scholarly journals Group B Streptococci Colonization in Pregnant Guatemalan Women: Prevalence, Risk Factors, and Vaginal Microbiome

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Anne-Marie Rick ◽  
Angie Aguilar ◽  
Rosita Cortes ◽  
Remei Gordillo ◽  
Mario Melgar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Low Income ◽  
Group B Streptococcus ◽  
Cross Sectional Study ◽  
Low Income Countries ◽  
Vaginal Microbiome ◽  
Group B Streptococci ◽  
Cross Sectional ◽  
Group B

Abstract Background Infection causes 1 of every 5 neonatal deaths globally. Group B Streptococcus (GBS) is the most significant pathogen, although little is known about its epidemiology and risk in low-income countries. Methods A cross-sectional study in 2015 at a public hospital in Guatemala City enrolled women ≥35 weeks’ gestation. Vaginal and rectal swabs were processed using Lim broth and GBS CHROMagar then agglutination testing. Risk factors were assessed using multivariate analysis. Vaginal microbiota were profiled by 16S ribosomal ribonucleic acid sequencing in a subset of 94 women. Results Of 896 pregnant women, 155 (17.3%; 95% confidence interval [CI], 14.9–19.9) were GBS colonized. Colonization was associated with history of previous infant with poor outcome (odds ratio [OR], 1.94; 95% CI, 1.15–3.27) and increasing maternal age (OR, 1.05; 95% CI, 1.02–1.09). Multiparity was protective (OR, .39; 95% CI, .21–.72). Four (6%) GBS-exposed infants had early-onset neonatal sepsis. Vaginal microbiome composition was associated with previous antibiotic exposure (P = .003) and previous low birth weight infant (P = .03), but not GBS colonization (P = .72). Several individual taxa differed in abundance between colonized and noncolonized women. Conclusions Group B Streptococcus is prevalent in pregnant women from Guatemala with different risk factors than previously described. Although the vaginal microbiome was not altered significantly in GBS-colonized women, use of antibiotics had an effect on its composition.

scholarly journals Macrolide-resistance, capsular genotyping and associated factors of group B Streptococci colonized pregnant women in Isfahan, Iran

2021 ◽  
Author(s):  
Soodabeh Rostami ◽  
Leila Moeineddini ◽  
Fereshteh Ghandehari ◽  
Marzieh Rahim Khorasani ◽  
Parisa Shoaei ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Group B Streptococcus ◽  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Macrolide Resistance ◽  
Capsular Type ◽  
Group B Streptococci ◽  
Cross Sectional ◽  
Group B

Background and Objectives: Group B streptococcus (GBS) can cause severe and invasive infections in pregnant women, infants, and adults. This study aimed to investigate the risk factors of GBS colonization in pregnant women and determine the macrolide resistance and capsular type of isolates. Materials and Methods: In a cross-sectional study, a total of 200 pregnant women were screened for GBS colonization by phenotypic methods. Antibiotic susceptibility pattern of colonizing isolates and ermB, ermTR, mefA/E genes were detected. Also, molecular capsular types of isolates were distinguished. Results: The overall prevalence of colonization of participates with GBS was 13.5%. Statistical analysis showed that there was no association between risk factors and colonization with GBS. The highest resistance was observed to erythromycin (44.4%) followed by clindamycin (29.6%), penicillin, ampicillin, and ceftriaxone (18.5%), levofloxacin (11.1%), and 29.6% isolates were multidrug-resistant. ermTR and mefA/E genes were detected in 37% and 11.1% isolates; respectively and the ermB gene was not detected. The most common capsular type was type Ib (44.4%) followed by type III (40.7%), type II (11.1), and type Ia (3.7%). Conclusion: In the present study, the prevalence of GBS was in the medium range. Resistance to key antibiotic agents was relatively high. Also, capsular serotype Ib was the predominant serotype, which emphasizes the importance of monitoring the molecular typing of the GBS isolates regularly.

scholarly journals Group B Streptococcus Colonisation, Prevalence, Associated Risk Factors and Antimicrobial Susceptibility Pattern Among Pregnant Women Attending Antenatal Care at Dschang District Hospital, West Region of Cameroun: A hospital-based Cross Sectional Study

2021 ◽  
Author(s):  
Leonard Sama ◽  
michel Noubom ◽  
Christelle KENNE ◽  
Thibau Tchouangueu ◽  
omer Ngouateu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Antimicrobial Susceptibility ◽  
District Hospital ◽  
Group B Streptococcus ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Group B ◽  
Associated Risk Factors

Background: Group B streptococcus (GBS), also name as Streptococcus agalactiae, is a gram-positive bacterium know for it capacity to colonises the vaginal and rectal areas of the mother and is a leading cause of neonatal mortality and morbidity. This study aimed at determining the prevalence, associated risk factors and antimicrobial susceptibility of GBS colonization among pregnant women attending antenatal care at Dschang District Hospital. Methods: This hospital-base cross-sectional study targeted pregnant women population attending hospitals for routine prenatal testing using a multistage sampling method. Pregnant women at 23.46 ± 6.44 weeks gestation completed a questionnaire and vaginal swabs were obtained for GBS analysis. Data were analysed using chi-squared (χ2) test or the Fisher’s exact test when appropriate and the multivariable logistic regression models. Results: The colonisation rate of GBS among pregnant women was 8.69%. Induce abortion (odds ratio [CI] = 3.09, 95% [1.56-6.21]), Spontaneaous abortions (OR= 2.82, 95% CI 1.14-7.29), Stillborn (OR [CI] = 7.75, 95% [2.61-21.71]), Fever (OR [CI] = 0.37, 95% [0.19-0.71]) and anemia (OR [CI] = 0.22, 95% [0.12-0.43]) were found to be influencing factors associated with GBS colonisation. Conclusion: Our findings suggest that none of the studied factors were significantly associated with GBS colonisation. Further longitudinal research is needed to establish the causal relationship and its biological mechanisms. Keys words: Group B Streptococcus, Prevalence, Risk Factors, Antimicrobial Susceptibility, Pregnant Women

scholarly journals Poor Adherence to the Screening-Based Strategy of Group B Streptococcus Despite Colonization of Pregnant Women in Greece

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 418
Author(s):  
Maria Maroudia Berikopoulou ◽  
Aikaterini Pana ◽  
Theodota Liakopoulou-Tsitsipi ◽  
Nikos F. Vlahos ◽  
Vasiliki Papaevangelou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Pregnant Women ◽  
Late Onset ◽  
Group B Streptococcus ◽  
Culture Collection ◽  
Carrier Status ◽  
Cross Sectional ◽  
Screening Guidelines ◽  
Group B

Group B streptococcus (GBS) is a leading cause of serious neonatal infections. Maternal GBS colonization is associated with early- and late-onset neonatal disease (EOD/LOD). In Greece, a screening-based strategy is recommended, in which concurrent vaginal-rectal cultures should be obtained between 36 0/7 and 37 6/7 weeks’ gestation. We sought to examine the level of adherence to the GBS screening guidelines and estimate the prevalence of GBS colonization among pregnant women. Although in Greece the screening-based strategy is followed, we also examined known EOD risk factors and linked them to GBS colonization. A cross-sectional study of 604 women postpartum in three hospitals and maternity clinics was conducted. Following written informed consent, data were collected via a short self-completed questionnaire and review of patients’ records. In 34.6% of the enrolled pregnant women, no culture had been taken. Of the remaining, 12.8% had proper vaginal-rectal sample collections. The overall maternal colonization rate was 9.6%. At least one risk factor for EOD was identified in 12.6% of participants. The presence of risk factors was associated with positive cultures (p = 0.014). The rate of culture collection did not differ between women with or without an EOD risk factor. Adherence to a universal screening of pregnant women with vaginal-rectal cultures was poor. Despite probable underestimation of GBS carrier status, almost 1 in 10 participants were GBS positive during pregnancy. Screening of women with risk factors for EOD should, at least, be prioritized to achieve prevention and prompt intervention of EOD.

scholarly journals Prevalence and Serotype Determination of Streptococcus agalactiae Isolated From Non-Pregnant Women in Tehran, Iran

2020 ◽  
Author(s):  
Leila Goudarzi ◽  
Mohammad Bagher Khalili ◽  
Mahmood Vakili ◽  
Maryam Sadeh
Keyword(s):  
Pregnant Women ◽  
Streptococcus Agalactiae ◽  
Group B Streptococcus ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Specific Pcr ◽  
Pcr Method ◽  
Group B ◽  
Tehran Area

Consequence of Streptococcus agalactiae, Group B Streptococcus (GBS) relating infant’s diseases are well documented. Although many women carry this bacterium in their vagina, they may transfer to their infant during delivery and may result in different neonatal invasive diseases. The aim of this study was to determine the prevalence of GBS and serotyping the isolated species among un-selective non-pregnant women who attended two gynecology clinics in Tehran. In this cross-sectional study, a total of 560 vaginal samples collected from non-pregnant women. Following inoculation of the specimen on Blood Agar, the standard technology was applied for the final identification of GBS. Detected GBS species were further confirmed using specific PCR directed on dlts gene. Capsular serotyping was done by using the multiplex PCR method. The chi-square method was used for statistical analysis. Fifty (8.9%) out of 560 non-pregnant women were carriers of GBS. The most common types were III (36%), followed by type II (32%), Ia (26%), and Ib (6%), respectively. Results represent that the prevalence rate of GBS in non-pregnant women was reliable and similar to what obtained from pregnant women. In addition, the serotype III was found the most dominant types, as well as other investigations in the Tehran area. Therefore, vaccine designation based on type III is recommended.

scholarly journals Knowledge and Acceptance of Labour Analgesia in Pregnant Women

2018 ◽  
Vol 16 (3) ◽  
pp. 302-306 ◽  
Author(s):  
Mona Sharma ◽  
Saurya Dhungel ◽  
Sujata Niroula ◽  
Manan Karki
Keyword(s):  
Pregnant Women ◽  
Low Income ◽  
Care Center ◽  
Tertiary Care ◽  
College Teaching ◽  
Cross Sectional Study ◽  
Acceptance Rate ◽  
Labour Analgesia ◽  
Low Income Countries ◽  
Cross Sectional

Background: Labour analgesia, though practiced worldwide, is not very popular in low-income countries. The aim of the study was to assess the awareness, attitude, acceptance, and reasons for hindrance of labour analgesia among patients visiting a tertiary care center in the capital cityMethods: It was a cross sectional study conducted in Obstetrics and Gynecology outpatient department of Kathmandu Medical College Teaching Hospital in the month of August 2017. All pregnant patients presenting for antenatal checkup was included. Data was collected based on a questionnaire after informed consent. Statistical analysis was done in SPSS version 20 and results were expressed in frequencies and percentage.Results: Total of 270 pregnant women participated in the study. Out of these forty-four (16.3%) patients were aware about labour analgesia. The acceptance rate was high (72.2%). Majority (84.6%) had no problem with expenditure associated with labour analgesia.Conclusions: Despite low awareness about painless delivery among the antenatal women, the acceptance rate is high.

scholarly journals Knowledge, attitude and current practices of pregnant women towards group B streptococcus screening: cross-sectional study, Al-Madinah, Saudi Arabia

BMJ Open ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. e032487
Author(s):  
Amer Alshengeti ◽  
Amjad Alharbi ◽  
Shahad Alraddadi ◽  
Abdulsalam Alawfi ◽  
Bushra Aljohani
Keyword(s):  
Saudi Arabia ◽  
Pregnant Women ◽  
Group B Streptococcus ◽  
Knowledge Score ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Screening Strategies ◽  
Group B ◽  
Universal Culture

AimsGroup B streptococcus (GBS) is one of the most frequent bacterial pathogens causing invasive infections in neonates. It can be transmitted from colonised mother to neonates around delivery. Screening strategies for GBS during pregnancy include either universal culture-based or risk-based screening. The present study aimed to assess the knowledge, attitude and current practices of pregnant women towards GBS screening in Al-Madinah City, Saudi Arabia.MethodsA hospital-based cross-sectional study was conducted at Madinah Maternity and Children Hospital, Al-Madinah, Saudi Arabia, from May to July 2018. Participants were recruited from postnatal wards. Participants were interviewed using a previously published validated survey that was divided into the following domains: demographic data, knowledge, experience and attitude towards different GBS screening strategies.ResultsA total of 377 out of 450 women (response rate 83.7%) were enrolled. The results showed that the overall mean knowledge score of the pregnant women towards GBS screening was 59.8%. Majority of the women (66.8%) were not aware of the GBS bacterium, while 86.5% of them had never been informed of GBS risk assessment during their pregnancies. The mean knowledge score among women who were aware of GBS (62.8%) was significantly higher than that among women who were not (58.4%) (p=0.015). However, majority of the pregnant women (61.8%) showed preference for universal culture-based GBS screening strategy over risk-based strategy.ConclusionThe study results have concluded that the level of awareness and knowledge about GBS among pregnant women were relatively poor; however, majority of the pregnant women prefer universal culture-based screening.

scholarly journals Prevalence and Associated Risk Factors for Anaemia Among Pregnant Women Attending Ante-Natal Clinic, Eswatini

2021 ◽  
Author(s):  
Rumbidzai Dodzo ◽  
Ropo Ebenezer Ogunsakin ◽  
Themba G. Ginindza
Keyword(s):  
Pregnant Women ◽  
Low Income ◽  
Cross Sectional Study ◽  
Low Income Countries ◽  
Health Concern ◽  
Cross Sectional ◽  
Neonatal Deaths ◽  
Factors Associated ◽  
Anaemia In Pregnancy ◽  
Associated Risk Factors

Abstract Background: Anaemia is one of the most common nutritional deficiency diseases observed globally and it affects about a third of the world’s population. Anaemia in pregnant women is a worldwide public health concern that has severe consequences for both mothers and infants, including maternal death and foetal and infant mortality. In Low-income countries (LICs), 25% of indirect maternal mortality and 30% of neonatal deaths are due to anaemia in pregnancy. Therefore, this study aimed to determine the prevalence of anaemia and assess associated factors among pregnant women attending ante-natal care (ANC) clinic in the Kingdom of Eswatini, which might help for screening, prevention and treatment of anaemia and ultimately prevent its adverse effects. Method: A total of 550 pregnant women between 15 and 49 years from three health facilities were randomly enrolled using a cross-sectional study design, from January to March 2021. Non-probability sampling approach was used to select the appropriate study unit. A face-toface interview was done using a structured questionnaire to collect data. Multiple logistic regression was performed to assess the factors associated with anaemia among the women.Results: The overall anaemia prevalence among pregnant women was 43.1% (95% CI: 38.947.3). The mild, moderate and severe cases of anaemia were 21.3% (95%CI: 17.9-24.9); 21.1% (95%CI: 17.8-24.7) and 0.7% (95%CI: 0.2-1.9), respectively. The prevalence of anaemia was high among women aged 20-24 (11.1%, 95%CI: 8.6-14.0) and 25-29years (11.1%, 95%CI: 8.6-14.0). Factors associated with anaemia included living in the urban area (OR=1.8, 95%CI: 1.19-2.72, p=0.005) and having anaemia 6 months before pregnancy (OR=4.64, 95%CI: 1.1518.71, p=0.031). Additionally, gestational age at first ANC also was positively associated with anaemia: 3rd trimester (OR=10.42, 95%CI: 4.27-25.4, p<0.001) and 2nd trimester (OR=1.62, 95%CI: 1.02-2.60, p=0.043) Conclusion: Anaemia remains prevalent among pregnant women in Eswatini. Thus, a comprehensive anaemia prevention program would be justified and could lower the country’s burden of anemia.

scholarly journals Changes in perceived knowledge about childbirth among pregnant women participating in the Senses of Birth Intervention in Brazil: A cross-sectional study

2020 ◽  
Author(s):  
Luísa M M Fernandes ◽  
Sônia Lansky ◽  
Bernardo J Oliveira ◽  
Amélia A L Friche ◽  
Christine T. Bozlak ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Low Income ◽  
Cross Sectional Study ◽  
Low Income Countries ◽  
Perceived Knowledge ◽  
Cross Sectional ◽  
Knowledge Domains ◽  
Normal Birth ◽  
The Mean ◽  
The Impact

Abstract Background: Senses of Birth (SoB) is a health education intervention in Brazil that addresses reproductive rights, the benefits and risks of normal birth and cesarean, and use of evidence-based practices (EBP) during labor and childbirth, aiming to reduce unnecessary cesareans in the country. This study evaluates the impact of the SoB intervention on pregnant women’s perceived knowledge about normal birth, cesarean, and use of EBP in childbirth. Method: 1,287 pregnant women answered a structured questionnaire, immediately after their visit to the exhibition, between March 2015 and March 2016, in four cities. To identify the impact of the intervention on women’s perceived knowledge and possible association with socioeconomic and demographic characteristics, statistical analyses were performed including paired T-tests, ANOVA, and logistic and linear regressions. Results: The mean score (MS) of perceived knowledge after the intervention was higher than the mean score before experiencing the SoB for all three knowledge domains: Normal Birth (MS Before= 3.71 x MS After= 4.49), Cesarean (MS Before= 3.54 x MS After= 4.26) and EBPs (MS Before= 3.14 x MS After= 4.14). The results suggest that SoB intervention was more effective for low income women (B = 0.206; p < 0.001 for EBP), women without private health insurance (OR 2.47, 95% CI: 1.49- 4.09 for normal birth), women with private prenatal care (OR 2.42, 95% CI: 1.59- 3.66 for normal birth), women experiencing their first pregnancy (OR 1.92, 95% CI: 1.31-2.82 for EBP; OR 1.37, 95% CI: 1.03-1.84 for normal birth; OR 1.37, 95% CI: 1.03-1.84 for cesarean), and women in their first or second trimester at the time of the intervention (OR 1.64, 95% CI: 1.13-2.39 for EBP; OR 1.48, 95% CI: 1.11-1.97 for normal birth; OR 1.85, 95% CI: 1.40-2.41 for cesarean). Conclusion: The study showed opportunities to increase knowledge among Brazilian pregnant women for the three knowledge domains, and a need to focus the discussion on how to achieve a positive experience of birth using EBP. The intervention gains relevance considering the lack of evidence of the efficacy of non-clinical interventions to reduce unnecessary cesareans in middle and low-income countries targeting women.

scholarly journals Group B Streptococcus Colonization among Pregnant Women Attending Antenatal Care at Tertiary Hospital in Rural Southwestern Uganda

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Abdul Namugongo ◽  
Joel Bazira ◽  
Yarine Fajardot ◽  
Ngonzi Joseph
Keyword(s):  
Antenatal Care ◽  
Pregnant Women ◽  
Univariate Analysis ◽  
Group B Streptococcus ◽  
Antenatal Clinic ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Group B ◽  
Southwestern Uganda

Objectives.This study sought to determine the prevalence and factors associated with group B streptococcal anogenital colonization among pregnant women attending antenatal care at Mbarara Regional Referral Hospital, a tertiary hospital.Methods.Cross-sectional study where 309 pregnant women ≥ thirty-five weeks of gestation attending antenatal clinic were consecutively recruited between January and March 2015. Anovaginal swabs were collected and tested qualitatively using rapid visual immunoassay GBS test kits for presence of GBS antigens. Data was analyzed using STATA version 12. In univariate analysis, GBS colonized mothers were presented as percentages and numbers, and in multivariate analysis logistic regression analysis was applied to determine the associations of exposure variable and GBS colonization; a value of less than 0.05 was considered significant.Results.Mothers’ median age was 25 years, 14.6% mothers being obese. GBS prevalence was 28.8%, 95% CI: 23.7–33.9. Obesity was the only significant factor associated with anogenital GBS colonization with odds ratio of 3.78, 95% CI: 1.78–8.35, apvalue of 0.001. Maternal ages, educational level, residence, and gravidity were not associated with GBS anogenital colonization.Conclusion.Group B streptococcal anogenital colonization among pregnant women attending antenatal care at tertiary hospital, in Southwestern Uganda, is high.

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