics and the Political: A Polemics of Reading Baudelaire in the 1930s

Nottingham French Studies ◽

10.3366/nfs.2019.0252 ◽

2019 ◽

Vol 58 (2) ◽

pp. 249-259

Author(s):

Joseph Acquisto

Keyword(s):

Twentieth Century ◽

Political Crisis ◽

The Political ◽

Modern Poetry ◽

Progressive Politics ◽

The World ◽

Relationship Of ◽

The Relationship ◽

This essay examines a polemic between two Baudelaire critics of the 1930s, Jean Cassou and Benjamin Fondane, which centered on the relationship of poetry to progressive politics and metaphysics. I argue that a return to Baudelaire's poetry can yield insight into what seems like an impasse in Cassou and Fondane. Baudelaire provides the possibility of realigning metaphysics and politics so that poetry has the potential to become the space in which we can begin to think the two of them together, as opposed to seeing them in unresolvable tension. Or rather, the tension that Baudelaire animates between the two allows us a new way of thinking about the role of esthetics in moments of political crisis. We can in some ways see Baudelaire as responding, avant la lettre, to two of his early twentieth-century readers who correctly perceived his work as the space that breathes a new urgency into the questions of how modern poetry relates to the world from which it springs and in which it intervenes.