scholarly journals Differences between Tumor Necrosis Factor-Alpha Levels and Interleukin-2 Levels in people with schizophrenia who get risperidone drugs in the acute phase of treatment in the Prof. DR. M. Ildrem Psychiatric Hospital, Medan

2021 ◽  
Vol 9 (T3) ◽  
pp. 232-236
Author(s):  
Muhammad Hasbi ◽  
Bahagia Loebis ◽  
Vita Camellia ◽  
Elmeida Effendy
Keyword(s):  
Acute Phase ◽  
Interleukin 2 ◽  
Necrosis Factor Alpha ◽  
Maximum Score ◽  
Tnf Α ◽  
Significant Difference ◽  
Minimum Score ◽  
Factor Alpha ◽  
And Control ◽  
Necrosis Factor

Background: We looked for differences between Tumor Necrosis Factor – Alpha and Interleukin-2 levels in people with schizophrenia who got risperidone medication in the acute phase of treatment at Prof.DR.M.Ildrem psychiatric hospital Medan. Methods: We conducted a cross-sectional study that included 40 subjects. This study is a numerical comparative analytical study not paired with a single measurement with subject retrieval performed in a non-probability sampling method of consecutive sampling type. Results: The analysis test results showed Median levels of TNF-α in the group of people with schizophrenia were obtained at 3.40 with a minimum score of 0.65 and with a maximum score of 43.8 while in the healthy control group the median score of TNF-α levels was 14.75 with a minimum score of 5.18 and a maximum score of 31.1. The average IL-2 level in people with schizophrenia was found at 5.26 with a standard deviation of ±0.987 and at the control was obtained at 3.43 with a standard deviation ± 0.665. Conclusions: There is a significant difference in TNF-α levels between groups of people with schizophrenia who get risperidone 4 mg in the acute phase of treatment and control. There was a significant difference between IL-2 levels between people with schizophrenia who got risperidone 4 mg in the acute phase of treatment and control.

scholarly journals Different cytokine patterns associate with melancholia severity among inpatients with major depressive disorder

2020 ◽  
Vol 10 ◽  
pp. 204512532093792 ◽  
Author(s):  
Lucas Primo de Carvalho Alves ◽  
Neusa Sica da Rocha
Keyword(s):  
Depressed Mood ◽  
Rating Scale ◽  
Interleukin 2 ◽  
Psychomotor Retardation ◽  
Necrosis Factor Alpha ◽  
Depressed Patients ◽  
Tnf Α ◽  
Inflammatory Pattern ◽  
Factor Alpha ◽  
Necrosis Factor

Background Six melancholic features (MFs) of the Hamilton Depression Rating Scale (HAM-D6) represent the construct of melancholia along a continuum of severity (from least to most severe: depressed mood, work and activities, somatic symptoms, psychic anxiety, guilty feelings, psychomotor retardation). We aimed to evaluate the association between these MFs and inflammatory cytokines (IC) in the blood. Methods Each IC [interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), IL-4, IL-6, IL-10, and IL-17] was associated with the HAM-D6 MFs of 139 severely depressed inpatients, using multiple linear regressions adjusted for covariates. Levels were compared with those of 100 healthy controls. Results Depressed mood was associated with higher levels of IL-4 ( β = 0.167; p = 0.041). Psychic anxiety: lower IL-17 levels ( β = –0.173; p = 0.039). Guilt feelings: lower IL-2 levels ( β = −0.168; p = 0.041) Psychomotor retardation: higher IL-6 levels ( β = 0.195; p = 0.017). Depressed patients’ TNF-α, INF-γ, and IL-4 levels were not significantly different from controls. Depressed patients’ IL-2, IL-6, IL-10, and IL-17 levels were higher than those of controls ( p <0.001). Conclusion Less severe MFs (depressed mood, psychic anxiety, and guilt feelings) were associated with an anti-inflammatory pattern (higher IL-4, lower IL-17 and lower IL-2, respectively). The presence of the most severe MF, psychomotor retardation, was associated with a higher pro-inflammatory response (higher IL-6).

scholarly journals Serum Tumor Necrosis Factor-alpha and Interleukin-2 Concentrations in Newly Diagnosed ERBB2 (HER2/neu) Positive Breast Cancer Patients

2009 ◽  
Vol 24 (3) ◽  
pp. 142-146 ◽  
Author(s):  
Sezer Saglam ◽  
Rafi Suzme ◽  
Figen Gurdol
Keyword(s):  
Breast Cancer ◽  
Tumor Necrosis Factor ◽  
Cancer Patients ◽  
Tumor Necrosis ◽  
Interleukin 2 ◽  
Breast Cancer Patients ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

Aim Cytokines have been associated with symptoms and adverse outcomes in breast cancer. Overexpression of ERBB2 (c-erb-b2; formerly HER2/neu), which is a member of the epidermal growth receptor family, is associated with involvement of lymph nodes, large tumor size, high grade, steroid receptor negativity, aneuploidy, high proliferation rate, and low overall survival in breast cancer. The aim of the study was to examine whether ERBB2 amplification has any effect on circulating levels of tumor necrosis factor-alpha (TNF-α) and interleukin-2 (IL-2) in breast cancer patients. Material and methods Fifty patients with primary breast carcinoma, classified as either ERBB2 (+) or (-) by the fluorescence in situ hybridization (FISH) technique, were included in the study. Cytokines were studied by ELISA according to the procedure described in the commercial kit. Results IL-2 levels were found significantly higher in ERBB2+ patients than in controls (p<0.05). A significant negative correlation existed between ERBB2 positivity and estrogen receptor status (p=0.004). Plasma TNF-α and IL-2 levels were positively correlated in ERBB2+ breast cancer patients (p<0.01). Conclusion The increase in IL-2 concentrations observed in our study suggests an activation of T cells by ERBB2 peptides.

scholarly journals Influence of Vector-Encoded Cytokines on Anti-Salmonella Immunity: Divergent Effects of Interleukin-2 and Tumor Necrosis Factor Alpha

2001 ◽  
Vol 69 (6) ◽  
pp. 3980-3988 ◽  
Author(s):  
Basel K. al-Ramadi ◽  
Mariam H. Al-Dhaheri ◽  
Nada Mustafa ◽  
Mounir AbouHaidar ◽  
Damu Xu ◽  
...  
Keyword(s):  
Immune Response ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Interleukin 2 ◽  
Fine Tuning ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

ABSTRACT Attenuated Salmonella strains are of interest as new vaccine candidates and as vectors of cloned genes of other organisms. Attenuated strains expressing specific cytokines were constructed as a means of manipulating the immune response in various disease settings. In the present study, interleukin-2 (IL-2)-expressing (GIDIL2) or tumor necrosis factor alpha (TNF-α)-expressing (GIDTNF) strains were compared with the parent strain (BRD509) for the effect of cytokines on anti-Salmonella immunity. Expression of IL-2 resulted in a rapid clearance of the organism soon after vaccination. The reduction in GIDIL2 CFU was 50- to 300-fold higher than that of BRD509 and correlated with a markedly decreased splenomegaly. Furthermore, no evidence for any significant activation, including upregulation of surface markers and production of nitric oxide (NO), was observed in spleens of GIDIL2-injected mice. In contrast, the host response to GIDTNF was marked by an early, strong, splenic cellular influx, but surprisingly, the degree of induced splenomegaly and NO secretion was only 50% of that observed in BRD509-treated mice. Despite this, bacterial colonization of the spleen in GIDTNF-immunized animals was either slightly decreased from or equivalent to that of the BRD509-treated group, suggesting the induction of additional antimicrobial mechanisms by TNF-α. In vivo protection studies demonstrated that, at limiting doses, GIDIL2 was inferior to GIDTNF and BRD509 in its capacity to protect against virulent challenge. At high doses, however, all three strains exhibited equal protective efficacy. These results demonstrate that the immune response against intracellular bacteria can be manipulated by pathogen-expressed cytokines and open the way for further fine tuning of immune responses not only to Salmonella strains themselves but also to the heterologous gene(s) carried by them.

scholarly journals Serum Cytokine Responses in Primary Pneumonic Plague Patients

2010 ◽  
Vol 18 (1) ◽  
pp. 184-186 ◽  
Author(s):  
Xiaoyi Wang ◽  
Zuyun Wang ◽  
Zhaobiao Guo ◽  
Baiqing Wei ◽  
Fuzhang Tian ◽  
...  
Keyword(s):  
Time Course ◽  
Interleukin 2 ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Necrosis Factor Alpha ◽  
Pneumonic Plague ◽  
Tnf Α ◽  
Factor Alpha ◽  
Ifn Γ ◽  
Necrosis Factor

ABSTRACTThe serum levels of interleukin-2 (IL-2), gamma interferon (IFN-γ), tumor necrosis factor alpha (TNF-α), IL-4, IL-6, and IL-10 of pneumonic plague patients were determined by enzyme-linked immunosorbent assay. IL-6 was the only elevated cytokine in the patients, and its level increased with a clear time course, indicating that IL-6 might be a prognostic marker for predicting the progression of plague.

scholarly journals Tumor Necrosis Factor alpha 238 G/A polymorphism and its relation to severity and cardiovascular risk in psoriasis

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M H ElSayed ◽  
S E Ahmed ◽  
K Ali ◽  
N N ElKhazragy ◽  
M S Attia
Keyword(s):  
Cardiovascular Risk ◽  
P Value ◽  
Necrosis Factor Alpha ◽  
Immune Mediated ◽  
Increased Risk ◽  
Tnf Α ◽  
Significant Difference ◽  
Inflammatory Processes ◽  
Factor Alpha ◽  
Necrosis Factor

Abstract Background Psoriasis is known as chronic immune-mediated inflammatory skin disease affecting about 3% of the world’s population. Cytokine gene polymorphism attracted considerable interest as they have been found to alter gene transcription thereby influencing inflammatory processes in response to various diseases. Subjects A total of 50 psoraitic patients and 50 controls were genotyped for TNF–α −238G/A polymorphism by using polymerase chain reaction. ECG and lipid profile were done to assess cardiovascular risk. Results Polymorphism of TNF–α −238 was not found to be associated with an increased risk for psoriasis (p value 0.98). There is significant difference between cases and controls as regard systolic and diastolic blood pressure . Conclusion Our findings suggest that there is no association between TNF alpha polymorphism and risk of psoriasis in Egyptian psoraitic patients.

scholarly journals Immunohistochemical study of tumor necrosis factor alpha ( TNF-α) in the tumor microenvironment sample of Iraqi breast cancer

2015 ◽  
Vol 9 (1) ◽  
pp. 67-73
Author(s):  
Fatima Samir Abdul- Razaq Abdul- Razaq ◽  
Ekhlass Mushref Edan Edan ◽  
Ahmed Rushadi Abdulla Abdulla
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Tumor Development ◽  
Necrosis Factor Alpha ◽  
Distinct Cell ◽  
Tnf Α ◽  
Significant Difference ◽  
Malignant Breast ◽  
Factor Alpha ◽  
Necrosis Factor

Breast cancer is the most common malignant tumor and the leading cause of carcinoma death inwomen. The tumor microenvironment consist from cellular microenvironment, cytokines andchemokines. Its plays an important role in tumor development such as initiation, progression,metastasis and drug resistance. It is becoming increasingly apparent that the malignant tumorprogression is maintained by dynamic interplay between tumor cells and many distinct cell typesexisting in the adjacent microenvironment. Objective of this study is to detect of TNF-α in tumormicroenvironment in histological sections of breast cancer and compare it with that of benign breastlesions. This study included 32 patients with breast cancer and 21 patients with benign breast lesions,prognostic factors were registered including: age, histopathological subtype, degree ofdifferentiation& stage of breast carcinoma. Results revealed positive expression of TNF-α in 20cases, while 12 cases were negative out of 32 samples of breast cancer. In benign lesions 11 cases werepositive, While 10cases were negative. Statistical analysis showed significant difference in rate ofTNF-α expression between malignant breast samples and benign samples(P ≤0.05).

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