Theoretical basis of pain

2021 ◽  
pp. 89-100
Author(s):  
Liesbet Goubert ◽  
Rebecca Pillai Riddell ◽  
Laura Simons ◽  
David Borsook
Keyword(s):  
Chronic Pain ◽  
Theoretical Basis ◽  
Theoretical Models ◽  
Clinical Implications ◽  
Neural Processes ◽  
Pain Models ◽  
Role Of Parents ◽  
Pain Experiences ◽  
Resilience Mechanisms

Pain experiences, both acute and chronic, are common in infants, children, and adolescents. The aim of this chapter is to give an overview of different biopsychosocial pediatric pain models that address acute or chronic pain. Recent insights in neural processes are discussed, as well as psychosocial mechanisms across a child’s development. The crucial role of parents in different theoretical conceptualizations is highlighted. We emphasize that both risk factors for the development of chronic pain-related disability and resilience mechanisms for adaptive child functioning should be considered. Finally, clinical implications are outlined ensuing from the different theoretical models discussed in this chapter.

What is the role of fear and escape/avoidance in chronic pain? Models, structural analysis and future directions

2012 ◽  
Vol 2 (3) ◽  
pp. 295-303 ◽  
Author(s):  
Gordon JG Asmundson ◽  
Holly A Parkerson ◽  
Mark Petter ◽  
Melanie Noel
Keyword(s):  
Chronic Pain ◽  
Structural Analysis ◽  
Future Directions ◽  
Pain Models

Catastrophizing in Comorbid Chronic Pain and Mental Illness

2020 ◽  
pp. 234-248
Author(s):  
Cynthia O. Townsend ◽  
Donald R. Townsend
Keyword(s):  
Chronic Pain ◽  
Mental Illness ◽  
Prognostic Factor ◽  
Pain Catastrophizing ◽  
Psychological Interventions ◽  
Clinical Implications ◽  
Specific Situation ◽  
Negative Consequences ◽  
Pain Chronification

Catastrophizing, or the tendency to emphasize and exaggerate the occurrence of negative consequences in a specific situation, has been shown to play an important role in the development and maintenance of chronic pain. Dynamically viewed as a contributor, mediator, and result of chronic pain suffering, catastrophizing has notable importance for clinicians treating patients’ comorbid chronic pain and mental illness. Exciting research on catastrophizing and neuroplasticity in persons with chronic pain promises to expand our understanding of pain catastrophizing, pain chronification, and cortical structural neuroplasticity in response to psychological interventions. This chapter provides a selective review of the assessment and neural correlates of pain catastrophizing as well as the role of catastrophizing as a prognostic factor for pain-related outcomes. The interactions between catastrophizing and chronic pain are also explored in the context of key comorbid mental conditions: depression and insomnia. Clinical implications for the practicing clinician are discussed.

Families and pain

2013 ◽  
pp. 111-118
Author(s):  
Kathryn A. Birnie ◽  
Katelynn E. Boerner ◽  
Christine T. Chambers
Keyword(s):  
Critical Role ◽  
Theoretical Models ◽  
Future Research ◽  
Illustrative Case ◽  
Comprehensive Review ◽  
Case Examples ◽  
Research Themes ◽  
The Family ◽  
Pain Experiences

The family has long been acknowledged as an important social context where children learn about and receive support for their pain. When a child is in pain, it is the family who is responsible for the initial pain assessment and seeking appropriate evaluation and care. Families may inadvertently encourage the expression of pain and play a critical role in influencing their children’s ability to cope with pain, both positively and negatively. Having a child in pain can also pose significant personal, familial, and economic strains. Therefore, consideration of the family is absolutely critical in the understanding of factors involved in children’s acute and chronic pain experiences (McGrath, 2008). A concentration of research has continued since the last comprehensive review on the topic was published (Chambers, 2003). This chapter considers relevant theoretical models and summarizes current major research themes regarding the role of the family in both acute and chronic paediatric pain. Two illustrative case examples are provided and key areas for future research are identified.

scholarly journals Characterization of New TRPM8 Modulators in Pain Perception

2019 ◽  
Vol 20 (22) ◽  
pp. 5544 ◽  
Author(s):  
Carmen De Caro ◽  
Claudia Cristiano ◽  
Carmen Avagliano ◽  
Alessia Bertamino ◽  
Carmine Ostacolo ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Pain Perception ◽  
Transient Receptor Potential ◽  
Pain Modulation ◽  
The Body ◽  
Sprague Dawley ◽  
Transient Receptor Potential Melastatin ◽  
Pain Models ◽  
Excessive Activation

Background: Transient Receptor Potential Melastatin-8 (TRPM8) is a non-selective cation channel activated by cold temperature and by cooling agents. Several studies have proved that this channel is involved in pain perception. Although some studies indicate that TRPM8 inhibition is necessary to reduce acute and chronic pain, it is also reported that TRPM8 activation produces analgesia. These conflicting results could be explained by extracellular Ca2+-dependent desensitization that is induced by an excessive activation. Likely, this effect is due to phosphatidylinositol 4,5-bisphosphate (PIP2) depletion that leads to modification of TRPM8 channel activity, shifting voltage dependence towards more positive potentials. This phenomenon needs further evaluation and confirmation that would allow us to understand better the role of this channel and to develop new therapeutic strategies for controlling pain. Experimental approach: To understand the role of TRPM8 in pain perception, we tested two specific TRPM8-modulating compounds, an antagonist (IGM-18) and an agonist (IGM-5), in either acute or chronic animal pain models using male Sprague-Dawley rats or CD1 mice, after systemic or topical routes of administration. Results: IGM-18 and IGM-5 were fully characterized in vivo. The wet-dog shake test and the body temperature measurements highlighted the antagonist activity of IGM-18 on TRPM8 channels. Moreover, IGM-18 exerted an analgesic effect on formalin-induced orofacial pain and chronic constriction injury-induced neuropathic pain, demonstrating the involvement of TRPM8 channels in these two pain models. Finally, the results were consistent with TRPM8 downregulation by agonist IGM-5, due to its excessive activation. Conclusions: TRPM8 channels are strongly involved in pain modulation, and their selective antagonist is able to reduce both acute and chronic pain.

scholarly journals Social Risk and Resilience Factors in Adolescent Chronic Pain: Examining the Role of Parents and Peers

2017 ◽  
Vol 43 (3) ◽  
pp. 303-313 ◽  
Author(s):  
Alexandra C Ross ◽  
Laura E Simons ◽  
Amanda B Feinstein ◽  
Isabel A Yoon ◽  
Rashmi P Bhandari
Keyword(s):  
Chronic Pain ◽  
Social Risk ◽  
Risk And Resilience ◽  
Resilience Factors ◽  
Role Of Parents

Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat

Neuroscience ◽  
2007 ◽  
Vol 144 (4) ◽  
pp. 1477-1485 ◽  
Author(s):  
L. Luo ◽  
L. Chang ◽  
S.M. Brown ◽  
H. Ao ◽  
D.H. Lee ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Cyclic Nucleotide ◽  
Pacemaker Channels ◽  
Pain Models

scholarly journals The Cyclical Relation Between Chronic Pain, Executive Functioning, Emotional Regulation, and Self-Management

2020 ◽  
Author(s):  
Line Caes ◽  
Bruce Dick ◽  
Christina Duncan ◽  
Julia Allan
Keyword(s):  
Chronic Pain ◽  
Executive Functioning ◽  
Parental Support ◽  
Emotional Regulation ◽  
Intervention Development ◽  
Self Report ◽  
Self Management ◽  
Cross Sectional ◽  
Pain Experiences

Abstract Objective  To propose a new model outlining a hypothesized cyclical relation between executive functioning, emotional regulation, and chronic pain in adolescence and to highlight the likely importance of such a relation for self-management behavior and pain-related disability. Methods  A review of the existing literature that critically explores the role of executive functioning in understanding chronic pain experiences and self-management in adolescence in order to develop the Cyclical model Of Pain, Executive function, emotion regulation, and Self-management (COPES). Results  Growing evidence points towards a potential cyclical relation between chronic pain and impaired executive functioning, which forms the basis of COPES. The COPES model proposes that the relative immaturity of executive functioning in adolescence negatively influences their ability to engage with self-management, which in turn increases adolescents’ disability due to pain and contributes to the maintenance of chronic pain, which perpetuates the reduced capacity of executive functioning. The moderating influence of flexible parental support is hypothesized to offset some of these influences. However, the available evidence is limited due to methodological shortcomings such as large variety in executive functioning operationalization, reliance on self-report and cross-sectional designs. Conclusions  It is anticipated that the COPES model will stimulate more systematic, theory-driven research to further our understanding of the links between executive functioning, chronic pain, self-management, and wellbeing. Such enhanced understanding has the potential to drive forward intervention development and refinement aimed at improving self-management uptake and adherence amongst adolescents with chronic pain.

scholarly journals Chronic Orofacial Pain: Models, Mechanisms, and Genetic and Related Environmental Influences

2021 ◽  
Vol 22 (13) ◽  
pp. 7112
Author(s):  
Barry J. Sessle
Keyword(s):  
Chronic Pain ◽  
Genetic Factors ◽  
Orofacial Pain ◽  
Trigeminal Neuropathic Pain ◽  
Behavioural Characteristics ◽  
Pain Models ◽  
Chronic Orofacial Pain ◽  
Underlying Mechanisms ◽  
Animal Strains

Chronic orofacial pain conditions can be particularly difficult to diagnose and treat because of their complexity and limited understanding of the mechanisms underlying their aetiology and pathogenesis. Furthermore, there is considerable variability between individuals in their susceptibility to risk factors predisposing them to the development and maintenance of chronic pain as well as in their expression of chronic pain features such as allodynia, hyperalgesia and extraterritorial sensory spread. The variability suggests that genetic as well as environmental factors may contribute to the development and maintenance of chronic orofacial pain. This article reviews these features of chronic orofacial pain, and outlines findings from studies in animal models of the behavioural characteristics and underlying mechanisms related to the development and maintenance of chronic orofacial pain and trigeminal neuropathic pain in particular. The review also considers the role of environmental and especially genetic factors in these models, focussing on findings of differences between animal strains in the features and underlying mechanisms of chronic pain. These findings are not only relevant to understanding underlying mechanisms and the variability between patients in the development, expression and maintenance of chronic orofacial pain, but also underscore the importance for considering the strain of the animal to model and explore chronic orofacial pain processes.

Prevention of the development and maintenance of paediatric chronic pain and disability

2013 ◽  
pp. 39-44 ◽  
Author(s):  
M. Gabrielle Pagé ◽  
Anna Huguet ◽  
Joel Katz
Keyword(s):  
Chronic Pain ◽  
Prognostic Factors ◽  
Protective Factors ◽  
Theoretical Models ◽  
Predisposing Factors ◽  
Clinical Implications ◽  
Essential Step

Understanding the predisposing factors that confer a greater risk of developing chronic pain is an essential step in pain prevention and management. This chapter focuses on current theoretical models that can inform prevention of paediatric pain and disability. We review the literature on known risk/protective factors, markers, correlates, and prognostic factors for the transition to chronic pain and disability across a variety of pain conditions. We distinguish between primary, secondary, and tertiary levels of pain prevention and discuss the clinical implications of this distinction.

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