scholarly journals Similarity-Based Codes Sequentially Assigned to Ebolavirus Genomes Are Informative of Species Membership, Associated Outbreaks, and Transmission Chains

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Alexandra J. Weisberg ◽  
Haitham A. Elmarakeby ◽  
Lenwood S. Heath ◽  
Boris A. Vinatzer
Keyword(s):  
Public Health ◽  
Ebola Virus ◽  
Virus Disease ◽  
Average Nucleotide Identity ◽  
Viral Isolate ◽  
Nomenclature System ◽  
Species Membership ◽  
Disease Epidemics ◽  
Viral Isolates ◽  
Epidemiological Information

Abstract Background.  Developing a universal standardized microbial typing and nomenclature system that provides phylogenetic and epidemiological information in real time has never been as urgent in public health as it is today. We previously proposed to use genome similarity as the basis for immediate and precise typing and naming of individual organisms or viruses. In this study, we tested the validity of the proposed system and applied it to the epidemiology of infectious diseases using Ebola virus disease (EVD) outbreaks as the example. Methods.  One hundred twenty-eight publicly available ebolavirus genomes were compared with each other, and average nucleotide identity (ANI) was calculated. The ANI was then used to assign unique codes, hereafter referred to as Life Ide.jpegication Numbers (LINs), to every viral isolate, whereby each LIN consisted of a series of positions reflecting increasing genome similarity. Congruence of LINs with phylogenetic and epidemiological relationships was then determined. Results.  Assigned LINs correlate with phylogeny at the species and infraspecies level and can even ide.jpegy some individual transmission chains during the 2014–2015 EVD epidemic in West Africa. Conclusions.  Life Ide.jpegication Numbers can provide a fast, automated, standardized, and scalable approach to precisely ide.jpegy and name viral isolates upon genome sequence submission, facilitating unambiguous communication during disease epidemics among clinicians, epidemiologists, and governments.

scholarly journals Reconstruction and prediction of viral disease epidemics

2018 ◽  
Vol 147 ◽  
Author(s):  
M. U. G. Kraemer ◽  
D. A. T. Cummings ◽  
S. Funk ◽  
R. C. Reiner ◽  
N. R. Faria ◽  
...  
Keyword(s):  
Public Health ◽  
Ebola Virus ◽  
Viral Infections ◽  
Yellow Fever Virus ◽  
Virus Disease ◽  
Viral Disease ◽  
Diagnostic Tools ◽  
Geographic Spread ◽  
Modelling Techniques ◽  
Disease Epidemics

AbstractA growing number of infectious pathogens are spreading among geographic regions. Some pathogens that were previously not considered to pose a general threat to human health have emerged at regional and global scales, such as Zika and Ebola Virus Disease. Other pathogens, such as yellow fever virus, were previously thought to be under control but have recently re-emerged, causing new challenges to public health organisations. A wide array of new modelling techniques, aided by increased computing capabilities, novel diagnostic tools, and the increased speed and availability of genomic sequencing allow researchers to identify new pathogens more rapidly, assess the likelihood of geographic spread, and quantify the speed of human-to-human transmission. Despite some initial successes in predicting the spread of acute viral infections, the practicalities and sustainability of such approaches will need to be evaluated in the context of public health responses.

scholarly journals The influence and enlightenment of five public health emergencies on public psychology since new century: A systematic review

2021 ◽  
pp. 002076402110022
Author(s):  
Zhifeng Wang ◽  
Dongmei Wang
Keyword(s):  
Public Health ◽  
Ebola Virus ◽  
Psychological Intervention ◽  
Virus Disease ◽  
H1n1 Influenza ◽  
Psychological State ◽  
Wild Animals ◽  
Post Traumatic Stress ◽  
Public Health Emergencies ◽  
The People

Background: Since the 21st century, humans have experienced five public health emergencies: the severe acute respiratory syndrome (SARS), type A H1N1 influenza (H1N1), Middle East respiratory syndrome (MERS), Ebola virus disease (EVD), and the new coronavirus pneumonia (COVID-19). They caused a large number of casualties and a wider psychological crisis, which might cause severe consequences such as post-traumatic stress disorder and suicide. Aims: To reveal the law of formation of public psychological crisis in public health emergencies, and draw lessons from it. To provide ideas for effectively deal with these psychological crisis problems and fundamentally curbing the occurrence of public health emergencies. Method: Through the method of literature research, ‘public health incidents’, ‘psychological crisis’, ‘mental health’, ‘psychological intervention’, ‘SARS’, ‘H1N1’, ‘MERS’, ‘EVD’, and ‘COVID-19’ were used to search literatures in the databases such as PubMed, Springer, and Sciencedirect, and the literatures were summarized, sorted, and studied. Results: (1) The public health emergencies caused a universal psychological crisis. The main manifestations were depression, compulsion, despair, etc. The people involved mainly include patients, suspected isolated patients, medical staff, and the general public in the epidemic situation. (2) People’s psychological state often experienced stress stage, shock stage, acceptance, and reorganization. Only some susceptible individuals couldn’t complete effective psychological reconstruction, resulting in serious psychological disorders. Individual susceptibility is related to genetic factors, adversity, and traumatic stimuli experienced in early life. Conclusion: To reduce these psychological crisis problems, we should establish and improve the psychological crisis intervention or rescue system of public health emergencies, it was still necessary to live in harmony with nature, get rid of the inappropriate habit of preying on wild animals, in order to prevent the cross-species transmission of the virus between wild animals and humans, and to fundamentally avoid the occurrence of major infectious diseases.

Screening at ports of entry for Ebola Virus Disease in England—a descriptive analysis of screening assessment data, 2014–2015

2020 ◽  
Author(s):  
Nicki L Boddington ◽  
Sophia Steinberger ◽  
Richard G Pebody
Keyword(s):  
Public Health ◽  
High Risk ◽  
Secondary Care ◽  
Ebola Virus ◽  
Virus Disease ◽  
Descriptive Analysis ◽  
Health Assessment ◽  
Ebola Virus Disease ◽  
Screening Assessment

Abstract Background In response to the outbreak of Ebola Virus Disease (EVD) in West Africa in 2014 and evidence of spread to other countries, pre-entry screening was introduced by PHE at five major ports of entry in the England. Methods All passengers that entered the England via the five ports returning from Liberia, Guinea and Sierra Leonne were required to complete a Health Assessment Form and have their temperature taken. The numbers, characteristics and outcomes of these passengers were analysed. Results Between 14 October 2014 and 13 October 2015, a total of 12 648 passengers from affected countries had been screened. The majority of passengers were assessed as having no direct contact with EVD cases or high-risk events (12 069, 95.4%), although 535 (4.2%) passengers were assessed as requiring public health follow-up. In total, 39 passengers were referred directly to secondary care, although none were diagnosed with EVD. One high-risk passenger was later referred to secondary care and diagnosed with EVD. Conclusions Collection of these screening data enabled timely monitoring of the numbers and characteristics of passengers screened for EVD, facilitated resourcing decisions and acted as a mechanism to inform passengers of the necessary public health actions.

scholarly journals The Threat of Ebola Virus Disease: a Call to Integrate all Sectors in Surveillance Activities in Ghana

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Dennis O. Laryea ◽  
Yaw Amoako ◽  
Dan V. Armooh ◽  
Emmanuel P. Abbeyquaye ◽  
Bernice N. Amartey
Keyword(s):  
Public Health ◽  
Health Service ◽  
West Africa ◽  
Health System ◽  
Disease Surveillance ◽  
Ebola Virus ◽  
Virus Disease ◽  
Public Health Importance ◽  
Ghana Health ◽  
Ghana Health Service

Surveillance for communicable diseases of public health importance is critical in preventing and controlling outbreaks. In Ghana, this responsibility lies with the Disease Surveillance Department of the Ghana Health Service (GHS). However, the structure of Ghana's health system means surveillance activities by the department are concentrated in GHS facilities. Active surveillance in non-GHS facilities usually occur during outbreaks. In light of the recent Ebola outbreak in West Africa, there is the need to integrate the surveillance activities to include all health facilities to ensure the prompt identification of cases.

scholarly journals The Healthcare Providers-Patients Relationship and State Obligations in Times of Public Health Emergency

2016 ◽  
Vol 9 (4) ◽  
pp. 268-298
Author(s):  
Gloria C. Nwafor ◽  
Anthony O. Nwafor
Keyword(s):  
Public Health ◽  
Ebola Virus ◽  
Virus Disease ◽  
Medical Profession ◽  
Healthcare Providers ◽  
Public Health Emergency ◽  
West African ◽  
The State ◽  
The West ◽  
State Obligations

The recent outbreak of Ebola Virus Disease (evd) in the West African sub-region sprung challenges on the healthcare providers in the observance of their ethical rules in dealing with their patients and the State in fulfilling its obligations to ensure that the rights of patients are respected in times of public health emergency. The ethical rules of medical practice demand that the healthcare providers prefer the interests of their patients to the preservation of self. The State is by law under obligation to protect and respect the rights of the patients in all situations. The paper argues that the responses by the healthcare providers and the States in the West African sub region in the wake of the public health emergency fell short of the demands of the ethical rules of the medical profession and the obligation to ensure that the rights of the patients are respected.

scholarly journals An analysis of International Health Regulations Emergency Committees and Public Health Emergency of International Concern Designations

2020 ◽  
Vol 5 (6) ◽  
pp. e002502 ◽  
Author(s):  
Lucia Mullen ◽  
Christina Potter ◽  
Lawrence O Gostin ◽  
Anita Cicero ◽  
Jennifer B Nuzzo
Keyword(s):  
Public Health ◽  
Influenza A ◽  
Ebola Virus ◽  
Virus Disease ◽  
International Health ◽  
Public Health Emergency ◽  
Director General ◽  
International Health Regulations ◽  
International Response ◽  
Health Regulations

IntroductionNine events have been assessed for potential declaration of a Public Health Emergency of International Concern (PHEIC). A PHEIC is defined as an extraordinary event that constitutes a public health risk to other states through international spread and requires a coordinated international response. The WHO Director-General convenes Emergency Committees (ECs) to provide their advice on whether an event constitutes a PHEIC. The EC rationales have been criticised for being non-transparent and contradictory to the International Health Regulations (IHR). This first comprehensive analysis of EC rationale provides recommendations to increase clarity of EC decisions which will strengthen the IHR and WHO’s legitimacy in future outbreaks.Methods66 EC statements were reviewed from nine public health outbreaks of influenza A, Middle East respiratory syndrome coronavirus, polio, Ebola virus disease, Zika, yellow fever and coronavirus disease-2019. Statements were analysed to determine which of the three IHR criteria were noted as contributing towards the EC’s justification on whether to declare a PHEIC and what language was used to explain the decision.ResultsInterpretation of the criteria were often vague and applied inconsistently. ECs often failed to describe and justify which criteria had been satisfied.DiscussionGuidelines must be developed for the standardised interpretation of IHR core criteria. The ECs must clearly identify and justify which criteria have contributed to their rationale for or against PHEIC declaration.ConclusionStriving for more consistency and transparency in EC justifications would benefit future deliberations and provide more understanding and support for the process.

scholarly journals Anthropology in public health emergencies:what is anthropology good for?

2018 ◽  
Vol 3 (2) ◽  
pp. e000534 ◽  
Author(s):  
Darryl Stellmach ◽  
Isabel Beshar ◽  
Juliet Bedford ◽  
Philipp du Cros ◽  
Beverley Stringer
Keyword(s):  
Public Health ◽  
Disease Transmission ◽  
Ebola Virus ◽  
Virus Disease ◽  
Disease Outbreak ◽  
Outbreak Response ◽  
Public Health Response ◽  
Health Crisis ◽  
Health Response ◽  
Increasing Demand

Recent outbreaks of Ebola virus disease (2013–2016) and Zika virus (2015–2016) bring renewed recognition of the need to understand social pathways of disease transmission and barriers to care. Social scientists, anthropologists in particular, have been recognised as important players in disease outbreak response because of their ability to assess social, economic and political factors in local contexts. However, in emergency public health response, as with any interdisciplinary setting, different professions may disagree over methods, ethics and the nature of evidence itself. A disease outbreak is no place to begin to negotiate disciplinary differences. Given increasing demand for anthropologists to work alongside epidemiologists, clinicians and public health professionals in health crises, this paper gives a basic introduction to anthropological methods and seeks to bridge the gap in disciplinary expectations within emergencies. It asks: ‘What can anthropologists do in a public health crisis and how do they do it?’ It argues for an interdisciplinary conception of emergency and the recognition that social, psychological and institutional factors influence all aspects of care.

The effect of the 2014 West Africa Ebola virus disease epidemic on multi-level violence against women

2016 ◽  
Vol 9 (3) ◽  
pp. 151-160 ◽  
Author(s):  
Melanie O’Brien ◽  
Maria Ximena Tolosa
Keyword(s):  
Public Health ◽  
Human Rights ◽  
West Africa ◽  
Violence Against Women ◽  
Ebola Virus ◽  
Virus Disease ◽  
Right To Health ◽  
Human Rights Law ◽  
Content Type ◽  
Women And Girls

Purpose The purpose of this paper is to provide an analysis of the disproportionate impact of the 2014 West Africa Ebola virus disease (EVD) epidemic on women, presenting an assessment of how this impact in particular is linked with violence against women and women’s right to health, and a critique of improvements that could avoid discrimination against women in healthcare crises. Design/methodology/approach This paper covers conceptual understandings of, and utilises a human rights law and public health lens to analyse how the EVD epidemic in West Africa both directly and indirectly caused greater harm to women and girls. All these factors which represent intersectional violations of the human rights of women are examined with a focus on violence against women and the right to health. Findings There are multiple reasons why the EVD outbreak harmed women disproportionately, and this intersectionality of discrimination must be considered in any response to a public health crisis. Addressing the vulnerability of women and girls to all forms of violence involves the coordinated efforts of public health, legal and political actors to empower women. Originality/value Specific issues of the 2014 West Africa EVD outbreak have been examined in medical journals, but there have been no academic studies that present a cross-disciplinary analysis of the gender concerns. This paper combines a public health perspective with a human rights law viewpoint in order to consider the impact of the EVD outbreak on women and provide suggestions as to how discrimination and disadvantage of women in such health crises can be avoided.

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