Reflection

2021 ◽  
pp. 317-325
Author(s):  
Alison Hanson ◽  
Rafael Yuste

A prevailing view considers the self a property of only the most evolutionarily advanced animals. We propose that a “protoself’ is already present in simple life forms and may be an inherent aspect of all living systems. A separation of the “self” from the “outside” world allows organisms to model the external environment and to act on it. The appearance of the nervous system in larger organisms, initially necessary for speed, enabled the generation of more sophisticated models of the environment and the organism that could be harnessed for more accurate predictions of the future. Spontaneous neuronal activity, such as the default mode network which is prevalent in humans, may serve as an integrator of the model, physically implementing the self as an emergent property.

2021 ◽  
Vol 15 ◽  
Author(s):  
Xiao Wu ◽  
Yue Zhang ◽  
Wen-ting Luo ◽  
Run-ru Mai ◽  
Xiao-yan Hou ◽  
...  

Transcutaneous auricular vagus nerve stimulation (taVNS) has been reported to be effective in the treatment of primary insomnia (PI); however, its efficacy varies considerably across individuals for reasons that are unclear. In order to clarify the underlying mechanisms, this study investigated the effects of taVNS on spontaneous neuronal activity and autonomic nervous system function by functional magnetic resonance imaging (fMRI) and measurement of heart rate variability (HRV), respectively, in patients with PI. Forty patients with PI were divided into effective (group A) and ineffective (group B) groups based on their response to taVNS as determined by Pittsburgh Sleep Quality Index score reduction rate (group A ≥ 25% and group B < 25%). Spontaneous neuronal activity was measured by fractional amplitude of low-frequency fluctuations (fALFF) and HRV values and was compared between the two groups as well as before vs after taVNS. We then analyzed the correlations among efficacy of taVNS for 4 weeks, the fALFF and HRV values during continuous taVNS state. The results showed that the HRV parameter values (i.e., root mean square of successive differences, percentage of adjacent NN intervals differing by >50 ms, and high frequency) of group A were higher than those of group B during continuous taVNS state. In the fMRI scan, the fALFF values of the right cerebellum, right medial superior frontal gyrus, and bilateral supplementary motor area—which belong to the sensorimotor network (SMN)—were lower in group A than in group B during continuous taVNS state. The correlation analysis revealed that the efficacy of continuous taVNS and HRV and fALFF values were interrelated. These findings demonstrate that differential regulation of the SMN by the autonomic nervous system may be responsible for inter-individual variations in the efficacy of taVNS and suggest that HRV and fALFF are potential biomarkers for predicting PI patients’ response to taVNS treatment.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yi Wen ◽  
Nazila Salamat-Miller ◽  
Keethkumar Jain ◽  
Katherine Taylor

AbstractDirect delivery of therapeutic enzymes to the Central Nervous System requires stringent formulation design. Not only should the formulation design consider the delicate balance of existing ions, proteins, and osmolality in the cerebrospinal fluid, it must also provide long term efficacy and stability for the enzyme. One fundamental approach to this predicament is designing formulations with no buffering species. In this study, we report a high concentration, saline-based formulation for a human sulfatase for its delivery into the intrathecal space. A high concentration formulation (≤ 40 mg/mL) was developed through a series of systematic studies that demonstrated the feasibility of a self-buffered formulation for this molecule. The self-buffering capacity phenomenon was found to be a product of both the protein itself and potentially the residual phosphates associated with the protein. To date, the self-buffered formulation for this molecule has been stable for up to 4 years when stored at 5 ± 3 °C, with no changes either in the pH values or other quality attributes of the molecule. The high concentration self-buffered protein formulation was also observed to be stable when exposed to multiple freeze–thaw cycles and was robust during in-use and agitation studies.


2021 ◽  
Vol 36 (2) ◽  
Author(s):  
Julian Kiverstein ◽  
Matt Sims

AbstractA mark of the cognitive should allow us to specify theoretical principles for demarcating cognitive from non-cognitive causes of behaviour in organisms. Specific criteria are required to settle the question of when in the evolution of life cognition first emerged. An answer to this question should however avoid two pitfalls. It should avoid overintellectualising the minds of other organisms, ascribing to them cognitive capacities for which they have no need given the lives they lead within the niches they inhabit. But equally it should do justice to the remarkable flexibility and adaptiveness that can be observed in the behaviour of microorganisms that do not have a nervous system. We should resist seeking non-cognitive explanations of behaviour simply because an organism fails to exhibit human-like feats of thinking, reasoning and problem-solving. We will show how Karl Friston’s Free-Energy Principle (FEP) can serve as the basis for a mark of the cognitive that avoids the twin pitfalls of overintellectualising or underestimating the cognitive achievements of evolutionarily primitive organisms. The FEP purports to describe principles of organisation that any organism must instantiate if it is to remain well-adapted to its environment. Living systems from plants and microorganisms all the way up to humans act in ways that tend in the long run to minimise free energy. If the FEP provides a mark of the cognitive, as we will argue it does, it mandates that cognition should indeed be ascribed to plants, microorganisms and other organisms that lack a nervous system.


Author(s):  
Jyothi M ◽  
Ramchander Merugu

Benzoxazoles being structurally similar to bases adenine and guanine interact with biomolecules present in living systems. These compounds possess antimicrobial, central nervous system activities, antihyperglycemic potentiating activity, analgesic, and anti-inflammatory activity. It can also be used as starting material for other bioactive molecules. Modifications in structure and the biological profiles of new generations of benzoxazoles were found to be more potent with enhanced biological activity. Considering all these, we have prepared this review and discussed the synthesis and biological activities of benzoxazoles.


2015 ◽  
Vol 15 (4) ◽  
pp. 451-465 ◽  
Author(s):  
Anthony Boyer ◽  
Jérémy Deverdun ◽  
Hugues Duffau ◽  
Emmanuelle Le Bars ◽  
François Molino ◽  
...  

2022 ◽  
Vol 14 (4) ◽  
pp. 962-984
Author(s):  
L. F. Fakhrutdinova ◽  
S. T. M. Shauamri

This paper presents the results of analyzing the psychological patterns of the development of ethnic identity and interethnic relations in the multinational Levant Region, where interethnic confrontation between Palestinians and Israelis has been noted in recent years. The main aim of the research is to reveal the relationship between the characteristics of Ethnic Identity and the Experience (“perezhivanie”) of Interethnic Relations of Palestinian Muslims in the multicultural Levant Region. In the process of investigating into ethnic self-awareness the authors used the Leary Test, the Semantic Diff erential of “Perezhivanie” ‘Experiencing’ Questionnaire by L.R. Fakhrutdinova aimed at studying the psychosemantic characteristics of the “perezhivanie” ‘experiencing’. The research has displayed that Ethnic Identity is a self-developing phenomenon, basically infl uenced by both the infrastructural relations and positions of ethnic self-awareness, and the processes associated with the relations of ethnic self-awareness with the external environment, with other ethnic groups. The most active points of development have been identifi ed. So, in intrastructural relations, they are active as ratios of I-real and I-mirror with a stronger position of I-ideal, since practically all dimensions of I-real and I-ideal (dominance, egoism, suspicion, etc.) have shown signifi cant diff erences that testify to the points and directions of development of ethnic self-awareness; positions in the relationship between the real self and the mirror self also exerted an active infl uence. The points of confl ict of the structures of ethnic self-consciousness were found, where, when the points of development coincided, the direction of development was diff erent. Thus, suspicion, obedience, dependence, friendliness, integrative indicators of dominance and friendliness have shown themselves to be confl ict points refl ecting confl ict zones between the infl uence of an external ethnic group (mirror self) and self-development processes manifested through the ideal self. In the situation of relations with the external environment, the most active was shown by the self-mirror, which infl uences the development of the subjectivity of the ethnic group through the components of the experience of the Palestinian-Israeli crisis. The infl uence of the real self on the characteristics of the “perezhivanie” ‘experiencing’ of the PalestinianIsraeli crisis was also manifested, and therefore, through the components of the “perezhivanie” ‘experiencing’ of this impression on the development of the self-awareness of the ethnic group.


2019 ◽  
Author(s):  
Wataru Yamamoto ◽  
Rafael Yuste

AbstractThe neural code relates the activity of the nervous system to the activity of the muscles to the generation of behavior. To decipher it, it would be ideal to comprehensively measure the activity of the entire nervous system and musculature in a behaving animal. As a step in this direction, we used the cnidarian Hydra vulgaris to explore how physiological and environmental conditions alter the activity of the entire neural and muscle tissue and affect behavior. We used whole-body calcium imaging of neurons and muscle cells and studied the effect of temperature, media osmolarity, nutritional state and body size on body contractions.In mounted Hydra, changes in temperature, nutrition or body size did not have a major effect on neural or muscle activity, or on behavior. But changes in media osmolarity altered body contractions, increasing them in hipo-osmolar media solutions and decreasing them in hyperosmolar media. Similar effects were seen in ectodermal, but not in endodermal muscle. Osmolarity also bidirectionally changed the activity of contraction bursts neurons, but not of rhythmic potential neurons.These findings show osmolarity-dependent changes in neuronal activity, muscle activity, and contractions, consistent with the hypothesis that contraction burst neurons respond to media osmolarity, activating ectodermal muscle to generate contraction bursts. This dedicated circuit could serve as an excretory system to prevent osmotic injury. This work demonstrates the feasibility of studying the entire neuronal and muscle activity of behaving animals.Significance StatementWe imaged whole-body muscle and neuronal activity in Hydra in response to different physiological and environmental conditions. Osmolarity bidirectionally altered Hydra contractile behavior. These changes were accompanied by corresponding changes in the activity of one neuronal circuit and one set of muscles. This work is a step toward comprehensive deciphering of the mechanisms of animal behavior by measuring the activity of all neurons and muscle cells.


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