scholarly journals Effects of vitamin B6 on one‐carbon metabolism in oral contraceptive users

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Luisa Rios‐Avila ◽  
Maria Ralat ◽  
Bonnie Coats ◽  
Peter W. Stacpoole ◽  
Jesse F. Gregory
Keyword(s):  
Oral Contraceptive ◽  
Carbon Metabolism ◽  
Vitamin B6 ◽  
One Carbon Metabolism

scholarly journals Flaxseed Increases Animal Lifespan and Reduces Ovarian Cancer Severity by Toxically Augmenting One-Carbon Metabolism

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5674
Author(s):  
William C. Weston ◽  
Karen H. Hales ◽  
Dale B. Hales
Keyword(s):  
Liver Function ◽  
Carbon Metabolism ◽  
Vitamin B6 ◽  
Ovarian Tumor ◽  
Tumor Metastasis ◽  
Plasma Homocysteine ◽  
Elevated Plasma ◽  
Polyamine Biosynthesis ◽  
Reduced Body ◽  
One Carbon Metabolism

We used an LC-MS/MS metabolomics approach to investigate one-carbon metabolism in the plasma of flaxseed-fed White Leghorn laying hens (aged 3.5 years). In our study, dietary flaxseed (via the activity of a vitamin B6 antagonist known as “1-amino d-proline”) induced at least 15-fold elevated plasma cystathionine. Surprisingly, plasma homocysteine (Hcy) was stable in flaxseed-fed hens despite such highly elevated cystathionine. To explain stable Hcy, our data suggest accelerated Hcy remethylation via BHMT and MS-B12. Also supporting accelerated Hcy remethylation, we observed elevated S-adenosylmethionine (SAM), an elevated SAM:SAH ratio, and elevated methylthioadenosine (MTA), in flaxseed-fed hens. These results suggest that flaxseed increases SAM biosynthesis and possibly increases polyamine biosynthesis. The following endpoint phenotypes were observed in hens consuming flaxseed: decreased physiological aging, increased empirical lifespan, 9–14% reduced body mass, and improved liver function. Overall, we suggest that flaxseed can protect women from ovarian tumor metastasis by decreasing omental adiposity. We also propose that flaxseed protects cancer patients from cancer-associated cachexia by enhancing liver function.

B-Vitamine und Lungenkrebsrisiko

2017 ◽  
Vol 49 (04) ◽  
pp. 195-197
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Clin Oncol ◽  
Carbon Metabolism ◽  
Vitamin B6 ◽  
Lung Cancer Risk ◽  
Vitamin B ◽  
One Carbon Metabolism

Brasky TM, White E, Cheng C-L. Long-term, supplemental, one-carbon metabolism-related vitamin B use in relation to lung cancer risk in the Vitamins and Lifestyle (VITAL) Cohort. J Clin Oncol 2017; 35: 3440–3448 Die jahrelange Einnahme von hoch dosierten Vitamin-B6- oder -B12-Einzelpräparaten ging in einer prospektiven Kohortenstudie bei älteren Männern mit einem stark erhöhten Lungenkrebsrisiko (2- bis 4-fach) einher.

The Vitamins Involved in One-Carbon Metabolisms are Associated with Reduced Risk of Breast Cancer in Overall and Subtypes

2020 ◽  
Vol 90 (1-2) ◽  
pp. 131-140 ◽  
Author(s):  
Mahshid Hatami ◽  
Farhad Vahid ◽  
Mohammad Esmaeil Akbari ◽  
Mahya Sadeghi ◽  
Fatemeh Ameri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin B12 ◽  
Carbon Metabolism ◽  
Vitamin B6 ◽  
Regulation Of Gene Expression ◽  
Folate Intake ◽  
Her2 Status ◽  
Total Intake ◽  
One Carbon Metabolism ◽  
The Relationship

Abstract. Background: Some micronutrients like folate, vitamin B12, B6, and B2 are the source of coenzymes, which participate in one-carbon metabolism. Any disruption in this metabolism can interfere with DNA replication, repair and regulation of gene expression and ultimately promote the likelihood of carcinogenesis. This study aimed at investigating the relationship between the intakes of micronutrients involved in one-carbon metabolism with breast cancer (BrCa) and its subtype’s odds. Methods: Nutrients’ intake from diet and supplements were collected through interviewing 151 cases and 154 controls by a 168-item semiquantitative food frequency questionnaire. Logistic regression was used to determine the relationship between dietary and/or total intake of studied nutrients and odds of BrCa and its subtypes. Results: After adjusting the effects of confounding variables in the models, the odds of BrCa was significantly lower in the highest intake quartile compared with the lowest quartile for total intake of vitamin B2 (OR = 0.17, 95% CI, 0.07–0.39; Ptrend < 0.001), vitamin B6 (OR = 0.11, 95% CI, 0.05–0.27; Ptrend < 0.001), vitamin B12 (OR = 0.20, 95% CI, 0.09–0.43; Ptrend < 0.001) and folate (OR = 0.09, 95% CI, 0.04–0.21; Ptrend < 0.001). Also, those with the highest quartile of vitamin B6, B12, B2 and folate intake compared with the lowest quartile were less likely to develop estrogen receptor (ER)+ and progesterone receptor (PR)+ subtypes, ER- status, PR- and human epidermal growth factor receptor 2 (HER2)+ subtypes and HER2- status. Conclusion: High intakes of vitamins B2, B6 and folate are associated with reduced odds of BrCa in overall and all ER, PR and HER2 subtypes. Also, high intakes of vitamin B12 reduced the odds of all subtypes of BrCa except ER- subtype.

scholarly journals B vitamin blood concentrations and one-carbon metabolism polymorphisms in a sample of Italian women and men attending a unit of transfusion medicine: a cross-sectional study

2020 ◽  
Author(s):  
Renata Bortolus ◽  
Francesca Filippini ◽  
Silvia Udali ◽  
Marianna Rinaldi ◽  
Sabrina Genesini ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Carbon Metabolism ◽  
Vitamin B6 ◽  
Blood Donors ◽  
Cross Sectional Study ◽  
Transfusion Medicine ◽  
Sectional Study ◽  
Cross Sectional ◽  
Plasma Folate ◽  
One Carbon Metabolism

Abstract Purpose To define blood status of folate, vitamin B12, vitamin B6, homocysteine, and major one-carbon metabolism-related polymorphisms in healthy, males and females blood donors, aged 18–65 years were evaluated. General characteristics and lifestyle factors were also investigated. Methods An explorative cross-sectional study design was used to evaluate a sample of blood donors attending the Unit of Transfusion Medicine of the Verona University Hospital, Italy. From April 2016 to May 2018, 499 subjects were enrolled (255 men, 244 women of whom 155 of childbearing age). Major clinical characteristics including lifestyle and dietary habits, B vitamins and homocysteine were analyzed. The MTHFR 677 C>T, cSHMT 1420 C>T, DHFR 19 bp ins/del, RFC1 80 G>A polymorphisms were also determined. Results Mean plasma concentrations of folate, vitamin B12, vitamin B6 and homocysteine were 14.2 nmol/L (95% CI 13.7–14.8), 271.9 pmol/L (95% CI 262.6–281.5), 51.0 nmol/L (95% CI 48.7–53.4) and 13.5 µmol/L (95% CI 13.1–14.0), respectively. Plasma folate, was adequate (> 15 nmol/L) in 44.7% of all subjects, 39.0% of males and 42.5% of women < 45 years. Similarly, vitamin B12 was adequate (> 350 pmol/L) in 25.1% of all subjects and in 20.3% of men ≥ 45 years. The rare allele frequencies were 0.21 for MTHFR 677TT, 0.11 for cSHMT 1420TT, 0.18 for DHFR 19 bp del/del, 0.20 for RFC1 80AA, and a gene–nutrient interaction was confirmed for folate concentrations according to MTHFR 677C>T and DHFR 19 bp del/del. Conclusion An Italian sample of healthy blood donors shows that an adequate concentration of plasma folate and vitamin B12 is reached only in a limited percentage of subjects, thus encouraging consideration for specific public health strategies.

scholarly journals Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER Case-Control Study

Blood ◽  
2006 ◽  
Vol 109 (7) ◽  
pp. 3050-3059 ◽  
Author(s):  
Unhee Lim ◽  
Sophia S. Wang ◽  
Patricia Hartge ◽  
Wendy Cozen ◽  
Linda E. Kelemen ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Carbon Metabolism ◽  
Vitamin B6 ◽  
Population Based ◽  
Nutrient Interactions ◽  
Protective Association ◽  
Non Hodgkin Lymphoma ◽  
Increased Risk ◽  
One Carbon Metabolism ◽  
Incident Cases

Abstract We previously reported a lower risk of non-Hodgkin lymphoma (NHL) associated with high consumption of vitamin B6 and methionine, dietary determinants of one-carbon metabolism. Evidence has linked genetic variants involved in one-carbon metabolism to NHL. We investigated 30 polymorphisms in 18 genes for their main effect on NHL among 1141 incident cases and 949 population-based controls and examined gene-nutrient interactions in a subgroup of 386 cases and 319 controls who provided detailed food-frequency information. Odds ratios (ORs) and 95% confidence intervals (CIs) were adjusted for age, sex, and race. We observed a decreased risk of NHL overall with BHMT Ex8+453A>T and increased risk with CBS Ex13+41C>T, FPGS Ex15-263T>C, and SHMT1 Ex12+138C>T and Ex12+236C>T. Furthermore, significant gene-nutrient interactions limited the protective association comparing high versus low vitamin B6 to FPGS Ex15-263T>C CC (OR = 0.22; 95% CI = 0.10-0.52), MTHFS IVS2-1411T>G TT/TG (OR = 0.54; 95% CI = 0.36-0.81), and MTR Ex26-20A>G AA (OR = 0.55; 95% CI = 0.35-0.86) genotypes, and the protective association of methionine to FTHFD Ex10-40G>T GG (OR = 0.63; 95% CI = 0.44-0.91), MTHFR Ex8-62A>C CC (OR = 0.13; 95% CI = 0.04-0.39), and MTRR Ex5+136T>C TT (OR = 0.67; 95% CI = 0.47-0.97) genotypes. Warranting replication, our finding of gene-nutrient interactions in one-carbon metabolism supports their etiologic involvement in lymphomagenesis.

Genetic Variation: Impact on Folate (and Choline) Bioefficacy

2010 ◽  
Vol 80 (45) ◽  
pp. 319-329 ◽  
Author(s):  
Allyson A. West ◽  
Marie A. Caudill
Keyword(s):  
Carbon Metabolism ◽  
Genetic Variants ◽  
Plasma Homocysteine ◽  
Water Soluble ◽  
Gene Interactions ◽  
Dietary Folate ◽  
Methyl Donors ◽  
Common Genetic Variants ◽  
One Carbon Metabolism ◽  
The Impact

Folate and choline are water-soluble micronutrients that serve as methyl donors in the conversion of homocysteine to methionine. Inadequacy of these nutrients can disturb one-carbon metabolism as evidenced by alterations in circulating folate and/or plasma homocysteine. Among common genetic variants that reside in genes regulating folate absorptive and metabolic processes, homozygosity for the MTHFR 677C > T variant has consistently been shown to have robust effects on status markers. This paper will review the impact of genetic variants in folate-metabolizing genes on folate and choline bioefficacy. Nutrient-gene and gene-gene interactions will be considered along with the need to account for these genetic variants when updating dietary folate and choline recommendations.

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