scholarly journals Tumor Necrosis Factor alpha 238 G/A polymorphism and its relation to severity and cardiovascular risk in psoriasis

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M H ElSayed ◽  
S E Ahmed ◽  
K Ali ◽  
N N ElKhazragy ◽  
M S Attia
Keyword(s):  
Cardiovascular Risk ◽  
P Value ◽  
Necrosis Factor Alpha ◽  
Immune Mediated ◽  
Increased Risk ◽  
Tnf Α ◽  
Significant Difference ◽  
Inflammatory Processes ◽  
Factor Alpha ◽  
Necrosis Factor

Abstract Background Psoriasis is known as chronic immune-mediated inflammatory skin disease affecting about 3% of the world’s population. Cytokine gene polymorphism attracted considerable interest as they have been found to alter gene transcription thereby influencing inflammatory processes in response to various diseases. Subjects A total of 50 psoraitic patients and 50 controls were genotyped for TNF–α −238G/A polymorphism by using polymerase chain reaction. ECG and lipid profile were done to assess cardiovascular risk. Results Polymorphism of TNF–α −238 was not found to be associated with an increased risk for psoriasis (p value 0.98). There is significant difference between cases and controls as regard systolic and diastolic blood pressure . Conclusion Our findings suggest that there is no association between TNF alpha polymorphism and risk of psoriasis in Egyptian psoraitic patients.

scholarly journals The association of tumor necrosis factor alpha levels with Depression symptoms in Systemic lupus erythematosus patients

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A M Okba ◽  
M N Farris ◽  
R Y Shaheen ◽  
H Abdelmonaem ◽  
S T Kamal ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
P Value ◽  
Depression Symptoms ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Axis I ◽  
Necrosis Factor

Abstract Background Effects of the cytokine system, in which of tumor necrosis factor alpha (TNF-α) is a part, on serotonin metabolism as well as on the hypothalamic-pituitary-adrenal (HPA)-axis, may induce changes in the structure and function of the brain, possibly leading to the development of depression in SLE patients. For this purpose, we aimed to assess serum TNF-α levels in SLE patients, and to explore its possible relationship with depression among these patients.Methods: 60 SLE adult patients were enrolled in this study and further subdivided into two equal groups (30 with active SLE and 30 with inactive SLE) using SLEDAI score, in addition to 30 age and sex matched healthy controls. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) to provide broad coverage of psychiatric diagnoses was done for all subjects, and severity of depression was assessed using Beck depression Inventory. TNF-α levels were measured using ELISA technique. Results: Depression was identified in 63.3% of active SLE group, 40% in the inactive SLE group and 16.7% in the control group with p value <0.001. TNF-α levels were higher significantly in the active group versus inactive group and control p value <0.001.In the multivariate analysis, sera TNF-α levels were independently associated with depressive symptoms odds ratio = 1.004, 95% CI = 1.001 to 1.006, p-value =0.020). Conclusions: Depression was more prevalent among SLE patients with active disease. Serum TNF-α was the only independent predictor of depression in SLE patients.

scholarly journals -308G/A polymorphism of tumor necrosis factor alpha (TNF-α) gene and metabolic syndrome susceptibility: a meta-analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dong Wang ◽  
Liqun He ◽  
Xiaotian Zhang
Keyword(s):  
Metabolic Syndrome ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Dominant Model ◽  
Necrosis Factor Alpha ◽  
Increased Risk ◽  
Tnf Α ◽  
Factor Alpha ◽  
Allele Model ◽  
Necrosis Factor

AbstractMany studies tried to assess the relationship between -308G/A polymorphism of tumor necrosis factor alpha (TNF-α) gene and risk of metabolic syndrome (MS), but their results were contradictory. This meta-analysis aimed to precisely evaluate this association. A systematic literature search was performed in Pubmed database and WanFang Med Online, STATA software 14.0 was used for the meta-analysis. Eleven independent studies containing 3277 cases and 3312 controls were included in our meta-analysis. In overall analysis, significant association was found between -308G/A polymorphism of TNF-α and MS in both allele model (OR 1.47, 95% CI 1.09–1.98, P 0.013) and dominant model (OR 1.77, 95% CI 1.21–2.58, P 0.003). In the subgroup analysis, the A allele was associated with increased risk of MS in Asia group (allele model: OR 1.82 95% CI 1.31–2.53, P < 0.001; dominant model: OR 2.30, 95% CI 1.64–3.21 P < 0.001; homozygous model: OR 2.29, 95% CI 1.31–4.01, P 0.004), and decreased risk of MS in Europe group (dominant model: OR 0.83, 95% CI 0.70–0.99, P < 0.001; recessive model: OR 0.51, 95% CI 0.28–0.92, P 0.025; homozygous model: OR 0.49 95% CI 0.27–0.89, P 0.02). The A allele also appeared to linked to increased risk of MS in CDS group and IDF groups. No significant association was observed in NCEPATPIII group. Our results suggested that -308G/A of TNF-α gene was a risk factor for MS, but it may played different roles in different ethnics, further studies with larger sample size and more other ethnics should be performed to confirm our conclusions.

scholarly journals MO741TUMOR NECROSIS FACTOR ALPHA AND MAGNESIUM ARE LINKED TO CARDIAC VALVE CALCIFICATION IN DIABETIC HEMODIALYSIS PATIENTS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Oleksandr Susla ◽  
Zoriana Litovkina ◽  
Ihor Mysula ◽  
Anatoliy Gozhenko
Keyword(s):  
Cardiovascular Risk ◽  
Chronic Inflammation ◽  
Cardiac Valve ◽  
Diabetic Patients ◽  
Necrosis Factor Alpha ◽  
Valve Calcification ◽  
Tnf Α ◽  
Cardiac Valve Calcification ◽  
Factor Alpha ◽  
Necrosis Factor

Abstract Background and Aims The processes of cardiac valve calcification (CVC) in diabetic hemodialysis (HD) patients are not fully understood. In this context, it is reasonable to complex and comprehensively research the activity of chronic inflammation and magnesium (Mg) imbalance as cardiovascular risk factors in end-stage renal disease (ESRD). The main purpose of the current study was to determine the relationship of tumor necrosis factor alpha (TNF-α) and Mg levels with the presence and severity of CVC in diabetic patients with ESRD. Method We enrolled 136 patients undergoing HD (male/female, 78/58;age, 53.9±1.0 years; HD duration, 47.6±4.2 month) in this observational cross-sectional study. The study was performed in accordance with the provisions of the Declaration of Helsinki last revision. Depending on the presence of type 2 diabetes mellitus (T2DM) all subjects were divided into two groups: the 1st one – non-diabetic patients (n=88); the 2nd one – diabetic patients (n=48). Presence of CVC was detected by ultrasound. The mitral (MVC) and aortic (AVC) valve calcification degree were scored as follows: 1, no calcification; 2, valve thickening without calcification; 3, valve annulus or cusps calcification. Serum content of TNF-α as one of the key proinflammatory cytokine was determined by enzyme-linked immunosorbent assay. Serum Mg concentration was estimated by biochemical method. Data are expressed as means±SEM. Used nonparametric statistics methods: Mann-Whitney U-test, χ2-test, Spearman’s rank R correlations. Results In diabetic HD patients TNF-α content was higher (13.86±1.34 vs. 8.73±0.60 ng/L; Z=3.04, p=0.002) whereas Mg concentration (0.87±0.02 vs. 1.00±0.02 mmol/L; Z=4.91, p&lt;0.001) – lower compared to non-diabetic ones, and in 2nd group indices of TNF-α and Mg were related (Rs=-0.68, p&lt;0.001). CVC was detected in 66.6% of T2DM patients with predominance of calcification of both valves (35.4%) over isolated MVC (20.8%) and AVC (10.4%). Combined MVC and AVC in the 2nd group was observed 2.6 times more often (χ2=8.78, p=0.003) than in the 1st one. For the first time it was established that in diabetic patients with ESRD the presence of CVC closely associated with indices of TNF-α (Rs=0.51, p&lt;0.001) and Mg (Rs=-0.57, p&lt;0.001). The MVC as well as AVC degree were related with the content of TNF-α (Rs=0.49, p&lt;0.001; Rs=0.52, p&lt;0.001) and Mg concentration (Rs=-0.47, p&lt;0.001; Rs=-0.50, p&lt;0.001) respectively. Conclusion (1) T2DM in HD patients is characterized with an increase of serum TNF-α activity and simultaneous decreased of Mg content. (2) In diabetic patients with ESRD, both MVC and AVC are closely linked with the TNF-α accumulation and hypomagnesemia. (3) Chronic inflammation and Mg deficiency can be important factors of CVC progression and very high cardiovascular risk in diabetic HD patients.

TNF-α and IL-6: The Link between Immune and Bone System

2020 ◽  
Vol 21 (3) ◽  
pp. 213-227 ◽  
Author(s):  
Tiantian Wang ◽  
Chengqi He
Keyword(s):  
Immune Responses ◽  
Macrophage Activation ◽  
Bone Diseases ◽  
Necrosis Factor Alpha ◽  
Immune Mediated ◽  
Pathogenic Factors ◽  
Tnf Α ◽  
Proliferation And Differentiation ◽  
Factor Alpha ◽  
Necrosis Factor

Osteoimmunology is a new subject which focuses on the communication between the immune and the skeletal systems. Both the immune system and bone communicate with each other. Proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) play important roles in immune responses and bone metabolism. TNF-α and IL-6 enhance macrophage activation and antigen presentation, as well as regulating immunity through different mechanisms. A variety of groups have reported that TNF-α suppresses osteoblasts activity at some stages of differentiation and stimulates osteoclast proliferation and differentiation. In contrast, IL-6 mediates the actions of osteoblasts and osteoclasts through sophisticated mechanisms, which reflect dual effects. Both TNF-α and IL-6 can mediate the activity of osteocytes. Furthermore, both TNF-α and IL-6 are important pathogenic factors related to immune-mediated bone diseases including rheumatoid arthritis and postmenopausal osteoporosis. This review will discuss the contradictory findings concerning TNF-α and IL-6 in osteoimmunology and their potential for clinical application.

scholarly journals The effect of acute ophiobolin A treatment on HO-mediated inflammatory processes

2016 ◽  
Vol 36 (6) ◽  
pp. 594-602 ◽  
Author(s):  
Anikó Pósa ◽  
Renáta Szabó ◽  
Zita Szalai ◽  
Krisztina Kupai ◽  
Zoltán Deim ◽  
...  
Keyword(s):  
Inflammatory Mediators ◽  
Cardiac Tissue ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Male Wistar Rats ◽  
Inflammatory Processes ◽  
Factor Alpha ◽  
Fungal Secondary Metabolite ◽  
Inflammatory Molecules ◽  
Necrosis Factor

Many microbial and plant-derived metabolites contribute to the production of inflammatory mediators and the expression of pro-inflammatory molecules. Ophiobolin A (OPA) is a fungal secondary metabolite produced by Bipolaris species. The aim of our study was to examine the acute effects of this compound on inflammatory processes. Male Wistar rats were treated with 5% ethanol, 0.01 mg/kg OPA, 0.1 mg/kg OPA and 1.0 mg/kg OPA per os. After 24 h of the administrations, inflammatory mediators such as interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α) and myeloperoxidase (MPO) enzyme as well as heme oxygenase (HO) activity were measured in both plasma and cardiac tissue, along with serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). We found that OPA caused a significant elevation in the concentrations of IL-6 and TNF-α, increased MPO activity and decreased HO enzyme activity in the plasma. While OPA induces inflammation in the plasma, it did not change the level of inflammatory mediators in the cardiac tissue and the concentrations of serum ALT and AST. Our findings indicate that rapid release of inflammatory mediators by OPA promotes systemic inflammation. However, this acute OPA treatment does not show toxic effects on the cardiac tissue and the concentrations of liver enzymes.

scholarly journals Immunohistochemical study of tumor necrosis factor alpha ( TNF-α) in the tumor microenvironment sample of Iraqi breast cancer

2015 ◽  
Vol 9 (1) ◽  
pp. 67-73
Author(s):  
Fatima Samir Abdul- Razaq Abdul- Razaq ◽  
Ekhlass Mushref Edan Edan ◽  
Ahmed Rushadi Abdulla Abdulla
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Tumor Development ◽  
Necrosis Factor Alpha ◽  
Distinct Cell ◽  
Tnf Α ◽  
Significant Difference ◽  
Malignant Breast ◽  
Factor Alpha ◽  
Necrosis Factor

Breast cancer is the most common malignant tumor and the leading cause of carcinoma death inwomen. The tumor microenvironment consist from cellular microenvironment, cytokines andchemokines. Its plays an important role in tumor development such as initiation, progression,metastasis and drug resistance. It is becoming increasingly apparent that the malignant tumorprogression is maintained by dynamic interplay between tumor cells and many distinct cell typesexisting in the adjacent microenvironment. Objective of this study is to detect of TNF-α in tumormicroenvironment in histological sections of breast cancer and compare it with that of benign breastlesions. This study included 32 patients with breast cancer and 21 patients with benign breast lesions,prognostic factors were registered including: age, histopathological subtype, degree ofdifferentiation& stage of breast carcinoma. Results revealed positive expression of TNF-α in 20cases, while 12 cases were negative out of 32 samples of breast cancer. In benign lesions 11 cases werepositive, While 10cases were negative. Statistical analysis showed significant difference in rate ofTNF-α expression between malignant breast samples and benign samples(P ≤0.05).

scholarly journals Differences between Tumor Necrosis Factor-Alpha Levels and Interleukin-2 Levels in people with schizophrenia who get risperidone drugs in the acute phase of treatment in the Prof. DR. M. Ildrem Psychiatric Hospital, Medan

2021 ◽  
Vol 9 (T3) ◽  
pp. 232-236
Author(s):  
Muhammad Hasbi ◽  
Bahagia Loebis ◽  
Vita Camellia ◽  
Elmeida Effendy
Keyword(s):  
Acute Phase ◽  
Interleukin 2 ◽  
Necrosis Factor Alpha ◽  
Maximum Score ◽  
Tnf Α ◽  
Significant Difference ◽  
Minimum Score ◽  
Factor Alpha ◽  
And Control ◽  
Necrosis Factor

Background: We looked for differences between Tumor Necrosis Factor – Alpha and Interleukin-2 levels in people with schizophrenia who got risperidone medication in the acute phase of treatment at Prof.DR.M.Ildrem psychiatric hospital Medan. Methods: We conducted a cross-sectional study that included 40 subjects. This study is a numerical comparative analytical study not paired with a single measurement with subject retrieval performed in a non-probability sampling method of consecutive sampling type. Results: The analysis test results showed Median levels of TNF-α in the group of people with schizophrenia were obtained at 3.40 with a minimum score of 0.65 and with a maximum score of 43.8 while in the healthy control group the median score of TNF-α levels was 14.75 with a minimum score of 5.18 and a maximum score of 31.1. The average IL-2 level in people with schizophrenia was found at 5.26 with a standard deviation of ±0.987 and at the control was obtained at 3.43 with a standard deviation ± 0.665. Conclusions: There is a significant difference in TNF-α levels between groups of people with schizophrenia who get risperidone 4 mg in the acute phase of treatment and control. There was a significant difference between IL-2 levels between people with schizophrenia who got risperidone 4 mg in the acute phase of treatment and control.

scholarly journals Association of tumor necrosis factor-alpha -308 G/A and -238 G/A polymorphism with diabetic retinopathy: a systematic review and updated meta-analysis.

2020 ◽  
Author(s):  
Wenna Gao ◽  
Ruilin Zhu ◽  
liu yang
Keyword(s):  
Diabetic Retinopathy ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Entire Group ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

Background: Mounting evidence has suggested tumor necrosis factor-alpha (TNF-α) can promote the development of diabetic retinopathy (DR), and TNF-α gene variants may influence DR risk. However, the results are quite different. Objectives: To comprehensively address this issue, we performed the meta-analysis to evaluate the association of TNF-α-308 G/A and -238 G/A polymorphism with DR. Method: Data were retrieved in a systematic manner and analyzed using STATA Statistical Software. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Allelic and genotypic comparisons between cases and controls were evaluated. Results: For the TNF-α-308 G/A polymorphism, overall analysis suggested a marginal association with DR [the OR(95%CI) of (GA versus GG), (GA + AA) versus GG, and (A versus G) are 1.21(1.04, 1.41), 1.20(1.03, 1.39), and 1.14(1.01, 1.30), respectively]. And the subgroup analysis indicated an enhanced association among the European population. For the TNF-α-238 G/A polymorphism, there was mild correlation in the entire group [the OR(95%CI) of (GA versus GG) is 1.55(1.14,2.11) ], which was strengthened among the Asian population. Conclusion: The meta-analysis suggested that -308 A and -238 A allele in TNF-α gene potentially increased DR risk and showed a discrepancy in different ethnicities.

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